Published in Proc Natl Acad Sci U S A on July 23, 1996
The pharmacology of sigma-1 receptors. Pharmacol Ther (2009) 3.12
Mutations in the Delta7-sterol reductase gene in patients with the Smith-Lemli-Opitz syndrome. Proc Natl Acad Sci U S A (1998) 2.22
The sigma-1 receptor chaperone as an inter-organelle signaling modulator. Trends Pharmacol Sci (2010) 2.11
Regulating ankyrin dynamics: Roles of sigma-1 receptors. Proc Natl Acad Sci U S A (2001) 1.92
Identification of the PGRMC1 protein complex as the putative sigma-2 receptor binding site. Nat Commun (2011) 1.86
Sigma receptors: biology and therapeutic potential. Psychopharmacology (Berl) (2004) 1.66
Mu opioids and their receptors: evolution of a concept. Pharmacol Rev (2013) 1.66
Sigma-2 receptors as a biomarker of proliferation in solid tumours. Br J Cancer (2000) 1.60
Pharmacology and therapeutic potential of sigma(1) receptor ligands. Curr Neuropharmacol (2008) 1.55
Molecular cloning and expression of the human delta7-sterol reductase. Proc Natl Acad Sci U S A (1998) 1.49
Molecular targets for treating cognitive dysfunction in schizophrenia. Schizophr Bull (2007) 1.45
Detergent-resistant microdomains determine the localization of sigma-1 receptors to the endoplasmic reticulum-mitochondria junction. Mol Pharmacol (2010) 1.44
The sigma-1 receptor modulates NMDA receptor synaptic transmission and plasticity via SK channels in rat hippocampus. J Physiol (2006) 1.40
Sigma receptor agonists: receptor binding and effects on mesolimbic dopamine neurotransmission assessed by microdialysis. Biol Psychiatry (2010) 1.39
Prevention of excitotoxicity in primary retinal ganglion cells by (+)-pentazocine, a sigma receptor-1 specific ligand. Invest Ophthalmol Vis Sci (2007) 1.35
In vivo protection against retinal neurodegeneration by sigma receptor 1 ligand (+)-pentazocine. Invest Ophthalmol Vis Sci (2008) 1.33
Role of sigma-1 receptor C-terminal segment in inositol 1,4,5-trisphosphate receptor activation: constitutive enhancement of calcium signaling in MCF-7 tumor cells. J Biol Chem (2008) 1.32
Dehydroepiandrosterone: a potential signalling molecule for neocortical organization during development. Proc Natl Acad Sci U S A (1998) 1.29
Membrane-delimited coupling between sigma receptors and K+ channels in rat neurohypophysial terminals requires neither G-protein nor ATP. J Physiol (2000) 1.26
Purification and characterization of the guinea pig sigma-1 receptor functionally expressed in Escherichia coli. Protein Expr Purif (2006) 1.22
Regulation of sigma-1 receptors and endoplasmic reticulum chaperones in the brain of methamphetamine self-administering rats. J Pharmacol Exp Ther (2009) 1.21
Expression, subcellular localization, and regulation of sigma receptor in retinal muller cells. Invest Ophthalmol Vis Sci (2006) 1.20
Sigma-1 receptors at galactosylceramide-enriched lipid microdomains regulate oligodendrocyte differentiation. Proc Natl Acad Sci U S A (2004) 1.18
Combination treatment with progesterone and vitamin D hormone may be more effective than monotherapy for nervous system injury and disease. Front Neuroendocrinol (2009) 1.16
The sigma-1 receptor protects against cellular oxidative stress and activates antioxidant response elements. Eur J Pharmacol (2012) 1.16
A Role for Sigma Receptors in Stimulant Self Administration and Addiction. Pharmaceuticals (Basel) (2011) 1.16
The sigma receptor: evolution of the concept in neuropsychopharmacology. Curr Neuropharmacol (2005) 1.16
Sigma 1 receptor modulation of G-protein-coupled receptor signaling: potentiation of opioid transduction independent from receptor binding. Mol Pharmacol (2010) 1.15
Voltage-gated sodium channel modulation by sigma-receptors in cardiac myocytes and heterologous systems. Am J Physiol Cell Physiol (2009) 1.13
Expression pattern of sigma receptor 1 mRNA and protein in mammalian retina. Brain Res Mol Brain Res (2001) 1.13
The σ2 receptor: a novel protein for the imaging and treatment of cancer. J Med Chem (2013) 1.13
The novel sigma-2 receptor ligand SW43 stabilizes pancreas cancer progression in combination with gemcitabine. Mol Cancer (2010) 1.11
Analysis of sigma receptor (sigmaR1) expression in retinal ganglion cells cultured under hyperglycemic conditions and in diabetic mice. Brain Res Mol Brain Res (2002) 1.10
Sigma-1 receptors regulate Bcl-2 expression by reactive oxygen species-dependent transcriptional regulation of nuclear factor kappaB. J Pharmacol Exp Ther (2009) 1.10
The sigma1 receptor interacts with N-alkyl amines and endogenous sphingolipids. Eur J Pharmacol (2009) 1.10
Sigma-1 receptor knockout mice display a depressive-like phenotype. Behav Brain Res (2008) 1.09
Sigma-1 receptor chaperones and diseases. Cent Nerv Syst Agents Med Chem (2009) 1.08
Development of molecular probes for imaging sigma-2 receptors in vitro and in vivo. Cent Nerv Syst Agents Med Chem (2009) 1.07
Juxtaposition of the steroid binding domain-like I and II regions constitutes a ligand binding site in the sigma-1 receptor. J Biol Chem (2008) 1.07
Demonstration of a direct interaction between sigma-1 receptors and acid-sensing ion channels. Biophys J (2010) 1.06
Sigma receptors: potential targets for a new class of antidepressant drug. Pharmacol Ther (2010) 1.05
Intracellular sigma1 receptor modulates phospholipase C and protein kinase C activities in the brainstem. Proc Natl Acad Sci U S A (1999) 1.05
The sigma-receptor antagonist BD-1063 decreases ethanol intake and reinforcement in animal models of excessive drinking. Neuropsychopharmacology (2008) 1.04
Crystal structure of the human σ1 receptor. Nature (2016) 1.03
Accelerated retinal ganglion cell death in mice deficient in the Sigma-1 receptor. Mol Vis (2011) 1.02
Sigma receptor 1 modulates endoplasmic reticulum stress in retinal neurons. Invest Ophthalmol Vis Sci (2011) 1.02
Antagonism of sigma-1 receptors blocks compulsive-like eating. Neuropsychopharmacology (2012) 1.01
Modulation of serotonergic neurotransmission by short- and long-term treatments with sigma ligands. Br J Pharmacol (2001) 0.99
Activation of σ-receptors induces binge-like drinking in Sardinian alcohol-preferring rats. Neuropsychopharmacology (2011) 0.98
Probing the steroid binding domain-like I (SBDLI) of the sigma-1 receptor binding site using N-substituted photoaffinity labels. Biochemistry (2008) 0.98
Sigma-1 receptor agonist PRE084 is protective against mutant huntingtin-induced cell degeneration: involvement of calpastatin and the NF-κB pathway. Cell Death Dis (2013) 0.98
Using guinea pigs in studies relevant to asthma and COPD. Pulm Pharmacol Ther (2008) 0.98
Antagonist action of progesterone at σ-receptors in the modulation of voltage-gated sodium channels. Am J Physiol Cell Physiol (2010) 0.97
Novel sigma (sigma) receptor agonists produce antidepressant-like effects in mice. Eur Neuropsychopharmacol (2007) 0.95
Sigma receptor 1 modulates ER stress and Bcl2 in murine retina. Cell Tissue Res (2014) 0.93
Expression of a truncated form of the endoplasmic reticulum chaperone protein, σ1 receptor, promotes mitochondrial energy depletion and apoptosis. J Biol Chem (2012) 0.93
Photoaffinity labeling of the sigma-1 receptor with N-[3-(4-nitrophenyl)propyl]-N-dodecylamine: evidence of receptor dimers. Biochemistry (2013) 0.93
Sigma-2 ligands induce tumour cell death by multiple signalling pathways. Br J Cancer (2012) 0.93
S2RSLDB: a comprehensive manually curated, internet-accessible database of the sigma-2 receptor selective ligands. J Cheminform (2017) 0.92
Antinociceptive effects of haloperidol and its metabolites in the formalin test in mice. Psychopharmacology (Berl) (2005) 0.92
The sigma-1 receptor binds to the Nav1.5 voltage-gated Na+ channel with 4-fold symmetry. J Biol Chem (2012) 0.92
The attenuation of learning impairments induced after exposure to CO or trimethyltin in mice by sigma (sigma) receptor ligands involves both sigma1 and sigma2 sites. Br J Pharmacol (1999) 0.92
Sigma 1 receptor regulates the oxidative stress response in primary retinal Müller glial cells via NRF2 signaling and system xc(-), the Na(+)-independent glutamate-cystine exchanger. Free Radic Biol Med (2015) 0.92
Sig1R protein regulates hERG channel expression through a post-translational mechanism in leukemic cells. J Biol Chem (2011) 0.91
New N-substituted 9-azabicyclo[3.3.1]nonan-3alpha-yl phenylcarbamate analogs as sigma2 receptor ligands: synthesis, in vitro characterization, and evaluation as PET imaging and chemosensitization agents. Bioorg Med Chem (2008) 0.91
σ-1 receptor at the mitochondrial-associated endoplasmic reticulum membrane is responsible for mitochondrial metabolic regulation. J Pharmacol Exp Ther (2012) 0.91
An unambiguous assay for the cloned human sigma1 receptor reveals high affinity interactions with dopamine D4 receptor selective compounds and a distinct structure-affinity relationship for butyrophenones. Eur J Pharmacol (2007) 0.90
Characterization of the human sigma-1 receptor chaperone domain structure and binding immunoglobulin protein (BiP) interactions. J Biol Chem (2013) 0.90
The Sigma-1 Receptor as a Pluripotent Modulator in Living Systems. Trends Pharmacol Sci (2016) 0.90
The oligomeric states of the purified sigma-1 receptor are stabilized by ligands. J Biol Chem (2014) 0.89
Characterization and evaluation of two novel fluorescent sigma-2 receptor ligands as proliferation probes. Mol Imaging (2011) 0.89
The Sigma-2 Receptor and Progesterone Receptor Membrane Component 1 are Different Binding Sites Derived From Independent Genes. EBioMedicine (2015) 0.89
The sigma-1 receptors are present in monomeric and oligomeric forms in living cells in the presence and absence of ligands. Biochem J (2015) 0.87
Functional assays to define agonists and antagonists of the sigma-2 receptor. Anal Biochem (2013) 0.86
Role of the mu-opioid receptor in opioid modulation of immune function. Amino Acids (2011) 0.86
A role for sigma receptors in stimulant self-administration and addiction. Behav Pharmacol (2016) 0.85
Antidiarrhoeal properties of a novel sigma ligand (JO 2871) on toxigenic diarrhoea in mice: mechanisms of action. Gut (2002) 0.85
The sigma-1 receptor: a regulator of cancer cell electrical plasticity? Front Physiol (2013) 0.84
The lifetime of UDP-galactose:ceramide galactosyltransferase is controlled by a distinct endoplasmic reticulum-associated degradation (ERAD) regulated by sigma-1 receptor chaperones. J Biol Chem (2012) 0.84
Radiosynthesis and biological evaluation of a promising sigma(2)-receptor ligand radiolabeled with fluorine-18 or iodine-125 as a PET/SPECT probe for imaging breast cancer. Appl Radiat Isot (2010) 0.84
Comparison of the administration of progesterone versus progesterone and vitamin D in improvement of outcomes in patients with traumatic brain injury: A randomized clinical trial with placebo group. Adv Biomed Res (2012) 0.84
The ligand binding region of the sigma-1 receptor: studies utilizing photoaffinity probes, sphingosine and N-alkylamines. Curr Pharm Des (2012) 0.84
Neuroprotective effects of high affinity Σ1 receptor selective compounds. Brain Res (2011) 0.83
Cholesterol at the endoplasmic reticulum: roles of the sigma-1 receptor chaperone and implications thereof in human diseases. Subcell Biochem (2010) 0.83
Anti-amnesic effect of dimemorfan in mice. Br J Pharmacol (2003) 0.83
Differential involvement of the sigma(1) (sigma(1)) receptor in the anti-amnesic effect of neuroactive steroids, as demonstrated using an in vivo antisense strategy in the mouse. Br J Pharmacol (2001) 0.83
Selective reduction of alcohol drinking in Sardinian alcohol-preferring rats by a sigma-1 receptor antagonist. Psychopharmacology (Berl) (2009) 0.82
Evidence for sigma-1-like receptors in isolated rat liver mitochondrial membranes. Br J Pharmacol (2002) 0.82
Effect of structural modification in the amine portion of substituted aminobutyl-benzamides as ligands for binding σ1 and σ2 receptors. Bioorg Med Chem (2011) 0.82
Sigma receptor 1 activation attenuates release of inflammatory cytokines MIP1γ, MIP2, MIP3α, and IL12 (p40/p70) by retinal Müller glial cells. J Neurochem (2015) 0.82
Ultra-performance liquid chromatography tandem mass spectrometry method for the determination of AZ66, a sigma receptor ligand, in rat plasma and its application to in vivo pharmacokinetics. Biomed Chromatogr (2013) 0.82
Synthesis and characterization of N,N-dialkyl and N-alkyl-N-aralkyl fenpropimorph-derived compounds as high affinity ligands for sigma receptors. Bioorg Med Chem (2010) 0.81
Characterization of interactions of 4-nitrophenylpropyl-N-alkylamine with ς receptors. Biochemistry (2011) 0.81
Determination of a highly selective mixed-affinity sigma receptor ligand, in rat plasma by ultra performance liquid chromatography mass spectrometry and its application to a pharmacokinetic study. J Chromatogr B Analyt Technol Biomed Life Sci (2011) 0.81
Effects of (+)-pentazocine and 1,3-di-o-tolylguanidine (DTG), sigma (sigma) ligands, on micturition in anaesthetized rats. Br J Pharmacol (2000) 0.81
Synthesis and pharmacological characterization of a novel sigma receptor ligand with improved metabolic stability and antagonistic effects against methamphetamine. AAPS J (2011) 0.81
Sigma receptor activation inhibits voltage-gated sodium channels in rat intracardiac ganglion neurons. Int J Physiol Pathophysiol Pharmacol (2009) 0.80
Cyproheptadine enhances the I(K) of mouse cortical neurons through sigma-1 receptor-mediated intracellular signal pathway. PLoS One (2012) 0.80
Identification of the Sigma-2 Receptor: Distinct from the Progesterone Receptor Membrane Component 1 (PGRMC1). J Alcohol Drug Depend (2016) 0.80
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