PD-1 immunoreceptor inhibits B cell receptor-mediated signaling by recruiting src homology 2-domain-containing tyrosine phosphatase 2 to phosphotyrosine.

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Published in Proc Natl Acad Sci U S A on November 06, 2001

Authors

T Okazaki1, A Maeda, H Nishimura, T Kurosaki, T Honjo

Author Affiliations

1: Department of Medical Chemistry, Graduate School of Medicine, Kyoto University, Yoshida-Konoe, Sakyo-ku, Kyoto 606-8501, Japan.

Associated clinical trials:

Pembrolizumab vs Topotecan in Patients With Small Cell Lung Cancer | NCT02963090

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Pembrolizumab-Epacadostat Combination to Treat Muscle-invasive Bladder UrotheLIAl canceR: PECULIAR Study (PECULIAR) | NCT03832673

Pepinemab in Combination With Pembrolizumab in Advanced, Recurrent or Metastatic Squamous Cell Carcinoma of the Head and Neck (KEYNOTE B84) | NCT04815720

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