Hepatocyte nuclear factor-1alpha is an essential regulator of bile acid and plasma cholesterol metabolism.

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Published in Nat Genet on April 01, 2001

Authors

D Q Shih1, M Bussen, E Sehayek, M Ananthanarayanan, B L Shneider, F J Suchy, S Shefer, J S Bollileni, F J Gonzalez, J L Breslow, M Stoffel

Author Affiliations

1: Laboratorie of Metabolic Diseases, The Rockefeller University, New York, New York, USA.

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Human dioxin-inducible cytochrome P1-450: complementary DNA and amino acid sequence. Science (1985) 2.11

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Long term freeze storage of Campylobacter pyloridis. J Clin Pathol (1987) 2.08

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Sitosterolemia. J Lipid Res (1992) 2.02

Molecular basis of the human dihydropyrimidine dehydrogenase deficiency and 5-fluorouracil toxicity. J Clin Invest (1996) 2.02

Proposed nomenclature of apoE isoproteins, apoE genotypes, and phenotypes. J Lipid Res (1982) 2.01

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Oxidation of midazolam and triazolam by human liver cytochrome P450IIIA4. Mol Pharmacol (1989) 1.87

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The rat canalicular conjugate export pump (Mrp2) is down-regulated in intrahepatic and obstructive cholestasis. Gastroenterology (1997) 1.83

Insulin secretory abnormalities in subjects with hyperglycemia due to glucokinase mutations. J Clin Invest (1994) 1.82

Two mutant alleles of the human cytochrome P-450db1 gene (P450C2D1) associated with genetically deficient metabolism of debrisoquine and other drugs. Proc Natl Acad Sci U S A (1988) 1.82

Laron dwarfism and non-insulin-dependent diabetes mellitus in the Hnf-1alpha knockout mouse. Mol Cell Biol (1998) 1.81

An inherited polymorphism in the human apolipoprotein A-I gene locus related to the development of atherosclerosis. Nature (1983) 1.80

Comparison of the flanking regions and introns of the mouse 2,3,7,8-tetrachlorodibenzo-p-dioxin-inducible cytochrome P1-450 and P3-450 genes. J Biol Chem (1985) 1.79

Delta 4-3-oxosteroid 5 beta-reductase deficiency causing neonatal liver failure and hemochromatosis. J Pediatr (1994) 1.79

Biliary atresia: current concepts and research directions. Summary of a symposium. Hepatology (1996) 1.78

Peroxisome proliferator activated receptor gamma in colonic epithelial cells protects against experimental inflammatory bowel disease. Gut (2006) 1.77

The murine Ah locus. Comparison of the complete cytochrome P1-450 and P3-450 cDNA nucleotide and amino acid sequences. J Biol Chem (1984) 1.75

Cytochrome P450 CYP1B1 determines susceptibility to 7, 12-dimethylbenz[a]anthracene-induced lymphomas. Proc Natl Acad Sci U S A (1999) 1.73

Constitutive regulation of cardiac fatty acid metabolism through peroxisome proliferator-activated receptor alpha associated with age-dependent cardiac toxicity. J Biol Chem (2000) 1.73

Hypoxia inducible factor promotes murine allergic airway inflammation and is increased in asthma and rhinitis. Allergy (2011) 1.73

Biliary cholesterol excretion: a novel mechanism that regulates dietary cholesterol absorption. Proc Natl Acad Sci U S A (1998) 1.73