TGF-β sensitivity restrains CD8+ T cell homeostatic proliferation by enforcing sensitivity to IL-7 and IL-15.

PubWeight™: 0.86‹?›

🔗 View Article (PMC 3412850)

Published in PLoS One on August 06, 2012

Authors

Lisa D S Johnson1, Stephen C Jameson

Author Affiliations

1: Lab Medicine and Pathology, Center for Immunology, University of Minnesota, Minneapolis, Minnesota, United States of America.

Articles cited by this

T cell receptor antagonist peptides induce positive selection. Cell (1994) 18.66

Inflammation directs memory precursor and short-lived effector CD8(+) T cell fates via the graded expression of T-bet transcription factor. Immunity (2007) 12.98

Transforming growth factor-beta regulation of immune responses. Annu Rev Immunol (2006) 9.53

Homeostasis of naive and memory T cells. Immunity (2008) 7.48

Interleukin (IL)-15 and IL-7 jointly regulate homeostatic proliferation of memory phenotype CD8+ cells but are not required for memory phenotype CD4+ cells. J Exp Med (2002) 7.11

Abrogation of TGFbeta signaling in T cells leads to spontaneous T cell differentiation and autoimmune disease. Immunity (2000) 6.97

IL-7 is critical for homeostatic proliferation and survival of naive T cells. Proc Natl Acad Sci U S A (2001) 6.91

TGF-beta1 maintains suppressor function and Foxp3 expression in CD4+CD25+ regulatory T cells. J Exp Med (2005) 6.87

Cytokine control of memory T-cell development and survival. Nat Rev Immunol (2003) 5.99

Transforming growth factor-beta controls development, homeostasis, and tolerance of T cells by regulatory T cell-dependent and -independent mechanisms. Immunity (2006) 5.91

Cytokine requirements for acute and Basal homeostatic proliferation of naive and memory CD8+ T cells. J Exp Med (2002) 5.09

TGF-beta: a master of all T cell trades. Cell (2008) 4.60

Cellular mechanisms of fatal early-onset autoimmunity in mice with the T cell-specific targeting of transforming growth factor-beta receptor. Immunity (2006) 4.06

Monitoring lymphocyte proliferation in vitro and in vivo with the intracellular fluorescent dye carboxyfluorescein diacetate succinimidyl ester. Nat Protoc (2007) 3.45

TGFbeta signalling in control of T-cell-mediated self-reactivity. Nat Rev Immunol (2007) 3.02

The generation of protective memory-like CD8+ T cells during homeostatic proliferation requires CD4+ T cells. Nat Immunol (2006) 2.96

The antigen-specific CD8+ T cell repertoire in unimmunized mice includes memory phenotype cells bearing markers of homeostatic expansion. J Exp Med (2009) 2.82

Cytokines and T-cell homeostasis. Curr Opin Immunol (2007) 2.58

Disruption of T cell homeostasis in mice expressing a T cell-specific dominant negative transforming growth factor beta II receptor. J Exp Med (2000) 2.45

T cell receptor-dependent regulation of lipid rafts controls naive CD8+ T cell homeostasis. Immunity (2010) 2.17

Opposing effects of TGF-beta and IL-15 cytokines control the number of short-lived effector CD8+ T cells. Immunity (2009) 2.04

Cell-intrinsic transforming growth factor-beta signaling mediates virus-specific CD8+ T cell deletion and viral persistence in vivo. Immunity (2009) 1.94

Requirement for transforming growth factor beta1 in controlling T cell apoptosis. J Exp Med (2001) 1.82

CD95, BIM and T cell homeostasis. Nat Rev Immunol (2009) 1.73

TGF-β signaling to T cells inhibits autoimmunity during lymphopenia-driven proliferation. Nat Immunol (2012) 1.58

Il-12 enhances CD8 T cell homeostatic expansion. J Immunol (2001) 1.51

TGF-beta in allogeneic stem cell transplantation: friend or foe? Blood (2005) 1.31

IL-15 is required for sustained lymphopenia-driven proliferation and accumulation of CD8 T cells. J Immunol (2007) 1.30

Dysregulation of IL-15-mediated T-cell homeostasis in TGF-beta dominant-negative receptor transgenic mice. Blood (2006) 1.19

MEK/ERK-mediated phosphorylation of Bim is required to ensure survival of T and B lymphocytes during mitogenic stimulation. J Immunol (2009) 1.17

Interleukin 7 worsens graft-versus-host disease. Blood (2002) 1.16

Signaling thresholds govern heterogeneity in IL-7-receptor-mediated responses of naïve CD8(+) T cells. Immunol Cell Biol (2011) 1.14

Transforming growth factor beta1 inhibits Fas ligand expression and subsequent activation-induced cell death in T cells via downregulation of c-Myc. J Exp Med (1999) 1.14

c-Myc acts downstream of IL-15 in the regulation of memory CD8 T-cell homeostasis. Blood (2006) 1.06

Distinct effects of TGF-beta 1 on CD4+ and CD8+ T cell survival, division, and IL-2 production: a role for T cell intrinsic Smad3. J Immunol (2005) 1.05

Negative regulators in homeostasis of naïve peripheral T cells. Immunol Res (2008) 1.05

Plasma levels of IL-7 and IL-15 in the first month after myeloablative BMT are predictive biomarkers of both acute GVHD and relapse. Bone Marrow Transplant (2010) 1.01

Interleukin-7 regulates Bim proapoptotic activity in peripheral T-cell survival. Mol Cell Biol (2009) 0.92

Importance of interleukin-7 in the development of experimental graft-versus-host disease. Biol Blood Marrow Transplant (2007) 0.91

Reduced surface expression of transforming growth factor beta receptor type II in mitogen-activated T cells from Sézary patients. Proc Natl Acad Sci U S A (1995) 0.91

Pleiotropic effects of transforming growth factor-β in hematopoietic stem-cell transplantation. Transplantation (2010) 0.86

TGF-beta signaling regulates CD8+ T cell responses to high- and low-affinity TCR interactions. Int Immunol (2005) 0.79

Articles by these authors

Naive CD4(+) T cell frequency varies for different epitopes and predicts repertoire diversity and response magnitude. Immunity (2007) 9.26

Positive and negative selection of T cells. Annu Rev Immunol (2002) 8.32

Kruppel-like factor 2 regulates thymocyte and T-cell migration. Nature (2006) 4.51

Central tolerance: learning self-control in the thymus. Nat Rev Immunol (2005) 3.49

The generation of protective memory-like CD8+ T cells during homeostatic proliferation requires CD4+ T cells. Nat Immunol (2006) 2.96

KLF2 transcription-factor deficiency in T cells results in unrestrained cytokine production and upregulation of bystander chemokine receptors. Immunity (2009) 2.90

The antigen-specific CD8+ T cell repertoire in unimmunized mice includes memory phenotype cells bearing markers of homeostatic expansion. J Exp Med (2009) 2.82

Naive T cell homeostasis: from awareness of space to a sense of place. Nat Rev Immunol (2009) 2.68

In vivo survival and homeostatic proliferation of natural killer cells. J Exp Med (2003) 2.59

T cells expressing the transcription factor PLZF regulate the development of memory-like CD8+ T cells. Nat Immunol (2010) 2.49

Distinct effects of STAT5 activation on CD4+ and CD8+ T cell homeostasis: development of CD4+CD25+ regulatory T cells versus CD8+ memory T cells. J Immunol (2003) 2.47

Steady-state production of IL-4 modulates immunity in mouse strains and is determined by lineage diversity of iNKT cells. Nat Immunol (2013) 2.33

Effector-like CD8⁺ T cells in the memory population mediate potent protective immunity. Immunity (2013) 2.30

Transcriptional downregulation of S1pr1 is required for the establishment of resident memory CD8+ T cells. Nat Immunol (2013) 2.23

Programming for CD8 T cell memory development requires IL-12 or type I IFN. J Immunol (2009) 2.15

Different T cell receptor signals determine CD8+ memory versus effector development. Science (2009) 2.08

Multiple choices: regulation of memory CD8 T cell generation and homeostasis by interleukin (IL)-7 and IL-15. J Exp Med (2002) 2.03

Selection of self-reactive T cells in the thymus. Annu Rev Immunol (2011) 1.98

Cutting edge: transpresentation of IL-15 by bone marrow-derived cells necessitates expression of IL-15 and IL-15R alpha by the same cells. J Immunol (2004) 1.87

The timing of TCR alpha expression critically influences T cell development and selection. J Exp Med (2005) 1.85

Sweet 'n' sour: the impact of differential glycosylation on T cell responses. Nat Immunol (2002) 1.65

Alternative memory in the CD8 T cell lineage. Trends Immunol (2011) 1.60

Langerin expressing cells promote skin immune responses under defined conditions. J Immunol (2008) 1.54

Murine thymic selection quantified using a unique method to capture deleted T cells. Proc Natl Acad Sci U S A (2013) 1.52

Competition for self ligands restrains homeostatic proliferation of naive CD4 T cells. Proc Natl Acad Sci U S A (2003) 1.47

IL-15 regulates both quantitative and qualitative features of the memory CD8 T cell pool. J Immunol (2009) 1.45

Detuning CD8 T cells: down-regulation of CD8 expression, tetramer binding, and response during CTL activation. J Exp Med (2007) 1.44

Rare, structurally homologous self-peptides promote thymocyte positive selection. Immunity (2002) 1.41

Derivation and maintenance of virtual memory CD8 T cells. J Immunol (2012) 1.40

The fourth way? Harnessing aggressive tendencies in the thymus. J Immunol (2004) 1.31

IL-15 is required for sustained lymphopenia-driven proliferation and accumulation of CD8 T cells. J Immunol (2007) 1.30

Homeostatic expansion versus antigen-driven proliferation: common ends by different means? Microbes Infect (2002) 1.27

Selective regulation of CD8 effector T cell migration by the p110 gamma isoform of phosphatidylinositol 3-kinase. J Immunol (2008) 1.20

Kruppel-like factor 2 is required for trafficking but not quiescence in postactivated T cells. J Immunol (2010) 1.19

Self-class I MHC molecules support survival of naive CD8 T cells, but depress their functional sensitivity through regulation of CD8 expression levels. J Exp Med (2009) 1.13

A spontaneous CD8 T cell-dependent autoimmune disease to an antigen expressed under the human keratin 14 promoter. J Immunol (2002) 1.12

Krüppel-like factor 2 (KLF2) regulates B-cell reactivity, subset differentiation, and trafficking molecule expression. Proc Natl Acad Sci U S A (2010) 1.12

IL-2 complex treatment can protect naive mice from bacterial and viral infection. J Immunol (2010) 1.11

CD8 T cell quiescence revisited. Trends Immunol (2012) 1.11

Positive selection optimizes the number and function of MHCII-restricted CD4+ T cell clones in the naive polyclonal repertoire. Proc Natl Acad Sci U S A (2009) 1.09

Characteristics of NK cell migration early after vaccinia infection. J Immunol (2005) 1.05

Virtual memory CD8 T cells display unique functional properties. Proc Natl Acad Sci U S A (2013) 1.04

Preexisting high frequencies of memory CD8+ T cells favor rapid memory differentiation and preservation of proliferative potential upon boosting. Immunity (2013) 1.03

Immunology. A chronic need for IL-21. Science (2009) 1.02

Krüppel-like factor 2 regulates trafficking and homeostasis of gammadelta T cells. J Immunol (2010) 1.02

Kruppel-like factor 2 protects against ischemic stroke by regulating endothelial blood brain barrier function. Am J Physiol Heart Circ Physiol (2013) 1.01

A role for CD28 in lymphopenia-induced proliferation of CD4 T cells. J Immunol (2004) 1.00

The nature of the lymphopenic environment dictates protective function of homeostatic-memory CD8+ T cells. Proc Natl Acad Sci U S A (2008) 1.00

Cutting edge: LFA-1 integrin-dependent T cell adhesion is regulated by both ag specificity and sensitivity. J Immunol (2004) 1.00

Loss of CD8 and TCR binding to Class I MHC ligands following T cell activation. Int Immunol (2005) 0.98

Thymoproteasome subunit-β5T generates peptide-MHC complexes specialized for positive selection. Proc Natl Acad Sci U S A (2013) 0.98

Krüppel-like factors in lymphocyte biology. J Immunol (2012) 0.97

Thymocyte sensitivity and supramolecular activation cluster formation are developmentally regulated: a partial role for sialylation. J Immunol (2003) 0.95

Epidermal Langerhans cells are not required for UV-induced immunosuppression. J Immunol (2009) 0.91

Postselection thymocyte maturation and emigration are independent of IL-7 and ERK5. J Immunol (2010) 0.91

Self-specific CD8+ T cells maintain a semi-naive state following lymphopenia-induced proliferation. J Immunol (2010) 0.90

The CD8 T cell response to vaccinia virus exhibits site-dependent heterogeneity of functional responses. Int Immunol (2007) 0.89

Location of the epitope for an anti-CD8alpha antibody 53.6.7 which enhances CD8alpha-MHC class I interaction indicates antibody stabilization of a higher affinity CD8 conformation. Immunol Lett (2004) 0.89

Receptor sensitivity: when T cells lose their sense of self. Curr Biol (2003) 0.89

Differential role for IL-7 in inducing lung Kruppel-like factor (Kruppel-like factor 2) expression by naive versus activated T cells. Int Immunol (2003) 0.87

CD8 T cell memory: it takes all kinds. Front Immunol (2012) 0.85

Cholera toxin activates nonconventional adjuvant pathways that induce protective CD8 T-cell responses after epicutaneous vaccination. Proc Natl Acad Sci U S A (2012) 0.85

The sialyltransferase ST3Gal-I is not required for regulation of CD8-class I MHC binding during T cell development. J Immunol (2006) 0.84

CD8(+) T cell differentiation: choosing a path through T-bet. Immunity (2007) 0.84

Characterizing the impact of CD8 antibodies on class I MHC multimer binding. J Immunol (2005) 0.83

Cutting edge: The signals for the generation of T cell memory are qualitatively different depending on TCR ligand strength. J Immunol (2013) 0.83

Keeping STATs on memory CD8+ T cells. Immunity (2011) 0.81

CD4+CD25+Foxp3+ regulatory T cells optimize diversity of the conventional T cell repertoire during reconstitution from lymphopenia. J Immunol (2010) 0.81

T-cell migration: Kruppeled T cells move again. Immunol Cell Biol (2008) 0.81

Environmental conservation: bystander CD4 T cells keep CD8 memories fresh. Nat Immunol (2004) 0.80

Fox factors fight over T cell quiescence. Nat Immunol (2011) 0.78

Cutting edge: Krűppel-like factor 2 is required for phenotypic maintenance but not development of B1 B cells. J Immunol (2012) 0.77

Pillars article: T cell receptor antagonist peptides induce positive selection. Cell. 1994. 76: 17-27. J Immunol (2012) 0.77

Not all naïve CD8 T cells are created equal. Immunol Cell Biol (2011) 0.76

Immunology. Remembering to be tolerant. Science (2012) 0.75

How protected are coral reefs? Science (2006) 0.75

Corrigendum: Spontaneous partial loss of the OT-I transgene. Nat Immunol (2017) 0.75

Reefs in trouble - the real root cause. Mar Pollut Bull (2008) 0.75