Published in Proc Natl Acad Sci U S A on September 18, 2001
Efficient targeted gene disruption in the soma and germ line of the frog Xenopus tropicalis using engineered zinc-finger nucleases. Proc Natl Acad Sci U S A (2011) 1.90
Genetic disorders of the skeleton: a developmental approach. Am J Hum Genet (2003) 1.52
A new subtype of brachydactyly type B caused by point mutations in the bone morphogenetic protein antagonist NOGGIN. Am J Hum Genet (2007) 1.31
GDF5 is a second locus for multiple-synostosis syndrome. Am J Hum Genet (2006) 1.24
Autosomal dominant stapes ankylosis with broad thumbs and toes, hyperopia, and skeletal anomalies is caused by heterozygous nonsense and frameshift mutations in NOG, the gene encoding noggin. Am J Hum Genet (2002) 1.16
Characterization of wise protein and its molecular mechanism to interact with both Wnt and BMP signals. J Biol Chem (2009) 1.14
Aggressive melanoma cells escape from BMP7-mediated autocrine growth inhibition through coordinated Noggin upregulation. Lab Invest (2008) 0.96
Noggin attenuates cerulein-induced acute pancreatitis and impaired autophagy. Pancreas (2013) 0.87
Modulation of Bone Morphogenetic Protein (BMP) 2 gene expression by Sp1 transcription factors. Gene (2007) 0.84
Secreted Protein Acidic and Rich in Cysteine (SPARC) Mediates Metastatic Dormancy of Prostate Cancer in Bone. J Biol Chem (2016) 0.82
Expression and functional study of extracellular BMP antagonists during the morphogenesis of the digits and their associated connective tissues. PLoS One (2013) 0.77
Neuroprotection by rAAV-mediated gene transfer of bone morphogenic protein 7. BMC Neurosci (2014) 0.76
Nucleotide polymorphisms in the canine Noggin gene and their distribution among dog (Canis lupus familiaris) breeds. Biochem Genet (2011) 0.76
Recurrent missense mutation of GDF5 (p.R438L) causes proximal symphalangism in a British family. World J Orthop (2016) 0.75
The Spemann organizer signal noggin binds and inactivates bone morphogenetic protein 4. Cell (1996) 5.66
Expression cloning of noggin, a new dorsalizing factor localized to the Spemann organizer in Xenopus embryos. Cell (1992) 5.31
Noggin, cartilage morphogenesis, and joint formation in the mammalian skeleton. Science (1998) 4.72
Limb alterations in brachypodism mice due to mutations in a new member of the TGF beta-superfamily. Nature (1994) 3.99
Noggin-mediated antagonism of BMP signaling is required for growth and patterning of the neural tube and somite. Genes Dev (1998) 3.46
Requirement for BMP signaling in interdigital apoptosis and scale formation. Science (1996) 3.40
Bone morphogenetic proteins in development. Curr Opin Genet Dev (1996) 3.37
Bone morphogenetic protein and bone morphogenetic protein gene family in bone formation and repair. Clin Orthop Relat Res (1998) 2.73
lefty-1 is required for left-right determination as a regulator of lefty-2 and nodal. Cell (1998) 2.63
Disruption of human limb morphogenesis by a dominant negative mutation in CDMP1. Nat Genet (1997) 2.38
Wnt signaling in Xenopus embryos inhibits bmp4 expression and activates neural development. Genes Dev (1999) 2.24
Mutations in CDMP1 cause autosomal dominant brachydactyly type C. Nat Genet (1997) 2.06
Secreted noggin protein mimics the Spemann organizer in dorsalizing Xenopus mesoderm. Nature (1993) 2.02
Regulation of bone morphogenetic protein activity by pro domains and proprotein convertases. J Cell Biol (1999) 1.87
Heterozygous mutations in the gene encoding noggin affect human joint morphogenesis. Nat Genet (1999) 1.67
Bone morphogenetic proteins in human bone regeneration. Eur J Endocrinol (2000) 1.62
Cation and voltage dependence of rat kidney electrogenic Na(+)-HCO(-)(3) cotransporter, rkNBC, expressed in oocytes. Am J Physiol (1999) 1.57
Head induction by simultaneous repression of Bmp and Wnt signalling in Xenopus. Nature (1997) 1.52
Expression and function of Gdf-5 during digit skeletogenesis in the embryonic chick leg bud. Dev Biol (1999) 1.28
Characterization and mutation analysis of human LEFTY A and LEFTY B, homologues of murine genes implicated in left-right axis development. Am J Hum Genet (1999) 1.23
Osteogenesis in the interior of intramuscular implants of decalcified bone matrix. Clin Orthop Relat Res (1966) 1.14
Xenopus GDF6, a new antagonist of noggin and a partner of BMPs. Development (1999) 1.06
Localization of a multiple synostoses-syndrome disease gene to chromosome 17q21-22. Am J Hum Genet (1998) 0.85
Three novel type I collagen mutations in osteogenesis imperfecta type IV probands are associated with discrepancies between electrophoretic migration of osteoblast and fibroblast collagen. Hum Mutat (1998) 0.84
LDL receptor-related protein 5 (LRP5) affects bone accrual and eye development. Cell (2001) 11.99
Cloning and characterization of a mammalian proton-coupled metal-ion transporter. Nature (1997) 9.98
Preparation of PCR-quality mouse genomic DNA with hot sodium hydroxide and tris (HotSHOT). Biotechniques (2000) 7.03
The Spemann organizer signal noggin binds and inactivates bone morphogenetic protein 4. Cell (1996) 5.66
Expression cloning of noggin, a new dorsalizing factor localized to the Spemann organizer in Xenopus embryos. Cell (1992) 5.31
Vascular dysmorphogenesis caused by an activating mutation in the receptor tyrosine kinase TIE2. Cell (1996) 5.10
Dishevelled controls cell polarity during Xenopus gastrulation. Nature (2000) 4.91
Noggin, cartilage morphogenesis, and joint formation in the mammalian skeleton. Science (1998) 4.72
A human Mad protein acting as a BMP-regulated transcriptional activator. Nature (1996) 4.36
Regulated replication of DNA microinjected into eggs of Xenopus laevis. Cell (1980) 4.24
A fibrillar collagen gene, Col11a1, is essential for skeletal morphogenesis. Cell (1995) 3.59
Expression cloning of a mammalian proton-coupled oligopeptide transporter. Nature (1994) 3.54
Noggin-mediated antagonism of BMP signaling is required for growth and patterning of the neural tube and somite. Genes Dev (1998) 3.46
Neural induction by the secreted polypeptide noggin. Science (1993) 3.45
Transcription of DNA injected into Xenopus oocytes is influenced by template topology. Nature (1983) 3.02
The Xenopus dorsalizing factor Gremlin identifies a novel family of secreted proteins that antagonize BMP activities. Mol Cell (1998) 2.89
Effect of expressing the water channel aquaporin-1 on the CO2 permeability of Xenopus oocytes. Am J Physiol (1998) 2.84
A mutation in the homeodomain of the human MSX2 gene in a family affected with autosomal dominant craniosynostosis. Cell (1993) 2.80
The organizer factors Chordin and Noggin are required for mouse forebrain development. Nature (2000) 2.78
Injected Xwnt-8 RNA acts early in Xenopus embryos to promote formation of a vegetal dorsalizing center. Cell (1991) 2.72
CACP, encoding a secreted proteoglycan, is mutated in camptodactyly-arthropathy-coxa vara-pericarditis syndrome. Nat Genet (1999) 2.60
A novel mesoderm inducer, Madr2, functions in the activin signal transduction pathway. Genes Dev (1996) 2.47
Association of articular cartilage degradation and loss of boundary-lubricating ability of synovial fluid following injury and inflammatory arthritis. Arthritis Rheum (2005) 2.47
Wnt signaling in Xenopus embryos inhibits bmp4 expression and activates neural development. Genes Dev (1999) 2.24
Mutations in the CCN gene family member WISP3 cause progressive pseudorheumatoid dysplasia. Nat Genet (1999) 2.23
Cell autonomous regulation of multiple Dishevelled-dependent pathways by mammalian Nkd. Proc Natl Acad Sci U S A (2001) 2.22
DNA synthesis in a cell-free system from Xenopus eggs: priming and elongation on single-stranded DNA in vitro. Cell (1982) 2.15
Expression of GATA-binding proteins during embryonic development in Xenopus laevis. Proc Natl Acad Sci U S A (1991) 2.12
The novel Cer-like protein Caronte mediates the establishment of embryonic left-right asymmetry. Nature (1999) 2.08
Mutations in CDMP1 cause autosomal dominant brachydactyly type C. Nat Genet (1997) 2.06
Essential requirement of BMPs-2/4 for both osteoblast and osteoclast formation in murine bone marrow cultures from adult mice: antagonism by noggin. J Bone Miner Res (2000) 2.03
Secreted noggin protein mimics the Spemann organizer in dorsalizing Xenopus mesoderm. Nature (1993) 2.02
The BMP antagonist Gremlin regulates outgrowth, chondrogenesis and programmed cell death in the developing limb. Development (1999) 1.96
The role of lubricin in the mechanical behavior of synovial fluid. Proc Natl Acad Sci U S A (2007) 1.94
Osteoporosis-pseudoglioma syndrome, a disorder affecting skeletal strength and vision, is assigned to chromosome region 11q12-13. Am J Hum Genet (1996) 1.89
Splicing mutations of 54-bp exons in the COL11A1 gene cause Marshall syndrome, but other mutations cause overlapping Marshall/Stickler phenotypes. Am J Hum Genet (1999) 1.88
Assignment of a locus for dominantly inherited venous malformations to chromosome 9p. Hum Mol Genet (1994) 1.83
Xenopus Dishevelled signaling regulates both neural and mesodermal convergent extension: parallel forces elongating the body axis. Development (2001) 1.82
Sequence-specific endonucleolytic cleavage and protection of mRNA in Xenopus and Drosophila. Genes Dev (1993) 1.82
Identification of mammalian noggin and its expression in the adult nervous system. J Neurosci (1995) 1.81
LEF-1/TCF proteins mediate wnt-inducible transcription from the Xenopus nodal-related 3 promoter. Dev Biol (1997) 1.78
Heterozygous mutations in the gene encoding noggin affect human joint morphogenesis. Nat Genet (1999) 1.67
Fibroblast growth factor is a direct neural inducer, which combined with noggin generates anterior-posterior neural pattern. Development (1995) 1.63
Skeletal overexpression of noggin results in osteopenia and reduced bone formation. Endocrinology (2003) 1.60
A gene for familial venous malformations maps to chromosome 9p in a second large kindred. J Med Genet (1995) 1.59
Replication origins in the eucaryotic chromosome. Cell (1981) 1.58
Cation and voltage dependence of rat kidney electrogenic Na(+)-HCO(-)(3) cotransporter, rkNBC, expressed in oocytes. Am J Physiol (1999) 1.57
Identification of a retinoic acid-sensitive period during primary axis formation in Xenopus laevis. Genes Dev (1990) 1.54
A nodal-related gene defines a physical and functional domain within the Spemann organizer. Cell (1995) 1.52
Localization of specific mRNAs in Xenopus embryos by whole-mount in situ hybridization. Development (1990) 1.52
The neural plate specifies somite size in the Xenopus laevis gastrula. Dev Cell (2001) 1.52
A mutation in the gene encoding the alpha 2 chain of the fibril-associated collagen IX, COL9A2, causes multiple epiphyseal dysplasia (EDM2). Nat Genet (1996) 1.47
Genetic and physical analysis of the chicken tk gene. Mol Cell Biol (1984) 1.47
Endonucleolytic cleavage of a maternal homeo box mRNA in Xenopus oocytes. Genes Dev (1990) 1.44
An electrogenic Na(+)-HCO(-)(3) cotransporter (NBC) with a novel COOH-terminus, cloned from rat brain. Am J Physiol Cell Physiol (2000) 1.44
Functional characterization of the Bcl-2 gene family in the zebrafish. Cell Death Differ (2006) 1.43
Regulation of convergent extension in Xenopus by Wnt5a and Frizzled-8 is independent of the canonical Wnt pathway. Int J Dev Biol (2001) 1.42
Genetic mapping of cleidocranial dysplasia and evidence of a microdeletion in one family. Hum Mol Genet (1995) 1.42
Cloning and characterization of a Na+-driven anion exchanger (NDAE1). A new bicarbonate transporter. J Biol Chem (2000) 1.42
Immunolocalization of the electrogenic Na+-HCO-3 cotransporter in mammalian and amphibian kidney. Am J Physiol (1999) 1.40
Cloning of cDNA and genomic DNA encoding human type XVIII collagen and localization of the alpha 1(XVIII) collagen gene to mouse chromosome 10 and human chromosome 21. Genomics (1994) 1.38
Electrogenic properties of the epithelial and neuronal high affinity glutamate transporter. J Biol Chem (1995) 1.37
A gene for inherited cutaneous venous anomalies ("glomangiomas") localizes to chromosome 1p21-22. Am J Hum Genet (1999) 1.37
Assays for gene function in developing Xenopus embryos. Methods Cell Biol (1991) 1.37
Cephalic expression and molecular characterization of Xenopus En-2. Development (1991) 1.37
Stoichiometry and pH dependence of the rabbit proton-dependent oligopeptide transporter PepT1. J Physiol (1997) 1.36
The camptodactyly-arthropathy-coxa vara-pericarditis syndrome: clinical features and genetic mapping to human chromosome 1. Arthritis Rheum (1998) 1.35
Cloning and characterization of a human electrogenic Na+-HCO-3 cotransporter isoform (hhNBC). Am J Physiol (1999) 1.34
Nomenclature: vertebrate mediators of TGFbeta family signals. Cell (1996) 1.34
Morphogenesis of digits in the avian limb is controlled by FGFs, TGFbetas, and noggin through BMP signaling. Dev Biol (1998) 1.32
Distinct enhancer elements control Hex expression during gastrulation and early organogenesis. Dev Biol (2001) 1.31
Calcium signaling during convergent extension in Xenopus. Curr Biol (2001) 1.28
Expression and function of Gdf-5 during digit skeletogenesis in the embryonic chick leg bud. Dev Biol (1999) 1.28
A member of a family of sulfate-activating enzymes causes murine brachymorphism. Proc Natl Acad Sci U S A (1998) 1.26
Expression of an engrailed-related protein is induced in the anterior neural ectoderm of early Xenopus embryos. Development (1989) 1.25
Stoichiometry of the rat kidney Na+-HCO3- cotransporter expressed in Xenopus laevis oocytes. Pflugers Arch (1999) 1.23
Dorsal-ventral patterning and differentiation of noggin-induced neural tissue in the absence of mesoderm. Development (1995) 1.23
Marshall syndrome associated with a splicing defect at the COL11A1 locus. Am J Hum Genet (1998) 1.17
A large family with features of pseudoachondroplasia and multiple epiphyseal dysplasia: exclusion of seven candidate gene loci that encode proteins of the cartilage extracellular matrix. Hum Genet (1994) 1.16
Stickler syndrome without eye involvement is caused by mutations in COL11A2, the gene encoding the alpha2(XI) chain of type XI collagen. J Pediatr (1998) 1.14
Inheritance of DNA methylation in microinjected eggs of Xenopus laevis. Proc Natl Acad Sci U S A (1982) 1.12
Genetic mapping of a locus for multiple epiphyseal dysplasia (EDM2) to a region of chromosome 1 containing a type IX collagen gene. Am J Hum Genet (1994) 1.12
A Stickler syndrome gene is linked to chromosome 6 near the COL11A2 gene. Hum Mol Genet (1994) 1.10
Expression of BMP-7 and USAG-1 (a BMP antagonist) in kidney development and injury. Kidney Int (2007) 1.10
Posterior expression of a homeobox gene in early Xenopus embryos. Development (1987) 1.10
Human uterine cervical epithelial cells grown on permeable support--a new model for the study of differentiation. Differentiation (1994) 1.10
Symmetry of H+ binding to the intra- and extracellular side of the H+-coupled oligopeptide cotransporter PepT1. J Biol Chem (1997) 1.09
From receptor to nucleus: the Smad pathway. Curr Opin Genet Dev (1997) 1.08
The bone morphogenetic proteins antagonist Noggin inhibits membranous ossification. J Bone Miner Res (2001) 1.06
Bone morphogenetic proteins induce gremlin, a protein that limits their activity in osteoblasts. Endocrinology (2000) 1.05
XBF-2 is a transcriptional repressor that converts ectoderm into neural tissue. Development (1998) 1.05
Biochemical and biophysical characterization of refolded Drosophila DPP, a homolog of bone morphogenetic proteins 2 and 4. J Biol Chem (1998) 1.05
Autosomal recessive disorder otospondylomegaepiphyseal dysplasia is associated with loss-of-function mutations in the COL11A2 gene. Am J Hum Genet (2000) 1.04
Analyzing bone, blood vessels, and biomaterials with microcomputed tomography. IEEE Eng Med Biol Mag (2003) 1.04
Expression pattern of two Frizzled-related genes, Frzb-1 and Sfrp-1, during mouse embryogenesis suggests a role for modulating action of Wnt family members. Dev Dyn (1998) 1.02
Ventral ectoderm of Xenopus forms neural tissue, including hindbrain, in response to activin. Development (1992) 0.99
Ras-mediated FGF signaling is required for the formation of posterior but not anterior neural tissue in Xenopus laevis. Dev Biol (2000) 0.98