Two domains of Nrf2 cooperatively bind CBP, a CREB binding protein, and synergistically activate transcription.

PubWeight™: 1.95‹?› | Rank: Top 2%

🔗 View Article (PMID 11683914)

Published in Genes Cells on October 01, 2001

Authors

Y Katoh1, K Itoh, E Yoshida, M Miyagishi, A Fukamizu, M Yamamoto

Author Affiliations

1: Center for Tsukuba Advanced Research Alliance, University of Tsukuba, Japan.

Articles citing this

The Nrf2-antioxidant response element signaling pathway and its activation by oxidative stress. J Biol Chem (2009) 5.80

Dual roles of Nrf2 in cancer. Pharmacol Res (2008) 3.41

The emerging role of the Nrf2-Keap1 signaling pathway in cancer. Genes Dev (2013) 3.40

Keap1 recruits Neh2 through binding to ETGE and DLG motifs: characterization of the two-site molecular recognition model. Mol Cell Biol (2006) 3.27

Stress-activated cap'n'collar transcription factors in aging and human disease. Sci Signal (2010) 3.19

Identification of a novel Nrf2-regulated antioxidant response element (ARE) in the mouse NAD(P)H:quinone oxidoreductase 1 gene: reassessment of the ARE consensus sequence. Biochem J (2003) 3.13

Molecular mechanisms of Nrf2-mediated antioxidant response. Mol Carcinog (2009) 2.94

Structure of the Keap1:Nrf2 interface provides mechanistic insight into Nrf2 signaling. EMBO J (2006) 2.67

Acetylation of Nrf2 by p300/CBP augments promoter-specific DNA binding of Nrf2 during the antioxidant response. Mol Cell Biol (2009) 1.80

Role of Nrf2 in the regulation of the Mrp2 (ABCC2) gene. Biochem J (2006) 1.67

The Keap1-Nrf2 system in cancers: stress response and anabolic metabolism. Front Oncol (2012) 1.64

BRG1 interacts with Nrf2 to selectively mediate HO-1 induction in response to oxidative stress. Mol Cell Biol (2006) 1.52

Molecular basis of electrophilic and oxidative defense: promises and perils of Nrf2. Pharmacol Rev (2012) 1.45

Acetylation-deacetylation of the transcription factor Nrf2 (nuclear factor erythroid 2-related factor 2) regulates its transcriptional activity and nucleocytoplasmic localization. J Biol Chem (2010) 1.45

CD36 participates in a signaling pathway that regulates ROS formation in murine VSMCs. J Clin Invest (2010) 1.41

Network inference algorithms elucidate Nrf2 regulation of mouse lung oxidative stress. PLoS Comput Biol (2008) 1.38

Regulation of NF-E2-related factor 2 signaling for cancer chemoprevention: antioxidant coupled with antiinflammatory. Antioxid Redox Signal (2010) 1.33

Nrf2-MafG heterodimers contribute globally to antioxidant and metabolic networks. Nucleic Acids Res (2012) 1.28

Increased cell migration and plasticity in Nrf2-deficient cancer cell lines. Oncogene (2010) 1.26

The carboxy-terminal Neh3 domain of Nrf2 is required for transcriptional activation. Mol Cell Biol (2005) 1.26

NF-E2 domination over Nrf2 promotes ROS accumulation and megakaryocytic maturation. Blood (2009) 1.20

Mechanisms of activation of the transcription factor Nrf2 by redox stressors, nutrient cues, and energy status and the pathways through which it attenuates degenerative disease. Free Radic Biol Med (2015) 1.17

Glucocorticoid receptor (GR)-associated SMRT binding to C/EBPbeta TAD and Nrf2 Neh4/5: role of SMRT recruited to GR in GSTA2 gene repression. Mol Cell Biol (2005) 1.08

Nuclear factor erythroid-derived factor 2-related factor 2 regulates transcription of CCAAT/enhancer-binding protein β during adipogenesis. Free Radic Biol Med (2011) 1.07

Oxidative stress induced lung cancer and COPD: opportunities for epigenetic therapy. J Cell Mol Med (2009) 1.03

4-Hydroxynonenal induces rat gamma-glutamyl transpeptidase through mitogen-activated protein kinase-mediated electrophile response element/nuclear factor erythroid 2-related factor 2 signaling. Am J Respir Cell Mol Biol (2005) 1.03

Nrf2 Neh5 domain is differentially utilized in the transactivation of cytoprotective genes. Biochem J (2007) 0.99

Oxidative stress response and Nrf2 signaling in aging. Free Radic Biol Med (2015) 0.99

Kaposi's sarcoma-associated herpesvirus induces Nrf2 during de novo infection of endothelial cells to create a microenvironment conducive to infection. PLoS Pathog (2014) 0.98

Dual roles of NRF2 in tumor prevention and progression: possible implications in cancer treatment. Free Radic Biol Med (2014) 0.98

Nrf2 suppresses macrophage inflammatory response by blocking proinflammatory cytokine transcription. Nat Commun (2016) 0.94

Signaling pathways involved in phase II gene induction by alpha, beta-unsaturated aldehydes. Toxicol Ind Health (2009) 0.93

Interaction with CREB binding protein modulates the activities of Nrf2 and NF-κB in cystic fibrosis airway epithelial cells. Am J Physiol Lung Cell Mol Physiol (2012) 0.92

Concerted action of Nrf2-ARE pathway, MRN complex, HMGB1 and inflammatory cytokines - implication in modification of radiation damage. Redox Biol (2014) 0.92

Impaired mitochondrial dynamics and Nrf2 signaling contribute to compromised responses to oxidative stress in striatal cells expressing full-length mutant huntingtin. PLoS One (2013) 0.92

Identification of age-specific Nrf2 binding to a novel antioxidant response element locus in the Gclc promoter: a compensatory means for the loss of glutathione synthetic capacity in the aging rat liver? Aging Cell (2012) 0.91

Nrf2b, novel zebrafish paralog of oxidant-responsive transcription factor NF-E2-related factor 2 (NRF2). J Biol Chem (2011) 0.91

Kinetic analyses of Keap1-Nrf2 interaction and determination of the minimal Nrf2 peptide sequence required for Keap1 binding using surface plasmon resonance. Chem Biol Drug Des (2011) 0.91

Monitoring Keap1-Nrf2 interactions in single live cells. Biotechnol Adv (2014) 0.91

Transcriptional regulation of the human ferritin gene by coordinated regulation of Nrf2 and protein arginine methyltransferases PRMT1 and PRMT4. FASEB J (2013) 0.90

Structural basis of Keap1 interactions with Nrf2. Free Radic Biol Med (2015) 0.88

Identification and functional studies of a new Nrf2 partner IQGAP1: a critical role in the stability and transactivation of Nrf2. Antioxid Redox Signal (2012) 0.88

The nuclear cofactor RAC3/AIB1/SRC-3 enhances Nrf2 signaling by interacting with transactivation domains. Oncogene (2012) 0.87

Discovery of direct inhibitors of Keap1-Nrf2 protein-protein interaction as potential therapeutic and preventive agents. Acta Pharm Sin B (2015) 0.86

Emerging roles of Nrf2 signal in non-small cell lung cancer. J Hematol Oncol (2016) 0.86

Nuclear factor-erythroid 2 (NF-E2) p45-related factor-2 (Nrf2) modulates dendritic cell immune function through regulation of p38 MAPK-cAMP-responsive element binding protein/activating transcription factor 1 signaling. J Biol Chem (2013) 0.86

Transcriptional regulation of rat gamma-glutamate cysteine ligase catalytic subunit gene is mediated through a distal antioxidant response element. Pharmacol Res (2009) 0.85

Activated Nrf2 Interacts with Kaposi's Sarcoma-Associated Herpesvirus Latency Protein LANA-1 and Host Protein KAP1 To Mediate Global Lytic Gene Repression. J Virol (2015) 0.84

Clinicopathological significance of nuclear factor (erythroid-2)-related factor 2 (Nrf2) expression in gastric cancer. BMC Cancer (2015) 0.84

Transcription factors in the cellular signaling network as prime targets of chemopreventive phytochemicals. Cancer Res Treat (2004) 0.84

Potent organo-osmium compound shifts metabolism in epithelial ovarian cancer cells. Proc Natl Acad Sci U S A (2015) 0.83

Ethanol sensitivity: a central role for CREB transcription regulation in the cerebellum. BMC Genomics (2006) 0.81

Nrf2: bane or blessing in cancer? J Cancer Res Clin Oncol (2014) 0.80

Transcription factor Nrf1 is topologically repartitioned across membranes to enable target gene transactivation through its acidic glucose-responsive domains. PLoS One (2014) 0.80

Coordinated regulation of Nrf2 and histone H3 serine 10 phosphorylation in arsenite-activated transcription of the human heme oxygenase-1 gene. Biochim Biophys Acta (2015) 0.80

Nuclear matrix protein (NRP/B) modulates the nuclear factor (Erythroid-derived 2)-related 2 (NRF2)-dependent oxidative stress response. J Biol Chem (2010) 0.79

The Mediator Subunit MED16 Transduces NRF2-Activating Signals into Antioxidant Gene Expression. Mol Cell Biol (2015) 0.79

Overview of Nrf2 as Therapeutic Target in Epilepsy. Int J Mol Sci (2015) 0.78

Non-electrophilic modulators of the canonical Keap1/Nrf2 pathway. Bioorg Med Chem Lett (2015) 0.78

Competition of nuclear factor-erythroid 2 factors related transcription factor isoforms, Nrf1 and Nrf2, in antioxidant enzyme induction. Redox Biol (2013) 0.78

Association between the NF-E2 Related Factor 2 Gene Polymorphism and Oxidative Stress, Anti-Oxidative Status, and Newly-Diagnosed Type 2 Diabetes Mellitus in a Chinese Population. Int J Mol Sci (2015) 0.78

NRF2 Regulates PINK1 Expression under Oxidative Stress Conditions. PLoS One (2015) 0.78

Nuclear Factor-Erythroid-2-Related Factor 2 in Aging and Lung Fibrosis. Am J Pathol (2016) 0.77

Correlation Between Nuclear Factor E2-Related Factor 2 Expression and Gastric Cancer Progression. Med Sci Monit (2015) 0.77

Examining the endogenous antioxidant response through immunofluorescent analysis of Nrf2 in tissue. Methods Mol Biol (2008) 0.77

The C-terminal domain of Nrf1 negatively regulates the full-length CNC-bZIP factor and its shorter isoform LCR-F1/Nrf1β; both are also inhibited by the small dominant-negative Nrf1γ/δ isoforms that down-regulate ARE-battery gene expression. PLoS One (2014) 0.77

Dual NRF2 paralogs in Coho salmon and their antioxidant response element targets. Redox Biol (2016) 0.76

Cell signaling pathways involved in drug-mediated fetal hemoglobin induction: Strategies to treat sickle cell disease. Exp Biol Med (Maywood) (2015) 0.76

Correlation between expression of NF-E2-related factor 2 and progression of gastric cancer. Int J Clin Exp Med (2015) 0.75

Role of Nuclear Factor Erythroid 2-Related Factor 2 in Diabetic Nephropathy. J Diabetes Res (2017) 0.75

Reduced mRNA expression levels of NFE2L2 are associated with poor outcome in breast cancer patients. BMC Cancer (2016) 0.75

Glucocorticoid Receptor Signaling Represses the Antioxidant Response by Inhibiting Histone Acetylation Mediated by the Transcriptional Activator NRF2. J Biol Chem (2017) 0.75

Genome-Wide Association Study to Identify Genes Related to Renal Mercury Concentrations in Mice. Environ Health Perspect (2016) 0.75

Collaborative Power of Nrf2 and PPARγ Activators against Metabolic and Drug-Induced Oxidative Injury. Oxid Med Cell Longev (2017) 0.75

Articles by these authors

Crystal structure of rhodopsin: A G protein-coupled receptor. Science (2000) 28.60

An Nrf2/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements. Biochem Biophys Res Commun (1997) 14.09

Essential Bacillus subtilis genes. Proc Natl Acad Sci U S A (2003) 14.01

Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain. Genes Dev (1999) 13.43

Confined lateral diffusion of membrane receptors as studied by single particle tracking (nanovid microscopy). Effects of calcium-induced differentiation in cultured epithelial cells. Biophys J (1993) 9.35

IL-17 in synovial fluids from patients with rheumatoid arthritis is a potent stimulator of osteoclastogenesis. J Clin Invest (1999) 7.66

Sensitivity to carcinogenesis is increased and chemoprotective efficacy of enzyme inducers is lost in nrf2 transcription factor-deficient mice. Proc Natl Acad Sci U S A (2001) 6.78

Structural basis of glutamate recognition by a dimeric metabotropic glutamate receptor. Nature (2000) 6.58

2-Arachidonoylglycerol: a possible endogenous cannabinoid receptor ligand in brain. Biochem Biophys Res Commun (1995) 6.55

Large-scale analysis of gene function in Caenorhabditis elegans by high-throughput RNAi. Curr Biol (2001) 6.05

Transcription factor Nrf2 coordinately regulates a group of oxidative stress-inducible genes in macrophages. J Biol Chem (2000) 5.75

The consensus motif for phosphorylation by cyclin D1-Cdk4 is different from that for phosphorylation by cyclin A/E-Cdk2. EMBO J (1996) 4.55

Regulation of transcription by dimerization of erythroid factor NF-E2 p45 with small Maf proteins. Nature (1994) 4.20

High sensitivity of Nrf2 knockout mice to acetaminophen hepatotoxicity associated with decreased expression of ARE-regulated drug metabolizing enzymes and antioxidant genes. Toxicol Sci (2001) 4.02

Structure of the bacterial flagellar protofilament and implications for a switch for supercoiling. Nature (2001) 3.92

Mice lacking the vitamin D receptor exhibit impaired bone formation, uterine hypoplasia and growth retardation after weaning. Nat Genet (1997) 3.89

Proposal for a new clinical entity, IgG4-positive multiorgan lymphoproliferative syndrome: analysis of 64 cases of IgG4-related disorders. Ann Rheum Dis (2008) 3.77

Phosphatidylinositol 4,5-bisphosphate induces actin-based movement of raft-enriched vesicles through WASP-Arp2/3. Curr Biol (2000) 3.75

Bach proteins belong to a novel family of BTB-basic leucine zipper transcription factors that interact with MafK and regulate transcription through the NF-E2 site. Mol Cell Biol (1996) 3.72

Interleukin-6 deficient mice are protected from bone loss caused by estrogen depletion. EMBO J (1994) 3.60

The Cap'n'Collar basic leucine zipper transcription factor Nrf2 (NF-E2 p45-related factor 2) controls both constitutive and inducible expression of intestinal detoxification and glutathione biosynthetic enzymes. Cancer Res (2001) 3.57

Role of a ras homolog in the life cycle of Schizosaccharomyces pombe. Cell (1986) 3.54

Pretreatment of plastic Petri dishes with fetal calf serum. A simple method for macrophage isolation. J Immunol Methods (1979) 3.33

Schizosaccharomyces pombe ste11+ encodes a transcription factor with an HMG motif that is a critical regulator of sexual development. Genes Dev (1991) 3.26

Genetic organization of the bacterial conjugative transposon Tn916. J Bacteriol (1988) 3.18

Crystal structure of the RNA-dependent RNA polymerase of hepatitis C virus. Structure (1999) 3.04

Differential roles of segmented filamentous bacteria and clostridia in development of the intestinal immune system. Infect Immun (1999) 3.03

Nrf2-deficient female mice develop lupus-like autoimmune nephritis. Kidney Int (2001) 2.90

Murine and human T-lymphocyte GATA-3 factors mediate transcription through a cis-regulatory element within the human T-cell receptor delta gene enhancer. Mol Cell Biol (1991) 2.88

Mucosal adjuvant effect of cholera toxin in mice results from induction of T helper 2 (Th2) cells and IL-4. J Immunol (1995) 2.87

Cloning and characterization of a novel erythroid cell-derived CNC family transcription factor heterodimerizing with the small Maf family proteins. Mol Cell Biol (1995) 2.84

Sequential alterations in the nuclear chromatin region during mitosis of the fission yeast Schizosaccharomyces pombe: video fluorescence microscopy of synchronously growing wild-type and cold-sensitive cdc mutants by using a DNA-binding fluorescent probe. J Cell Sci (1981) 2.75

The S.pombe mei2 gene encoding a crucial molecule for commitment to meiosis is under the regulation of cAMP. EMBO J (1988) 2.74

Qualitative comparison of carbon dioxide-induced change in cerebral near-infrared spectroscopy versus jugular venous oxygen saturation in adults with acute brain disease. Crit Care Med (1995) 2.74

Improvement of survival in patients with diffuse panbronchiolitis treated with low-dose erythromycin. Am J Respir Crit Care Med (1998) 2.69

Negative control for the initiation of meiosis in Schizosaccharomyces pombe. Proc Natl Acad Sci U S A (1985) 2.69

Coronary aneurysms in infants and young children with acute febrile mucocutaneous lymph node syndrome. J Pediatr (1975) 2.66

Spatial regulation of axonal glycoprotein expression on subsets of embryonic spinal neurons. Neuron (1988) 2.66

Gelsolin, a multifunctional actin regulatory protein. J Biol Chem (1999) 2.64

Portal vein anomaly associated with deviation of the ligamentum teres to the right and malposition of the gallbladder. Radiology (1998) 2.62

S. pombe mei2+ encodes an RNA-binding protein essential for premeiotic DNA synthesis and meiosis I, which cooperates with a novel RNA species meiRNA. Cell (1994) 2.57

Mutations in exons 2 and 3 of the cationic trypsinogen gene in Japanese families with hereditary pancreatitis. Gut (1999) 2.51

Mapping of a cluster of genes for components of the transcriptional and translational machineries of Escherichia coli. J Mol Biol (1977) 2.50

Clinicopathological study of fatal myocardial sarcoidosis. Ann N Y Acad Sci (1976) 2.47

Interleukin-6 (IL-6) functions as an in vitro autocrine growth factor in renal cell carcinomas. FEBS Lett (1989) 2.43

Type II myosin heavy chain encoded by the myo2 gene composes the contractile ring during cytokinesis in Schizosaccharomyces pombe. J Cell Biol (1997) 2.43

Role of glycogen synthase kinase 3 beta as a negative regulator of dorsoventral axis formation in Xenopus embryos. Proc Natl Acad Sci U S A (1995) 2.42

Serum undercarboxylated osteocalcin was inversely associated with plasma glucose level and fat mass in type 2 diabetes mellitus. Osteoporos Int (2010) 2.40

Accelerated DNA adduct formation in the lung of the Nrf2 knockout mouse exposed to diesel exhaust. Toxicol Appl Pharmacol (2001) 2.40

The Nrf2 transcription factor contributes both to the basal expression of glutathione S-transferases in mouse liver and to their induction by the chemopreventive synthetic antioxidants, butylated hydroxyanisole and ethoxyquin. Biochem Soc Trans (2000) 2.40

Characterization of a fission yeast gene, gpa2, that encodes a G alpha subunit involved in the monitoring of nutrition. Genes Dev (1992) 2.36

Evaluation and characterization of catabolite-responsive elements (cre) of Bacillus subtilis. Nucleic Acids Res (2000) 2.35

Sarcoplasmic reticulum Ca2+ release is not a dominating factor in sinoatrial node pacemaker activity. Circ Res (2003) 2.32

Heme mediates derepression of Maf recognition element through direct binding to transcription repressor Bach1. EMBO J (2001) 2.32

Contranscription of genes for RNA polymerase subunits beta and beta' with genes for ribosomal proteins in Escherichia coli. Proc Natl Acad Sci U S A (1978) 2.30

The world according to Maf. Nucleic Acids Res (1997) 2.30

Regulation of mucosal and systemic antibody responses by T helper cell subsets, macrophages, and derived cytokines following oral immunization with live recombinant Salmonella. J Immunol (1996) 2.30

Combined transcriptome and proteome analysis as a powerful approach to study genes under glucose repression in Bacillus subtilis. Nucleic Acids Res (2001) 2.28

The signal-dependent coactivator CBP is a nuclear target for pp90RSK. Cell (1996) 2.26

A simple method for estimating 24 h urinary sodium and potassium excretion from second morning voiding urine specimen in adults. Clin Exp Pharmacol Physiol (1993) 2.26

Erythroid transcription factor GATA-1 is abundantly transcribed in mouse testis. Nature (1993) 2.25

Retention of multilineage differentiation potential of mesenchymal cells during proliferation in response to FGF. Biochem Biophys Res Commun (2001) 2.24

Induction of inflammatory arthropathy resembling rheumatoid arthritis in mice transgenic for HTLV-I. Science (1991) 2.18

Structural analyses of DNA recognition by the AML1/Runx-1 Runt domain and its allosteric control by CBFbeta. Cell (2001) 2.15

An updatable holographic three-dimensional display. Nature (2008) 2.14

PETT VI: a positron emission tomograph utilizing cesium fluoride scintillation detectors. J Comput Assist Tomogr (1982) 2.14

Identification of Bach2 as a B-cell-specific partner for small maf proteins that negatively regulate the immunoglobulin heavy chain gene 3' enhancer. EMBO J (1998) 2.13

Characterization of clostridia isolated from faeces of limited flora mice and their effect on caecal size when associated with germ-free mice. Lab Anim (1985) 2.12

Localization of myosin II A and B isoforms in cultured neurons. J Cell Sci (1995) 2.11

Homologous activators of ras in fission and budding yeast. Nature (1990) 2.11

Angiotensinogen-deficient mice with hypotension. J Biol Chem (1994) 2.11

Role of transcription factor Nrf2 in the induction of hepatic phase 2 and antioxidative enzymes in vivo by the cancer chemoprotective agent, 3H-1, 2-dimethiole-3-thione. Mol Med (2001) 2.10

Molecular cloning and functional characterization of a new Cap'n' collar family transcription factor Nrf3. J Biol Chem (1999) 2.09

Adipose angiotensinogen is involved in adipose tissue growth and blood pressure regulation. FASEB J (2001) 2.09

A nontoxic mutant of cholera toxin elicits Th2-type responses for enhanced mucosal immunity. Proc Natl Acad Sci U S A (1997) 2.07

Activation of TBK1 and IKKvarepsilon kinases by vesicular stomatitis virus infection and the role of viral ribonucleoprotein in the development of interferon antiviral immunity. J Virol (2004) 2.06

Arrest in primitive erythroid cell development caused by promoter-specific disruption of the GATA-1 gene. J Biol Chem (1997) 2.05

Mouse Ror2 receptor tyrosine kinase is required for the heart development and limb formation. Genes Cells (2000) 2.05

Naturally occurring escape mutants of hepatitis B virus with various mutations in the S gene in carriers seropositive for antibody to hepatitis B surface antigen. J Virol (1994) 2.05

Hypertension induced in pregnant mice by placental renin and maternal angiotensinogen. Science (1996) 2.04

Leu-11+ lymphocytes with natural killer (NK) activity are precursors of recombinant interleukin 2 (rIL 2)-induced activated killer (AK) cells. J Immunol (1985) 2.03

Essential requirement of BMPs-2/4 for both osteoblast and osteoclast formation in murine bone marrow cultures from adult mice: antagonism by noggin. J Bone Miner Res (2000) 2.03

Regulation of lens fiber cell differentiation by transcription factor c-Maf. J Biol Chem (1999) 2.00

Involvement of outer membrane protein TolC, a possible member of the mar-sox regulon, in maintenance and improvement of organic solvent tolerance of Escherichia coli K-12. J Bacteriol (1998) 1.98

Inhibition of carnitine palmitoyltransferase I augments sphingolipid synthesis and palmitate-induced apoptosis. J Biol Chem (1997) 1.98

Isolation and characterization of a gene encoding a G-protein alpha subunit from Schizosaccharomyces pombe: involvement in mating and sporulation pathways. Proc Natl Acad Sci U S A (1991) 1.98

Adenylyl cyclase is dispensable for vegetative cell growth in the fission yeast Schizosaccharomyces pombe. Proc Natl Acad Sci U S A (1990) 1.97

Cytokine messenger RNA expression in the labial salivary glands of patients with Sjögren's syndrome. Arthritis Rheum (1996) 1.97

Cloning of the pka1 gene encoding the catalytic subunit of the cAMP-dependent protein kinase in Schizosaccharomyces pombe. J Biol Chem (1994) 1.97

Small Maf proteins heterodimerize with Fos and may act as competitive repressors of the NF-E2 transcription factor. Mol Cell Biol (1995) 1.97