Published in J Mol Biol on November 02, 2001
Rab GTPases as coordinators of vesicle traffic. Nat Rev Mol Cell Biol (2009) 13.01
Rab27a and Rab27b control different steps of the exosome secretion pathway. Nat Cell Biol (2009) 5.44
Macronuclear genome sequence of the ciliate Tetrahymena thermophila, a model eukaryote. PLoS Biol (2006) 5.44
Role of Rab GTPases in membrane traffic and cell physiology. Physiol Rev (2011) 5.20
Human RAS superfamily proteins and related GTPases. Sci STKE (2004) 3.80
Genomic analysis of the host response to hepatitis B virus infection. Proc Natl Acad Sci U S A (2004) 3.16
Rab38 and Rab32 control post-Golgi trafficking of melanogenic enzymes. J Cell Biol (2006) 2.79
AS160, the Akt substrate regulating GLUT4 translocation, has a functional Rab GTPase-activating protein domain. Biochem J (2005) 2.76
Mechanism of phagolysosome biogenesis block by viable Mycobacterium tuberculosis. Proc Natl Acad Sci U S A (2005) 2.55
Thirty-one flavors of Drosophila rab proteins. Genetics (2007) 2.46
Analysis of the small GTPase gene superfamily of Arabidopsis. Plant Physiol (2003) 2.45
Genetic analysis of lysosomal trafficking in Caenorhabditis elegans. Mol Biol Cell (2005) 2.44
Caenorhabditis elegans functional orthologue of human protein h-mucolipin-1 is required for lysosome biogenesis. Proc Natl Acad Sci U S A (2004) 2.28
Structural basis of family-wide Rab GTPase recognition by rabenosyn-5. Nature (2005) 2.23
RAB-10 is required for endocytic recycling in the Caenorhabditis elegans intestine. Mol Biol Cell (2006) 2.12
GTPase networks in membrane traffic. Annu Rev Biochem (2012) 2.10
Molecular mechanisms of biogenesis and exocytosis of cytotoxic granules. Nat Rev Immunol (2010) 1.93
Rab-A2 and Rab-A3 GTPases define a trans-golgi endosomal membrane domain in Arabidopsis that contributes substantially to the cell plate. Plant Cell (2008) 1.92
Rab10 regulates membrane transport through early endosomes of polarized Madin-Darby canine kidney cells. Mol Biol Cell (2006) 1.92
An elaborate classification of SNARE proteins sheds light on the conservation of the eukaryotic endomembrane system. Mol Biol Cell (2007) 1.89
Mutations in the small GTPase gene RAB39B are responsible for X-linked mental retardation associated with autism, epilepsy, and macrocephaly. Am J Hum Genet (2010) 1.87
Refinement and prediction of protein prenylation motifs. Genome Biol (2005) 1.84
Control systems for membrane fusion in the ancestral eukaryote; evolution of tethering complexes and SM proteins. BMC Evol Biol (2007) 1.82
Manipulation of rab GTPase function by intracellular bacterial pathogens. Microbiol Mol Biol Rev (2007) 1.82
Functional redundancy of Rab27 proteins and the pathogenesis of Griscelli syndrome. J Clin Invest (2002) 1.81
DENN domain proteins: regulators of Rab GTPases. J Biol Chem (2011) 1.81
A general role for Rab27a in secretory cells. Mol Biol Cell (2003) 1.76
RAB23 mutations in Carpenter syndrome imply an unexpected role for hedgehog signaling in cranial-suture development and obesity. Am J Hum Genet (2007) 1.72
A genomic view of the sea urchin nervous system. Dev Biol (2006) 1.68
Structural basis for Rab GTPase activation by VPS9 domain exchange factors. Nat Struct Mol Biol (2007) 1.66
Rab27b regulates number and secretion of platelet dense granules. Proc Natl Acad Sci U S A (2007) 1.66
Effect of the secretory small GTPase Rab27B on breast cancer growth, invasion, and metastasis. J Natl Cancer Inst (2010) 1.65
Regulation of endocytic recycling by C. elegans Rab35 and its regulator RME-4, a coated-pit protein. EMBO J (2008) 1.65
Rab11 GTPase-regulated membrane trafficking is crucial for tip-focused pollen tube growth in tobacco. Plant Cell (2005) 1.64
Regulation of synaptic transmission by RAB-3 and RAB-27 in Caenorhabditis elegans. Mol Biol Cell (2006) 1.61
Rab14 is critical for maintenance of Mycobacterium tuberculosis phagosome maturation arrest. EMBO J (2006) 1.59
Membrane targeting of Rab GTPases is influenced by the prenylation motif. Mol Biol Cell (2003) 1.57
The regulatory RAB and ARF GTPases for vesicular trafficking. Plant Physiol (2008) 1.57
Membrane targeting and activation of the Lowe syndrome protein OCRL1 by rab GTPases. EMBO J (2006) 1.57
Towards complete sets of farnesylated and geranylgeranylated proteins. PLoS Comput Biol (2007) 1.57
TIP47 is a key effector for Rab9 localization. J Cell Biol (2006) 1.55
Regulation of mTORC1 by PI3K signaling. Trends Cell Biol (2015) 1.54
The Ras protein superfamily: evolutionary tree and role of conserved amino acids. J Cell Biol (2012) 1.50
Large-scale profiling of Rab GTPase trafficking networks: the membrome. Mol Biol Cell (2005) 1.49
Alternative splicing in class V myosins determines association with Rab10. J Biol Chem (2008) 1.45
Thousands of rab GTPases for the cell biologist. PLoS Comput Biol (2011) 1.44
The plant endosomal system--its structure and role in signal transduction and plant development. Planta (2004) 1.43
Induction of salt and osmotic stress tolerance by overexpression of an intracellular vesicle trafficking protein AtRab7 (AtRabG3e). Plant Physiol (2003) 1.43
A retromerlike complex is a novel Rab7 effector that is involved in the transport of the virulence factor cysteine protease in the enteric protozoan parasite Entamoeba histolytica. Mol Biol Cell (2005) 1.41
The Rab GTPase RabA4d regulates pollen tube tip growth in Arabidopsis thaliana. Plant Cell (2009) 1.40
EHBP-1 functions with RAB-10 during endocytic recycling in Caenorhabditis elegans. Mol Biol Cell (2010) 1.38
Pancreatic beta-cell protein granuphilin binds Rab3 and Munc-18 and controls exocytosis. Mol Biol Cell (2002) 1.38
Phylogeny of endocytic components yields insight into the process of nonendosymbiotic organelle evolution. Proc Natl Acad Sci U S A (2008) 1.35
Lightoid and Claret: a rab GTPase and its putative guanine nucleotide exchange factor in biogenesis of Drosophila eye pigment granules. Proc Natl Acad Sci U S A (2004) 1.34
The actin-binding domain of Slac2-a/melanophilin is required for melanosome distribution in melanocytes. Mol Cell Biol (2003) 1.32
Rab13 regulates membrane trafficking between TGN and recycling endosomes in polarized epithelial cells. J Cell Biol (2008) 1.30
Mutation of the zebrafish choroideremia gene encoding Rab escort protein 1 devastates hair cells. Proc Natl Acad Sci U S A (2004) 1.29
Rab3D is not required for exocrine exocytosis but for maintenance of normally sized secretory granules. Mol Cell Biol (2002) 1.26
Higher order Rab programming in phagolysosome biogenesis. J Cell Biol (2006) 1.26
Rab-alphaGDI activity is regulated by a Hsp90 chaperone complex. EMBO J (2002) 1.26
Sculpting the endomembrane system in deep time: high resolution phylogenetics of Rab GTPases. J Cell Sci (2012) 1.25
Structural mechanisms for regulation of membrane traffic by rab GTPases. Traffic (2009) 1.25
A Rab-E GTPase mutant acts downstream of the Rab-D subclass in biosynthetic membrane traffic to the plasma membrane in tobacco leaf epidermis. Plant Cell (2005) 1.24
The small GTPase Rab2 functions in the removal of apoptotic cells in Caenorhabditis elegans. J Cell Biol (2008) 1.23
Rab27b regulates mast cell granule dynamics and secretion. Traffic (2007) 1.22
Interorganellar regulation of lysosome positioning by the Golgi apparatus through Rab34 interaction with Rab-interacting lysosomal protein. Mol Biol Cell (2002) 1.21
Untangling the evolution of Rab G proteins: implications of a comprehensive genomic analysis. BMC Biol (2012) 1.21
Assembly of the biogenesis of lysosome-related organelles complex-3 (BLOC-3) and its interaction with Rab9. J Biol Chem (2010) 1.19
Differential expression of Rab27A/B correlates with clinical outcome in hepatocellular carcinoma. World J Gastroenterol (2012) 1.16
TBC-2 regulates RAB-5/RAB-7-mediated endosomal trafficking in Caenorhabditis elegans. Mol Biol Cell (2010) 1.16
The secretory system of Arabidopsis. Arabidopsis Book (2008) 1.16
Rab protein evolution and the history of the eukaryotic endomembrane system. Cell Mol Life Sci (2010) 1.15
Rab GTPases implicated in inherited and acquired disorders. Semin Cell Dev Biol (2010) 1.15
Functional cross-talk between Rab14 and Rab4 through a dual effector, RUFY1/Rabip4. Mol Biol Cell (2010) 1.14
Crag is a GEF for Rab11 required for rhodopsin trafficking and maintenance of adult photoreceptor cells. PLoS Biol (2012) 1.13
Protein prenyltransferases. Genome Biol (2003) 1.11
glo-3, a novel Caenorhabditis elegans gene, is required for lysosome-related organelle biogenesis. Genetics (2008) 1.11
The Hsp90 chaperone complex regulates GDI-dependent Rab recycling. Mol Biol Cell (2006) 1.09
Structural basis for Rab GTPase recognition and endosome tethering by the C2H2 zinc finger of Early Endosomal Autoantigen 1 (EEA1). Proc Natl Acad Sci U S A (2010) 1.07
Rab3GEP is the non-redundant guanine nucleotide exchange factor for Rab27a in melanocytes. J Biol Chem (2008) 1.07
Conserved subgroups and developmental regulation in the monocot rop gene family. Plant Physiol (2003) 1.06
Autophagy, an immunologic magic bullet: Mycobacterium tuberculosis phagosome maturation block and how to bypass it. Future Microbiol (2008) 1.05
Mutations in RAB28, encoding a farnesylated small GTPase, are associated with autosomal-recessive cone-rod dystrophy. Am J Hum Genet (2013) 1.03
Rab25 regulates invasion and metastasis in head and neck cancer. Clin Cancer Res (2013) 1.02
Identification of genes responsive to brown planthopper Nilaparvata lugens Stal (Homoptera: Delphacidae) feeding in rice. Planta (2004) 1.01
Comprehensive analysis reveals dynamic and evolutionary plasticity of Rab GTPases and membrane traffic in Tetrahymena thermophila. PLoS Genet (2010) 1.00
Unique mechanism of plant endocytic/vacuolar transport pathways. J Plant Res (2008) 1.00
Functional separation of endosomal fusion factors and the class C core vacuole/endosome tethering (CORVET) complex in endosome biogenesis. J Biol Chem (2012) 1.00
Endogenously tagged rab proteins: a resource to study membrane trafficking in Drosophila. Dev Cell (2015) 0.99
Rab38 modulates proteinuria in model of hypertension-associated renal disease. J Am Soc Nephrol (2013) 0.98
Intron presence-absence polymorphisms in Daphnia. Mol Biol Evol (2008) 0.98
A Rab21/LIM-only/CH-LIM complex regulates phagocytosis via both activating and inhibitory mechanisms. EMBO J (2005) 0.97
The interaction properties of the human Rab GTPase family--comparative analysis reveals determinants of molecular binding selectivity. PLoS One (2012) 0.96
Functional role(s) of phagosomal Rab GTPases. Small GTPases (2013) 0.94
Endosomal trafficking pathway regulated by ARA6, a RAB5 GTPase unique to plants. Small GTPases (2012) 0.94
Identification and characterization of multiple novel Rab-myosin Va interactions. Mol Biol Cell (2013) 0.94
Direct interaction between Rab3D and the polymeric immunoglobulin receptor and trafficking through regulated secretory vesicles in lacrimal gland acinar cells. Am J Physiol Cell Physiol (2008) 0.94
Rab27b regulates exocytosis of secretory vesicles in acinar epithelial cells from the lacrimal gland. Am J Physiol Cell Physiol (2011) 0.94
The role of the hypervariable C-terminal domain in Rab GTPases membrane targeting. Proc Natl Acad Sci U S A (2014) 0.93
RAB-5 and RAB-10 cooperate to regulate neuropeptide release in Caenorhabditis elegans. Proc Natl Acad Sci U S A (2012) 0.93
Inhibition of purified p21ras farnesyl:protein transferase by Cys-AAX tetrapeptides. Cell (1990) 3.99
The mammalian Rab family of small GTPases: definition of family and subfamily sequence motifs suggests a mechanism for functional specificity in the Ras superfamily. J Mol Biol (2000) 3.75
Protein prenyltransferases. J Biol Chem (1996) 3.52
The melanosome: membrane dynamics in black and white. Nat Rev Mol Cell Biol (2001) 3.44
GTPase activity of Rab5 acts as a timer for endocytic membrane fusion. Nature (1996) 3.23
Rab27a regulates the peripheral distribution of melanosomes in melanocytes. J Cell Biol (2001) 2.76
Rab27a is required for regulated secretion in cytotoxic T lymphocytes. J Cell Biol (2001) 2.74
Isoprenylcysteine carboxyl methyltransferase deficiency in mice. J Biol Chem (2000) 2.09
cDNA cloning of component A of Rab geranylgeranyl transferase and demonstration of its role as a Rab escort protein. Cell (1993) 2.02
Rab escort protein-1 is a multifunctional protein that accompanies newly prenylated rab proteins to their target membranes. EMBO J (1994) 1.81
REP-2, a Rab escort protein encoded by the choroideremia-like gene. J Biol Chem (1994) 1.62
Rab geranylgeranyl transferase alpha mutation in the gunmetal mouse reduces Rab prenylation and platelet synthesis. Proc Natl Acad Sci U S A (2000) 1.48
Nonidentical subunits of p21H-ras farnesyltransferase. Peptide binding and farnesyl pyrophosphate carrier functions. J Biol Chem (1991) 1.36
Targeting of Rab GTPases to cellular membranes. Biochem Soc Trans (2005) 1.36
Evaluation of retinal photoreceptors and pigment epithelium in a female carrier of choroideremia. Ophthalmology (2001) 1.34
A practical diagnostic test for choroideremia. Ophthalmology (1998) 1.32
Prenylation of Rab GTPases: molecular mechanisms and involvement in genetic disease. FEBS Lett (2001) 1.29
Identification of a novel phosphonocarboxylate inhibitor of Rab geranylgeranyl transferase that specifically prevents Rab prenylation in osteoclasts and macrophages. J Biol Chem (2001) 1.22
Crystal structure of Rab geranylgeranyltransferase at 2.0 A resolution. Structure (2000) 1.21
Rab geranylgeranyl transferase catalyzes the geranylgeranylation of adjacent cysteines in the small GTPases Rab1A, Rab3A, and Rab5A. Proc Natl Acad Sci U S A (1994) 1.20
Chromosomal mapping, gene structure and characterization of the human and murine RAB27B gene. BMC Genet (2001) 1.15
Mechanism of digeranylgeranylation of Rab proteins. Formation of a complex between monogeranylgeranyl-Rab and Rab escort protein. J Biol Chem (1996) 1.13
cDNA cloning and expression of the alpha and beta subunits of rat Rab geranylgeranyl transferase. J Biol Chem (1993) 1.12
Mechanism of Rab geranylgeranylation: formation of the catalytic ternary complex. Biochemistry (1998) 1.08
Cloning, mapping and characterization of the human RAB27A gene. Gene (1999) 1.08
Geranylgeranylated Rab proteins terminating in Cys-Ala-Cys, but not Cys-Cys, are carboxyl-methylated by bovine brain membranes in vitro. Proc Natl Acad Sci U S A (1994) 1.02
New insights into the pathogenesis of choroideremia: a tale of two REPs. Ophthalmic Genet (1996) 1.00
Expression of the VLDL receptor in endothelial cells. Arterioscler Thromb Vasc Biol (1996) 0.97
Geranylgeranylation of Rab proteins. Biochem Soc Trans (1996) 0.97
Preparation of recombinant Rab geranylgeranyltransferase and Rab escort proteins. Methods Enzymol (1995) 0.93
Mouse genetic corneal disease resulting from transgenic insertional mutagenesis. Br J Ophthalmol (2004) 0.84
Apolipoprotein(a) kringle 4-containing fragments in human urine. Relationship to plasma levels of lipoprotein(a). J Clin Invest (1996) 0.81
Single prenyl-binding site on protein prenyl transferases. Proc Natl Acad Sci U S A (1998) 0.80
p21ras farnesyltransferase: purification and properties of the enzyme. Biochem Soc Trans (1992) 0.75