Published in J Clin Invest on October 01, 1975
Interaction of coagulation factor Xa with human platelets. Proc Natl Acad Sci U S A (1977) 2.03
The human complement system in thrombin-mediated platelet function. J Exp Med (1978) 1.36
Reduced thrombin binding and aggregation in Bernard-Soulier platelets. J Clin Invest (1978) 1.22
Human complement in thrombin-mediated platelet function: uptake of the C5b-9 complex. J Exp Med (1979) 1.13
Human thrombomodulin is not an efficient inhibitor of the procoagulant activity of thrombin. J Clin Invest (1985) 1.07
Thrombin generation and secretion of platelet Factor 4 during blood clotting. J Clin Invest (1978) 0.94
Properdin factor D: effects on thrombin-induced platelet aggregation. J Clin Invest (1979) 0.82
A spectrophotometric determination of trypsin and chymotrypsin. Biochim Biophys Acta (1955) 7.79
The binding of thrombin to the surface of human platelets. J Biol Chem (1974) 3.41
Isolation and properties of a thrombin-sensitive protein of human platelets. J Biol Chem (1972) 2.54
Thrombin-induced protein phosphorylation in human platelets. J Clin Invest (1975) 1.76
The binding of phytohemagglutinins to human platelet plasma membranes. J Biol Chem (1972) 1.59
Inhibition of human platelet aggregation by monovalent antifibrinogen antibody fragments. J Clin Invest (1975) 1.32
Polyethylene glycol 6,000 enhancement of the clotting of fibrinogen solutions in visual and mechanical assays. Thromb Res (1974) 1.26
The effects of thrombin on adenyl cyclase activity and a membrane protein from human platelets. J Clin Invest (1972) 1.24
Induction of the platelet release reaction by phytohemagglutinin. J Clin Invest (1974) 1.23
Adherence of platelets to a collagen-coated surface: development of a quantitative method. J Lab Clin Med (1973) 1.12
Binding of insulin and other hormones to non-receptor materials: saturability, specificity and apparent "negative cooperativity". Biochem Biophys Res Commun (1975) 1.10
Binding of the products of prothrombin activation to human platelets. J Clin Invest (1975) 1.00
Relation of glucagon-specific binding sites to glucagon-dependent stimulation of adenylyl cyclase activity in plasma membranes of rat liver. J Biol Chem (1973) 0.99
Effects of anions on the substrate affinities of the pyridoxal and pyridoxamine forms of mitochondrial and supernatant aspartate transaminases. J Biol Chem (1971) 0.92
Acetylation of prostaglandin synthase by aspirin. Proc Natl Acad Sci U S A (1975) 4.92
Anti-VEGF antibody treatment of glioblastoma prolongs survival but results in increased vascular cooption. Neoplasia (2001) 4.22
The metabolism of phosphoinositide-derived messenger molecules. Science (1986) 3.58
Diglyceride lipase: a pathway for arachidonate release from human platelets. Proc Natl Acad Sci U S A (1979) 3.48
The binding of thrombin to the surface of human platelets. J Biol Chem (1974) 3.41
The mechanism of the effect of aspirin on human platelets. I. Acetylation of a particulate fraction protein. J Clin Invest (1975) 3.40
A platelet alpha-granule membrane protein (GMP-140) is expressed on the plasma membrane after activation. J Cell Biol (1985) 3.02
A thrombin-sensitive protein of human platelet membranes. Proc Natl Acad Sci U S A (1971) 2.97
SopB, a protein required for virulence of Salmonella dublin, is an inositol phosphate phosphatase. Proc Natl Acad Sci U S A (1998) 2.73
The 145-kDa protein induced to associate with Shc by multiple cytokines is an inositol tetraphosphate and phosphatidylinositol 3,4,5-triphosphate 5-phosphatase. Proc Natl Acad Sci U S A (1996) 2.68
Fraud in medical research. Presidential address delivered before the 74th annual meeting of the American Society for Clinical Investigation, Washington, DC, 8 May 1982. J Clin Invest (1982) 2.62
Properties of the factor Xa binding site on human platelets. J Biol Chem (1978) 2.59
Isolation of a phosphomonoesterase from human platelets that specifically hydrolyzes the 5-phosphate of inositol 1,4,5-trisphosphate. J Biol Chem (1985) 2.55
Isolation and properties of a thrombin-sensitive protein of human platelets. J Biol Chem (1972) 2.54
Inhibition of platelet prostaglandin synthetase by oral aspirin. J Clin Invest (1978) 2.40
Formation of phosphatidylinositol 3-phosphate by isomerization from phosphatidylinositol 4-phosphate. Proc Natl Acad Sci U S A (1991) 2.35
Detection and sequence of mutations in the factor VIII gene of haemophiliacs. Nature (1985) 2.30
Cultured human skin fibroblasts and arterial cells produce a labile platelet-inhibitory prostaglandin. Biochem Biophys Res Commun (1977) 2.30
Protein kinase C phosphorylates human platelet inositol trisphosphate 5'-phosphomonoesterase, increasing the phosphatase activity. Cell (1986) 2.15
Association of androgenic-anabolic steroid therapy with development of hepatocellular carcinoma. Lancet (1972) 2.13
Prothrombin is activated on vascular endothelial cells by factor Xa and calcium. Proc Natl Acad Sci U S A (1983) 2.06
Redistribution of alpha-granules and their contents in thrombin-stimulated platelets. J Cell Biol (1984) 2.06
Identification, cloning, and expression of a cytosolic megakaryocyte protein-tyrosine-phosphatase with sequence homology to cytoskeletal protein 4.1. Proc Natl Acad Sci U S A (1991) 2.04
Interaction of coagulation factor Xa with human platelets. Proc Natl Acad Sci U S A (1977) 2.03
Reverse biochemistry: use of macromolecular protease inhibitors to dissect complex biological processes and identify a membrane-type serine protease in epithelial cancer and normal tissue. Proc Natl Acad Sci U S A (1999) 2.01
Isolation and characterization of the inositol cyclic phosphate products of polyphosphoinositide cleavage by phospholipase C. Physiological effects in permeabilized platelets and Limulus photoreceptor cells. J Biol Chem (1985) 1.98
Structure and function of thrombomodulin: a natural anticoagulant. Blood (1990) 1.96
Isolation and quantitation of the platelet membrane glycoprotein deficient in thrombasthenia using a monoclonal hybridoma antibody. J Clin Invest (1980) 1.95
Thrombomodulin is found on endothelium of arteries, veins, capillaries, and lymphatics, and on syncytiotrophoblast of human placenta. J Cell Biol (1985) 1.92
Isolation of human platelets and platelet surface membranes. Methods Enzymol (1974) 1.91
Acetyl coenzyme A carboxylase. The roles of synthesis and degradation in regulation of enzyme levels in rat liver. J Biol Chem (1969) 1.91
The synthesis of sulfated dextran beads for isolation of human plasma coagulation factors II, IX, and X. Anal Biochem (1980) 1.89
The protein deficient in Lowe syndrome is a phosphatidylinositol-4,5-bisphosphate 5-phosphatase. Proc Natl Acad Sci U S A (1995) 1.87
Prevention of metastasis by inhibition of the urokinase receptor. Proc Natl Acad Sci U S A (1993) 1.82
Thrombin-induced protein phosphorylation in human platelets. J Clin Invest (1975) 1.76
Structure and function of the acyl carrier protein. Fed Proc (1967) 1.76
Phosphoinositide interconversion in thrombin-stimulated human platelets. J Biol Chem (1985) 1.74
Human thrombomodulin: complete cDNA sequence and chromosome localization of the gene. Biochemistry (1987) 1.72
Vascular endothelial growth factor and basic fibroblast growth factor urine levels as predictors of outcome in hormone-refractory prostate cancer patients: a cancer and leukemia group B study. Cancer Res (2001) 1.71
Characterization of a human Kaposi's sarcoma cell line that induces angiogenic tumors in animals. AIDS (1994) 1.68
Purification and characterization of human coagulation factor V. J Biol Chem (1981) 1.67
Phosphatidylinositol 3-phosphate is present in normal and transformed fibroblasts and is resistant to hydrolysis by bovine brain phospholipase C II. J Biol Chem (1989) 1.67
Cyclic adenosine 3',5'-monophosphate inhibits the availability of arachidonate to prostaglandin synthetase in human platelet suspensions. J Clin Invest (1977) 1.63
Characterization of the effects of cultured vascular cells on the activation of blood coagulation. Blood (1983) 1.63
Lipid metabolism in human platelets. II. De novo phospholipid synthesis and the effect of thrombin on the pattern of synthesis. J Clin Invest (1969) 1.62
Purification and properties of human coagulation factor VII. J Biol Chem (1980) 1.61
The cDNA cloning and characterization of inositol polyphosphate 4-phosphatase type II. Evidence for conserved alternative splicing in the 4-phosphatase family. J Biol Chem (1997) 1.60
Development of antithrombin antibodies following surgery in patients with prosthetic cardiac valves. Blood (1988) 1.60
Hydrolysis of polyphosphoinositides by purified sheep seminal vesicle phospholipase C enzymes. J Biol Chem (1984) 1.60
Identification of a missense mutation in the factor VIII gene of a mild hemophiliac. Science (1986) 1.60
Characterization of 1,2-diacylglycerol hydrolysis in human platelets. Demonstration of an arachidonoyl-monoacylglycerol intermediate. J Biol Chem (1983) 1.59
The binding of phytohemagglutinins to human platelet plasma membranes. J Biol Chem (1972) 1.59
The isolation and characterization of a cDNA encoding phospholipid-specific inositol polyphosphate 5-phosphatase. J Biol Chem (2000) 1.58
An AIDS-related cytotoxic autoantibody reacts with a specific antigen on stimulated CD4+ T cells. Nature (1987) 1.57
Multiple forms of an inositol polyphosphate 5-phosphatase form signaling complexes with Shc and Grb2. Curr Biol (1996) 1.57
Cell lines from kidney proximal tubules of a patient with Lowe syndrome lack OCRL inositol polyphosphate 5-phosphatase and accumulate phosphatidylinositol 4,5-bisphosphate. J Biol Chem (1998) 1.56
The measurement of thrombin in clotting blood by radioimmunoassay. J Clin Invest (1976) 1.56
Characterization of prostacyclin synthesis in cultured human arterial smooth muscle cells, venous endothelial cells and skin fibroblasts. Cell (1979) 1.55
Production of phosphoinositide-derived messengers. Cell (1984) 1.54
The isolation and characterization of cDNA encoding human and rat brain inositol polyphosphate 4-phosphatase. J Biol Chem (1995) 1.54
Identification and properties of two distinct phosphatidylinositol-specific phospholipase C enzymes from sheep seminal vesicular glands. J Biol Chem (1982) 1.54
Pathway for inositol 1,3,4-trisphosphate and 1,4-bisphosphate metabolism. Proc Natl Acad Sci U S A (1987) 1.53
Isolation and characterization of thrombomodulin from human placenta. J Biol Chem (1984) 1.50
Inositol cyclic phosphates are produced by cleavage of phosphatidylphosphoinositols (polyphosphoinositides) with purified sheep seminal vesicle phospholipase C enzymes. Proc Natl Acad Sci U S A (1985) 1.49
Definition of a metal-dependent/Li(+)-inhibited phosphomonoesterase protein family based upon a conserved three-dimensional core structure. Proc Natl Acad Sci U S A (1995) 1.47
Thrombin-cellular interactions. Ann N Y Acad Sci (1986) 1.47
The platelet fibrinogen receptor: an immunogold-surface replica study of agonist-induced ligand binding and receptor clustering. J Cell Biol (1987) 1.47
Urokinase receptor antagonists inhibit angiogenesis and primary tumor growth in syngeneic mice. Cancer Res (1996) 1.45
Arachidonate metabolism in vascular disorders. J Clin Invest (1983) 1.43
Patients with congenital factor V deficiency have decreased factor Xa binding sites on their platelets. J Clin Invest (1978) 1.42
The metabolism of tris- and tetraphosphates of inositol by 5-phosphomonoesterase and 3-kinase enzymes. J Biol Chem (1987) 1.41
Anaphylactoid reactions to vascular graft material presenting with vasodilation and subsequent disseminated intravascular coagulation. Anesthesiology (1989) 1.39
Thrombin-induced hydrolysis of phosphatidylinositol in human platelets. J Biol Chem (1980) 1.39
Prevention of thrombosis in patients on hemodialysis by low-dose aspirin. N Engl J Med (1979) 1.39
Properties of type II inositol polyphosphate 5-phosphatase. J Biol Chem (1995) 1.38
Inositol polyphosphate 1-phosphatase from calf brain. Purification and inhibition by Li+, Ca2+, and Mn2+. J Biol Chem (1987) 1.38
Biogenesis of the platelet receptor for fibrinogen: evidence for separate precursors for glycoproteins IIb and IIIa. Proc Natl Acad Sci U S A (1986) 1.37
Discovery of an arachidonoyl coenzyme A synthetase in human platelets. J Biol Chem (1982) 1.36
Retracted Target platelet antigen in homosexual men with immune thrombocytopenia. N Engl J Med (1985) 1.36
The urokinase receptor is expressed in invasive breast cancer but not in normal breast tissue. Cancer Res (1994) 1.36
Acyl carrier protein. VII. The primary structure of the substrate-binding site. J Biol Chem (1965) 1.35
Vascular endothelial growth factor promotes tumor dissemination by a mechanism distinct from its effect on primary tumor growth. Cancer Res (1996) 1.35
The activation loop of phosphatidylinositol phosphate kinases determines signaling specificity. Mol Cell (2000) 1.34
The structure and function of mouse thrombomodulin. Phorbol myristate acetate stimulates degradation and synthesis of thrombomodulin without affecting mRNA levels in hemangioma cells. J Biol Chem (1988) 1.34
The metabolism of inositol 1,3,4-trisphosphate to inositol 1,3-bisphosphate. J Biol Chem (1987) 1.32
Inositol hexakisphosphate binds to clathrin assembly protein 3 (AP-3/AP180) and inhibits clathrin cage assembly in vitro. J Biol Chem (1995) 1.32
Phosphatidylinositol-4-phosphate 5-kinase isozymes catalyze the synthesis of 3-phosphate-containing phosphatidylinositol signaling molecules. J Biol Chem (1997) 1.32
Inhibition of human platelet aggregation by monovalent antifibrinogen antibody fragments. J Clin Invest (1975) 1.32
Platelet glycoprotein IIb. Chromosomal localization and tissue expression. J Clin Invest (1987) 1.31
Isolation of inositol 1,3,4-trisphosphate 5/6-kinase, cDNA cloning and expression of the recombinant enzyme. J Biol Chem (1996) 1.30
Lack of covalent modification of prostaglandin synthetase (cyclo-oxygenase) by indomethacin. Prostaglandins (1977) 1.30
The regulation of fatty acid biosynthesis in rat hepatomas. J Biol Chem (1968) 1.29
The effects of mepacrine and p-bromophenacyl bromide on arachidonic acid release in human platelets. Arch Biochem Biophys (1982) 1.29
Factor Va-dependent binding of factor Xa to human platelets. J Biol Chem (1980) 1.28
Isolation and characterization of two 3-phosphatases that hydrolyze both phosphatidylinositol 3-phosphate and inositol 1,3-bisphosphate. J Biol Chem (1991) 1.27
Cloning of glycoprotein IIIa cDNA from human erythroleukemia cells and localization of the gene to chromosome 17. Blood (1988) 1.27
Isolation and characterization of the inositol cyclic phosphate products of phosphoinositide cleavage by phospholipase C. Metabolism in cell-free extracts. J Biol Chem (1986) 1.25
Hydrolysis of phosphatidylinositol 3,4-bisphosphate by inositol polyphosphate 4-phosphatase isolated by affinity elution chromatography. J Biol Chem (1994) 1.25
Endocytosis of fibrinogen into megakaryocyte and platelet alpha-granules is mediated by alpha IIb beta 3 (glycoprotein IIb-IIIa) Blood (1993) 1.25