Published in J Gerontol A Biol Sci Med Sci on October 25, 2010
Testing the oxidative stress hypothesis of aging in primate fibroblasts: is there a correlation between species longevity and cellular ROS production? J Gerontol A Biol Sci Med Sci (2012) 1.69
Age-associated vascular oxidative stress, Nrf2 dysfunction, and NF-{kappa}B activation in the nonhuman primate Macaca mulatta. J Gerontol A Biol Sci Med Sci (2011) 1.31
Disruption of Nrf2 signaling impairs angiogenic capacity of endothelial cells: implications for microvascular aging. J Gerontol A Biol Sci Med Sci (2012) 1.09
A diet rich in olive oil phenolics reduces oxidative stress in the heart of SAMP8 mice by induction of Nrf2-dependent gene expression. Rejuvenation Res (2012) 0.91
Carbonic anhydrase III regulates peroxisome proliferator-activated receptor-γ2. Exp Cell Res (2012) 0.86
The role of transcription factor Nrf2 in skin cells metabolism. Arch Dermatol Res (2015) 0.83
Membrane-bound CYB5R3 is a common effector of nutritional and oxidative stress response through FOXO3a and Nrf2. Antioxid Redox Signal (2014) 0.80
Mitochondrial permeabilization without caspase activation mediates the increase of basal apoptosis in cells lacking Nrf2. Free Radic Biol Med (2016) 0.79
DNA Damage: A Main Determinant of Vascular Aging. Int J Mol Sci (2016) 0.77
Rapamycin inhibits the secretory phenotype of senescent cells by a Nrf2-independent mechanism. Aging Cell (2017) 0.75
Sirtuin activation: a role for plasma membrane in the cell growth puzzle. J Gerontol A Biol Sci Med Sci (2012) 0.75
Quantitative studies of the growth of mouse embryo cells in culture and their development into established lines. J Cell Biol (1963) 29.15
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Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis. Nature (2005) 15.83
Selective killing of oncogenically transformed cells through a ROS-mediated mechanism by beta-phenylethyl isothiocyanate. Cancer Cell (2006) 10.10
Oxygen sensitivity severely limits the replicative lifespan of murine fibroblasts. Nat Cell Biol (2003) 8.42
Isolation of NF-E2-related factor 2 (Nrf2), a NF-E2-like basic leucine zipper transcriptional activator that binds to the tandem NF-E2/AP1 repeat of the beta-globin locus control region. Proc Natl Acad Sci U S A (1994) 6.72
Structural basis for defects of Keap1 activity provoked by its point mutations in lung cancer. Mol Cell (2006) 6.09
SIRT1 redistribution on chromatin promotes genomic stability but alters gene expression during aging. Cell (2008) 5.76
Identification of Nrf2-regulated genes induced by the chemopreventive agent sulforaphane by oligonucleotide microarray. Cancer Res (2002) 5.43
Cellular senescence: mitotic clock or culture shock? Cell (2000) 5.17
Cellular senescence as a tumor-suppressor mechanism. Trends Cell Biol (2001) 4.81
Nrf2, a Cap'n'Collar transcription factor, regulates induction of the heme oxygenase-1 gene. J Biol Chem (1999) 4.77
Nrf2 signaling in coordinated activation of antioxidant gene expression. Free Radic Biol Med (2004) 4.60
p38alpha MAP kinase as a sensor of reactive oxygen species in tumorigenesis. Cancer Cell (2007) 3.55
Oxidative stress and gene regulation. Free Radic Biol Med (2000) 3.24
Stress-activated cap'n'collar transcription factors in aging and human disease. Sci Signal (2010) 3.19
Keap1/Nrf2 signaling regulates oxidative stress tolerance and lifespan in Drosophila. Dev Cell (2008) 2.66
Nrf2, a multi-organ protector? FASEB J (2005) 2.61
Declining p53 function in the aging process: a possible mechanism for the increased tumor incidence in older populations. Proc Natl Acad Sci U S A (2007) 2.36
Nrf2: a potential molecular target for cancer chemoprevention by natural compounds. Antioxid Redox Signal (2006) 2.22
Antioxidants enhance mammalian proteasome expression through the Keap1-Nrf2 signaling pathway. Mol Cell Biol (2003) 2.19
Reversal of senescence in mouse fibroblasts through lentiviral suppression of p53. J Biol Chem (2003) 2.14
Nrf2 mediates cancer protection but not prolongevity induced by caloric restriction. Proc Natl Acad Sci U S A (2008) 1.97
Retracted Phosphorylation of tyrosine 568 controls nuclear export of Nrf2. J Biol Chem (2006) 1.84
Beta-actin is not a reliable loading control in Western blot analysis. Electrophoresis (2006) 1.84
Human prx1 gene is a target of Nrf2 and is up-regulated by hypoxia/reoxygenation: implication to tumor biology. Cancer Res (2007) 1.80
Redox regulation of the G1 to S phase transition in the mouse embryo fibroblast cell cycle. Cancer Res (2003) 1.62
Activation of the Nrf2-ARE signaling pathway: a promising strategy in cancer prevention. Bioessays (2006) 1.55
Nrf2 signaling, a mechanism for cellular stress resistance in long-lived mice. Mol Cell Biol (2009) 1.52
The role of Nrf2 in increased reactive oxygen species and DNA damage in prostate tumorigenesis. Oncogene (2008) 1.50
Constitutive overexpression of Nrf2-dependent heme oxygenase-1 in A549 cells contributes to resistance to apoptosis induced by epigallocatechin 3-gallate. J Biol Chem (2006) 1.47
Genetic dissection of the Nrf2-dependent redox signaling-regulated transcriptional programs of cell proliferation and cytoprotection. Physiol Genomics (2007) 1.45
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Deficiency in Nrf2-GSH signaling impairs type II cell growth and enhances sensitivity to oxidants. Am J Respir Cell Mol Biol (2007) 1.36
Calorie restriction up-regulates the plasma membrane redox system in brain cells and suppresses oxidative stress during aging. Proc Natl Acad Sci U S A (2006) 1.35
Reactive oxygen species as mediators of cellular senescence. IUBMB Life (2005) 1.34
Genetic disruption of the Nrf2 compromises cell-cycle progression by impairing GSH-induced redox signaling. Oncogene (2008) 1.31
Nrf2 gene transfer induces antioxidant enzymes and suppresses smooth muscle cell growth in vitro and reduces oxidative stress in rabbit aorta in vivo. Arterioscler Thromb Vasc Biol (2007) 1.30
The importance of plasma membrane coenzyme Q in aging and stress responses. Mitochondrion (2007) 1.25
A redox signaling mechanism for density-dependent inhibition of cell growth. J Biol Chem (2000) 1.18
Nrf2 establishes a glutathione-mediated gradient of UVB cytoprotection in the epidermis. Genes Dev (2010) 1.17
The double-edged sword of Nrf2: subversion of redox homeostasis during the evolution of cancer. Mol Cell (2006) 1.16
Nuclear erythroid factor 2-mediated proteasome activation delays senescence in human fibroblasts. J Biol Chem (2010) 1.16
DNA damage response activation in mouse embryonic fibroblasts undergoing replicative senescence and following spontaneous immortalization. Cell Cycle (2008) 1.11
Runx2 disruption promotes immortalization and confers resistance to oncogene-induced senescence in primary murine fibroblasts. Cancer Res (2007) 1.07
Disruption of the mGsta4 gene increases life span of C57BL mice. J Gerontol A Biol Sci Med Sci (2009) 1.06
MEF immortalization to investigate the ins and outs of mutagenesis. Carcinogenesis (2006) 1.04
Cellular senescence bypass screen identifies new putative tumor suppressor genes. Oncogene (2007) 1.03
Nrf2 and p53 cooperatively protect against BBN-induced urinary bladder carcinogenesis. Carcinogenesis (2007) 0.99
Rac1 GTPase regulates cell genomic stability and senescence. J Biol Chem (2006) 0.95
A phospholipid-dependent NADH-coenzyme Q reductase from liver plasma membrane. Biochem Biophys Res Commun (1995) 0.90
Hydrogen peroxide- and cell-density-regulated expression of NADH-cytochrome b5 reductase in HeLa cells. J Bioenerg Biomembr (2003) 0.87
Molecular mechanisms of cellular senescence and immortalization of human cells. Expert Opin Ther Targets (2007) 0.79
Resveratrol improves health and survival of mice on a high-calorie diet. Nature (2006) 20.91
Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase. Science (2004) 11.39
Nutrient-sensitive mitochondrial NAD+ levels dictate cell survival. Cell (2007) 6.47
Resveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending life span. Cell Metab (2008) 6.22
Rapamycin, but not resveratrol or simvastatin, extends life span of genetically heterogeneous mice. J Gerontol A Biol Sci Med Sci (2010) 5.54
Impact of caloric restriction on health and survival in rhesus monkeys from the NIA study. Nature (2012) 5.00
The SIRT1 deacetylase suppresses intestinal tumorigenesis and colon cancer growth. PLoS One (2008) 4.32
Growth hormone receptor deficiency is associated with a major reduction in pro-aging signaling, cancer, and diabetes in humans. Sci Transl Med (2011) 3.84
SIRT1 is required for AMPK activation and the beneficial effects of resveratrol on mitochondrial function. Cell Metab (2012) 3.69
Suppression of oxidative stress by β-hydroxybutyrate, an endogenous histone deacetylase inhibitor. Science (2012) 3.52
Intermittent fasting dissociates beneficial effects of dietary restriction on glucose metabolism and neuronal resistance to injury from calorie intake. Proc Natl Acad Sci U S A (2003) 2.82
Metformin improves healthspan and lifespan in mice. Nat Commun (2013) 2.68
Resveratrol induces mitochondrial biogenesis in endothelial cells. Am J Physiol Heart Circ Physiol (2009) 2.65
miR-519 suppresses tumor growth by reducing HuR levels. Cell Cycle (2010) 2.63
Fasting cycles retard growth of tumors and sensitize a range of cancer cell types to chemotherapy. Sci Transl Med (2012) 2.58
Dietary deprivation extends lifespan in Caenorhabditis elegans. Aging Cell (2006) 2.54
Mechanisms of vascular aging: new perspectives. J Gerontol A Biol Sci Med Sci (2010) 2.24
Are sirtuins viable targets for improving healthspan and lifespan? Nat Rev Drug Discov (2012) 2.22
JNK1 phosphorylates SIRT1 and promotes its enzymatic activity. PLoS One (2009) 2.07
Nrf2 mediates cancer protection but not prolongevity induced by caloric restriction. Proc Natl Acad Sci U S A (2008) 1.97
Development of calorie restriction mimetics as a prolongevity strategy. Ann N Y Acad Sci (2004) 1.92
Vasoprotective effects of resveratrol and SIRT1: attenuation of cigarette smoke-induced oxidative stress and proinflammatory phenotypic alterations. Am J Physiol Heart Circ Physiol (2008) 1.87
Mitochondrial biogenesis and healthy aging. Exp Gerontol (2008) 1.85
SRT1720 improves survival and healthspan of obese mice. Sci Rep (2011) 1.81
Mechanisms underlying caloric restriction and lifespan regulation: implications for vascular aging. Circ Res (2008) 1.75
Resveratrol confers endothelial protection via activation of the antioxidant transcription factor Nrf2. Am J Physiol Heart Circ Physiol (2010) 1.73
SIRT1 is essential for normal cognitive function and synaptic plasticity. J Neurosci (2010) 1.71
Anti-oxidative and anti-inflammatory vasoprotective effects of caloric restriction in aging: role of circulating factors and SIRT1. Mech Ageing Dev (2009) 1.69
Resveratrol prevents monocrotaline-induced pulmonary hypertension in rats. Hypertension (2009) 1.63
Age-associated learning and memory deficits in two mouse versions of the Stone T-maze. Neurobiol Aging (2012) 1.55
Ubiquitin-mediated proteolysis of HuR by heat shock. EMBO J (2009) 1.52
Calorie restriction in humans inhibits the PI3K/AKT pathway and induces a younger transcription profile. Aging Cell (2013) 1.48
Of mice and men: the benefits of caloric restriction, exercise, and mimetics. Ageing Res Rev (2011) 1.47
Adaptive induction of NF-E2-related factor-2-driven antioxidant genes in endothelial cells in response to hyperglycemia. Am J Physiol Heart Circ Physiol (2011) 1.42
Cockayne syndrome group B protein prevents the accumulation of damaged mitochondria by promoting mitochondrial autophagy. J Exp Med (2012) 1.42
Regulation of SIRT6 protein levels by nutrient availability. FEBS Lett (2008) 1.36
Negative regulation of STAT3 protein-mediated cellular respiration by SIRT1 protein. J Biol Chem (2011) 1.35
Calorie restriction up-regulates the plasma membrane redox system in brain cells and suppresses oxidative stress during aging. Proc Natl Acad Sci U S A (2006) 1.35
Fumarate is cardioprotective via activation of the Nrf2 antioxidant pathway. Cell Metab (2012) 1.35
RAP1 protects from obesity through its extratelomeric role regulating gene expression. Cell Rep (2013) 1.31
Evaluation of resveratrol, green tea extract, curcumin, oxaloacetic acid, and medium-chain triglyceride oil on life span of genetically heterogeneous mice. J Gerontol A Biol Sci Med Sci (2012) 1.29
Mitochondrial UCP4 mediates an adaptive shift in energy metabolism and increases the resistance of neurons to metabolic and oxidative stress. Neuromolecular Med (2006) 1.28
Calorie restriction attenuates Alzheimer's disease type brain amyloidosis in Squirrel monkeys (Saimiri sciureus). J Alzheimers Dis (2006) 1.27
RNA-binding protein HuD controls insulin translation. Mol Cell (2012) 1.25
The importance of plasma membrane coenzyme Q in aging and stress responses. Mitochondrion (2007) 1.25
Dietary interventions to extend life span and health span based on calorie restriction. J Gerontol A Biol Sci Med Sci (2010) 1.23
Vascular oxidative stress in aging: a homeostatic failure due to dysregulation of NRF2-mediated antioxidant response. Am J Physiol Heart Circ Physiol (2011) 1.22
FOXOs attenuate bone formation by suppressing Wnt signaling. J Clin Invest (2013) 1.21
A regulatory role for microRNA 33* in controlling lipid metabolism gene expression. Mol Cell Biol (2013) 1.21
MicroRNA 33 regulates glucose metabolism. Mol Cell Biol (2013) 1.19
Sirtuin activators and inhibitors. Biofactors (2012) 1.19
Dietary restriction: standing up for sirtuins. Science (2010) 1.17
Telomere shortening in chronic obstructive pulmonary disease. Respir Med (2008) 1.16
Resveratrol improves adipose insulin signaling and reduces the inflammatory response in adipose tissue of rhesus monkeys on high-fat, high-sugar diet. Cell Metab (2013) 1.14
Perinatal exercise improves glucose homeostasis in adult offspring. Am J Physiol Endocrinol Metab (2012) 1.13
Sirtuin activators. Expert Opin Ther Pat (2009) 1.10
Disruption of Nrf2 signaling impairs angiogenic capacity of endothelial cells: implications for microvascular aging. J Gerontol A Biol Sci Med Sci (2012) 1.09
Conserved and differential effects of dietary energy intake on the hippocampal transcriptomes of females and males. PLoS One (2008) 1.07
Comparative approaches to facilitate the discovery of prolongevity interventions: effects of tocopherols on lifespan of three invertebrate species. Mech Ageing Dev (2006) 1.06
SIRT1 but not its increased expression is essential for lifespan extension in caloric-restricted mice. Aging Cell (2013) 1.06
Oxidative stress accumulates in adipose tissue during aging and inhibits adipogenesis. PLoS One (2011) 1.05
AsSIRTing the DNA damage response. Trends Cell Biol (2008) 1.05
Sirtuin inhibitors. Expert Opin Ther Pat (2009) 1.05
Resveratrol prevents β-cell dedifferentiation in nonhuman primates given a high-fat/high-sugar diet. Diabetes (2013) 1.04
The plasma membrane redox system in aging. Ageing Res Rev (2006) 1.03
Chronic ingestion of 2-deoxy-D-glucose induces cardiac vacuolization and increases mortality in rats. Toxicol Appl Pharmacol (2009) 1.03
Aging biology and novel targets for drug discovery. J Gerontol A Biol Sci Med Sci (2011) 1.01
Bioenergetics of aging and calorie restriction. Ageing Res Rev (2006) 1.01
The potential for dietary restriction to increase longevity in humans: extrapolation from monkey studies. Biogerontology (2006) 1.00
Age-associated miRNA alterations in skeletal muscle from rhesus monkeys reversed by caloric restriction. Aging (Albany NY) (2013) 1.00
Up-regulation of plasma membrane-associated redox activities in neuronal cells lacking functional mitochondria. J Neurochem (2007) 1.00
Dietary activators of Sirt1. Mol Cell Endocrinol (2008) 0.98
Mitochondrial protection by resveratrol. Exerc Sport Sci Rev (2011) 0.98
Mitochondrial metabolic reprogramming induced by calorie restriction. Antioxid Redox Signal (2012) 0.98
In vitro cellular adaptations of indicators of longevity in response to treatment with serum collected from humans on calorie restricted diets. PLoS One (2008) 0.97
N-acetylcysteine, coenzyme Q10 and superoxide dismutase mimetic prevent mitochondrial cell dysfunction and cell death induced by d-galactosamine in primary culture of human hepatocytes. Chem Biol Interact (2009) 0.96
Complex I-associated hydrogen peroxide production is decreased and electron transport chain enzyme activities are altered in n-3 enriched fat-1 mice. PLoS One (2010) 0.96
Dicoumarol impairs mitochondrial electron transport and pyrimidine biosynthesis in human myeloid leukemia HL-60 cells. Biochem Pharmacol (2006) 0.95
SRT2104 extends survival of male mice on a standard diet and preserves bone and muscle mass. Aging Cell (2014) 0.94
Effects of calorie restriction on cardioprotection and cardiovascular health. J Mol Cell Cardiol (2011) 0.93
The effect of resveratrol on lifespan depends on both gender and dietary nutrient composition in Drosophila melanogaster. Age (Dordr) (2011) 0.93
Calorie restriction alters physical performance but not cognition in two models of altered neuroendocrine signaling. Behav Brain Res (2008) 0.92
Enhanced anti-oxidant protection of liver membranes in long-lived rats fed on a coenzyme Q10-supplemented diet. Exp Gerontol (2005) 0.90
Inhibition of breast cancer metastasis by resveratrol-mediated inactivation of tumor-evoked regulatory B cells. J Immunol (2013) 0.90
NQR1 controls lifespan by regulating the promotion of respiratory metabolism in yeast. Aging Cell (2009) 0.90
Hungry for life: How the arcuate nucleus and neuropeptide Y may play a critical role in mediating the benefits of calorie restriction. Mol Cell Endocrinol (2008) 0.89
Cell survival from chemotherapy depends on NF-kappaB transcriptional up-regulation of coenzyme Q biosynthesis. PLoS One (2009) 0.89
A strawberry fruit-specific and ripening-related gene codes for a HyPRP protein involved in polyphenol anchoring. Plant Mol Biol (2004) 0.89
A patent review of sirtuin activators: an update. Expert Opin Ther Pat (2012) 0.89
The influence of dietary lipid composition on liver mitochondria from mice following 1 month of calorie restriction. Biosci Rep (2012) 0.88
Hydrogen peroxide- and cell-density-regulated expression of NADH-cytochrome b5 reductase in HeLa cells. J Bioenerg Biomembr (2003) 0.87