Published in Nature on October 11, 2001
DCs induce CD40-independent immunoglobulin class switching through BLyS and APRIL. Nat Immunol (2002) 6.85
Aberrant expansion of segmented filamentous bacteria in IgA-deficient gut. Proc Natl Acad Sci U S A (2004) 5.93
Metagenomic approaches for defining the pathogenesis of inflammatory bowel diseases. Cell Host Microbe (2008) 4.14
The biology of intestinal immunoglobulin A responses. Immunity (2008) 3.18
The role of retinoic acid in tolerance and immunity. Immunity (2011) 3.16
The regulation of IgA class switching. Nat Rev Immunol (2008) 2.92
Intestinal villous M cells: an antigen entry site in the mucosal epithelium. Proc Natl Acad Sci U S A (2004) 2.75
Regulation of AID expression in the immune response. J Exp Med (2007) 2.35
Local B cells and IgE production in the oesophageal mucosa in eosinophilic oesophagitis. Gut (2010) 2.31
Segmented filamentous bacteria antigens presented by intestinal dendritic cells drive mucosal Th17 cell differentiation. Immunity (2014) 2.20
C-type lectin-like receptor LOX-1 promotes dendritic cell-mediated class-switched B cell responses. Immunity (2014) 2.20
Activation-induced deaminase (AID)-directed hypermutation in the immunoglobulin Smu region: implication of AID involvement in a common step of class switch recombination and somatic hypermutation. J Exp Med (2002) 2.18
Human memory B cells originate from three distinct germinal center-dependent and -independent maturation pathways. Blood (2011) 2.15
Regulation of B1 cell migration by signals through Toll-like receptors. J Exp Med (2006) 2.11
Chemokine receptor CCR9 contributes to the localization of plasma cells to the small intestine. J Exp Med (2004) 1.97
CCR10 expression is a common feature of circulating and mucosal epithelial tissue IgA Ab-secreting cells. J Clin Invest (2003) 1.93
Immune responses that adapt the intestinal mucosa to commensal intestinal bacteria. Immunology (2005) 1.89
Toll-like receptor signaling in small intestinal epithelium promotes B-cell recruitment and IgA production in lamina propria. Gastroenterology (2008) 1.89
Dendritic cells in intestinal homeostasis and disease. J Clin Invest (2009) 1.83
Immunoglobulin responses at the mucosal interface. Annu Rev Immunol (2011) 1.82
New concepts in the generation and functions of IgA. Nat Rev Immunol (2012) 1.81
Impaired induction of DNA lesions during immunoglobulin class-switch recombination in humans influences end-joining repair. Proc Natl Acad Sci U S A (2010) 1.62
IL-6 transgenic mouse model for extraosseous plasmacytoma. Proc Natl Acad Sci U S A (2002) 1.55
APRIL secreted by neutrophils binds to heparan sulfate proteoglycans to create plasma cell niches in human mucosa. J Clin Invest (2008) 1.50
De novo protein synthesis is required for the activation-induced cytidine deaminase function in class-switch recombination. Proc Natl Acad Sci U S A (2003) 1.43
A T cell-dependent mechanism for the induction of human mucosal homing immunoglobulin A-secreting plasmablasts. Immunity (2009) 1.33
Negative regulation of activation-induced cytidine deaminase in B cells. Proc Natl Acad Sci U S A (2006) 1.30
Epstein-Barr virus infection of polarized epithelial cells via the basolateral surface by memory B cell-mediated transfer infection. PLoS Pathog (2011) 1.29
Dysregulated LIGHT expression on T cells mediates intestinal inflammation and contributes to IgA nephropathy. J Clin Invest (2004) 1.28
Immune responses of TLR5(+) lamina propria dendritic cells in enterobacterial infection. J Gastroenterol (2009) 1.25
Innate-like B cells. Springer Semin Immunopathol (2005) 1.24
Vaccination strategies to promote mucosal antibody responses. Immunity (2010) 1.24
Immature B cells preferentially switch to IgE with increased direct Sμ to Sε recombination. J Exp Med (2011) 1.24
Innate control of B cell responses. Trends Immunol (2011) 1.21
B cell-dependent T cell responses: IgM antibodies are required to elicit contact sensitivity. J Exp Med (2002) 1.20
Tissue-resident macrophages: then and now. Immunology (2015) 1.10
Evolution of phosphorylation-dependent regulation of activation-induced cytidine deaminase. Mol Cell (2008) 1.05
CD27(-) B-cells produce class switched and somatically hyper-mutated antibodies during chronic HIV-1 infection. PLoS One (2009) 1.02
Actions of BAFF in B cell maturation and its effects on the development of autoimmune disease. Ann Rheum Dis (2003) 1.00
IL-10R blockade during chronic schistosomiasis mansoni results in the loss of B cells from the liver and the development of severe pulmonary disease. PLoS Pathog (2012) 1.00
A unique B2 B cell subset in the intestine. J Exp Med (2008) 1.00
Dietary fructooligosaccharides up-regulate immunoglobulin A response and polymeric immunoglobulin receptor expression in intestines of infant mice. Clin Exp Immunol (2004) 1.00
Ongoing in vivo immunoglobulin class switch DNA recombination in chronic lymphocytic leukemia B cells. J Immunol (2002) 0.98
Innate signaling networks in mucosal IgA class switching. Adv Immunol (2010) 0.97
The short isoform of the CEACAM1 receptor in intestinal T cells regulates mucosal immunity and homeostasis via Tfh cell induction. Immunity (2012) 0.97
Regulation of mucosal IgA responses: lessons from primary immunodeficiencies. Ann N Y Acad Sci (2011) 0.95
Circulating Human CD27-IgA+ Memory B Cells Recognize Bacteria with Polyreactive Igs. J Immunol (2015) 0.93
Two distinctive pathways for recruitment of naive and primed IgM+ B cells to the gut lamina propria. Proc Natl Acad Sci U S A (2005) 0.93
Loss of ileal IgA+ plasma cells and of CD4+ lymphocytes in ileal Peyer's patches of vitamin A deficient rats. Clin Exp Immunol (2002) 0.92
Interleukin (IL)-21 promotes intestinal IgA response to microbiota. Mucosal Immunol (2015) 0.91
Long-lived plasma cells are generated in mucosal immune responses and contribute to the bone marrow plasma cell pool in mice. Mucosal Immunol (2015) 0.91
Origin and homing of intestinal IgA antibody-secreting cells. J Exp Med (2002) 0.90
Complement receptors and the shaping of the natural antibody repertoire. Springer Semin Immunopathol (2004) 0.90
IgA response in preterm neonates shows little evidence of antigen-driven selection. J Immunol (2012) 0.90
Uracil DNA glycosylase counteracts APOBEC3G-induced hypermutation of hepatitis B viral genomes: excision repair of covalently closed circular DNA. PLoS Pathog (2013) 0.89
Health-Promoting Properties of Lactobacillus helveticus. Front Microbiol (2012) 0.88
Expression of plasma cell alloantigen 1 defines layered development of B-1a B-cell subsets with distinct innate-like functions. Proc Natl Acad Sci U S A (2012) 0.87
From B to A the mucosal way. Nat Immunol (2001) 0.86
Immunologic and Hematological Abnormalities in Necrotizing Enterocolitis. Clin Perinatol (2015) 0.86
IgA subclass switch recombination in human mucosal and systemic immune compartments. Mucosal Immunol (2013) 0.85
Microbe-dependent CD11b+ IgA+ plasma cells mediate robust early-phase intestinal IgA responses in mice. Nat Commun (2013) 0.84
The intestinal B-cell response in celiac disease. Front Immunol (2012) 0.84
Oral-nasopharyngeal dendritic cells mediate T cell-independent IgA class switching on B-1 B cells. PLoS One (2011) 0.84
The human intestinal IgA response; burning questions. Front Immunol (2012) 0.84
CD47-deficient mice have decreased production of intestinal IgA following oral immunization but a maintained capacity to induce oral tolerance. Immunology (2012) 0.83
Plasma cells in immunopathology: concepts and therapeutic strategies. Semin Immunopathol (2014) 0.83
Isolation, maturational level, and functional capacity of human colon lamina propria plasma cells. Gut (2003) 0.83
Toxicological effects of nickel chloride on IgA+ B Cells and sIgA, IgA, IgG, IgM in the intestinal mucosal immunity in broilers. Int J Environ Res Public Health (2014) 0.82
Regulation of frontline antibody responses by innate immune signals. Immunol Res (2012) 0.81
Role of lymphotoxin and homeostatic chemokines in the development and function of local lymphoid tissues in the respiratory tract. Inmunologia (2007) 0.80
Antibody repertoire diversification through VH gene replacement in mice cloned from an IgA plasma cell. Proc Natl Acad Sci U S A (2015) 0.79
Impaired B cell responses to orally administered antigens in lamina propria but not Peyer's patches of Galphai2-deficient mice prior to colitis. Immunology (2005) 0.78
Where do IgA plasma cells in the gut come from? Gut (2002) 0.78
B1a lymphocytes in the rectal mucosa of ulcerative colitis patients. World J Gastroenterol (2012) 0.78
Development and maturation of the immune system in preterm neonates: results from a whole genome expression study. Biomed Res Int (2014) 0.78
Gender bias in lupus: does immune response initiated in the gut mucosa have a role? Clin Exp Immunol (2015) 0.78
Role of Natural Autoantibodies and Natural IgM Anti-Leucocyte Autoantibodies in Health and Disease. Front Immunol (2016) 0.77
Dendritic cells in the gut: interaction with intestinal helminths. J Biomed Biotechnol (2010) 0.77
Use of gnotobiotic mice to identify and characterize key microbes responsible for the development of the intestinal immune system. Proc Jpn Acad Ser B Phys Biol Sci (2014) 0.76
Peyer's patches: organizing B-cell responses at the intestinal frontier. Immunol Rev (2016) 0.76
Deletion of the α immunoglobulin chain membrane-anchoring region reduces but does not abolish IgA secretion. Immunology (2012) 0.76
Tissue adaptation: Implications for gut immunity and tolerance. J Exp Med (2017) 0.75
AID to overcome the limitations of genomic information by introducing somatic DNA alterations. Proc Jpn Acad Ser B Phys Biol Sci (2006) 0.75
Pre-existing neutralizing antibody mitigates B cell dysregulation and enhances the Env-specific antibody response in SHIV-infected rhesus macaques. PLoS One (2017) 0.75
Recombinant retroviral production and infection of B cells. J Vis Exp (2011) 0.75
TGF-β1 improves mucosal IgA dysfunction and dysbiosis following intestinal ischaemia-reperfusion in mice. J Cell Mol Med (2016) 0.75
The regulation of gut mucosal IgA B-cell responses: recent developments. Mucosal Immunol (2017) 0.75
Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme. Cell (2000) 20.83
Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation. J Exp Med (2000) 19.81
Development of lupus-like autoimmune diseases by disruption of the PD-1 gene encoding an ITIM motif-carrying immunoreceptor. Immunity (1999) 12.36
PD-L2 is a second ligand for PD-1 and inhibits T cell activation. Nat Immunol (2001) 12.26
Activation-induced cytidine deaminase (AID) deficiency causes the autosomal recessive form of the Hyper-IgM syndrome (HIGM2). Cell (2000) 9.99
Induced expression of PD-1, a novel member of the immunoglobulin gene superfamily, upon programmed cell death. EMBO J (1992) 8.86
Autoimmune dilated cardiomyopathy in PD-1 receptor-deficient mice. Science (2001) 8.31
Notch signalling controls pancreatic cell differentiation. Nature (1999) 7.18
Expression of the PD-1 antigen on the surface of stimulated mouse T and B lymphocytes. Int Immunol (1996) 6.79
Specific expression of activation-induced cytidine deaminase (AID), a novel member of the RNA-editing deaminase family in germinal center B cells. J Biol Chem (1999) 6.67
Delineating developmental and metabolic pathways in vivo by expression profiling using the RIKEN set of 18,816 full-length enriched mouse cDNA arrays. Proc Natl Acad Sci U S A (2001) 6.07
Complete nucleotide sequence of mouse immunoglobulin mu gene and comparison with other immunoglobulin heavy chain genes. Nucleic Acids Res (1980) 5.20
Cloning and complete nucleotide sequence of mouse immunoglobulin gamma 1 chain gene. Cell (1979) 5.04
Thermostabilization and thermoactivation of thermolabile enzymes by trehalose and its application for the synthesis of full length cDNA. Proc Natl Acad Sci U S A (1998) 4.95
Molecular cloning of cDNA encoding human interleukin-2 receptor. Nature (1984) 4.95
Signal sequence trap: a cloning strategy for secreted proteins and type I membrane proteins. Science (1993) 4.64
Generation of lymphohematopoietic cells from embryonic stem cells in culture. Science (1994) 4.41
High-efficiency full-length cDNA cloning by biotinylated CAP trapper. Genomics (1996) 4.41
Control of microtubule dynamics by the antagonistic activities of XMAP215 and XKCM1 in Xenopus egg extracts. Nat Cell Biol (2000) 4.31
A novel GTP-binding protein, Sar1p, is involved in transport from the endoplasmic reticulum to the Golgi apparatus. J Cell Biol (1989) 4.29
Immunological studies on PD-1 deficient mice: implication of PD-1 as a negative regulator for B cell responses. Int Immunol (1998) 4.14
A novel octamer binding transcription factor is differentially expressed in mouse embryonic cells. Cell (1990) 3.97
Organization of immunoglobulin heavy chain genes and allelic deletion model. Proc Natl Acad Sci U S A (1978) 3.95
Fractionation and reconstitution of factors required for accurate transcription of mammalian ribosomal RNA genes: identification of a species-dependent initiation factor. Nucleic Acids Res (1982) 3.87
Diphtheria toxin-dependent adenosine diphosphate ribosylation of aminoacyl transferase II and inhibition of protein synthesis. J Biol Chem (1968) 3.81
The nucleotide sequence of human fibroblast interferon cDNA. Gene (1980) 3.80
Distribution of androgen and estrogen receptor mRNA-containing cells in the rat brain: an in situ hybridization study. J Comp Neurol (1990) 3.80
Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes. Genome Res (2000) 3.78
Transcriptional sequencing: A method for DNA sequencing using RNA polymerase. Proc Natl Acad Sci U S A (1998) 3.78
Organization of the constant-region gene family of the mouse immunoglobulin heavy chain. Cell (1982) 3.72
Immunoglobulin genes. Annu Rev Immunol (1983) 3.72
Rearrangement of immunoglobulin gamma 1-chain gene and mechanism for heavy-chain class switch. Proc Natl Acad Sci U S A (1980) 3.70
The gene for the embryonic stem cell coactivator UTF1 carries a regulatory element which selectively interacts with a complex composed of Oct-3/4 and Sox-2. Mol Cell Biol (1999) 3.70
Structure and chromosomal localization of the human stromal cell-derived factor 1 (SDF1) gene. Genomics (1995) 3.60
Human leukocyte and fibroblast interferons are structurally related. Nature (1980) 3.57
Physical interaction between a novel domain of the receptor Notch and the transcription factor RBP-J kappa/Su(H). Curr Biol (1995) 3.46
Involvement of RBP-J in biological functions of mouse Notch1 and its derivatives. Development (1997) 3.42
Recognition sequence of a highly conserved DNA binding protein RBP-J kappa. Nucleic Acids Res (1994) 3.36
PD-1 immunoreceptor inhibits B cell receptor-mediated signaling by recruiting src homology 2-domain-containing tyrosine phosphatase 2 to phosphotyrosine. Proc Natl Acad Sci U S A (2001) 3.32
Alternative transcription and two modes of splicing results in two myosin light chains from one gene. Nature (1984) 3.31
The monoclonal antibody TER-119 recognizes a molecule associated with glycophorin A and specifically marks the late stages of murine erythroid lineage. Br J Haematol (2000) 3.31
Disruption of the mouse RBP-J kappa gene results in early embryonic death. Development (1995) 3.30
TCGF (IL 2)-receptor inducing factor(s). I. Regulation of IL 2 receptor on a natural killer-like cell line (YT cells). J Immunol (1985) 3.18
Alymphoplasia is caused by a point mutation in the mouse gene encoding Nf-kappa b-inducing kinase. Nat Genet (1999) 3.17
STAT5 as a molecular regulator of proliferation, differentiation and apoptosis in hematopoietic cells. EMBO J (1999) 3.14
Conservation of the Notch signalling pathway in mammalian neurogenesis. Development (1997) 3.13
Binding of the adenomatous polyposis coli protein to microtubules increases microtubule stability and is regulated by GSK3 beta phosphorylation. Curr Biol (2001) 3.13
Switch region of immunoglobulin Cmu gene is composed of simple tandem repetitive sequences. Nature (1981) 3.10
Multiple DNA fragment polymorphisms associated with immunoglobulin mu chain switch-like regions in man. Proc Natl Acad Sci U S A (1983) 3.07
Plasma elevation of stromal cell-derived factor-1 induces mobilization of mature and immature hematopoietic progenitor and stem cells. Blood (2001) 3.01
Complete nucleotide sequence of immunoglobulin gamma2b chain gene cloned from newborn nouse DNA. Nature (1980) 2.97
Human ribosomal RNA gene: nucleotide sequence of the transcription initiation region and comparison of three mammalian genes. Proc Natl Acad Sci U S A (1982) 2.89
Role of cytosolic phospholipase A2 in allergic response and parturition. Nature (1997) 2.88
Repetitive sequences in class-switch recombination regions of immunoglobulin heavy chain genes. Cell (1981) 2.84
The nucleotide sequence of the putative transcription initiation site of a cloned ribosomal RNA gene of the mouse. Nucleic Acids Res (1980) 2.83
Two human homologues of Saccharomyces cerevisiae SWI2/SNF2 and Drosophila brahma are transcriptional coactivators cooperating with the estrogen receptor and the retinoic acid receptor. Nucleic Acids Res (1994) 2.81
Functional heterogeneity is associated with the cell cycle status of murine hematopoietic stem cells. J Cell Biol (1993) 2.73
The recombination signal sequence-binding protein RBP-2N functions as a transcriptional repressor. Mol Cell Biol (1994) 2.71
PD-1: an inhibitory immunoreceptor involved in peripheral tolerance. Trends Immunol (2001) 2.71
Nomenclature for human glutathione transferases. Biochem J (1992) 2.71
Nucleotide sequence divergence of mouse immunoglobulin gamma 1 and gamma 2b chain genes and the hypothesis of intervening sequence-mediated domain transfer. Proc Natl Acad Sci U S A (1980) 2.68
Delta-induced Notch signaling mediated by RBP-J inhibits MyoD expression and myogenesis. J Biol Chem (1999) 2.65
T-Independent immune response: new aspects of B cell biology. Science (2000) 2.63
The complete nucleotide sequence of the human immunoglobulin heavy chain variable region locus. J Exp Med (1998) 2.56
Antigen-induced apoptotic death of Ly-1 B cells responsible for autoimmune disease in transgenic mice. Nature (1992) 2.52
Functional interaction between the mouse notch1 intracellular region and histone acetyltransferases PCAF and GCN5. J Biol Chem (2000) 2.38
The nucleotide sequences of rearranged and germline immunoglobulin VH genes of a mouse myeloma MC101 and evolution of VH genes in mouse. J Biol Chem (1982) 2.37
The reeler gene encodes a protein with an EGF-like motif expressed by pioneer neurons. Nat Genet (1995) 2.34
Structure of human immunoglobulin gamma genes: implications for evolution of a gene family. Cell (1982) 2.32
Identification of mouse ULK1, a novel protein kinase structurally related to C. elegans UNC-51. Biochem Biophys Res Commun (1998) 2.31
A protein binding to the J kappa recombination sequence of immunoglobulin genes contains a sequence related to the integrase motif. Nature (1990) 2.29
Ordering of mouse immunoglobulin heavy chain genes by molecular cloning. Nature (1981) 2.28
A novel family of variable region genes of the human immunoglobulin heavy chain. J Mol Biol (1987) 2.27
The complete nucleotide sequence of mouse immunoglobin gamma 2a gene and evolution of heavy chain genes: further evidence for intervening sequence-mediated domain transfer. Nucleic Acids Res (1981) 2.26
Molecular cloning and characterization of rat estrogen receptor cDNA. Nucleic Acids Res (1987) 2.26
Adenosine diphosphate ribosylation of aminoacyl transferase II and inhibition of protein synthesis by diphtheria toxin. J Biol Chem (1971) 2.23
Circular DNA is excised by immunoglobulin class switch recombination. Cell (1990) 2.22
Roles of the ankyrin repeats and C-terminal region of the mouse notch1 intracellular region. Nucleic Acids Res (1998) 2.20
Primary structure of a cytochrome P-450: coding nucleotide sequence of phenobarbital-inducible cytochrome P-450 cDNA from rat liver. Proc Natl Acad Sci U S A (1982) 2.19
Determination of the promoter region of mouse ribosomal RNA gene by an in vitro transcription system. Proc Natl Acad Sci U S A (1984) 2.18
Organization and evolution of variable region genes of the human immunoglobulin heavy chain. J Mol Biol (1986) 2.17
Cloning and the nucleotide sequence of rat glutathione S-transferase P cDNA. Nucleic Acids Res (1985) 2.15
B-cell apoptosis induced by antigen receptor crosslinking is blocked by a T-cell signal through CD40. Nature (1993) 2.14
High efficiency selection of full-length cDNA by improved biotinylated cap trapper. DNA Res (1997) 2.11
Characteristics of the clinical findings in patients with idiopathic thrombocytopenic purpura who are positive for anti-phospholipid antibodies. Intern Med (1997) 2.07
Mouse hematopoietic stem cells. Blood (1991) 2.07
Identification of novel lymphoid tissues in murine intestinal mucosa where clusters of c-kit+ IL-7R+ Thy1+ lympho-hemopoietic progenitors develop. J Exp Med (1996) 2.06
Notch1 and Notch3 instructively restrict bFGF-responsive multipotent neural progenitor cells to an astroglial fate. Neuron (2001) 2.06
Isolation of a novel mouse gene MA-3 that is induced upon programmed cell death. Gene (1995) 2.05
p300-mediated acetylation facilitates the transfer of histone H2A-H2B dimers from nucleosomes to a histone chaperone. Genes Dev (2000) 2.03
A hallmark of active class switch recombination: transcripts directed by I promoters on looped-out circular DNAs. Proc Natl Acad Sci U S A (2001) 2.03