Requirement for transforming growth factor beta1 in controlling T cell apoptosis.

PubWeight™: 1.82‹?› | Rank: Top 3%

🔗 View Article (PMC 2193497)

Published in J Exp Med on August 20, 2001

Authors

W Chen1, W Jin, H Tian, P Sicurello, M Frank, J M Orenstein, S M Wahl

Author Affiliations

1: Cellular Immunology Section, Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland 20892, USA.

Articles citing this

Conversion of peripheral CD4+CD25- naive T cells to CD4+CD25+ regulatory T cells by TGF-beta induction of transcription factor Foxp3. J Exp Med (2003) 26.05

Transforming growth factor-beta signaling curbs thymic negative selection promoting regulatory T cell development. Immunity (2010) 3.69

IL-7 promotes the transition of CD4 effectors to persistent memory cells. J Exp Med (2003) 2.87

Apoptotic neutrophils and T cells sequester chemokines during immune response resolution through modulation of CCR5 expression. Nat Immunol (2006) 2.37

'Yin-Yang' functions of transforming growth factor-beta and T regulatory cells in immune regulation. Immunol Rev (2007) 1.98

Control of the development of CD8αα+ intestinal intraepithelial lymphocytes by TGF-β. Nat Immunol (2011) 1.94

TGF-beta and regulatory T cell in immunity and autoimmunity. J Clin Immunol (2008) 1.49

T cell apoptosis and reactive oxygen species. J Clin Invest (2003) 1.35

The potential of human regulatory T cells generated ex vivo as a treatment for lupus and other chronic inflammatory diseases. Arthritis Res (2002) 1.30

Transforming growth factor-beta suppresses the activation of CD8+ T-cells when naive but promotes their survival and function once antigen experienced: a two-faced impact on autoimmunity. Diabetes (2008) 1.25

Gamma interferon-induced T-cell loss in virulent Mycobacterium avium infection. Infect Immun (2005) 1.21

The mitochondrial component of intracrine action. Am J Physiol Heart Circ Physiol (2010) 1.03

TGF beta 1 inhibits Ca2+-calcineurin-mediated activation in thymocytes. J Immunol (2003) 1.02

Self-antigen recognition by TGF beta1-deficient T cells causes their activation and systemic inflammation. Lab Invest (2006) 1.01

Mechanism of oral tolerance induction to therapeutic proteins. Adv Drug Deliv Rev (2012) 0.96

TGF-beta signaling in thymic epithelial cells regulates thymic involution and postirradiation reconstitution. Blood (2008) 0.92

Mutual antagonism of TGF-beta and Interleukin-2 in cell survival and lineage commitment of induced regulatory T cells. Cell Death Differ (2012) 0.88

Homeostatic role of transforming growth factor-beta in the oral cavity and esophagus of mice and its expression by mast cells in these tissues. Am J Pathol (2009) 0.86

TGF-β sensitivity restrains CD8+ T cell homeostatic proliferation by enforcing sensitivity to IL-7 and IL-15. PLoS One (2012) 0.86

TGFβ in T cell biology and tumor immunity: Angel or devil? Cytokine Growth Factor Rev (2014) 0.85

Tuftsin-driven experimental autoimmune encephalomyelitis recovery requires neuropilin-1. Glia (2016) 0.85

Development of thymic Foxp3(+) regulatory T cells: TGF-β matters. Eur J Immunol (2015) 0.83

Lethal effect of CD3-specific antibody in mice deficient in TGF-beta1 by uncontrolled flu-like syndrome. J Immunol (2009) 0.82

Calcineurin deficiency decreases inflammatory lesions in transforming growth factor beta1-deficient mice. Clin Exp Immunol (2009) 0.77

T cell death and transforming growth factor beta1. J Exp Med (2001) 0.75

Articles cited by this

Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation. J Cell Biol (1992) 34.17

Induction of apoptotic program in cell-free extracts: requirement for dATP and cytochrome c. Cell (1996) 16.73

Targeted disruption of the mouse transforming growth factor-beta 1 gene results in multifocal inflammatory disease. Nature (1992) 16.46

Prevention of apoptosis by Bcl-2: release of cytochrome c from mitochondria blocked. Science (1997) 16.09

The release of cytochrome c from mitochondria: a primary site for Bcl-2 regulation of apoptosis. Science (1997) 15.25

Molecular characterization of mitochondrial apoptosis-inducing factor. Nature (1999) 14.41

An essential role for NF-kappaB in preventing TNF-alpha-induced cell death. Science (1996) 13.87

The Fas death factor. Science (1995) 13.81

Macrophages that have ingested apoptotic cells in vitro inhibit proinflammatory cytokine production through autocrine/paracrine mechanisms involving TGF-beta, PGE2, and PAF. J Clin Invest (1998) 13.05

Transforming growth factor beta 1 null mutation in mice causes excessive inflammatory response and early death. Proc Natl Acad Sci U S A (1993) 10.82

Production of transforming growth factor beta by human T lymphocytes and its potential role in the regulation of T cell growth. J Exp Med (1986) 9.86

The TNF receptor superfamily of cellular and viral proteins: activation, costimulation, and death. Cell (1994) 9.25

Molecular cloning and expression of the Fas ligand, a novel member of the tumor necrosis factor family. Cell (1993) 9.06

Regulatory T cell clones induced by oral tolerance: suppression of autoimmune encephalomyelitis. Science (1994) 8.69

Autocrine T-cell suicide mediated by APO-1/(Fas/CD95) Nature (1995) 8.23

Fas(CD95)/FasL interactions required for programmed cell death after T-cell activation. Nature (1995) 7.52

Cell-autonomous Fas (CD95)/Fas-ligand interaction mediates activation-induced apoptosis in T-cell hybridomas. Nature (1995) 6.85

Antibodies to CD3/T-cell receptor complex induce death by apoptosis in immature T cells in thymic cultures. Nature (1989) 6.70

T-cell apoptosis detected in situ during positive and negative selection in the thymus. Nature (1994) 6.20

CD28 costimulation can promote T cell survival by enhancing the expression of Bcl-XL. Immunity (1995) 5.77

Targeted disruption of SMAD3 results in impaired mucosal immunity and diminished T cell responsiveness to TGF-beta. EMBO J (1999) 5.49

Induction of apoptosis in mature T cells by tumour necrosis factor. Nature (1995) 5.26

T cell memory. Annu Rev Immunol (1998) 5.20

Sequential reduction of mitochondrial transmembrane potential and generation of reactive oxygen species in early programmed cell death. J Exp Med (1995) 4.88

Mitochondrial control of apoptosis. Immunol Today (1997) 4.74

The fas antigen is involved in peripheral but not thymic deletion of T lymphocytes in T cell receptor transgenic mice. Immunity (1994) 4.26

Cloning and expression of cDNAs for two distinct murine tumor necrosis factor receptors demonstrate one receptor is species specific. Proc Natl Acad Sci U S A (1991) 3.76

Engagement of cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) induces transforming growth factor beta (TGF-beta) production by murine CD4(+) T cells. J Exp Med (1998) 3.56

TGFbeta signaling: receptors, transducers, and Mad proteins. Cell (1996) 3.31

Selective events in T cell development. Annu Rev Immunol (1994) 3.01

Transforming growth factor beta: the good, the bad, and the ugly. J Exp Med (1994) 2.86

Reactive oxygen species regulate activation-induced T cell apoptosis. Immunity (1999) 2.84

The central executioner of apoptosis: multiple connections between protease activation and mitochondria in Fas/APO-1/CD95- and ceramide-induced apoptosis. J Exp Med (1997) 2.83

Mitochondrial release of caspase-2 and -9 during the apoptotic process. J Exp Med (1999) 2.79

Mitochondria and apoptosis. Eur J Biochem (1998) 2.58

Reciprocal IFN-gamma and TGF-beta responses regulate the occurrence of mucosal inflammation. Immunol Today (1997) 2.52

Activation interferes with the APO-1 pathway in mature human T cells. Int Immunol (1993) 2.45

Oral tolerance: immune mechanisms and treatment of autoimmune diseases. Immunol Today (1997) 2.44

Maternal rescue of transforming growth factor-beta 1 null mice. Science (1994) 2.28

Immune dysregulation in TGF-beta 1-deficient mice. J Immunol (1994) 2.00

Transforming growth factor beta: a matter of life and death. J Leukoc Biol (1994) 1.97

Membrane Fas ligand kills human peripheral blood T lymphocytes, and soluble Fas ligand blocks the killing. J Exp Med (1997) 1.80

Bcl-x(L) can inhibit apoptosis in cells that have undergone Fas-induced protease activation. Proc Natl Acad Sci U S A (1997) 1.78

Selective apoptosis of CD4+CD8+ thymocytes by the anti-Fas antibody. J Exp Med (1995) 1.57

Factors involved in the differentiation of TGF-beta-producing cells from naive CD4+ T cells: IL-4 and IFN-gamma have opposing effects, while TGF-beta positively regulates its own production. J Immunol (1998) 1.56

Control of CD4 effector fate: transforming growth factor beta 1 and interleukin 2 synergize to prevent apoptosis and promote effector expansion. J Exp Med (1995) 1.41

Differential regulation of transforming growth factor beta and interleukin 2 genes in human T cells: demonstration by usage of novel competitor DNA constructs in the quantitative polymerase chain reaction. J Exp Med (1991) 1.40

Expression and function of mouse Fas antigen on immature and mature T cells. J Immunol (1995) 1.38

Macrophage production of TGF-beta and regulation by TGF-beta. Ann N Y Acad Sci (1990) 1.33

In vivo expression of transforming growth factor-beta1 in humans: stimulation by cyclosporine. Transplantation (1998) 1.29

Intrathymic and extrathymic clonal deletion of T cells. Curr Opin Immunol (1995) 1.20

T cell growth cytokines cause the superinduction of molecules mediating antigen-induced T lymphocyte death. J Immunol (1998) 1.19

Localization of transforming growth factor-beta 1 in mitochondria of murine heart and liver. Cell Regul (1991) 1.17

Transforming growth factor beta1 inhibits Fas ligand expression and subsequent activation-induced cell death in T cells via downregulation of c-Myc. J Exp Med (1999) 1.14

Oral delivery of group A streptococcal cell walls augments circulating TGF-beta and suppresses streptococcal cell wall arthritis. J Immunol (1998) 1.10

Fas- and activation-induced apoptosis are reduced in human T cells preactivated in the presence of TGF-beta 1. J Immunol (1996) 1.01

The mitochondrion as an integrator/coordinator of cell death pathways. Cell Death Differ (1998) 0.97

Mechanisms of acquired thymic tolerance in vivo: intrathymic injection of antigen induces apoptosis of thymocytes and peripheral T cell anergy. J Immunol (1998) 0.89

Articles by these authors

HIV infection is active and progressive in lymphoid tissue during the clinically latent stage of disease. Nature (1993) 15.54

Electrophoretic separations of large DNA molecules by periodic inversion of the electric field. Science (1986) 13.57

Detection of AIDS virus in macrophages in brain tissue from AIDS patients with encephalopathy. Science (1986) 11.74

N-formylmethionyl peptides as chemoattractants for leucocytes. Proc Natl Acad Sci U S A (1975) 9.24

Efficient isolation and propagation of human immunodeficiency virus on recombinant colony-stimulating factor 1-treated monocytes. J Exp Med (1988) 9.21

A novel phenotypic drug susceptibility assay for human immunodeficiency virus type 1. Antimicrob Agents Chemother (2000) 8.54

p6Gag is required for particle production from full-length human immunodeficiency virus type 1 molecular clones expressing protease. J Virol (1995) 6.87

Accumulation of dietary cholesterol in sitosterolemia caused by mutations in adjacent ABC transporters. Science (2000) 6.73

Random-clone strategy for genomic restriction mapping in yeast. Proc Natl Acad Sci U S A (1986) 6.44

Transforming growth factor type beta induces monocyte chemotaxis and growth factor production. Proc Natl Acad Sci U S A (1987) 6.43

The human immunodeficiency virus type 1-specific protein vpu is required for efficient virus maturation and release. J Virol (1990) 6.08

Studies in subjects with long-term nonprogressive human immunodeficiency virus infection. N Engl J Med (1995) 5.69

Mice lacking Smad3 show accelerated wound healing and an impaired local inflammatory response. Nat Cell Biol (1999) 5.58

Nogo-A is a myelin-associated neurite outgrowth inhibitor and an antigen for monoclonal antibody IN-1. Nature (2000) 5.22

Hemizygosity at the elastin locus in a developmental disorder, Williams syndrome. Nat Genet (1993) 5.09

Single amino acid changes in the human immunodeficiency virus type 1 matrix protein block virus particle production. J Virol (1994) 4.40

Multiple effects of mutations in human immunodeficiency virus type 1 integrase on viral replication. J Virol (1995) 4.27

Molecular cloning of mRNA from 3T3 adipocytes. Regulation of mRNA content for glycerophosphate dehydrogenase and other differentiation-dependent proteins during adipocyte development. J Biol Chem (1983) 4.14

Lipid composition and fluidity of the human immunodeficiency virus envelope and host cell plasma membranes. Proc Natl Acad Sci U S A (1993) 4.11

The macrophage in the persistence and pathogenesis of HIV infection. AIDS (1989) 4.06

PA-457: a potent HIV inhibitor that disrupts core condensation by targeting a late step in Gag processing. Proc Natl Acad Sci U S A (2003) 4.03

Macrophages as a source of HIV during opportunistic infections. Science (1997) 3.92

Sexual transmission of an HIV-1 variant resistant to multiple reverse-transcriptase and protease inhibitors. N Engl J Med (1998) 3.81

The presynaptic particle web: ultrastructure, composition, dissolution, and reconstitution. Neuron (2001) 3.68

Engagement of cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) induces transforming growth factor beta (TGF-beta) production by murine CD4(+) T cells. J Exp Med (1998) 3.56

Interferon-alpha but not AZT suppresses HIV expression in chronically infected cell lines. Science (1989) 3.43

Isolation of human mononuclear cell subsets by counterflow centrifugal elutriation (CCE). I. Characterization of B-lymphocyte-, T-lymphocyte-, and monocyte-enriched fractions by flow cytometric analysis. Cell Immunol (1984) 3.36

A mutant of human immunodeficiency virus with reduced RNA packaging and abnormal particle morphology. J Virol (1990) 3.33

Gene expression profiling of cells, tissues, and developmental stages of the nematode C. elegans. Cold Spring Harb Symp Quant Biol (2003) 3.22

TGF-beta released by apoptotic T cells contributes to an immunosuppressive milieu. Immunity (2001) 3.20

Lymphocyte-mediated activation of fibroblast proliferation and collagen production. J Immunol (1978) 3.16

Collagenase production by endotoxin-activated macrophages. Proc Natl Acad Sci U S A (1974) 3.05

Surface proteins from Helicobacter pylori exhibit chemotactic activity for human leukocytes and are present in gastric mucosa. J Exp Med (1992) 3.03

Soluble surface proteins from Helicobacter pylori activate monocytes/macrophages by lipopolysaccharide-independent mechanism. J Clin Invest (1991) 3.00

Suppression of arthritis by an inhibitor of nitric oxide synthase. J Exp Med (1993) 2.98

Isolation and characterization of a new human microsporidian, Encephalitozoon hellem (n. sp.), from three AIDS patients with keratoconjunctivitis. J Infect Dis (1991) 2.95

Secretory leukocyte protease inhibitor: a human saliva protein exhibiting anti-human immunodeficiency virus 1 activity in vitro. J Clin Invest (1995) 2.95

A transmembrane guanylyl cyclase (DAF-11) and Hsp90 (DAF-21) regulate a common set of chemosensory behaviors in caenorhabditis elegans. Genetics (2000) 2.90

Role of the Gag matrix domain in targeting human immunodeficiency virus type 1 assembly. J Virol (2000) 2.85

Collagenase production by lymphokine-activated macrophages. Science (1975) 2.64

Inflammatory and immunomodulatory roles of TGF-beta. Immunol Today (1989) 2.56

Infection and replication of HIV-1 in purified progenitor cells of normal human bone marrow. Science (1988) 2.55

Genetically controlled total deficiency of the fourth component of complement in the guinea pig. Science (1970) 2.55

HIV-1 induces phenotypic and functional perturbations of B cells in chronically infected individuals. Proc Natl Acad Sci U S A (2001) 2.54

Contribution of increasing CO2 and climate to carbon storage by ecosystems in the United States. Science (2000) 2.51

Secretory leukocyte protease inhibitor mediates non-redundant functions necessary for normal wound healing. Nat Med (2000) 2.48

Septata intestinalis N. G., N. Sp., an intestinal microsporidian associated with chronic diarrhea and dissemination in AIDS patients. J Eukaryot Microbiol (1993) 2.48

Inhibition of human immunodeficiency virus type 1 infectivity by secretory leukocyte protease inhibitor occurs prior to viral reverse transcription. Blood (1997) 2.41

Macrophage activation by mycobacterial water soluble compounds and synthetic muramyl dipeptide. J Immunol (1979) 2.39

BRCA1 physically associates with p53 and stimulates its transcriptional activity. Oncogene (1998) 2.39

Lipopolysaccharide, tumor necrosis factor-alpha, and IL-1 beta prevent programmed cell death (apoptosis) in human peripheral blood monocytes. J Immunol (1991) 2.39

Role of a peptidase in phagocyte chemotaxis. Proc Natl Acad Sci U S A (1976) 2.38

High-level variability in the ORF-K1 membrane protein gene at the left end of the Kaposi's sarcoma-associated herpesvirus genome defines four major virus subtypes and multiple variants or clades in different human populations. J Virol (1999) 2.27

Severe hypoglycemia in children with insulin-dependent diabetes mellitus: frequency and predisposing factors. J Pediatr (1989) 2.24

Differential regulation of human monocyte programmed cell death (apoptosis) by chemotactic factors and pro-inflammatory cytokines. J Immunol (1991) 2.23

Small intestinal injury and parasitic diseases in AIDS. Ann Intern Med (1990) 2.21

Rapid onset synovial inflammation and hyperplasia induced by transforming growth factor beta. J Exp Med (1990) 2.19

Transforming growth factor beta 1 suppresses acute and chronic arthritis in experimental animals. J Clin Invest (1991) 2.18

Molecular characterization of two mammalian bHLH-PAS domain proteins selectively expressed in the central nervous system. Proc Natl Acad Sci U S A (1997) 2.15

Association of circulating receptor Fc gamma RIII-positive monocytes in AIDS patients with elevated levels of transforming growth factor-beta. J Clin Invest (1991) 2.11

Monocyte function in the acquired immune deficiency syndrome. Defective chemotaxis. J Clin Invest (1984) 2.10

GIS-based measures of environmental equity: exploring their sensitivity and significance. J Expo Anal Environ Epidemiol (1999) 2.07

Comparison of genetic variability at multiple loci across the genomes of the major subtypes of Kaposi's sarcoma-associated herpesvirus reveals evidence for recombination and for two distinct types of open reading frame K15 alleles at the right-hand end. J Virol (1999) 2.04

Immune dysregulation in TGF-beta 1-deficient mice. J Immunol (1994) 2.00

Transforming growth factor beta: a matter of life and death. J Leukoc Biol (1994) 1.97

Intestinal macrophages lack CD14 and CD89 and consequently are down-regulated for LPS- and IgA-mediated activities. J Immunol (2001) 1.95

Increased steady state mRNA levels of the STM and KNAT1 homeobox genes in cytokinin overproducing Arabidopsis thaliana indicate a role for cytokinins in the shoot apical meristem. Plant J (1999) 1.88

Comparison of three staining methods for detecting microsporidia in fluids. J Clin Microbiol (1995) 1.85

The pathogenesis of group A streptococcal cell wall-induced polyarthritis in the rat. Comparative studies in arthritis resistant and susceptible inbred rat strains. Arthritis Rheum (1983) 1.83

Candidate microbicides block HIV-1 infection of human immature Langerhans cells within epithelial tissue explants. J Exp Med (2000) 1.80

Candida albicans in patients with the acquired immunodeficiency syndrome: absence of a novel of hypervirulent strain. J Infect Dis (1990) 1.77

Production and application of electron vortex beams. Nature (2010) 1.76

Intestinal macrophages and response to microbial encroachment. Mucosal Immunol (2010) 1.76

Role of the thymus in streptococcal cell wall-induced arthritis and hepatic granuloma formation. Comparative studies of pathology and cell wall distribution in athymic and euthymic rats. J Clin Invest (1985) 1.73

Prevalence of intestinal microsporidiosis in HIV-infected individuals referred for gastroenterological evaluation. Am J Gastroenterol (1994) 1.73

Topical estrogen accelerates cutaneous wound healing in aged humans associated with an altered inflammatory response. Am J Pathol (1999) 1.70

Secretory leukocyte protease inhibitor suppresses the production of monocyte prostaglandin H synthase-2, prostaglandin E2, and matrix metalloproteinases. J Clin Invest (1997) 1.67

Cytotoxic T lymphocytes after oral immunization with attenuated vaccine strains of Salmonella typhi in humans. J Immunol (1995) 1.67

Cardiologists' practices compared with practice guidelines: use of beta-blockade after acute myocardial infarction. J Am Coll Cardiol (1995) 1.67

Lead poisoning in children of lead workers: home contamination with industrial dust. N Engl J Med (1977) 1.66

Tissue diagnosis of intestinal microsporidiosis using the chromotrope-2R modified trichrome stain. Arch Pathol Lab Med (1993) 1.64

Macrophage-HIV interaction: viral isolation and target cell tropism. AIDS (1990) 1.64

NIH conference. Rheumatoid arthritis: evolving concepts of pathogenesis and treatment. Ann Intern Med (1984) 1.61

A novel member of the netrin family, beta-netrin, shares homology with the beta chain of laminin: identification, expression, and functional characterization. J Cell Biol (2000) 1.59

Treatment with albendazole for intestinal disease due to Enterocytozoon bieneusi in patients with AIDS. J Infect Dis (1994) 1.59

Do picture archiving and communication systems improve report turnaround times? J Digit Imaging (2000) 1.59

Secretory leukocyte protease inhibitor (SLPI) in mucosal fluids inhibits HIV-I. Oral Dis (1997) 1.58

Macrophage production of fibronectin, a chemoattractant for fibroblasts. J Immunol (1981) 1.58

Fractal morphology, imaging and mass spectrometry of single aerosol particles in flight. Nature (2012) 1.56

Cryptotomography: reconstructing 3D Fourier intensities from randomly oriented single-shot diffraction patterns. Phys Rev Lett (2010) 1.55

Role of complement activation in a model of adult respiratory distress syndrome. J Clin Invest (1980) 1.55

Interferon gamma induces the expression of human immunodeficiency virus in persistently infected promonocytic cells (U1) and redirects the production of virions to intracytoplasmic vacuoles in phorbol myristate acetate-differentiated U1 cells. J Exp Med (1992) 1.55

Macrophage- and astrocyte-derived transforming growth factor beta as a mediator of central nervous system dysfunction in acquired immune deficiency syndrome. J Exp Med (1991) 1.55

Supravalvular aortic stenosis associated with a deletion disrupting the elastin gene. J Clin Invest (1994) 1.54

Gambling and pathological gambling among university students. Addict Behav (1991) 1.53

Induction of guinea pig B-cell lymphokine synthesis by mitogenic and nonmitogenic signals to Fc, Ig, and C3 receptors. J Exp Med (1974) 1.53