Published in J Clin Invest on September 01, 2001
The cytochrome P450scc system opens an alternate pathway of vitamin D3 metabolism. FEBS J (2005) 2.12
Social approach in genetically engineered mouse lines relevant to autism. Genes Brain Behav (2008) 1.94
Malformation syndromes caused by disorders of cholesterol synthesis. J Lipid Res (2010) 1.88
Biological activities of 7-dehydrocholesterol-derived oxysterols: implications for Smith-Lemli-Opitz syndrome. J Lipid Res (2010) 1.44
Malformation syndromes due to inborn errors of cholesterol synthesis. J Clin Invest (2002) 1.39
Lipid rafts, cholesterol, and the brain. Neuropharmacology (2008) 1.38
The use of the Dhcr7 knockout mouse to accurately determine the origin of fetal sterols. J Lipid Res (2006) 1.34
Severe facial clefting in Insig-deficient mouse embryos caused by sterol accumulation and reversed by lovastatin. J Clin Invest (2006) 1.32
Lipid metabolism in myelinating glial cells: lessons from human inherited disorders and mouse models. J Lipid Res (2010) 1.31
Oxysterols from free radical chain oxidation of 7-dehydrocholesterol: product and mechanistic studies. J Am Chem Soc (2010) 1.27
An oxysterol biomarker for 7-dehydrocholesterol oxidation in cell/mouse models for Smith-Lemli-Opitz syndrome. J Lipid Res (2011) 1.25
Recent insights into the Smith-Lemli-Opitz syndrome. Clin Genet (2005) 1.23
Retinal degeneration in a rodent model of Smith-Lemli-Opitz syndrome: electrophysiologic, biochemical, and morphologic features. Arch Ophthalmol (2004) 1.16
Formation of 7-dehydrocholesterol-containing membrane rafts in vitro and in vivo, with relevance to the Smith-Lemli-Opitz syndrome. J Lipid Res (2003) 1.14
Mouse knockout of the cholesterogenic cytochrome P450 lanosterol 14alpha-demethylase (Cyp51) resembles Antley-Bixler syndrome. J Biol Chem (2011) 1.10
Cholesterol: its regulation and role in central nervous system disorders. Cholesterol (2012) 1.08
DHCEO accumulation is a critical mediator of pathophysiology in a Smith-Lemli-Opitz syndrome model. Neurobiol Dis (2011) 1.05
Activation of Rho GTPases in Smith-Lemli-Opitz syndrome: pathophysiological and clinical implications. Hum Mol Genet (2010) 1.05
Lipid biomarkers of oxidative stress in a genetic mouse model of Smith-Lemli-Opitz syndrome. J Inherit Metab Dis (2012) 1.04
The mechanism of TGF-β signaling during palate development. Oral Dis (2011) 1.04
Metabolism of oxysterols derived from nonenzymatic oxidation of 7-dehydrocholesterol in cells. J Lipid Res (2013) 1.02
Molecular consequences of altered neuronal cholesterol biosynthesis. J Neurosci Res (2009) 1.02
Novel oxysterols observed in tissues and fluids of AY9944-treated rats: a model for Smith-Lemli-Opitz syndrome. J Lipid Res (2011) 0.99
Atypical antipsychotics alter cholesterol and fatty acid metabolism in vitro. J Lipid Res (2012) 0.98
7-Dehydrocholesterol-derived oxysterols and retinal degeneration in a rat model of Smith-Lemli-Opitz syndrome. Biochim Biophys Acta (2012) 0.96
Cholesterol biosynthesis from birth to adulthood in a mouse model for 7-dehydrosterol reductase deficiency (Smith-Lemli-Opitz syndrome). Steroids (2007) 0.95
A model of Costeff Syndrome reveals metabolic and protective functions of mitochondrial OPA3. Development (2010) 0.94
Ion-current-based proteomic profiling of the retina in a rat model of Smith-Lemli-Opitz syndrome. Mol Cell Proteomics (2013) 0.93
No evidence for mevalonate shunting in moderately affected children with Smith-Lemli-Opitz syndrome. J Inherit Metab Dis (2012) 0.91
Smith-Lemli-Opitz syndrome. Expert Rev Mol Med (2011) 0.90
Reduced cholesterol levels impair Smoothened activation in Smith-Lemli-Opitz syndrome. Hum Mol Genet (2015) 0.88
Novel N-terminal cleavage of APP precludes Abeta generation in ACAT-defective AC29 cells. J Mol Neurosci (2008) 0.87
Late gestational lung hypoplasia in a mouse model of the Smith-Lemli-Opitz syndrome. BMC Dev Biol (2004) 0.87
Functional significance of SRJ domain mutations in CITED2. PLoS One (2012) 0.85
Cholesterol metabolism is required for intracellular hedgehog signal transduction in vivo. PLoS Genet (2011) 0.84
Developmental expression pattern of the cholesterogenic enzyme NSDHL and negative selection of NSDHL-deficient cells in the heterozygous Bpa(1H)/+ mouse. Mol Genet Metab (2009) 0.84
Comparison of the liquid-ordered bilayer phases containing cholesterol or 7-dehydrocholesterol in modeling Smith-Lemli-Opitz syndrome. J Lipid Res (2010) 0.82
Analysis by liquid chromatography-mass spectrometry of sterols and oxysterols in brain of the newborn Dhcr7(Δ3-5/T93M) mouse: a model of Smith-Lemli-Opitz syndrome. Biochem Pharmacol (2013) 0.81
Selective reconstitution of liver cholesterol biosynthesis promotes lung maturation but does not prevent neonatal lethality in Dhcr7 null mice. BMC Dev Biol (2007) 0.81
Modulation of lipid metabolic defects rescues cleft palate in Tgfbr2 mutant mice. Hum Mol Genet (2013) 0.80
Alterations in membrane caveolae and BKCa channel activity in skin fibroblasts in Smith-Lemli-Opitz syndrome. Mol Genet Metab (2011) 0.80
A highly sensitive method for analysis of 7-dehydrocholesterol for the study of Smith-Lemli-Opitz syndrome. J Lipid Res (2013) 0.79
Molecular basis of cleft palates in mice. World J Biol Chem (2015) 0.78
Loss of apolipoprotein E exacerbates the neonatal lethality of the Smith-Lemli-Opitz syndrome mouse. Mol Genet Metab (2007) 0.77
Differential cytotoxic effects of 7-dehydrocholesterol-derived oxysterols on cultured retina-derived cells: Dependence on sterol structure, cell type, and density. Exp Eye Res (2016) 0.76
7-dehydrocholesterol efficiently supports Ret signaling in a mouse model of Smith-Opitz-Lemli syndrome. Sci Rep (2016) 0.76
Downregulation of cholesterol biosynthesis genes in the forebrain of ERCC1-deficient mice. Neurobiol Dis (2011) 0.76
Hidden disease susceptibility and sexual dimorphism in the heterozygous knockout of Cyp51 from cholesterol synthesis. PLoS One (2014) 0.76
Steroid production and excretion by the pregnant mouse, particularly in relation to pregnancies with fetuses deficient in Delta7-sterol reductase (Dhcr7), the enzyme associated with Smith-Lemli-Opitz syndrome. J Steroid Biochem Mol Biol (2009) 0.75
Altered cholesterol biosynthesis causes precocious neurogenesis in the developing mouse forebrain. Neurobiol Dis (2016) 0.75
Clinical and Neurobiological Relevance of Current Animal Models of Autism Spectrum Disorders. Biomol Ther (Seoul) (2016) 0.75
Desmosterol in brain is elevated because DHCR24 needs REST for Robust Expression but REST is poorly expressed. Dev Neurosci (2014) 0.75
Protein measurement with the Folin phenol reagent. J Biol Chem (1951) 1743.91
A proteolytic pathway that controls the cholesterol content of membranes, cells, and blood. Proc Natl Acad Sci U S A (1999) 7.48
Cholesterol modification of hedgehog signaling proteins in animal development. Science (1996) 5.66
Hedgehog and Bmp genes are coexpressed at many diverse sites of cell-cell interaction in the mouse embryo. Dev Biol (1995) 5.36
Defective cholesterol biosynthesis associated with the Smith-Lemli-Opitz syndrome. N Engl J Med (1994) 5.35
Teratogen-mediated inhibition of target tissue response to Shh signaling. Science (1998) 5.28
A NEWLY RECOGNIZED SYNDROME OF MULTIPLE CONGENITAL ANOMALIES. J Pediatr (1964) 4.60
The teratogenic Veratrum alkaloid cyclopamine inhibits sonic hedgehog signal transduction. Development (1998) 3.89
Sonic hedgehog regulates branching morphogenesis in the mammalian lung. Curr Biol (1998) 3.29
The Smith-Lemli-Opitz syndrome. J Med Genet (2000) 3.05
Mutations in the Delta7-sterol reductase gene in patients with the Smith-Lemli-Opitz syndrome. Proc Natl Acad Sci U S A (1998) 2.22
Sterols regulate cycling of SREBP cleavage-activating protein (SCAP) between endoplasmic reticulum and Golgi. Proc Natl Acad Sci U S A (1999) 2.00
Diagnosis of Smith-Lemli-Opitz syndrome by gas chromatography/mass spectrometry of 7-dehydrocholesterol in plasma, amniotic fluid and cultured skin fibroblasts. Clin Chim Acta (1995) 1.99
Knockout of the mouse apolipoprotein B gene results in embryonic lethality in homozygotes and protection against diet-induced hypercholesterolemia in heterozygotes. Proc Natl Acad Sci U S A (1995) 1.93
The effect of partial replacements of membrane cholesterol by other steroids on the osmotic fragility and glycerol permeability of erythrocytes. Biochim Biophys Acta (1969) 1.70
Smith-Lemli-Opitz syndrome-type II: multiple congenital anomalies with male pseudohermaphroditism and frequent early lethality. Am J Med Genet (1987) 1.69
CHILD syndrome caused by deficiency of 3beta-hydroxysteroid-delta8, delta7-isomerase. Am J Med Genet (2000) 1.63
Mutational spectrum in the Delta7-sterol reductase gene and genotype-phenotype correlation in 84 patients with Smith-Lemli-Opitz syndrome. Am J Hum Genet (2000) 1.61
Biochemical, phenotypic and neurophysiological characterization of a genetic mouse model of RSH/Smith--Lemli--Opitz syndrome. Hum Mol Genet (2001) 1.60
Familial hypobetalipoproteinemia. J Lipid Res (1993) 1.57
Clinical and biochemical spectrum of patients with RSH/Smith-Lemli-Opitz syndrome and abnormal cholesterol metabolism. Am J Med Genet (1997) 1.56
Knockout of the abetalipoproteinemia gene in mice: reduced lipoprotein secretion in heterozygotes and embryonic lethality in homozygotes. Proc Natl Acad Sci U S A (1998) 1.53
Molecular cloning and expression of the human delta7-sterol reductase. Proc Natl Acad Sci U S A (1998) 1.49
Mutations in the NSDHL gene, encoding a 3beta-hydroxysteroid dehydrogenase, cause CHILD syndrome. Am J Med Genet (2000) 1.48
Mutations in the gene encoding 3 beta-hydroxysteroid-delta 8, delta 7-isomerase cause X-linked dominant Conradi-Hünermann syndrome. Nat Genet (1999) 1.47
A human membrane-associated folate binding protein is anchored by a glycosyl-phosphatidylinositol tail. J Biol Chem (1989) 1.46
Correlation of severity and outcome with plasma sterol levels in variants of the Smith-Lemli-Opitz syndrome. J Pediatr (1995) 1.46
Partial deletion of membrane-bound domain of 3-hydroxy-3-methylglutaryl coenzyme A reductase eliminates sterol-enhanced degradation and prevents formation of crystalloid endoplasmic reticulum. J Cell Biol (1987) 1.45
Borderline normal intelligence in the Smith-Lemli-Opitz (RSH) syndrome. Am J Med Genet (1980) 1.45
Regulation of HMG-CoA reductase degradation requires the P-type ATPase Cod1p/Spf1p. J Cell Biol (2000) 1.43
Preparation of delipidized serum protein for use in cell culture systems. In Vitro (1976) 1.40
Markedly inhibited 7-dehydrocholesterol-delta 7-reductase activity in liver microsomes from Smith-Lemli-Opitz homozygotes. J Clin Invest (1995) 1.30
Mevalonic aciduria--an inborn error of cholesterol and nonsterol isoprene biosynthesis. N Engl J Med (1986) 1.27
The membrane domain of 3-hydroxy-3-methylglutaryl-coenzyme A reductase confers endoplasmic reticulum localization and sterol-regulated degradation onto beta-galactosidase. J Biol Chem (1988) 1.20
Lethal thalassemia after insertional disruption of the mouse major adult beta-globin gene. Proc Natl Acad Sci U S A (1993) 1.16
Abnormal sterol metabolism in patients with Conradi-Hünermann-Happle syndrome and sporadic lethal chondrodysplasia punctata. Am J Med Genet (1999) 1.15
A molecular defect in hepatic cholesterol biosynthesis in sitosterolemia with xanthomatosis. J Clin Invest (1990) 1.15
Branching morphogenesis of the lung: new models for a classical problem. Cold Spring Harb Symp Quant Biol (1997) 1.12
Identification of 8-dehydrocholesterol (cholesta-5,8-dien-3 beta-ol) in patients with Smith-Lemli-Opitz syndrome. J Lipid Res (1995) 1.11
Distinct sterol and nonsterol signals for the regulated degradation of 3-hydroxy-3-methylglutaryl-CoA reductase. J Biol Chem (1992) 1.11
Frequency gradients of DHCR7 mutations in patients with Smith-Lemli-Opitz syndrome in Europe: evidence for different origins of common mutations. Eur J Hum Genet (2001) 1.09
Limb, genital, CNS, and facial malformations result from gene/environment-induced cholesterol deficiency: further evidence for a link to sonic hedgehog. Am J Med Genet (1997) 1.09
Thyroid hormone rapidly induces hepatic LDL receptor mRNA levels in hypophysectomized rats. Arch Biochem Biophys (1994) 1.04
Cyclosporin-induced dyslipoproteinemia is associated with selective activation of SREBP-2. Am J Physiol (1999) 1.03
Sterol balance in the Smith-Lemli-Opitz syndrome. Reduction in whole body cholesterol synthesis and normal bile acid production. J Lipid Res (2000) 1.02
Markedly increased tissue concentrations of 7-dehydrocholesterol combined with low levels of cholesterol are characteristic of the Smith-Lemli-Opitz syndrome. J Lipid Res (1995) 1.02
Degradation of HMG-CoA reductase in vitro. Cleavage in the membrane domain by a membrane-bound cysteine protease. J Biol Chem (1998) 0.98
Desmosterolosis: a new inborn error of cholesterol biosynthesis. Lancet (1996) 0.96
Teratogenic effect of an inhibitor of cholesterol synthesis (AY 9944) in rats: correlation with maternal cholesterolemia. J Nutr (1980) 0.94
7-Dehydrocholesterol down-regulates cholesterol biosynthesis in cultured Smith-Lemli-Opitz syndrome skin fibroblasts. J Lipid Res (1998) 0.94
Characteristics of rat liver microsomal 3-hydroxy-3-methylglutaryl-coenzyme A reductase. Biochem J (1986) 0.94
Effect of squalene synthase inhibition on the expression of hepatic cholesterol biosynthetic enzymes, LDL receptor, and cholesterol 7 alpha hydroxylase. Arch Biochem Biophys (1994) 0.93
Cholesterol deficit but not accumulation of aberrant sterols is the major cause of the teratogenic activity in the Smith-Lemli-Opitz syndrome animal model. J Lipid Res (2000) 0.92
Measurement of 3 beta-hydroxysteroid delta 7-reductase activity in cultured skin fibroblasts utilizing ergosterol as a substrate: a new method for the diagnosis of the Smith-Lemli-Opitz syndrome. J Lipid Res (1996) 0.90
Quantitation and localization of ENaC subunit expression in fetal, newborn, and adult mouse lung. Am J Respir Cell Mol Biol (1999) 0.87
Non-sterol compounds that regulate cholesterogenesis. Analogues of farnesyl pyrophosphate reduce 3-hydroxy-3-methylglutaryl-coenzyme A reductase levels. J Biol Chem (1994) 0.87
Involvement of calcium in the mevalonate-accelerated degradation of 3-hydroxy-3-methylglutaryl-CoA reductase. J Biol Chem (1991) 0.87
[TRANSFER AND SYNTHESIS OF CHOLESTEROL IN RATS DURING THEIR GROWTH]. Biochim Biophys Acta (1964) 0.85
The Smith-Lemli-Opitz syndrome: a potentially fatal birth defect caused by a block in the last enzymatic step in cholesterol biosynthesis. Subcell Biochem (1997) 0.85
The LDL receptor gene family, apolipoprotein B and cholesterol in embryonic development. J Nutr (1999) 0.85
Compensatory responses to inhibition of hepatic squalene synthase. Arch Biochem Biophys (1998) 0.85
Maternal high density lipoproteins affect fetal mass and extra-embryonic fetal tissue sterol metabolism in the mouse. J Lipid Res (2000) 0.85
Expression of Sonic Hedgehog downstream genes is modified in rat embryos exposed in utero to a distal inhibitor of cholesterol biosynthesis. Dev Dyn (2001) 0.83
Regulation of cholesterol biosynthetic pathway in patients with the Smith-Lemli-Opitz syndrome. J Inherit Metab Dis (2000) 0.82
Dietary cholesterol regulates hepatic 3-hydroxy-3-methylglutaryl coenzyme A reductase gene expression in rats primarily at the level of translation. Arch Biochem Biophys (1998) 0.82
Molecular genetic analysis of human folate receptors in neural tube defects. Eur J Hum Genet (1999) 0.79
The transcriptional landscape of the mammalian genome. Science (2005) 37.63
Spontaneous hypercholesterolemia and arterial lesions in mice lacking apolipoprotein E. Science (1992) 11.83
A CBP integrator complex mediates transcriptional activation and AP-1 inhibition by nuclear receptors. Cell (1996) 11.02
DMC1: a meiosis-specific yeast homolog of E. coli recA required for recombination, synaptonemal complex formation, and cell cycle progression. Cell (1992) 10.48
Deletions and a translocation interrupt a cloned gene at the neurofibromatosis type 1 locus. Cell (1990) 6.94
Efficient and rapid induction of a chronic myelogenous leukemia-like myeloproliferative disease in mice receiving P210 bcr/abl-transduced bone marrow. Blood (1998) 6.81
Targetted correction of a mutant HPRT gene in mouse embryonic stem cells. Nature (1988) 6.12
Genome-wide distribution of ORC and MCM proteins in S. cerevisiae: high-resolution mapping of replication origins. Science (2001) 6.06
GENIES: a natural-language processing system for the extraction of molecular pathways from journal articles. Bioinformatics (2001) 6.05
The checkpoint protein MAD2 and the mitotic regulator CDC20 form a ternary complex with the anaphase-promoting complex to control anaphase initiation. Genes Dev (1998) 5.96
Elevated blood pressures in mice lacking endothelial nitric oxide synthase. Proc Natl Acad Sci U S A (1996) 5.94
Mad2-Independent inhibition of APCCdc20 by the mitotic checkpoint protein BubR1. Dev Cell (2001) 5.82
Generation of mice carrying a mutant apolipoprotein E gene inactivated by gene targeting in embryonic stem cells. Proc Natl Acad Sci U S A (1992) 5.75
Severe reduction in leukocyte adhesion and monocyte extravasation in mice deficient in CC chemokine receptor 2. Proc Natl Acad Sci U S A (1997) 5.54
In vivo measurement of gene expression, angiogenesis and physiological function in tumors using multiphoton laser scanning microscopy. Nat Med (2001) 5.54
Defective cholesterol biosynthesis associated with the Smith-Lemli-Opitz syndrome. N Engl J Med (1994) 5.35
Notch1 expression in early lymphopoiesis influences B versus T lineage determination. Immunity (1999) 5.34
Direct binding of CDC20 protein family members activates the anaphase-promoting complex in mitosis and G1. Mol Cell (1998) 5.28
Glycoproteins of cell surfaces. A comparative study of three different cell surfaces of the rat. J Biol Chem (1971) 5.25
Human DNA-(cytosine-5) methyltransferase-PCNA complex as a target for p21WAF1. Science (1997) 5.05
Primary structure and functional expression of the inositol 1,4,5-trisphosphate-binding protein P400. Nature (1989) 5.02
In vivo high-resolution video-rate spectral-domain optical coherence tomography of the human retina and optic nerve. Opt Express (2004) 4.96
Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing. Nature (2000) 4.68
Association of diabetes mellitus and chronic hepatitis C virus infection. Hepatology (1999) 4.59
Inactivation of the mouse melanocortin-3 receptor results in increased fat mass and reduced lean body mass. Nat Genet (2000) 4.57
Two binding orientations for peptides to the Src SH3 domain: development of a general model for SH3-ligand interactions. Science (1994) 4.57
Pluripotent, cytokine-dependent, hematopoietic stem cells are immortalized by constitutive Notch1 signaling. Nat Med (2000) 4.55
Transcription factor-specific requirements for coactivators and their acetyltransferase functions. Science (1998) 4.55
Reverse phase protein microarrays which capture disease progression show activation of pro-survival pathways at the cancer invasion front. Oncogene (2001) 4.40
Distinct cellular interactions of secreted and transmembrane Ebola virus glycoproteins. Science (1998) 4.24
Hydrolysis of GTP on rab11 is required for the direct delivery of transferrin from the pericentriolar recycling compartment to the cell surface but not from sorting endosomes. Proc Natl Acad Sci U S A (1998) 4.03
Constitutive activation of Stat3 by the Src and JAK tyrosine kinases participates in growth regulation of human breast carcinoma cells. Oncogene (2001) 3.96
High-level semi-synthetic production of the potent antimalarial artemisinin. Nature (2013) 3.80
Atherosclerosis in mice lacking apo E. Evaluation of lesional development and progression. Arterioscler Thromb (1994) 3.75
Lack of myocardial perfusion immediately after successful thrombolysis. A predictor of poor recovery of left ventricular function in anterior myocardial infarction. Circulation (1992) 3.73
Direct evidence for the importance of endothelium-derived nitric oxide in vascular remodeling. J Clin Invest (1998) 3.71
Sugar transport. Properties of mutant bacteria defective in proteins of the phosphoenolpyruvate: sugar phosphotransferase system. J Biol Chem (1976) 3.57
Regulation of blood pressure by the type 1A angiotensin II receptor gene. Proc Natl Acad Sci U S A (1995) 3.54
Mice deficient in cystathionine beta-synthase: animal models for mild and severe homocyst(e)inemia. Proc Natl Acad Sci U S A (1995) 3.51
Complete DNA sequence of yeast chromosome XI. Nature (1994) 3.51
Molecular weight determination of membrane protein and glycoprotein subunits by discontinuous gel electrophoresis in dodecyl sulfate. Methods Enzymol (1974) 3.50
Hypercholesterolemia accelerates the Alzheimer's amyloid pathology in a transgenic mouse model. Neurobiol Dis (2000) 3.46
Genetic control of blood pressure and the angiotensinogen locus. Proc Natl Acad Sci U S A (1995) 3.46
Purification, molecular cloning, and expression of the mammalian sigma1-binding site. Proc Natl Acad Sci U S A (1996) 3.39
Overexpression of the focal adhesion kinase (p125FAK) in invasive human tumors. Cancer Res (1995) 3.38
Genome scan of human systemic lupus erythematosus: evidence for linkage on chromosome 1q in African-American pedigrees. Proc Natl Acad Sci U S A (1998) 3.35
Homocysteine-induced endoplasmic reticulum stress causes dysregulation of the cholesterol and triglyceride biosynthetic pathways. J Clin Invest (2001) 3.24
Role of the Kv4.3 K+ channel in ventricular muscle. A molecular correlate for the transient outward current. Circ Res (1996) 3.23
Distribution of mRNA encoding the growth hormone secretagogue receptor in brain and peripheral tissues. Brain Res Mol Brain Res (1997) 3.21
Targeted mutation of the Hprt gene in mouse embryonic stem cells. Proc Natl Acad Sci U S A (1988) 3.20
Coupling of energy to active transport of amino acids in Escherichia coli. Proc Natl Acad Sci U S A (1972) 3.18
The energetics of bacterial active transport. Annu Rev Biochem (1975) 3.17
Early and selective loss of neuromuscular synapse subtypes with low sprouting competence in motoneuron diseases. J Neurosci (2000) 3.14
High rate of recombination throughout the human immunodeficiency virus type 1 genome. J Virol (2000) 3.09
E2F-4, a new member of the E2F transcription factor family, interacts with p107. Genes Dev (1994) 3.05
Targeted replacement of the mouse apolipoprotein E gene with the common human APOE3 allele enhances diet-induced hypercholesterolemia and atherosclerosis. J Biol Chem (1997) 3.04
Immunohistochemical analyses of focal adhesion kinase expression in benign and malignant human breast and colon tissues: correlation with preinvasive and invasive phenotypes. Clin Cancer Res (2000) 3.03
Genetic evidence for the role of a bacterial phosphotransferase system in sugar transport. Proc Natl Acad Sci U S A (1967) 3.00
Biochemical analysis of the secreted and virion glycoproteins of Ebola virus. J Virol (1998) 2.99
Age- and sex-related risk factors for adolescent suicide. J Am Acad Child Adolesc Psychiatry (1999) 2.99
Hypertension, cardiac hypertrophy, and sudden death in mice lacking natriuretic peptide receptor A. Proc Natl Acad Sci U S A (1997) 2.99
Contrasting effects of CCR5 and CCR2 deficiency in the pulmonary inflammatory response to influenza A virus. Am J Pathol (2000) 2.98
Resolution of a staphylococcal phosphotransferase system into four protein components and its relation to sugar transport. Biochem Biophys Res Commun (1968) 2.96
Distribution of orexin receptor mRNA in the rat brain. FEBS Lett (1998) 2.90
Microsomal triglyceride transfer protein expression during mouse development. J Lipid Res (2000) 2.90
Mutations of the UMOD gene are responsible for medullary cystic kidney disease 2 and familial juvenile hyperuricaemic nephropathy. J Med Genet (2002) 2.90
The TGF beta receptor activation process: an inhibitor- to substrate-binding switch. Mol Cell (2001) 2.87
A constipation scoring system to simplify evaluation and management of constipated patients. Dis Colon Rectum (1996) 2.87
CheA protein, a central regulator of bacterial chemotaxis, belongs to a family of proteins that control gene expression in response to changing environmental conditions. Proc Natl Acad Sci U S A (1988) 2.85
Single-copy transgenic mice with chosen-site integration. Proc Natl Acad Sci U S A (1996) 2.84
Identification of a gene, ABCG5, important in the regulation of dietary cholesterol absorption. Nat Genet (2001) 2.84
Efficacy and safety of the dipeptidyl peptidase-4 inhibitor sitagliptin as monotherapy in patients with type 2 diabetes mellitus. Diabetologia (2006) 2.82
Essential roles for ankyrin repeat and transactivation domains in induction of T-cell leukemia by notch1. Mol Cell Biol (2000) 2.80
Defective cholesterol biosynthesis in Smith-Lemli-Opitz syndrome. Lancet (1993) 2.79
Controlled production of proliferating somatic cell hybrids. J Cell Biol (1970) 2.78
Identification of defensin-1, defensin-2, and CAP37/azurocidin as T-cell chemoattractant proteins released from interleukin-8-stimulated neutrophils. J Biol Chem (1996) 2.78
Long-term treatment of cerebrotendinous xanthomatosis with chenodeoxycholic acid. N Engl J Med (1984) 2.77
alpha 1D (Cav1.3) subunits can form l-type Ca2+ channels activating at negative voltages. J Biol Chem (2001) 2.77
Hepatocyte nuclear factor-1alpha is an essential regulator of bile acid and plasma cholesterol metabolism. Nat Genet (2001) 2.73
Paternal population history of East Asia: sources, patterns, and microevolutionary processes. Am J Hum Genet (2001) 2.71
Cyclin A-kinase regulation of E2F-1 DNA binding function underlies suppression of an S phase checkpoint. Cell (1995) 2.70
Nuclear integration of JAK/STAT and Ras/AP-1 signaling by CBP and p300. Proc Natl Acad Sci U S A (1997) 2.63
In vivo evidence for the role of the epsilon subunit as an inhibitor of the proton-translocating ATPase of Escherichia coli. J Bacteriol (1984) 2.60
Germ-line transmission of a planned alteration made in a hypoxanthine phosphoribosyltransferase gene by homologous recombination in embryonic stem cells. Proc Natl Acad Sci U S A (1989) 2.59
Dynamics and time-averaged chemical potential of proteins: importance in oligomer association. Proc Natl Acad Sci U S A (1982) 2.58
Preliminary results of a randomized study on therapeutic gain by concurrent chemotherapy for regionally-advanced nasopharyngeal carcinoma: NPC-9901 Trial by the Hong Kong Nasopharyngeal Cancer Study Group. J Clin Oncol (2005) 2.54
Nucleotide sequence of a ripening-related cDNA from avocado fruit. Plant Mol Biol (1990) 2.53
Structure of the Mad2 spindle assembly checkpoint protein and its interaction with Cdc20. Nat Struct Biol (2000) 2.49
Distribution and prevalence of hyperpolarization-activated cation channel (HCN) mRNA expression in cardiac tissues. Circ Res (1999) 2.47
Comparison of the prevalence of knee osteoarthritis between the elderly Chinese population in Beijing and whites in the United States: The Beijing Osteoarthritis Study. Arthritis Rheum (2001) 2.45
Case study of the effects of atmospheric aerosols and regional haze on agriculture: an opportunity to enhance crop yields in China through emission controls? Proc Natl Acad Sci U S A (1999) 2.44
Control of AlgU, a member of the sigma E-like family of stress sigma factors, by the negative regulators MucA and MucB and Pseudomonas aeruginosa conversion to mucoidy in cystic fibrosis. J Bacteriol (1996) 2.43