Published in Trends Cell Biol on November 01, 2001
Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis. Nature (2005) 15.83
Oxygen sensitivity severely limits the replicative lifespan of murine fibroblasts. Nat Cell Biol (2003) 8.42
Human SIR2 deacetylates p53 and antagonizes PML/p53-induced cellular senescence. EMBO J (2002) 6.37
Incipient Alzheimer's disease: microarray correlation analyses reveal major transcriptional and tumor suppressor responses. Proc Natl Acad Sci U S A (2004) 5.65
Control of the replicative life span of human fibroblasts by p16 and the polycomb protein Bmi-1. Mol Cell Biol (2003) 4.05
Cellular senescence and the senescent secretory phenotype: therapeutic opportunities. J Clin Invest (2013) 3.47
p63 deficiency activates a program of cellular senescence and leads to accelerated aging. Genes Dev (2005) 3.02
Telomeres, stem cells, senescence, and cancer. J Clin Invest (2004) 2.87
Hypersensitivity to contact inhibition provides a clue to cancer resistance of naked mole-rat. Proc Natl Acad Sci U S A (2009) 2.84
Senescence, aging, and malignant transformation mediated by p53 in mice lacking the Brca1 full-length isoform. Genes Dev (2003) 2.78
Akt negatively regulates the in vitro lifespan of human endothelial cells via a p53/p21-dependent pathway. EMBO J (2004) 2.50
The mutant form of lamin A that causes Hutchinson-Gilford progeria is a biomarker of cellular aging in human skin. PLoS One (2007) 2.41
Senescent cells as a source of inflammatory factors for tumor progression. Cancer Metastasis Rev (2010) 2.32
Distinct tumor suppressor mechanisms evolve in rodent species that differ in size and lifespan. Aging Cell (2008) 2.21
Cellular senescence: a link between cancer and age-related degenerative disease? Semin Cancer Biol (2011) 1.98
Telomerase activity coevolves with body mass not lifespan. Aging Cell (2006) 1.91
Frequent recombination in telomeric DNA may extend the proliferative life of telomerase-negative cells. Nucleic Acids Res (2004) 1.89
Growth retardation and premature aging phenotypes in mice with disruption of the SNF2-like gene, PASG. Genes Dev (2004) 1.84
Critical pathways in cellular senescence and immortalization revealed by gene expression profiling. Oncogene (2008) 1.81
Transformation of human and murine fibroblasts without viral oncoproteins. Mol Cell Biol (2005) 1.81
Aging, autoimmunity and arthritis: T-cell senescence and contraction of T-cell repertoire diversity - catalysts of autoimmunity and chronic inflammation. Arthritis Res Ther (2003) 1.61
Apoptosis and beyond: cytometry in studies of programmed cell death. Methods Cell Biol (2011) 1.61
Induction of telomere dysfunction mediated by the telomerase substrate precursor 6-thio-2'-deoxyguanosine. Cancer Discov (2014) 1.59
Comparative genetics of longevity and cancer: insights from long-lived rodents. Nat Rev Genet (2014) 1.58
SIRT1 overexpression antagonizes cellular senescence with activated ERK/S6k1 signaling in human diploid fibroblasts. PLoS One (2008) 1.58
A novel form of the telomere-associated protein TIN2 localizes to the nuclear matrix. Cell Cycle (2009) 1.58
Deconstructing PML-induced premature senescence. EMBO J (2002) 1.56
Cell senescence and hypermitogenic arrest. EMBO Rep (2003) 1.52
5-Lipoxygenase regulates senescence-like growth arrest by promoting ROS-dependent p53 activation. EMBO J (2004) 1.42
Prohibitin facilitates cellular senescence by recruiting specific corepressors to inhibit E2F target genes. Mol Cell Biol (2006) 1.38
Epidemiologic evidence for a role of telomere dysfunction in cancer etiology. Mutat Res (2011) 1.37
Caveolin-1 regulates the antagonistic pleiotropic properties of cellular senescence through a novel Mdm2/p53-mediated pathway. Cancer Res (2009) 1.36
NF-κB in Aging and Disease. Aging Dis (2011) 1.28
Manganese superoxide dismutase induces p53-dependent senescence in colorectal cancer cells. Mol Cell Biol (2005) 1.26
p53-dependent release of Alarmin HMGB1 is a central mediator of senescent phenotypes. J Cell Biol (2013) 1.25
Role of progerin-induced telomere dysfunction in HGPS premature cellular senescence. J Cell Sci (2010) 1.24
Mechanisms of chemotherapy-induced human ovarian aging: double strand DNA breaks and microvascular compromise. Aging (Albany NY) (2011) 1.21
Beta-catenin expression results in p53-independent DNA damage and oncogene-induced senescence in prelymphomagenic thymocytes in vivo. Mol Cell Biol (2007) 1.21
FoxM1c counteracts oxidative stress-induced senescence and stimulates Bmi-1 expression. J Biol Chem (2008) 1.19
Ionizing radiation and aging: rejuvenating an old idea. Aging (Albany NY) (2009) 1.18
DNA damage-induced cellular senescence is sufficient to suppress tumorigenesis: a mouse model. J Exp Med (2007) 1.16
Epstein-Barr virus LMP1 blocks p16INK4a-RB pathway by promoting nuclear export of E2F4/5. J Cell Biol (2003) 1.16
Aging and amyloid beta-induced oxidative DNA damage and mitochondrial dysfunction in Alzheimer's disease: implications for early intervention and therapeutics. Biochim Biophys Acta (2011) 1.16
Cell senescence: role in aging and age-related diseases. Interdiscip Top Gerontol (2014) 1.14
Cell divisions are required for L1 retrotransposition. Mol Cell Biol (2006) 1.13
Stem cells, senescence, neosis and self-renewal in cancer. Cancer Cell Int (2006) 1.11
IGFBP-rP1 induces p21 expression through a p53-independent pathway, leading to cellular senescence of MCF-7 breast cancer cells. J Cancer Res Clin Oncol (2012) 1.10
Using mice to examine p53 functions in cancer, aging, and longevity. Cold Spring Harb Perspect Biol (2009) 1.10
Senescence mediates pituitary hypoplasia and restrains pituitary tumor growth. Cancer Res (2007) 1.09
SnoN functions as a tumour suppressor by inducing premature senescence. EMBO J (2009) 1.09
Human papillomavirus oncoprotein E7 targets the promyelocytic leukemia protein and circumvents cellular senescence via the Rb and p53 tumor suppressor pathways. Mol Cell Biol (2005) 1.08
Glucocorticoids suppress selected components of the senescence-associated secretory phenotype. Aging Cell (2012) 1.08
New biomarkers probing depth of cell senescence assessed by laser scanning cytometry. Cytometry A (2010) 1.07
Pak4 induces premature senescence via a pathway requiring p16INK4/p19ARF and mitogen-activated protein kinase signaling. Mol Cell Biol (2005) 1.05
Transcriptome signature of irreversible senescence in human papillomavirus-positive cervical cancer cells. Proc Natl Acad Sci U S A (2003) 1.05
Exploring the mechanisms regulating regeneration of deer antlers. Philos Trans R Soc Lond B Biol Sci (2004) 1.05
CSIG inhibits PTEN translation in replicative senescence. Mol Cell Biol (2008) 1.04
How does proliferative homeostasis change with age? What causes it and how does it contribute to aging? J Gerontol A Biol Sci Med Sci (2009) 1.04
Coevolution of telomerase activity and body mass in mammals: from mice to beavers. Mech Ageing Dev (2008) 1.03
Paternal age at birth is associated with offspring leukocyte telomere length in the nurses' health study. Hum Reprod (2012) 1.03
Differential roles for the interferon-inducible IFI16 and AIM2 innate immune sensors for cytosolic DNA in cellular senescence of human fibroblasts. Mol Cancer Res (2011) 1.03
Cell cycle arrest by human cytomegalovirus 86-kDa IE2 protein resembles premature senescence. J Virol (2002) 1.03
Retracted DDB2, an essential mediator of premature senescence. Mol Cell Biol (2010) 1.03
Induction of extracellular matrix-remodeling genes by the senescence-associated protein APA-1. Mol Cell Biol (2002) 1.01
The molecular scaffold kinase suppressor of Ras 1 is a modifier of RasV12-induced and replicative senescence. Mol Cell Biol (2006) 1.01
Senescent keratinocytes die by autophagic programmed cell death. Am J Pathol (2009) 1.01
Re-expression of ABI3-binding protein suppresses thyroid tumor growth by promoting senescence and inhibiting invasion. Endocr Relat Cancer (2008) 1.01
Sp1 is essential for p16 expression in human diploid fibroblasts during senescence. PLoS One (2007) 1.00
Induction of the Cdk inhibitor p21 by LY83583 inhibits tumor cell proliferation in a p53-independent manner. J Clin Invest (2002) 1.00
Premature aging and cancer in nucleotide excision repair-disorders. DNA Repair (Amst) (2011) 0.99
DNA-damage response network at the crossroads of cell-cycle checkpoints, cellular senescence and apoptosis. J Zhejiang Univ Sci B (2007) 0.99
Radiation-induced senescence in securin-deficient cancer cells promotes cell invasion involving the IL-6/STAT3 and PDGF-BB/PDGFR pathways. Sci Rep (2013) 0.99
Cellular senescence and cancer chemotherapy resistance. Drug Resist Updat (2012) 0.99
Cellular Senescence - its role in cancer and the response to ionizing radiation. Genome Integr (2011) 0.98
Iron deprivation in cancer--potential therapeutic implications. Nutrients (2013) 0.98
Transition of kidney tubule cells to a senescent phenotype in early experimental diabetes. Am J Physiol Cell Physiol (2010) 0.97
Do different neurons age differently? Direct genome-wide analysis of aging in single identified cholinergic neurons. Front Aging Neurosci (2010) 0.96
p35 is required for CDK5 activation in cellular senescence. J Biol Chem (2010) 0.96
How to learn new and interesting things from model systems based on "exotic" biological species. Proc Natl Acad Sci U S A (2009) 0.96
The BH3 mimetic ABT-737 induces cancer cell senescence. Cancer Res (2010) 0.96
Rodents for comparative aging studies: from mice to beavers. Age (Dordr) (2008) 0.95
Purinergic P2Y₁₄ receptor modulates stress-induced hematopoietic stem/progenitor cell senescence. J Clin Invest (2014) 0.95
Regulation of cellular senescence by the essential caveolar component PTRF/Cavin-1. Cell Res (2011) 0.95
Up-regulating sphingosine 1-phosphate receptor-2 signaling impairs chemotactic, wound-healing, and morphogenetic responses in senescent endothelial cells. J Biol Chem (2008) 0.95
Impairment of lon-induced protection against the accumulation of oxidized proteins in senescent wi-38 fibroblasts. J Gerontol A Biol Sci Med Sci (2011) 0.94
The senescent methylome and its relationship with cancer, ageing and germline genetic variation in humans. Genome Biol (2015) 0.94
miR-127 regulates cell proliferation and senescence by targeting BCL6. PLoS One (2013) 0.94
Senescence-associated SIN3B promotes inflammation and pancreatic cancer progression. J Clin Invest (2014) 0.94
Transcriptional control of SV40 T-antigen expression allows a complete reversion of immortalization. Nucleic Acids Res (2004) 0.93
miR-20a and miR-290, multi-faceted players with a role in tumourigenesis and senescence. J Cell Mol Med (2010) 0.93
Cancer chemoprevention: Evidence of a nonlinear dose response for the protective effects of resveratrol in humans and mice. Sci Transl Med (2015) 0.92
MicroRNA-152 and -181a participate in human dermal fibroblasts senescence acting on cell adhesion and remodeling of the extra-cellular matrix. Aging (Albany NY) (2012) 0.92
Small-molecule-based identification of dynamic assembly of E2F-pocket protein-histone deacetylase complex for telomerase regulation in human cells. Proc Natl Acad Sci U S A (2004) 0.92
Incorporating biomarkers into cancer and aging research. J Clin Oncol (2014) 0.92
Cellular Pathways in Response to Ionizing Radiation and Their Targetability for Tumor Radiosensitization. Int J Mol Sci (2016) 0.91
Immortalization of human adipose-derived stromal cells: production of cell lines with high growth rate, mesenchymal marker expression and capability to secrete high levels of angiogenic factors. Stem Cell Res Ther (2014) 0.91
HDACs and the senescent phenotype of WI-38 cells. BMC Cell Biol (2005) 0.90
Genetic deletion of Nrf2 promotes immortalization and decreases life span of murine embryonic fibroblasts. J Gerontol A Biol Sci Med Sci (2010) 0.90