Published in J Cell Biol on August 01, 1985
GMP-140, a platelet alpha-granule membrane protein, is also synthesized by vascular endothelial cells and is localized in Weibel-Palade bodies. J Clin Invest (1989) 4.59
The role of saliva in tick feeding. Front Biosci (Landmark Ed) (2009) 2.73
Structure and expression of human thrombomodulin, a thrombin receptor on endothelium acting as a cofactor for protein C activation. EMBO J (1987) 1.60
Glycosaminoglycans and the regulation of blood coagulation. Biochem J (1993) 1.57
Eosinophil cationic granule proteins impair thrombomodulin function. A potential mechanism for thromboembolism in hypereosinophilic heart disease. J Clin Invest (1993) 1.45
Complete antithrombin deficiency in mice results in embryonic lethality. J Clin Invest (2000) 1.44
Chondroitin-4-sulfate impairs in vitro and in vivo cytoadherence of Plasmodium falciparum infected erythrocytes. Mol Med (1997) 1.39
Thrombomodulin and its role in inflammation. Semin Immunopathol (2011) 1.30
Ex vivo desequestration of Plasmodium falciparum-infected erythrocytes from human placenta by chondroitin sulfate A. Infect Immun (1999) 1.29
Plasmodium falciparum-infected erythrocytes adhere both in the intervillous space and on the villous surface of human placenta by binding to the low-sulfated chondroitin sulfate proteoglycan receptor. Am J Pathol (2004) 1.19
Release of thrombomodulin from endothelial cells by concerted action of TNF-alpha and neutrophils: in vivo and in vitro studies. Immunology (1996) 1.17
Thrombomodulin is present in human plasma and urine. J Clin Invest (1985) 1.17
Activation mechanism of anticoagulant protein C in large blood vessels involving the endothelial cell protein C receptor. J Exp Med (1998) 1.13
Thrombomodulin expression by human keratinocytes. Induction of cofactor activity during epidermal differentiation. J Clin Invest (1994) 1.07
Fetomaternal cross talk in the placental vascular bed: control of coagulation by trophoblast cells. Blood (2005) 1.05
Rare glomerular capillary regeneration and subsequent capillary regression with endothelial cell apoptosis in progressive glomerulonephritis. Am J Pathol (1997) 1.03
Thrombomodulin is a determinant of metastasis through a mechanism linked to the thrombin binding domain but not the lectin-like domain. Blood (2011) 1.00
Proteasome inhibitors enhance endothelial thrombomodulin expression via induction of Krüppel-like transcription factors. Arterioscler Thromb Vasc Biol (2009) 0.99
Circulating endothelial cells in Kawasaki disease. Clin Exp Immunol (2003) 0.99
Vascular origin of Kaposi's sarcoma. Expression of leukocyte adhesion molecule-1, thrombomodulin, and tissue factor. Am J Pathol (1994) 0.97
AbetaPP/APLP2 family of Kunitz serine proteinase inhibitors regulate cerebral thrombosis. J Neurosci (2009) 0.97
Thrombomodulin modulates growth of tumor cells independent of its anticoagulant activity. J Clin Invest (1998) 0.95
Cellular localization of thrombomodulin in human epithelium and squamous malignancies. Am J Pathol (1995) 0.92
The volumetric composition of human term placentae: altitudinal, ethnic and sex differences in Bolivia. J Anat (1987) 0.92
Thrombomodulin expression in malignant pleural mesothelioma and pulmonary adenocarcinoma. Am J Pathol (1992) 0.89
Soluble thrombomodulin and antibodies to bovine glomerular endothelial cells in patients with Henoch-Schönlein purpura. Arch Dis Child (1998) 0.86
Elevated plasma thrombomodulin and angiopoietin-2 predict the development of acute kidney injury in patients with acute myocardial infarction. Crit Care (2014) 0.86
Molecular aspects of Plasmodium falciparum Infection during pregnancy. J Biomed Biotechnol (2007) 0.85
Thrombomodulin is silenced in malignant mesothelioma by a poly(ADP-ribose) polymerase-1-mediated epigenetic mechanism. J Biol Chem (2011) 0.85
Thrombomodulin expression in colorectal carcinoma is protective and correlates with survival. Br J Cancer (2006) 0.83
Production of endothelin-1 and thrombomodulin by human pancreatic cancer cells. Br J Cancer (1994) 0.83
Detection of thrombomodulin in human lung cancer cells. Am J Pathol (1993) 0.82
Up-regulation of thrombomodulin by activation of histamine H1-receptors in human umbilical-vein endothelial cells in vitro. Biochem J (1991) 0.82
Thrombomodulin promotes corneal epithelial wound healing. PLoS One (2015) 0.80
Placental thrombomodulin expression in recurrent miscarriage. Reprod Biol Endocrinol (2010) 0.79
Expression and localization of thrombomodulin in preneoplastic bronchial lesions and in lung cancer. Virchows Arch (1997) 0.79
Victims of lethal hypothermia have decreased levels of thrombomodulin in myocardium and urine. Int J Legal Med (2014) 0.78
The Normal anticoagulant system and risk of placental abruption: protein C, protein S and resistance to activated protein C. J Matern Fetal Neonatal Med (2010) 0.77
Thrombomodulin Protects Against Bacterial Keratitis, Is Anti-Inflammatory, but Not Angiogenic. Invest Ophthalmol Vis Sci (2015) 0.77
Altered expression of antithrombotic molecules in human glioma vessels. Acta Neuropathol (1994) 0.76
Reconstruction of mouse testicular cellular microenvironments in long-term seminiferous tubule culture. PLoS One (2014) 0.76
Association between arsenic exposure and soluble thrombomodulin: A cross sectional study in Bangladesh. PLoS One (2017) 0.75
Urinary thrombomodulin and catecholamine levels are interrelated in healthy volunteers immersed in cold and warm water. Temperature (Austin) (2015) 0.75
Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature (1970) 1528.65
"Western blotting": electrophoretic transfer of proteins from sodium dodecyl sulfate--polyacrylamide gels to unmodified nitrocellulose and radiographic detection with antibody and radioiodinated protein A. Anal Biochem (1981) 71.15
Culture of human endothelial cells derived from umbilical veins. Identification by morphologic and immunologic criteria. J Clin Invest (1973) 31.28
Arterial walls generate from prostaglandin endoperoxides a substance (prostaglandin X) which relaxes strips of mesenteric and coeliac ateries and inhibits platelet aggregation. Prostaglandins (1976) 4.54
Stimulation of endothelial cell prostacyclin production by thrombin, trypsin, and the ionophore A 23187. J Clin Invest (1978) 4.35
Identification of an endothelial cell cofactor for thrombin-catalyzed activation of protein C. Proc Natl Acad Sci U S A (1981) 3.88
Isolation of a membrane-bound cofactor for thrombin-catalyzed activation of protein C. J Biol Chem (1982) 3.51
Production of antisera with small doses of immunogen: multiple intradermal injections. Methods Enzymol (1981) 3.37
Properties of the factor Xa binding site on human platelets. J Biol Chem (1978) 2.59
Cultured human skin fibroblasts and arterial cells produce a labile platelet-inhibitory prostaglandin. Biochem Biophys Res Commun (1977) 2.30
Complex formation between thrombin and thrombomodulin inhibits both thrombin-catalyzed fibrin formation and factor V activation. J Biol Chem (1982) 2.04
Evidence for the formation of an ester between thrombin and heparin cofactor. Biochim Biophys Acta (1975) 1.97
Inactivation of human coagulation factor V by activated protein C. J Biol Chem (1983) 1.76
Isolation and characterization of thrombomodulin from human placenta. J Biol Chem (1984) 1.50
Cardiac and renal prostaglandin I2. Biosynthesis and biological effects in isolated perfused rabbit tissues. J Clin Invest (1978) 1.48
Microvascular heparin-like species with anticoagulant activity. Am J Physiol (1983) 1.34
Thrombomodulin blocks the ability of thrombin to activate platelets. J Biol Chem (1983) 1.33
Histamine stimulate prostacyclin synthesis in cultured human umbilical vein endothelial cells. Biochem Biophys Res Commun (1980) 1.19
Human thrombomodulin is not an efficient inhibitor of the procoagulant activity of thrombin. J Clin Invest (1985) 1.07
Coagulation factor Va binds to human umbilical vein endothelial cells and accelerates protein C activation. J Clin Invest (1984) 1.05
Enzymes in lymph: a review. J Clin Chem Clin Biochem (1983) 0.81
Acetylation of prostaglandin synthase by aspirin. Proc Natl Acad Sci U S A (1975) 4.92
The metabolism of phosphoinositide-derived messenger molecules. Science (1986) 3.58
Diglyceride lipase: a pathway for arachidonate release from human platelets. Proc Natl Acad Sci U S A (1979) 3.48
The binding of thrombin to the surface of human platelets. J Biol Chem (1974) 3.41
The mechanism of the effect of aspirin on human platelets. I. Acetylation of a particulate fraction protein. J Clin Invest (1975) 3.40
A thrombin-sensitive protein of human platelet membranes. Proc Natl Acad Sci U S A (1971) 2.97
SopB, a protein required for virulence of Salmonella dublin, is an inositol phosphate phosphatase. Proc Natl Acad Sci U S A (1998) 2.73
The 145-kDa protein induced to associate with Shc by multiple cytokines is an inositol tetraphosphate and phosphatidylinositol 3,4,5-triphosphate 5-phosphatase. Proc Natl Acad Sci U S A (1996) 2.68
Fraud in medical research. Presidential address delivered before the 74th annual meeting of the American Society for Clinical Investigation, Washington, DC, 8 May 1982. J Clin Invest (1982) 2.62
Properties of the factor Xa binding site on human platelets. J Biol Chem (1978) 2.59
Isolation of a phosphomonoesterase from human platelets that specifically hydrolyzes the 5-phosphate of inositol 1,4,5-trisphosphate. J Biol Chem (1985) 2.55
Isolation and properties of a thrombin-sensitive protein of human platelets. J Biol Chem (1972) 2.54
Human beta-glucuronidase: in vivo clearance and in vitro uptake by a glycoprotein recognition system on reticuloendothelial cells. Cell (1978) 2.50
Inhibition of platelet prostaglandin synthetase by oral aspirin. J Clin Invest (1978) 2.40
Efficacy and safety of recombinant human soluble thrombomodulin (ART-123) in disseminated intravascular coagulation: results of a phase III, randomized, double-blind clinical trial. J Thromb Haemost (2006) 2.40
Formation of phosphatidylinositol 3-phosphate by isomerization from phosphatidylinositol 4-phosphate. Proc Natl Acad Sci U S A (1991) 2.35
Cultured human skin fibroblasts and arterial cells produce a labile platelet-inhibitory prostaglandin. Biochem Biophys Res Commun (1977) 2.30
Chronic inflammatory arthropathy associated with HTLV-I. Lancet (1989) 2.28
Predominant recognition of human T cell leukemia virus type I (HTLV-I) pX gene products by human CD8+ cytotoxic T cells directed against HTLV-I-infected cells. Int Immunol (1991) 2.27
Greatly raised vascular endothelial growth factor (VEGF) in POEMS syndrome. Lancet (1996) 2.17
Protein kinase C phosphorylates human platelet inositol trisphosphate 5'-phosphomonoesterase, increasing the phosphatase activity. Cell (1986) 2.15
Association of androgenic-anabolic steroid therapy with development of hepatocellular carcinoma. Lancet (1972) 2.13
Overproduction of vascular endothelial growth factor/vascular permeability factor is causative in Crow-Fukase (POEMS) syndrome. Muscle Nerve (1998) 2.06
Identification, cloning, and expression of a cytosolic megakaryocyte protein-tyrosine-phosphatase with sequence homology to cytoskeletal protein 4.1. Proc Natl Acad Sci U S A (1991) 2.04
Interaction of coagulation factor Xa with human platelets. Proc Natl Acad Sci U S A (1977) 2.03
Evaluation of suicide awareness programmes delivered to veterinary undergraduates and academic staff. Vet Rec (2010) 2.03
Isolation and characterization of the inositol cyclic phosphate products of polyphosphoinositide cleavage by phospholipase C. Physiological effects in permeabilized platelets and Limulus photoreceptor cells. J Biol Chem (1985) 1.98
Structure and function of thrombomodulin: a natural anticoagulant. Blood (1990) 1.96
Isolation and quantitation of the platelet membrane glycoprotein deficient in thrombasthenia using a monoclonal hybridoma antibody. J Clin Invest (1980) 1.95
Isolation of human platelets and platelet surface membranes. Methods Enzymol (1974) 1.91
Acetyl coenzyme A carboxylase. The roles of synthesis and degradation in regulation of enzyme levels in rat liver. J Biol Chem (1969) 1.91
The synthesis of sulfated dextran beads for isolation of human plasma coagulation factors II, IX, and X. Anal Biochem (1980) 1.89
The protein deficient in Lowe syndrome is a phosphatidylinositol-4,5-bisphosphate 5-phosphatase. Proc Natl Acad Sci U S A (1995) 1.87
Thrombin-induced protein phosphorylation in human platelets. J Clin Invest (1975) 1.76
Structure and function of the acyl carrier protein. Fed Proc (1967) 1.76
Phosphoinositide interconversion in thrombin-stimulated human platelets. J Biol Chem (1985) 1.74
Human thrombomodulin: complete cDNA sequence and chromosome localization of the gene. Biochemistry (1987) 1.72
Purification and characterization of human coagulation factor V. J Biol Chem (1981) 1.67
Phosphatidylinositol 3-phosphate is present in normal and transformed fibroblasts and is resistant to hydrolysis by bovine brain phospholipase C II. J Biol Chem (1989) 1.67
Cyclic adenosine 3',5'-monophosphate inhibits the availability of arachidonate to prostaglandin synthetase in human platelet suspensions. J Clin Invest (1977) 1.63
Ocular manifestations in patients infected with human T-lymphotropic virus type I. Jpn J Ophthalmol (1989) 1.63
Lipid metabolism in human platelets. II. De novo phospholipid synthesis and the effect of thrombin on the pattern of synthesis. J Clin Invest (1969) 1.62
Purification and properties of human coagulation factor VII. J Biol Chem (1980) 1.61
Structure and expression of human thrombomodulin, a thrombin receptor on endothelium acting as a cofactor for protein C activation. EMBO J (1987) 1.60
The cDNA cloning and characterization of inositol polyphosphate 4-phosphatase type II. Evidence for conserved alternative splicing in the 4-phosphatase family. J Biol Chem (1997) 1.60
Hydrolysis of polyphosphoinositides by purified sheep seminal vesicle phospholipase C enzymes. J Biol Chem (1984) 1.60
Characterization of 1,2-diacylglycerol hydrolysis in human platelets. Demonstration of an arachidonoyl-monoacylglycerol intermediate. J Biol Chem (1983) 1.59
The binding of phytohemagglutinins to human platelet plasma membranes. J Biol Chem (1972) 1.59
The isolation and characterization of a cDNA encoding phospholipid-specific inositol polyphosphate 5-phosphatase. J Biol Chem (2000) 1.58
Multiple forms of an inositol polyphosphate 5-phosphatase form signaling complexes with Shc and Grb2. Curr Biol (1996) 1.57
Increased circulating vascular endothelial growth factor is correlated with disease activity in polyarticular juvenile rheumatoid arthritis. J Rheumatol (1999) 1.57
Cell lines from kidney proximal tubules of a patient with Lowe syndrome lack OCRL inositol polyphosphate 5-phosphatase and accumulate phosphatidylinositol 4,5-bisphosphate. J Biol Chem (1998) 1.56
The measurement of thrombin in clotting blood by radioimmunoassay. J Clin Invest (1976) 1.56
Characterization of prostacyclin synthesis in cultured human arterial smooth muscle cells, venous endothelial cells and skin fibroblasts. Cell (1979) 1.55
Marked increase in plasma interleukin-6 in burn patients. J Lab Clin Med (1992) 1.55
The isolation and characterization of cDNA encoding human and rat brain inositol polyphosphate 4-phosphatase. J Biol Chem (1995) 1.54
Production of phosphoinositide-derived messengers. Cell (1984) 1.54
Identification and properties of two distinct phosphatidylinositol-specific phospholipase C enzymes from sheep seminal vesicular glands. J Biol Chem (1982) 1.54
Pathway for inositol 1,3,4-trisphosphate and 1,4-bisphosphate metabolism. Proc Natl Acad Sci U S A (1987) 1.53
Isolation and characterization of thrombomodulin from human placenta. J Biol Chem (1984) 1.50
Inositol cyclic phosphates are produced by cleavage of phosphatidylphosphoinositols (polyphosphoinositides) with purified sheep seminal vesicle phospholipase C enzymes. Proc Natl Acad Sci U S A (1985) 1.49
Definition of a metal-dependent/Li(+)-inhibited phosphomonoesterase protein family based upon a conserved three-dimensional core structure. Proc Natl Acad Sci U S A (1995) 1.47
Arachidonate metabolism in vascular disorders. J Clin Invest (1983) 1.43
Patients with congenital factor V deficiency have decreased factor Xa binding sites on their platelets. J Clin Invest (1978) 1.42
High-mobility group box 1 protein promotes development of microvascular thrombosis in rats. J Thromb Haemost (2007) 1.42
The metabolism of tris- and tetraphosphates of inositol by 5-phosphomonoesterase and 3-kinase enzymes. J Biol Chem (1987) 1.41
Thrombin-induced hydrolysis of phosphatidylinositol in human platelets. J Biol Chem (1980) 1.39
Prevention of thrombosis in patients on hemodialysis by low-dose aspirin. N Engl J Med (1979) 1.39
Inositol polyphosphate 1-phosphatase from calf brain. Purification and inhibition by Li+, Ca2+, and Mn2+. J Biol Chem (1987) 1.38
Properties of type II inositol polyphosphate 5-phosphatase. J Biol Chem (1995) 1.38
Purification and properties of beta-glucuronidase from human placenta. Biochemistry (1978) 1.37
Discovery of an arachidonoyl coenzyme A synthetase in human platelets. J Biol Chem (1982) 1.36
Acyl carrier protein. VII. The primary structure of the substrate-binding site. J Biol Chem (1965) 1.35
The activation loop of phosphatidylinositol phosphate kinases determines signaling specificity. Mol Cell (2000) 1.34
The structure and function of mouse thrombomodulin. Phorbol myristate acetate stimulates degradation and synthesis of thrombomodulin without affecting mRNA levels in hemangioma cells. J Biol Chem (1988) 1.34
Thrombomodulin: protectorate God of the vasculature in thrombosis and inflammation. J Thromb Haemost (2011) 1.32
Phosphatidylinositol-4-phosphate 5-kinase isozymes catalyze the synthesis of 3-phosphate-containing phosphatidylinositol signaling molecules. J Biol Chem (1997) 1.32
The metabolism of inositol 1,3,4-trisphosphate to inositol 1,3-bisphosphate. J Biol Chem (1987) 1.32
Inositol hexakisphosphate binds to clathrin assembly protein 3 (AP-3/AP180) and inhibits clathrin cage assembly in vitro. J Biol Chem (1995) 1.32
Inhibition of human platelet aggregation by monovalent antifibrinogen antibody fragments. J Clin Invest (1975) 1.32
Isolation of inositol 1,3,4-trisphosphate 5/6-kinase, cDNA cloning and expression of the recombinant enzyme. J Biol Chem (1996) 1.30
Lack of covalent modification of prostaglandin synthetase (cyclo-oxygenase) by indomethacin. Prostaglandins (1977) 1.30
The regulation of fatty acid biosynthesis in rat hepatomas. J Biol Chem (1968) 1.29
The effects of mepacrine and p-bromophenacyl bromide on arachidonic acid release in human platelets. Arch Biochem Biophys (1982) 1.29
Factor Va-dependent binding of factor Xa to human platelets. J Biol Chem (1980) 1.28
Isolation and characterization of two 3-phosphatases that hydrolyze both phosphatidylinositol 3-phosphate and inositol 1,3-bisphosphate. J Biol Chem (1991) 1.27
Highly concentrated vascular endothelial growth factor in platelets in Crow-Fukase syndrome. Muscle Nerve (2000) 1.26
Isolation and characterization of the inositol cyclic phosphate products of phosphoinositide cleavage by phospholipase C. Metabolism in cell-free extracts. J Biol Chem (1986) 1.25
Hydrolysis of phosphatidylinositol 3,4-bisphosphate by inositol polyphosphate 4-phosphatase isolated by affinity elution chromatography. J Biol Chem (1994) 1.25
The effects of thrombin on adenyl cyclase activity and a membrane protein from human platelets. J Clin Invest (1972) 1.24
Glutathione synthetase deficiency as a cause of hereditary hemolytic disease. N Engl J Med (1970) 1.23
Induction of the platelet release reaction by phytohemagglutinin. J Clin Invest (1974) 1.23
Intestinal pseudo-obstruction as the presenting manifestation of small-cell carcinoma of the lung. A paraneoplastic neuropathy of the gastrointestinal tract. Ann Intern Med (1983) 1.22
Glutathione biosynthesis in human erythrocytes. I. Identification of the enzymes of glutathione synthesis in hemolysates. J Clin Invest (1971) 1.20
Deficiency of factor Xa-factor Va binding sites on the platelets of a patient with a bleeding disorder. Blood (1979) 1.20
The protein tyrosine phosphatase SHP-1 regulates integrin-mediated adhesion of macrophages. Curr Biol (1998) 1.19
Phosphatidylinositol signalling reactions. Semin Cell Dev Biol (1998) 1.18
Properties of inositol polyphosphate 1-phosphatase. J Biol Chem (1988) 1.17
Sensitivity of fatty acid cyclooxygenase from human aorta to acetylation by aspirin. Proc Natl Acad Sci U S A (1978) 1.17