Published in Proc Natl Acad Sci U S A on August 07, 2001
Persistent and transient replication of full-length hepatitis C virus genomes in cell culture. J Virol (2002) 5.21
Hepatitis C virus core protein blocks interferon signaling by interaction with the STAT1 SH2 domain. J Virol (2006) 1.87
Viral RNA mutations are region specific and increased by ribavirin in a full-length hepatitis C virus replication system. J Virol (2002) 1.52
Alpha interferon inhibits hepatitis C virus replication in primary human hepatocytes infected in vitro. J Virol (2002) 1.35
The role of the phosphatidylinositol 4-kinase PI4KA in hepatitis C virus-induced host membrane rearrangement. PLoS One (2011) 1.19
PKR-dependent mechanisms of gene expression from a subgenomic hepatitis C virus clone. J Virol (2002) 1.04
Involvement of PKR and RNase L in translational control and induction of apoptosis after Hepatitis C polyprotein expression from a vaccinia virus recombinant. Virol J (2005) 0.91
Protein kinase R modulates c-Fos and c-Jun signaling to promote proliferation of hepatocellular carcinoma with hepatitis C virus infection. PLoS One (2013) 0.90
Replicative homeostasis: a fundamental mechanism mediating selective viral replication and escape mutation. Virol J (2005) 0.88
Hepatitis C virus experimental model systems and antiviral drug research. Virol Sin (2010) 0.87
Human systems immunology: hypothesis-based modeling and unbiased data-driven approaches. Semin Immunol (2013) 0.80
Genetic evolution of structural region of hepatitis C virus in primary infection. World J Gastroenterol (2002) 0.80
Subcellular forms and biochemical events triggered in human cells by HCV polyprotein expression from a viral vector. Virol J (2008) 0.79
Replicative homeostasis III: implications for antiviral therapy and mechanisms of response and non-response. Virol J (2007) 0.79
Cell-based models of sustained, interferon-sensitive hepatitis C virus genotype 1 replication. J Virol Methods (2005) 0.78
Nanomedicines in the treatment of patients with hepatitis C co-infected with HIV--focus on pegylated interferon-alpha. Int J Nanomedicine (2006) 0.77
A vaccinia replication system for producing recombinant hepatitis C virus. World J Gastroenterol (2004) 0.75
Eukaryotic transient-expression system based on recombinant vaccinia virus that synthesizes bacteriophage T7 RNA polymerase. Proc Natl Acad Sci U S A (1986) 32.58
Replication of subgenomic hepatitis C virus RNAs in a hepatoma cell line. Science (1999) 24.31
Rising incidence of hepatocellular carcinoma in the United States. N Engl J Med (1999) 17.03
The prevalence of hepatitis C virus infection in the United States, 1988 through 1994. N Engl J Med (1999) 16.35
Efficient initiation of HCV RNA replication in cell culture. Science (2000) 15.12
Structure, sequence and expression of the hepatitis delta (delta) viral genome. Nature (1986) 7.38
Interferon alfa-2b alone or in combination with ribavirin for the treatment of relapse of chronic hepatitis C. International Hepatitis Interventional Therapy Group. N Engl J Med (1998) 6.23
Inhibition of the interferon-inducible protein kinase PKR by HCV E2 protein. Science (1999) 6.21
Transcripts from a single full-length cDNA clone of hepatitis C virus are infectious when directly transfected into the liver of a chimpanzee. Proc Natl Acad Sci U S A (1997) 6.09
The broad-spectrum antiviral ribonucleoside ribavirin is an RNA virus mutagen. Nat Med (2000) 5.73
The outcome of acute hepatitis C predicted by the evolution of the viral quasispecies. Science (2000) 5.49
Lack of protective immunity against reinfection with hepatitis C virus. Science (1992) 4.94
Mutations in the nonstructural protein 5A gene and response to interferon in patients with chronic hepatitis C virus 1b infection. N Engl J Med (1996) 4.61
Control of PKR protein kinase by hepatitis C virus nonstructural 5A protein: molecular mechanisms of kinase regulation. Mol Cell Biol (1998) 4.52
Tolerance and efficacy of oral ribavirin treatment of chronic hepatitis C: a multicenter trial. Hepatology (1997) 1.77
Broad-spectrum antiviral activity of the IMP dehydrogenase inhibitor VX-497: a comparison with ribavirin and demonstration of antiviral additivity with alpha interferon. Antimicrob Agents Chemother (2000) 1.58
Combination therapy with interferon plus ribavirin for the initial treatment of chronic hepatitis C. Semin Liver Dis (1999) 1.45
Pilot study of triple antiviral therapy for chronic hepatitis C in interferon alpha non-responders. Ital J Gastroenterol Hepatol (1999) 1.43
Molecular mechanisms of action of ribavirin. Rev Infect Dis (1991) 1.26
Heterogeneous nuclear ribonucleoprotein I (hnRNP-I/PTB) selectively binds the conserved 3' terminus of hepatitis C viral RNA. Biochem Biophys Res Commun (1999) 1.16
Mutations in nonstructural protein 5A gene and response to interferon in hepatitis C virus genotype 2 infection. Hepatology (1999) 1.10
Characterization of hepatitis C virus replication in cloned cells obtained from a human T-cell leukemia virus type 1-infected cell line, MT-2. J Virol (1996) 1.06
Management of hepatitis C: current and future perspectives. J Hepatol (1999) 1.04
Possible mechanisms of action and reasons for failure of antiviral therapy in chronic hepatitis C. J Hepatol (1999) 1.02
Evading the interferon response: hepatitis C virus and the interferon-induced protein kinase, PKR. Curr Top Microbiol Immunol (2000) 0.88
Interferon-alpha-induced gene expression: evidence for a selective effect of ouabain on activation of the ISGF3 transcription complex. Virology (1992) 0.85
Yeast Sm-like proteins function in mRNA decapping and decay. Nature (2000) 5.95
Succinate is an inflammatory signal that induces IL-1β through HIF-1α. Nature (2013) 5.44
Mammary hyperplasia and carcinoma in MMTV-cyclin D1 transgenic mice. Nature (1994) 5.34
TBX1 is responsible for cardiovascular defects in velo-cardio-facial/DiGeorge syndrome. Cell (2001) 4.60
Minimally important differences were estimated for the Functional Assessment of Cancer Therapy-Colorectal (FACT-C) instrument using a combination of distribution- and anchor-based approaches. J Clin Epidemiol (2005) 4.29
Concurrent enteric helminth infection modulates inflammation and gastric immune responses and reduces helicobacter-induced gastric atrophy. Nat Med (2000) 4.09
Salmonellosis associated with marijuana: a multistate outbreak traced by plasmid fingerprinting. N Engl J Med (1982) 4.03
Timing of CNS cell generation: a programmed sequence of neuron and glial cell production from isolated murine cortical stem cells. Neuron (2000) 3.99
Signaling by phosphoinositide-3,4,5-trisphosphate through proteins containing pleckstrin and Sec7 homology domains. Science (1997) 3.91
Patterns of nucleotide misincorporations during enzymatic amplification and direct large-scale sequencing of ancient DNA. Proc Natl Acad Sci U S A (2006) 3.40
Coupling of cell division to cell growth by translational control of the G1 cyclin CLN3 in yeast. Genes Dev (1997) 3.31
Hypertrophic gastropathy in Helicobacter felis-infected wild-type C57BL/6 mice and p53 hemizygous transgenic mice. Gastroenterology (1996) 3.15
Slowed recovery of rod photoresponse in mice lacking the GTPase accelerating protein RGS9-1. Nature (2000) 3.11
IKKalpha provides an essential link between RANK signaling and cyclin D1 expression during mammary gland development. Cell (2001) 3.10
Elevated levels of cyclin D1 protein in response to increased expression of eukaryotic initiation factor 4E. Mol Cell Biol (1993) 2.75
Improved insulin-sensitivity in mice heterozygous for PPAR-gamma deficiency. J Clin Invest (2000) 2.67
The human homologue of the yeast proteins Skb1 and Hsl7p interacts with Jak kinases and contains protein methyltransferase activity. J Biol Chem (1999) 2.64
A functional PtdIns(3)P-binding motif. Nature (1998) 2.38
A randomized trial comparing fluconazole with clotrimazole troches for the prevention of fungal infections in patients with advanced human immunodeficiency virus infection. NIAID AIDS Clinical Trials Group. N Engl J Med (1995) 2.29
Increased expression of eukaryotic translation initiation factors eIF-4E and eIF-2 alpha in response to growth induction by c-myc. Proc Natl Acad Sci U S A (1993) 2.29
Gene-centric association mapping of chromosome 3p implicates MST1 in IBD pathogenesis. Mucosal Immunol (2008) 2.28
An antagonist peptide-EPO receptor complex suggests that receptor dimerization is not sufficient for activation. Nat Struct Biol (1998) 2.24
An essential E box in the promoter of the gene encoding the mRNA cap-binding protein (eukaryotic initiation factor 4E) is a target for activation by c-myc. Mol Cell Biol (1996) 2.22
Structural determinants for regulation of phosphodiesterase by a G protein at 2.0 A. Nature (2001) 2.20
Binding of the Ras activator son of sevenless to insulin receptor substrate-1 signaling complexes. Science (1993) 2.14
Structural basis of 3-phosphoinositide recognition by pleckstrin homology domains. Mol Cell (2000) 2.13
Eukaryotic translation initiation factor 4E regulates expression of cyclin D1 at transcriptional and post-transcriptional levels. J Biol Chem (1995) 2.09
A double leucine within the GLUT4 glucose transporter COOH-terminal domain functions as an endocytosis signal. J Cell Biol (1994) 2.08
CpG ODN-induced matrix metalloproteinase-13 expression is mediated via activation of the ERK and NF-κB signalling pathways in odontoblast cells. Int Endod J (2013) 2.03
Identification of a novel syntaxin- and synaptobrevin/VAMP-binding protein, SNAP-23, expressed in non-neuronal tissues. J Biol Chem (1996) 1.94
A randomized trial of three antipneumocystis agents in patients with advanced human immunodeficiency virus infection. NIAID AIDS Clinical Trials Group. N Engl J Med (1995) 1.89
Coordination of cell growth with cell division. Curr Opin Genet Dev (1999) 1.87
Periorbital and orbital cellulitis before and after the advent of Haemophilus influenzae type B vaccination. Ophthalmology (2000) 1.86
Cabin 1, a negative regulator for calcineurin signaling in T lymphocytes. Immunity (1998) 1.85
Distinct stages in adipogenesis revealed by retinoid inhibition of differentiation after induction of PPARgamma. Mol Cell Biol (1996) 1.84
Total parenteral nutrition and bowel rest modify the metabolic response to endotoxin in humans. Ann Surg (1989) 1.79
Phosphotyrosine-dependent interaction of SHC and insulin receptor substrate 1 with the NPEY motif of the insulin receptor via a novel non-SH2 domain. Mol Cell Biol (1995) 1.77
Neural network diagnosis of malignant melanoma from color images. IEEE Trans Biomed Eng (1994) 1.69
Common acute lymphoblastic leukemia antigen (CALLA) is active neutral endopeptidase 24.11 ("enkephalinase"): direct evidence by cDNA transfection analysis. Proc Natl Acad Sci U S A (1989) 1.67
Genetic variants in the region harbouring IL2/IL21 associated with ulcerative colitis. Gut (2009) 1.65
Liquid chromatography/mass spectrometry of phospholipids using electrospray ionization. Anal Chem (1994) 1.61
Female genital tuberculosis: hysterosalpingographic appearances. Br J Radiol (2004) 1.59
The type I serine/threonine kinase receptor ActRIA (ALK2) is required for gastrulation of the mouse embryo. Development (1999) 1.59
Pancreatic gastrin stimulates islet differentiation of transforming growth factor alpha-induced ductular precursor cells. J Clin Invest (1993) 1.55
High-salt diet induces gastric epithelial hyperplasia and parietal cell loss, and enhances Helicobacter pylori colonization in C57BL/6 mice. Cancer Res (1999) 1.55
ADP-ribosylation factor 6 as a target of guanine nucleotide exchange factor GRP1. J Biol Chem (1999) 1.53
Peroxynitrite-induced rat colitis--a new model of colonic inflammation. Gastroenterology (1993) 1.53
Study of the distribution of non-point source pollution in the watershed of the Miyun Reservoir, Beijing, China. Water Sci Technol (2001) 1.49
In vivo proton MRS of normal pancreas metabolites during breath-holding and free-breathing. Clin Radiol (2012) 1.48
Hepatocyte growth factor inhibits growth of hepatocellular carcinoma cells. Proc Natl Acad Sci U S A (1992) 1.48
Phase-modulated stored waveform inverse Fourier transform excitation for trapped ion mass spectrometry. Anal Chem (1987) 1.48
Mechanisms for recF-dependent and recB-dependent pathways of postreplication repair in UV-irradiated Escherichia coli uvrB. J Bacteriol (1983) 1.47
Experimental colitis impairs linear bone growth independent of nutritional factors. J Pediatr Gastroenterol Nutr (1997) 1.46
Gastrin deficiency results in altered gastric differentiation and decreased colonic proliferation in mice. Gastroenterology (1997) 1.45
Multiple factors conferring high radioresistance in insect Sf9 cells. Mutagenesis (2009) 1.45
Distinct polyphosphoinositide binding selectivities for pleckstrin homology domains of GRP1-like proteins based on diglycine versus triglycine motifs. J Biol Chem (2000) 1.45
Fungal diarrhoea: association of different fungi and seasonal variation in their incidence. Mycopathologia (1990) 1.44
Gastrin is a target of the beta-catenin/TCF-4 growth-signaling pathway in a model of intestinal polyposis. J Clin Invest (2000) 1.44
Interactions of Drosophila Cbl with epidermal growth factor receptors and role of Cbl in R7 photoreceptor cell development. Mol Cell Biol (1997) 1.43
Examination of reproductive aging milestones among women who carry the FMR1 premutation. Hum Reprod (2007) 1.42
Prediction and confirmation of a site critical for effector regulation of RGS domain activity. Nat Struct Biol (2001) 1.42
The targeting of the cyclin D1 oncogene by an Epstein-Barr virus promoter in transgenic mice causes dysplasia in the tongue, esophagus and forestomach. Oncogene (1997) 1.40
Laboratory investigation of ecological factors influencing the environmental presence of Burkholderia pseudomallei. Microbiol Immunol (1996) 1.40
Enalapril does not improve left ventricular diastolic dysfunction in young and mild hypertensives without concomitant hypertrophy. Am J Hypertens (1996) 1.39
Cloning and characterization of RGS9-2: a striatal-enriched alternatively spliced product of the RGS9 gene. J Neurosci (1999) 1.37
Insulin action on GLUT4 traffic visualized in single 3T3-l1 adipocytes by using ultra-fast microscopy. Mol Biol Cell (2001) 1.36
HIV-1 tat binds TAFII250 and represses TAFII250-dependent transcription of major histocompatibility class I genes. Proc Natl Acad Sci U S A (1998) 1.36
Primary leiomyosarcoma of inferior vena cava, a rare entity: Imaging features. Australas Radiol (2001) 1.32
Cell-specific expression of tubby gene family members (tub, Tulp1,2, and 3) in the retina. Invest Ophthalmol Vis Sci (1999) 1.31
Determinants of accrual of women to a large, multicenter clinical trials program of human immunodeficiency virus infection. The AIDS Clinical Trials Group. J Acquir Immune Defic Syndr (1993) 1.31
Exofacial epitope-tagged glucose transporter chimeras reveal COOH-terminal sequences governing cellular localization. J Cell Biol (1993) 1.30
Helicobacter pylori--not a good bug after all! N Engl J Med (2001) 1.30
Association of copy number variation in the FCGR3B gene with risk of autoimmune diseases. Genes Immun (2009) 1.29
Enzyme replacement therapy for Gaucher disease: skeletal responses to macrophage-targeted glucocerebrosidase. Pediatrics (1995) 1.29
Elevated plasma chitotriosidase activity in various lysosomal storage disorders. J Inherit Metab Dis (1995) 1.28
Overexpression of glycine-extended gastrin in transgenic mice results in increased colonic proliferation. J Clin Invest (1999) 1.28
Hepatocyte growth factor in transgenic mice: effects on hepatocyte growth, liver regeneration and gene expression. Hepatology (1994) 1.28
Transgenic expression of tpr-met oncogene leads to development of mammary hyperplasia and tumors. J Clin Invest (1996) 1.27
Inducible expression of transforming growth factor beta1 in papillomas causes rapid metastasis. Cancer Res (2001) 1.27
Inviability of dam recA and dam recB cells of Escherichia coli is correlated with their inability to repair DNA double-strand breaks produced by mismatch repair. J Bacteriol (1986) 1.24
SEK1/MKK4 is required for maintenance of a normal peripheral lymphoid compartment but not for lymphocyte development. Immunity (1998) 1.22
Atheroembolic renal failure after invasive procedures. Natural history based on 52 histologically proven cases. Medicine (Baltimore) (1995) 1.21
Primary hyperparathyroidism caused by parathyroid-targeted overexpression of cyclin D1 in transgenic mice. J Clin Invest (2001) 1.20
Cyclin D1 (PRAD1) protein expression in breast cancer: approximately one-third of infiltrating mammary carcinomas show overexpression of the cyclin D1 oncogene. Mod Pathol (1995) 1.19
Co-expression of Gbeta5 enhances the function of two Ggamma subunit-like domain-containing regulators of G protein signaling proteins. J Biol Chem (2000) 1.19
Spasmolytic polypeptide: a trefoil peptide secreted by rat gastric mucous cells. Gastroenterology (1994) 1.19
Mechanisms of arsenic-induced cell transformation. Biol Trace Elem Res (1990) 1.18
The oncoprotein kinase chaperone CDC37 functions as an oncogene in mice and collaborates with both c-myc and cyclin D1 in transformation of multiple tissues. Mol Cell Biol (2000) 1.18
The keratin 19 promoter is potent for cell-specific targeting of genes in transgenic mice. Gastroenterology (2001) 1.16
Modulation of gastrointestinal function by MuDelta, a mixed µ opioid receptor agonist/ µ opioid receptor antagonist. Br J Pharmacol (2012) 1.16
A role for phospholipase D in GLUT4 glucose transporter translocation. J Biol Chem (2000) 1.15
A regulator of G protein signaling interaction surface linked to effector specificity. Proc Natl Acad Sci U S A (2000) 1.15
Transforming growth factor alpha disrupts the normal program of cellular differentiation in the gastric mucosa of transgenic mice. Development (1995) 1.14
Progastrin expression predisposes mice to colon carcinomas and adenomas in response to a chemical carcinogen. Gastroenterology (2000) 1.14
Characterization of unique amphipathic antimicrobial peptides from venom of the scorpion Pandinus imperator. Biochem J (2001) 1.14
Association of Helicobacter pylori infection with dyspeptic symptoms in patients undergoing gastroduodenoscopy. Am J Med (1990) 1.13