Published in Dig Dis Sci on July 01, 2001
Role of transactivation of the EGF receptor in signalling by G-protein-coupled receptors. Nature (1996) 5.40
Inhibition of histamine secretion by wortmannin through the blockade of phosphatidylinositol 3-kinase in RBL-2H3 cells. J Biol Chem (1993) 3.88
Activation of p70/p85 S6 kinase by a pathway independent of p21ras. Nature (1994) 3.67
Substrate recognition determinants of the mitogen-activated 70K S6 kinase from rat liver. J Biol Chem (1992) 2.38
Structure, expression, and regulation of protein kinases involved in the phosphorylation of ribosomal protein S6. J Biol Chem (1991) 2.27
p70 S6 kinase: an enigma with variations. Trends Biochem Sci (1996) 1.83
Trophic action of epidermal growth factor on the pancreas and gastroduodenal mucosa in rats. J Physiol (1982) 1.80
Tyrosine kinases in activation of the MAP kinase cascade by G-protein-coupled receptors. Nature (1996) 1.58
Stimulation of pancreatic growth by secretin, caerulein, and pentagastrin. Endocrinology (1980) 1.54
EGF induces biphasic S6 kinase activation: late phase is protein kinase C-dependent and contributes to mitogenicity. Cell (1989) 1.28
The heterotrimeric G q protein-coupled angiotensin II receptor activates p21 ras via the tyrosine kinase-Shc-Grb2-Sos pathway in cardiac myocytes. EMBO J (1996) 1.22
Stimulation of pancreatic acinar cell growth by CCK, epidermal growth factor, and insulin in vitro. Am J Physiol (1986) 1.16
Cell site and time course of DNA synthesis in pancreas after caerulein and secretin. Am J Physiol (1983) 1.15
Activation of Src family kinase activity by the G protein-coupled thrombin receptor in growth-responsive fibroblasts. J Biol Chem (1994) 1.15
Insulin, via its own receptor, regulates growth and amylase synthesis in pancreatic acinar AR42J cells. Diabetes (1985) 1.04
Phosphatidylinositol-3 kinase is activated in v-src, v-yes, and v-fps transformed chicken embryo fibroblasts. Oncogene (1991) 1.03
Cholecystokinin rapidly activates mitogen-activated protein kinase in rat pancreatic acini. Am J Physiol (1994) 1.02
Gastrin stimulates tyrosine phosphorylation of insulin receptor substrate 1 and its association with Grb2 and the phosphatidylinositol 3-kinase. J Biol Chem (1996) 0.96
Phosphatidylinositol 3'-kinase-independent p70 S6 kinase activation by fibroblast growth factor receptor-1 is important for proliferation but not differentiation of endothelial cells. J Biol Chem (1997) 0.88
p70s6k is activated by CCK in rat pancreatic acini. Am J Physiol (1997) 0.87
Src kinase pathways in extracellular Ca(2+)-dependent pancreatic enzyme secretion. Biochem Biophys Res Commun (1996) 0.83
EGF-induced activation of 70-kDa S6 kinase in CHO cells expressing human EGF receptors. Biochem Biophys Res Commun (1995) 0.79
A novel potent vasoconstrictor peptide produced by vascular endothelial cells. Nature (1988) 27.60
The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity. Nat Med (2001) 16.51
A new concept for macromolecular therapeutics in cancer chemotherapy: mechanism of tumoritropic accumulation of proteins and the antitumor agent smancs. Cancer Res (1986) 15.83
Tumor vascular permeability and the EPR effect in macromolecular therapeutics: a review. J Control Release (2000) 14.89
Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase. Nat Med (2002) 14.15
Mutation of the mouse klotho gene leads to a syndrome resembling ageing. Nature (1997) 13.77
Activation of the ATM kinase by ionizing radiation and phosphorylation of p53. Science (1998) 11.90
HLA-A2.1-associated peptides from a mutant cell line: a second pathway of antigen presentation. Science (1992) 8.68
The human endothelin family: three structurally and pharmacologically distinct isopeptides predicted by three separate genes. Proc Natl Acad Sci U S A (1989) 7.41
Cloning of a cDNA encoding a non-isopeptide-selective subtype of the endothelin receptor. Nature (1991) 7.11
Identification of a human melanoma antigen recognized by tumor-infiltrating lymphocytes associated with in vivo tumor rejection. Proc Natl Acad Sci U S A (1994) 6.93
Immune system impairment and hepatic fibrosis in mice lacking the dioxin-binding Ah receptor. Science (1995) 6.03
Characterization of peptides bound to the class I MHC molecule HLA-A2.1 by mass spectrometry. Science (1992) 5.99
DNA damage induces phosphorylation of the amino terminus of p53. Genes Dev (1997) 5.76
Identification of the immunodominant peptides of the MART-1 human melanoma antigen recognized by the majority of HLA-A2-restricted tumor infiltrating lymphocytes. J Exp Med (1994) 5.67
Monitoring the expression pattern of 1300 Arabidopsis genes under drought and cold stresses by using a full-length cDNA microarray. Plant Cell (2001) 5.11
Insulin stimulates the phosphorylation of the 95,000-dalton subunit of its own receptor. Science (1982) 5.01
Expression of endothelin-1 in the lungs of patients with pulmonary hypertension. N Engl J Med (1993) 4.91
Expression of cyclooxygenase-1 and -2 in human colorectal cancer. Cancer Res (1995) 4.52
The core protein of hepatitis C virus induces hepatocellular carcinoma in transgenic mice. Nat Med (1998) 4.48
Biological profiles of highly potent novel endothelin antagonists selective for the ETA receptor. Life Sci (1992) 4.39
Recognition of multiple epitopes in the human melanoma antigen gp100 by tumor-infiltrating T lymphocytes associated with in vivo tumor regression. J Immunol (1995) 4.31
Loss of Nkx2.1 homeobox gene function results in a ventral to dorsal molecular respecification within the basal telencephalon: evidence for a transformation of the pallidum into the striatum. Development (1999) 4.26
Insulin stimulates tyrosine phosphorylation of the insulin receptor in a cell-free system. Nature (1982) 3.90
Evaluation of acridinium-ester-labeled DNA probes for identification of Mycobacterium tuberculosis and Mycobacterium avium-Mycobacterium intracellulare complex in culture. J Clin Microbiol (1991) 3.88
Characterization of the common genetic defect in humans deficient in debrisoquine metabolism. Nature (1988) 3.69
Purification and properties of DNA gyrase from a fluoroquinolone-resistant strain of Escherichia coli. Antimicrob Agents Chemother (1986) 3.69
Human DNA-activated protein kinase phosphorylates serines 15 and 37 in the amino-terminal transactivation domain of human p53. Mol Cell Biol (1992) 3.68
The role of diffusion-weighted imaging in patients with brain tumors. AJNR Am J Neuroradiol (2001) 3.58
Phosphorylation of human p53 by p38 kinase coordinates N-terminal phosphorylation and apoptosis in response to UV radiation. EMBO J (1999) 3.46
Activation of phosphoinositide 3-kinase is required for PDGF-stimulated membrane ruffling. Curr Biol (1994) 3.44
Ghrelin is an appetite-stimulatory signal from stomach with structural resemblance to motilin. Gastroenterology (2001) 3.40
Peptides presented to the immune system by the murine class II major histocompatibility complex molecule I-Ad. Science (1992) 3.39
Isolation and characterization of linear deoxyribonucleic acid plasmids from Kluyveromyces lactis and the plasmid-associated killer character. J Bacteriol (1981) 3.30
Immunologic 'ignorance' of vascularized organ transplants in the absence of secondary lymphoid tissue. Nat Med (2000) 3.25
Dilation of the human immunodeficiency virus-1 envelope glycoprotein fusion pore revealed by the inhibitory action of a synthetic peptide from gp41. J Cell Biol (1998) 3.23
Wip1, a novel human protein phosphatase that is induced in response to ionizing radiation in a p53-dependent manner. Proc Natl Acad Sci U S A (1997) 3.19
Regulation of the phosphate regulon of Escherichia coli. Activation of pstS transcription by PhoB protein in vitro. J Mol Biol (1988) 3.14
Promoter analysis of the mouse sterol regulatory element-binding protein-1c gene. J Biol Chem (2000) 3.11
Some properties of subunits of DNA gyrase from Pseudomonas aeruginosa PAO1 and its nalidixic acid-resistant mutant. J Bacteriol (1987) 3.04
PI 3-kinase: structural and functional analysis of intersubunit interactions. EMBO J (1994) 3.02
Disruption of insulin receptor substrate 2 causes type 2 diabetes because of liver insulin resistance and lack of compensatory beta-cell hyperplasia. Diabetes (2000) 3.01
Human thyroid peroxidase: complete cDNA and protein sequence, chromosome mapping, and identification of two alternately spliced mRNAs. Proc Natl Acad Sci U S A (1987) 3.00
Primary structure, synthesis, and biological activity of rat endothelin, an endothelium-derived vasoconstrictor peptide. Proc Natl Acad Sci U S A (1988) 2.99
High-resolution structure of the oligomerization domain of p53 by multidimensional NMR. Science (1994) 2.98
Reduced hippocampal LTP and spatial learning in mice lacking NMDA receptor epsilon 1 subunit. Nature (1995) 2.91
Refined solution structure of the oligomerization domain of the tumour suppressor p53. Nat Struct Biol (1995) 2.75
Clonal isolation of muscle-derived cells capable of enhancing muscle regeneration and bone healing. J Cell Biol (2000) 2.75
Regulation of eIF-4E BP1 phosphorylation by mTOR. J Biol Chem (1997) 2.73
The mechanisms by which both heterozygous peroxisome proliferator-activated receptor gamma (PPARgamma) deficiency and PPARgamma agonist improve insulin resistance. J Biol Chem (2001) 2.69
Defects in tracheoesophageal and lung morphogenesis in Nkx2.1(-/-) mouse embryos. Dev Biol (1999) 2.69
Identification of liver X receptor-retinoid X receptor as an activator of the sterol regulatory element-binding protein 1c gene promoter. Mol Cell Biol (2001) 2.68
Induction of cyclooxygenase 2 in gastric mucosal lesions and its inhibition by the specific antagonist delays healing in mice. Gastroenterology (1997) 2.67
Impairment of suckling response, trigeminal neuronal pattern formation, and hippocampal LTD in NMDA receptor epsilon 2 subunit mutant mice. Neuron (1996) 2.62
Doppler ultrasound examination of multiple sclerosis patients and control participants: inter-observer agreement and association with disease. Eur J Vasc Endovasc Surg (2013) 2.62
Pathogenesis of Chiari malformation: a morphometric study of the posterior cranial fossa. J Neurosurg (1997) 2.60
Isolation and characterization of four plasmids from Bacillus subtilis. J Bacteriol (1977) 2.59
Requirement for activation of the serine-threonine kinase Akt (protein kinase B) in insulin stimulation of protein synthesis but not of glucose transport. Mol Cell Biol (1998) 2.59
Insulin stimulation of phosphorylation of the beta subunit of the insulin receptor. Formation of both phosphoserine and phosphotyrosine. J Biol Chem (1982) 2.58
De novo mutations of voltage-gated sodium channel alphaII gene SCN2A in intractable epilepsies. Neurology (2009) 2.53
Tyrosine-specific protein kinase activity is associated with the purified insulin receptor. Proc Natl Acad Sci U S A (1983) 2.49
A role for phosphoinositide 3-kinase in bacterial invasion. Science (1996) 2.46
Association of structural polymorphisms in the human period3 gene with delayed sleep phase syndrome. EMBO Rep (2001) 2.43
Insulin-induced phosphorylation and activation of cyclic nucleotide phosphodiesterase 3B by the serine-threonine kinase Akt. Mol Cell Biol (1999) 2.37
Localization of allodeterminants on H-2Kb antigens determined with monoclonal antibodies and H-2 mutant mice. Proc Natl Acad Sci U S A (1982) 2.33
Requirement of atypical protein kinase clambda for insulin stimulation of glucose uptake but not for Akt activation in 3T3-L1 adipocytes. Mol Cell Biol (1998) 2.32
Inhibition of the translocation of GLUT1 and GLUT4 in 3T3-L1 cells by the phosphatidylinositol 3-kinase inhibitor, wortmannin. Biochem J (1994) 2.30
Role of SH-PTP2, a protein-tyrosine phosphatase with Src homology 2 domains, in insulin-stimulated Ras activation. Mol Cell Biol (1994) 2.30
A novel membrane glycoprotein, SHPS-1, that binds the SH2-domain-containing protein tyrosine phosphatase SHP-2 in response to mitogens and cell adhesion. Mol Cell Biol (1996) 2.29
Impairment of motor coordination, Purkinje cell synapse formation, and cerebellar long-term depression in GluR delta 2 mutant mice. Cell (1995) 2.25
Structural studies of two ovalbumin glycopeptides in relation to the endo-beta-N-acetylglucosaminidase specificity. J Biol Chem (1975) 2.23
Insulin-induced receptor loss in cultured human lymphocytes is due to accelerated receptor degradation. Proc Natl Acad Sci U S A (1981) 2.18
Positive inotropic action of novel vasoconstrictor peptide endothelin on guinea pig atria. Am J Physiol (1988) 2.18
An Arabidopsis gene family encoding DRE/CRT binding proteins involved in low-temperature-responsive gene expression. Biochem Biophys Res Commun (1998) 2.18
Frequent presence of HBV in the sera of HBsAg-negative, anti-HBc-positive blood donors. Transfusion (2001) 2.16
Nodeless superconducting gap in A(x)Fe2Se2 (A=K,Cs) revealed by angle-resolved photoemission spectroscopy. Nat Mater (2011) 2.16
Structure of the mouse klotho gene and its two transcripts encoding membrane and secreted protein. FEBS Lett (1998) 2.15
Clonal rat parathyroid cell line expresses a parathyroid hormone-related peptide but not parathyroid hormone itself. Biochem Biophys Res Commun (1989) 2.15
Connectin, an elastic protein of muscle. Characterization and Function. J Biochem (1977) 2.14
A new photosystem II reaction center component (4.8 kDa protein) encoded by chloroplast genome. FEBS Lett (1988) 2.13
Definition of specific peptide motifs for four major HLA-A alleles. J Immunol (1994) 2.11
Developmental changes in distribution of NMDA receptor channel subunit mRNAs. Neuroreport (1992) 2.11
Protection of recurrent laryngeal nerve during neck surgery: a new combination of neutracer, laryngeal mask airway, and fiberoptic bronchoscope. Anesthesiology (1991) 2.10
Estimates of the cost-effectiveness of a single course of interferon-alpha 2b in patients with histologically mild chronic hepatitis C. Ann Intern Med (1997) 2.09
A novel oncogene, ost, encodes a guanine nucleotide exchange factor that potentially links Rho and Rac signaling pathways. EMBO J (1994) 2.09
Lymphatic manifestations of lymphangioleiomyomatosis. Lymphology (2014) 2.06
Regulation of nuclear translocation of forkhead transcription factor AFX by protein kinase B. Proc Natl Acad Sci U S A (1999) 2.04
An outbreak of enteritis due to Yersinia enterocolitica occurring at a junior high school. Jpn J Microbiol (1973) 2.02
Stomach regulates energy balance via acylated ghrelin and desacyl ghrelin. Gut (2005) 2.02
Molecular interactions between interferon consensus sequence binding protein and members of the interferon regulatory factor family. Proc Natl Acad Sci U S A (1994) 1.98
Measurement of soil contamination by radionuclides due to the Fukushima Dai-ichi Nuclear Power Plant accident and associated estimated cumulative external dose estimation. J Environ Radioact (2011) 1.98
Inhibition of RXR and PPARgamma ameliorates diet-induced obesity and type 2 diabetes. J Clin Invest (2001) 1.97
DNA binding of PhoB and its interaction with RNA polymerase. J Mol Biol (1996) 1.97
Curing of the killer deoxyribonucleic acid plasmids of Kluyveromyces lactis. J Bacteriol (1981) 1.97
Intergeneric transfer of deoxyribonucleic acid killer plasmids, pGKl1 and pGKl2, from Kluyveromyces lactis into Saccharomyces cerevisiae by cell fusion. J Bacteriol (1981) 1.97
Antagonism of ghrelin receptor reduces food intake and body weight gain in mice. Gut (2003) 1.96
Solvolytic desulfation of glycosaminoglycuronan sulfates with dimethyl sulfoxide containing water or methanol. Carbohydr Res (1977) 1.96
Phase I/II study of S-1 combined with cisplatin in patients with advanced gastric cancer. Br J Cancer (2003) 1.95
Selective scarcity of NMDA receptor channel subunits in the stratum lucidum (mossy fibre-recipient layer) of the mouse hippocampal CA3 subfield. Eur J Neurosci (1998) 1.95