Published in Proc Natl Acad Sci U S A on April 01, 1987
Cell signaling during cold, drought, and salt stress. Plant Cell (2002) 6.67
Metabolism of the inositol phosphates produced upon receptor activation. Biochem J (1989) 2.64
Synthesis of myo-inositol 1,3,4,5,6-pentakisphosphate from inositol phosphates generated by receptor activation. Biochem J (1988) 1.81
The purification and properties of myo-inositol monophosphatase from bovine brain. Biochem J (1988) 1.80
The dephosphorylation of inositol 1,4-bisphosphate to inositol in liver and brain involves two distinct Li+-sensitive enzymes and proceeds via inositol 4-phosphate. Biochem J (1988) 1.49
Two dephosphorylation pathways of inositol 1,4,5-trisphosphate in homogenates of the cellular slime mould Dictyostelium discoideum. Biochem J (1988) 1.23
Accumulation of inositol polyphosphate isomers in agonist-stimulated cerebral-cortex slices. Comparison with metabolic profiles in cell-free preparations. Biochem J (1989) 1.22
Isolation and heterologous expression of a cDNA encoding bovine inositol polyphosphate 1-phosphatase. Proc Natl Acad Sci U S A (1990) 1.15
Formation of inositol phosphate isomers in GH3 pituitary tumour cells stimulated with thyrotropin-releasing hormone. Acute effects of lithium ions. Biochem J (1987) 1.11
Metabolism of inositol bis-, tris-, tetrakis- and pentakis-phosphates in GH3 cells. Biochem J (1988) 1.09
Rapid accumulation and sustained turnover of inositol phosphates in cerebral-cortex slices after muscarinic-receptor stimulation. Biochem J (1989) 0.99
Purification and properties of inositol-1,4-bisphosphatase from bovine brain. Biochem J (1988) 0.99
Altered diacylglycerol level and metabolism in neutrophils from patients with localized juvenile periodontitis. Infect Immun (1992) 0.97
The dephosphorylation pathway of D-myo-inositol 1,3,4,5-tetrakisphosphate in rat brain. Biochem J (1987) 0.94
The quantitative spectrum of inositol phosphate metabolites in avian erythrocytes, analysed by proton n.m.r. and h.p.l.c. with direct isomer detection. Biochem J (1989) 0.92
Thrombin induces a biphasic 1,2-diacylglycerol production in human platelets. Biochem J (1991) 0.90
The pathway of myo-inositol 1,3,4-trisphosphate dephosphorylation in liver. Biochem J (1987) 0.88
Systematic analysis of transcription-level effects of neurodegenerative diseases on human brain metabolism by a newly reconstructed brain-specific metabolic network. FEBS Open Bio (2014) 0.88
Salt tolerance. Arabidopsis Book (2002) 0.85
Bradykinin and thrombin effects on polyphosphoinositide hydrolysis and prostacyclin production in endothelial cells. Biochem J (1989) 0.81
Metabolism of inositol phosphates in ATP-stimulated vascular endothelial cells. Biochem J (1991) 0.81
A simple enzymic method to separate [3H]inositol 1,4,5- and 1,3,4-trisphosphate isomers in tissue extracts. Biochem J (1989) 0.80
Subcellular localization of the enzymes that dephosphorylate myo-inositol polyphosphates in human platelets. Biochem J (1988) 0.80
Inositol phosphate formation and its relationship to calcium signaling. Environ Health Perspect (1990) 0.78
Differences between muscarinic-receptor- and Ca2(+)-induced inositol polyphosphate isomer accumulation in rat cerebral-cortex slices. Biochem J (1990) 0.78
Cloning, heterologous expression, and chromosomal localization of human inositol polyphosphate 1-phosphatase. Proc Natl Acad Sci U S A (1993) 0.77
Dephosphorylation of 1D-myo-inositol 1,4-bisphosphate in rat liver. Biochem J (1988) 0.76
Phospholipase C and D regulation of Src, calcium release and membrane fusion during Xenopus laevis development. Dev Biol (2015) 0.76
Inositol trisphosphate, a novel second messenger in cellular signal transduction. Nature (1984) 25.71
Studies and perspectives of protein kinase C. Science (1986) 14.73
Changes in the levels of inositol phosphates after agonist-dependent hydrolysis of membrane phosphoinositides. Biochem J (1983) 10.35
The inositol trisphosphate phosphomonoesterase of the human erythrocyte membrane. Biochem J (1982) 6.82
The effects of lithium ion and other agents on the activity of myo-inositol-1-phosphatase from bovine brain. J Biol Chem (1980) 6.02
Rapid formation of inositol 1,3,4,5-tetrakisphosphate following muscarinic receptor stimulation of rat cerebral cortical slices. Biochem J (1985) 5.79
The inositol tris/tetrakisphosphate pathway--demonstration of Ins(1,4,5)P3 3-kinase activity in animal tissues. Nature (1986) 5.41
Inositol trisphosphates in carbachol-stimulated rat parotid glands. Biochem J (1984) 4.05
The second messenger linking receptor activation to internal Ca release in liver. Nature (1984) 3.73
The metabolism of phosphoinositide-derived messenger molecules. Science (1986) 3.58
Stepwise enzymatic dephosphorylation of inositol 1,4,5-trisphosphate to inositol in liver. Nature (1984) 3.46
Inositol 1,3,4,5-tetrakisphosphate and not phosphatidylinositol 3,4-bisphosphate is the probable precursor of inositol 1,3,4-trisphosphate in agonist-stimulated parotid gland. Biochem J (1986) 3.04
Inositol 1,4,5-trisphosphate and inositol 1,3,4-trisphosphate formation in Ca2+-mobilizing-hormone-activated cells. Biochem J (1985) 2.82
Formation and metabolism of inositol 1,3,4,5-tetrakisphosphate in liver. J Biol Chem (1986) 2.81
Isolation of a phosphomonoesterase from human platelets that specifically hydrolyzes the 5-phosphate of inositol 1,4,5-trisphosphate. J Biol Chem (1985) 2.55
Specificity of inositol phosphate-stimulated Ca2+ mobilization from Swiss-mouse 3T3 cells. Biochem J (1986) 2.30
The enzymic formation of myoinositol 1:2-cyclic phosphate from phosphatidylinositol. Biochem J (1971) 2.15
Isolation and characterization of the inositol cyclic phosphate products of polyphosphoinositide cleavage by phospholipase C. Physiological effects in permeabilized platelets and Limulus photoreceptor cells. J Biol Chem (1985) 1.98
Purification and properties of myo-inositol-1-phosphatase from rat brain. J Biochem (1985) 1.62
Hydrolysis of polyphosphoinositides by purified sheep seminal vesicle phospholipase C enzymes. J Biol Chem (1984) 1.60
Identification and properties of two distinct phosphatidylinositol-specific phospholipase C enzymes from sheep seminal vesicular glands. J Biol Chem (1982) 1.54
Inositol cyclic phosphates are produced by cleavage of phosphatidylphosphoinositols (polyphosphoinositides) with purified sheep seminal vesicle phospholipase C enzymes. Proc Natl Acad Sci U S A (1985) 1.49
Human erythrocyte cytosol phosphatidyl-inositol-bisphosphate phosphatase. Biochim Biophys Acta (1981) 1.36
Effects of systemically administered lithium on phosphoinositide metabolism in rat brain, kidney, and testis. J Neurochem (1985) 1.26
Isolation and characterization of the inositol cyclic phosphate products of phosphoinositide cleavage by phospholipase C. Metabolism in cell-free extracts. J Biol Chem (1986) 1.25
Glucose-induced accumulation of inositol trisphosphates in isolated pancreatic islets. Predominance of the 1,3,4-isomer. Biochem J (1986) 1.25
Evidence for the formation of inositol 4-monophosphate in stimulated human platelets. FEBS Lett (1985) 1.21
Isolation of D-myo-inositol 1:2-cyclic phosphate 2-inositolphosphohydrolase from human placenta. J Biol Chem (1986) 0.90
Synthesis of inositol 1,2-(cyclic)-4,5-trisphosphate. Proc Natl Acad Sci U S A (1987) 0.83
Acetylation of prostaglandin synthase by aspirin. Proc Natl Acad Sci U S A (1975) 4.92
The metabolism of phosphoinositide-derived messenger molecules. Science (1986) 3.58
Diglyceride lipase: a pathway for arachidonate release from human platelets. Proc Natl Acad Sci U S A (1979) 3.48
The binding of thrombin to the surface of human platelets. J Biol Chem (1974) 3.41
The mechanism of the effect of aspirin on human platelets. I. Acetylation of a particulate fraction protein. J Clin Invest (1975) 3.40
A thrombin-sensitive protein of human platelet membranes. Proc Natl Acad Sci U S A (1971) 2.97
SopB, a protein required for virulence of Salmonella dublin, is an inositol phosphate phosphatase. Proc Natl Acad Sci U S A (1998) 2.73
The 145-kDa protein induced to associate with Shc by multiple cytokines is an inositol tetraphosphate and phosphatidylinositol 3,4,5-triphosphate 5-phosphatase. Proc Natl Acad Sci U S A (1996) 2.68
Fraud in medical research. Presidential address delivered before the 74th annual meeting of the American Society for Clinical Investigation, Washington, DC, 8 May 1982. J Clin Invest (1982) 2.62
Properties of the factor Xa binding site on human platelets. J Biol Chem (1978) 2.59
Isolation of a phosphomonoesterase from human platelets that specifically hydrolyzes the 5-phosphate of inositol 1,4,5-trisphosphate. J Biol Chem (1985) 2.55
JAK2 associates with the beta c chain of the receptor for granulocyte-macrophage colony-stimulating factor, and its activation requires the membrane-proximal region. Mol Cell Biol (1994) 2.55
Isolation and properties of a thrombin-sensitive protein of human platelets. J Biol Chem (1972) 2.54
Inhibition of platelet prostaglandin synthetase by oral aspirin. J Clin Invest (1978) 2.40
Formation of phosphatidylinositol 3-phosphate by isomerization from phosphatidylinositol 4-phosphate. Proc Natl Acad Sci U S A (1991) 2.35
Cultured human skin fibroblasts and arterial cells produce a labile platelet-inhibitory prostaglandin. Biochem Biophys Res Commun (1977) 2.30
Protein kinase C phosphorylates human platelet inositol trisphosphate 5'-phosphomonoesterase, increasing the phosphatase activity. Cell (1986) 2.15
Association of androgenic-anabolic steroid therapy with development of hepatocellular carcinoma. Lancet (1972) 2.13
Identification, cloning, and expression of a cytosolic megakaryocyte protein-tyrosine-phosphatase with sequence homology to cytoskeletal protein 4.1. Proc Natl Acad Sci U S A (1991) 2.04
Interaction of coagulation factor Xa with human platelets. Proc Natl Acad Sci U S A (1977) 2.03
Isolation and characterization of the inositol cyclic phosphate products of polyphosphoinositide cleavage by phospholipase C. Physiological effects in permeabilized platelets and Limulus photoreceptor cells. J Biol Chem (1985) 1.98
Structure and function of thrombomodulin: a natural anticoagulant. Blood (1990) 1.96
Isolation and quantitation of the platelet membrane glycoprotein deficient in thrombasthenia using a monoclonal hybridoma antibody. J Clin Invest (1980) 1.95
Thrombomodulin is found on endothelium of arteries, veins, capillaries, and lymphatics, and on syncytiotrophoblast of human placenta. J Cell Biol (1985) 1.92
Isolation of human platelets and platelet surface membranes. Methods Enzymol (1974) 1.91
Acetyl coenzyme A carboxylase. The roles of synthesis and degradation in regulation of enzyme levels in rat liver. J Biol Chem (1969) 1.91
Zaragozic acids: a family of fungal metabolites that are picomolar competitive inhibitors of squalene synthase. Proc Natl Acad Sci U S A (1993) 1.89
The synthesis of sulfated dextran beads for isolation of human plasma coagulation factors II, IX, and X. Anal Biochem (1980) 1.89
The protein deficient in Lowe syndrome is a phosphatidylinositol-4,5-bisphosphate 5-phosphatase. Proc Natl Acad Sci U S A (1995) 1.87
Inositol phosphates: synthesis and degradation. J Biol Chem (1988) 1.81
Tyrosine phosphorylation of p95Vav in myeloid cells is regulated by GM-CSF, IL-3 and steel factor and is constitutively increased by p210BCR/ABL. EMBO J (1995) 1.78
Thrombin-induced protein phosphorylation in human platelets. J Clin Invest (1975) 1.76
Structure and function of the acyl carrier protein. Fed Proc (1967) 1.76
Phosphoinositide interconversion in thrombin-stimulated human platelets. J Biol Chem (1985) 1.74
Human thrombomodulin: complete cDNA sequence and chromosome localization of the gene. Biochemistry (1987) 1.72
Purification and characterization of human coagulation factor V. J Biol Chem (1981) 1.67
Phosphatidylinositol 3-phosphate is present in normal and transformed fibroblasts and is resistant to hydrolysis by bovine brain phospholipase C II. J Biol Chem (1989) 1.67
Cyclic adenosine 3',5'-monophosphate inhibits the availability of arachidonate to prostaglandin synthetase in human platelet suspensions. J Clin Invest (1977) 1.63
Lipid metabolism in human platelets. II. De novo phospholipid synthesis and the effect of thrombin on the pattern of synthesis. J Clin Invest (1969) 1.62
Purification and properties of human coagulation factor VII. J Biol Chem (1980) 1.61
The cDNA cloning and characterization of inositol polyphosphate 4-phosphatase type II. Evidence for conserved alternative splicing in the 4-phosphatase family. J Biol Chem (1997) 1.60
Hydrolysis of polyphosphoinositides by purified sheep seminal vesicle phospholipase C enzymes. J Biol Chem (1984) 1.60
Characterization of 1,2-diacylglycerol hydrolysis in human platelets. Demonstration of an arachidonoyl-monoacylglycerol intermediate. J Biol Chem (1983) 1.59
The binding of phytohemagglutinins to human platelet plasma membranes. J Biol Chem (1972) 1.59
The isolation and characterization of a cDNA encoding phospholipid-specific inositol polyphosphate 5-phosphatase. J Biol Chem (2000) 1.58
Multiple forms of an inositol polyphosphate 5-phosphatase form signaling complexes with Shc and Grb2. Curr Biol (1996) 1.57
Cell lines from kidney proximal tubules of a patient with Lowe syndrome lack OCRL inositol polyphosphate 5-phosphatase and accumulate phosphatidylinositol 4,5-bisphosphate. J Biol Chem (1998) 1.56
The measurement of thrombin in clotting blood by radioimmunoassay. J Clin Invest (1976) 1.56
Characterization of prostacyclin synthesis in cultured human arterial smooth muscle cells, venous endothelial cells and skin fibroblasts. Cell (1979) 1.55
The isolation and characterization of cDNA encoding human and rat brain inositol polyphosphate 4-phosphatase. J Biol Chem (1995) 1.54
Production of phosphoinositide-derived messengers. Cell (1984) 1.54
Identification and properties of two distinct phosphatidylinositol-specific phospholipase C enzymes from sheep seminal vesicular glands. J Biol Chem (1982) 1.54
Isolation and characterization of thrombomodulin from human placenta. J Biol Chem (1984) 1.50
Inositol cyclic phosphates are produced by cleavage of phosphatidylphosphoinositols (polyphosphoinositides) with purified sheep seminal vesicle phospholipase C enzymes. Proc Natl Acad Sci U S A (1985) 1.49
Definition of a metal-dependent/Li(+)-inhibited phosphomonoesterase protein family based upon a conserved three-dimensional core structure. Proc Natl Acad Sci U S A (1995) 1.47
Recent insights in phosphatidylinositol signaling. Cell (1990) 1.46
Arachidonate metabolism in vascular disorders. J Clin Invest (1983) 1.43
Patients with congenital factor V deficiency have decreased factor Xa binding sites on their platelets. J Clin Invest (1978) 1.42
The metabolism of tris- and tetraphosphates of inositol by 5-phosphomonoesterase and 3-kinase enzymes. J Biol Chem (1987) 1.41
Thrombin-induced hydrolysis of phosphatidylinositol in human platelets. J Biol Chem (1980) 1.39
Prevention of thrombosis in patients on hemodialysis by low-dose aspirin. N Engl J Med (1979) 1.39
Inositol polyphosphate 1-phosphatase from calf brain. Purification and inhibition by Li+, Ca2+, and Mn2+. J Biol Chem (1987) 1.38
Properties of type II inositol polyphosphate 5-phosphatase. J Biol Chem (1995) 1.38
Discovery of an arachidonoyl coenzyme A synthetase in human platelets. J Biol Chem (1982) 1.36
Acyl carrier protein. VII. The primary structure of the substrate-binding site. J Biol Chem (1965) 1.35
The activation loop of phosphatidylinositol phosphate kinases determines signaling specificity. Mol Cell (2000) 1.34
The structure and function of mouse thrombomodulin. Phorbol myristate acetate stimulates degradation and synthesis of thrombomodulin without affecting mRNA levels in hemangioma cells. J Biol Chem (1988) 1.34
The metabolism of inositol 1,3,4-trisphosphate to inositol 1,3-bisphosphate. J Biol Chem (1987) 1.32
Phosphatidylinositol-4-phosphate 5-kinase isozymes catalyze the synthesis of 3-phosphate-containing phosphatidylinositol signaling molecules. J Biol Chem (1997) 1.32
Inositol hexakisphosphate binds to clathrin assembly protein 3 (AP-3/AP180) and inhibits clathrin cage assembly in vitro. J Biol Chem (1995) 1.32
Inhibition of human platelet aggregation by monovalent antifibrinogen antibody fragments. J Clin Invest (1975) 1.32
Isolation of inositol 1,3,4-trisphosphate 5/6-kinase, cDNA cloning and expression of the recombinant enzyme. J Biol Chem (1996) 1.30
Lack of covalent modification of prostaglandin synthetase (cyclo-oxygenase) by indomethacin. Prostaglandins (1977) 1.30
The regulation of fatty acid biosynthesis in rat hepatomas. J Biol Chem (1968) 1.29
The effects of mepacrine and p-bromophenacyl bromide on arachidonic acid release in human platelets. Arch Biochem Biophys (1982) 1.29
Factor Va-dependent binding of factor Xa to human platelets. J Biol Chem (1980) 1.28
Isolation and characterization of two 3-phosphatases that hydrolyze both phosphatidylinositol 3-phosphate and inositol 1,3-bisphosphate. J Biol Chem (1991) 1.27
Isolation and characterization of the inositol cyclic phosphate products of phosphoinositide cleavage by phospholipase C. Metabolism in cell-free extracts. J Biol Chem (1986) 1.25
Hydrolysis of phosphatidylinositol 3,4-bisphosphate by inositol polyphosphate 4-phosphatase isolated by affinity elution chromatography. J Biol Chem (1994) 1.25
The effects of thrombin on adenyl cyclase activity and a membrane protein from human platelets. J Clin Invest (1972) 1.24
Glutathione synthetase deficiency as a cause of hereditary hemolytic disease. N Engl J Med (1970) 1.23
Induction of the platelet release reaction by phytohemagglutinin. J Clin Invest (1974) 1.23
Deficiency of factor Xa-factor Va binding sites on the platelets of a patient with a bleeding disorder. Blood (1979) 1.20
Glutathione biosynthesis in human erythrocytes. I. Identification of the enzymes of glutathione synthesis in hemolysates. J Clin Invest (1971) 1.20
The protein tyrosine phosphatase SHP-1 regulates integrin-mediated adhesion of macrophages. Curr Biol (1998) 1.19
Phosphatidylinositol signalling reactions. Semin Cell Dev Biol (1998) 1.18
Properties of inositol polyphosphate 1-phosphatase. J Biol Chem (1988) 1.17
Identification and isolation of a 75-kDa inositol polyphosphate-5-phosphatase from human platelets. J Biol Chem (1989) 1.17
Sensitivity of fatty acid cyclooxygenase from human aorta to acetylation by aspirin. Proc Natl Acad Sci U S A (1978) 1.17
Thrombomodulin is present in human plasma and urine. J Clin Invest (1985) 1.17
Fatty acid biosynthesis and the role of the acyl carrier protein. Adv Lipid Res (1967) 1.17
Diverse proteins homologous to inositol monophosphatase. FEBS Lett (1991) 1.16
Modulation of phosphatidylinositol-specific phospholipase C activity by phospholipid interactions, diglycerides, and calcium ions. J Biol Chem (1982) 1.16
Cloning and expression of human 75-kDa inositol polyphosphate-5-phosphatase. J Biol Chem (1991) 1.16