Published in JAMA on November 14, 2001
Exploring the public understanding of basic genetic concepts. J Genet Couns (2004) 3.53
Metabolomics in premature labor: a novel approach to identify patients at risk for preterm delivery. J Matern Fetal Neonatal Med (2010) 1.77
Do intrauterine or genetic influences explain the foetal origins of chronic disease? A novel experimental method for disentangling effects. BMC Med Res Methodol (2007) 1.38
The full-ORF clone resource of the German cDNA Consortium. BMC Genomics (2007) 1.11
Identification of Down's syndrome critical locus gene SIM2-s as a drug therapy target for solid tumors. Proc Natl Acad Sci U S A (2003) 1.09
The independence of our genome assemblies. Proc Natl Acad Sci U S A (2003) 1.07
Translational research on the way to effective therapy for Alzheimer disease. Arch Gen Psychiatry (2005) 1.03
The challenges for molecular nutrition research 1: linking genotype to healthy nutrition. Genes Nutr (2008) 0.96
Closing the gap between knowledge and clinical application: challenges for genomic translation. PLoS Genet (2015) 0.94
Pharmacogenetics in drug development. Philos Trans R Soc Lond B Biol Sci (2005) 0.91
Segmental duplications flank the multiple sclerosis locus on chromosome 17q. Genome Res (2004) 0.88
Long-term consequences of hematopoietic stem cell transplantation: current state of the science. Biol Blood Marrow Transplant (2009) 0.87
Chronic health conditions in childhood cancer survivors: is it all treatment-related--or do genetics play a role? J Gen Intern Med (2009) 0.87
Science, medicine, and the future: Bioinformatics. BMJ (2002) 0.84
Genome science: a video tour of the Washington University Genome Sequencing Center for high school and undergraduate students. Cell Biol Educ (2005) 0.79
Bench-to-bedside review: fulfilling promises of the Human Genome Project. Crit Care (2002) 0.78
Drug discovery and mental illness. Dialogues Clin Neurosci (2002) 0.77
The sequence of the human genome. Science (2001) 101.55
The genome sequence of Drosophila melanogaster. Science (2000) 74.32
Whole-genome random sequencing and assembly of Haemophilus influenzae Rd. Science (1995) 68.34
Complete genome sequence of the methanogenic archaeon, Methanococcus jannaschii. Science (1996) 41.35
A whole-genome assembly of Drosophila. Science (2000) 38.48
The complete genome sequence of the gastric pathogen Helicobacter pylori. Nature (1997) 34.00
The minimal gene complement of Mycoplasma genitalium. Science (1995) 32.41
Complete genome sequence of a virulent isolate of Streptococcus pneumoniae. Science (2001) 21.99
DNA sequence of both chromosomes of the cholera pathogen Vibrio cholerae. Nature (2000) 19.93
Genomic sequence of a Lyme disease spirochaete, Borrelia burgdorferi. Nature (1997) 19.08
Complete genome sequence of Neisseria meningitidis serogroup B strain MC58. Science (2000) 16.04
Evidence for lateral gene transfer between Archaea and bacteria from genome sequence of Thermotoga maritima. Nature (1999) 14.42
The complete genome sequence of the hyperthermophilic, sulphate-reducing archaeon Archaeoglobus fulgidus. Nature (1997) 14.38
A gene map of the human genome. Science (1996) 14.32
Global transposon mutagenesis and a minimal Mycoplasma genome. Science (1999) 11.36
A monoclonal antibody (anti-Tac) reactive with activated and functionally mature human T cells. I. Production of anti-Tac monoclonal antibody and distribution of Tac (+) cells. J Immunol (1981) 10.92
3'-Azido-3'-deoxythymidine (BW A509U): an antiviral agent that inhibits the infectivity and cytopathic effect of human T-lymphotropic virus type III/lymphadenopathy-associated virus in vitro. Proc Natl Acad Sci U S A (1985) 10.71
Sequence identification of 2,375 human brain genes. Nature (1992) 9.53
Mutation of a mutL homolog in hereditary colon cancer. Science (1994) 9.04
Whole-genome comparison of Mycobacterium tuberculosis clinical and laboratory strains. J Bacteriol (2002) 8.88
Phosphorylation of 3'-azido-3'-deoxythymidine and selective interaction of the 5'-triphosphate with human immunodeficiency virus reverse transcriptase. Proc Natl Acad Sci U S A (1986) 8.48
Role of suppressor T cells in pathogenesis of common variable hypogammaglobulinaemia. Lancet (1974) 8.13
Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana. Nature (1999) 8.04
Genome sequence of the radioresistant bacterium Deinococcus radiodurans R1. Science (1999) 8.01
Complete genome sequence of Treponema pallidum, the syphilis spirochete. Science (1998) 7.96
Identification of vaccine candidates against serogroup B meningococcus by whole-genome sequencing. Science (2000) 7.41
Rapid cDNA sequencing (expressed sequence tags) from a directionally cloned human infant brain cDNA library. Nat Genet (1993) 7.38
Inhibition of the in vitro infectivity and cytopathic effect of human T-lymphotrophic virus type III/lymphadenopathy-associated virus (HTLV-III/LAV) by 2',3'-dideoxynucleosides. Proc Natl Acad Sci U S A (1986) 6.63
E-CELL: software environment for whole-cell simulation. Bioinformatics (1999) 6.29
Complete genome sequence of Caulobacter crescentus. Proc Natl Acad Sci U S A (2001) 5.58
A tool for analyzing and annotating genomic sequences. Genomics (1997) 5.33
Phosphorothioate analogs of oligodeoxynucleotides: inhibitors of replication and cytopathic effects of human immunodeficiency virus. Proc Natl Acad Sci U S A (1987) 5.17
Molecular targets for AIDS therapy. Science (1990) 4.28
Infectious mutants of HTLV-III with changes in the 3' region and markedly reduced cytopathic effects. Science (1986) 4.17
Shotgun sequencing of the human genome. Science (1998) 3.97
Chromosome 2 sequence of the human malaria parasite Plasmodium falciparum. Science (1998) 3.83
Impaired synthesis of polyclonal (non-paraprotein) immunoglobulins by circulating lymphocytes from patients with multiple myeloma Role of suppressor cells. N Engl J Med (1975) 3.81
Whole-genome shotgun optical mapping of Deinococcus radiodurans. Science (1999) 3.56
Frequency and distribution of DNA uptake signal sequences in the Haemophilus influenzae Rd genome. Science (1995) 3.44
3,400 new expressed sequence tags identify diversity of transcripts in human brain. Nat Genet (1993) 3.41
A pathogenic retrovirus (HTLV-III) linked to AIDS. N Engl J Med (1984) 3.41
DNA repeats identify novel virulence genes in Haemophilus influenzae. Proc Natl Acad Sci U S A (1996) 3.38
How many genes in the human genome? Nat Genet (1994) 3.30
Dextran sulfate suppression of viruses in the HIV family: inhibition of virion binding to CD4+ cells. Science (1988) 3.01
Strategies for antiviral therapy in AIDS. Nature (1987) 2.95
Plasma and cerebrospinal fluid pharmacokinetics of 3'-azido-3'-deoxythymidine: a novel pyrimidine analog with potential application for the treatment of patients with AIDS and related diseases. Clin Pharmacol Ther (1987) 2.92
In vivo activity against HIV and favorable toxicity profile of 2',3'-dideoxyinosine. Science (1989) 2.70
Suramin protection of T cells in vitro against infectivity and cytopathic effect of HTLV-III. Science (1984) 2.70
Analysis of the complete genome of smallpox variola major virus strain Bangladesh-1975. Virology (1994) 2.69
Regulation of viral expression of human immunodeficiency virus in vitro by an antisense phosphorothioate oligodeoxynucleotide against rev (art/trs) in chronically infected cells. Proc Natl Acad Sci U S A (1989) 2.62
Sequence and analysis of the 60 kb conjugative, bacteriocin-producing plasmid pMRC01 from Lactococcus lactis DPC3147. Mol Microbiol (1998) 2.61
Hormone and neurotransmitter receptors in an established vascular endothelial cell line. Proc Natl Acad Sci U S A (1976) 2.40
CD4 count and the risk for death in patients infected with HIV receiving antiretroviral therapy. Ann Intern Med (1991) 2.35
The Sézary syndrome: a malignant proliferation of helper T cells. J Clin Invest (1976) 2.32
Differential phosphorylation of azidothymidine, dideoxycytidine, and dideoxyinosine in resting and activated peripheral blood mononuclear cells. J Clin Invest (1993) 2.27
Human BAC ends quality assessment and sequence analyses. Genomics (2000) 2.25
Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana. Nature (2000) 2.17
Clinical pharmacology of 3'-azido-2',3'-dideoxythymidine (zidovudine) and related dideoxynucleosides. N Engl J Med (1989) 2.17
Fraud in breast-cancer trials. N Engl J Med (1994) 2.16
NIH conference. T-cell lymphoproliferative syndrome associated with human T-cell leukemia/lymphoma virus. Ann Intern Med (1984) 2.10
Initial studies on the cellular pharmacology of 2',3'-dideoxyinosine, an inhibitor of HIV infectivity. Biochem Pharmacol (1987) 2.10
Caenorhabditis elegans expressed sequence tags identify gene families and potential disease gene homologues. Nat Genet (1992) 2.10
Long-term toxicity/activity profile of 2',3'-dideoxyinosine in AIDS or AIDS-related complex. Lancet (1990) 2.02
Suppressor cells in the regulation of the immune response. Prog Clin Immunol (1977) 1.99
Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q. Genomics (1999) 1.99
Long-term inhibition of human T-lymphotropic virus type III/lymphadenopathy-associated virus (human immunodeficiency virus) DNA synthesis and RNA expression in T cells protected by 2',3'-dideoxynucleosides in vitro. Proc Natl Acad Sci U S A (1987) 1.96
Changes in drug sensitivity of human immunodeficiency virus type 1 during therapy with azidothymidine, dideoxycytidine, and dideoxyinosine: an in vitro comparative study. Proc Natl Acad Sci U S A (1993) 1.92
Projections of the incidence of non-Hodgkin's lymphoma related to acquired immunodeficiency syndrome. J Natl Cancer Inst (1991) 1.91
Development of antiretroviral therapy for the acquired immunodeficiency syndrome and related disorders. A progress report. N Engl J Med (1987) 1.88
Pharmacokinetics of 2',3'-dideoxyadenosine and 2',3'-dideoxyinosine in patients with severe human immunodeficiency virus infection. Clin Pharmacol Ther (1990) 1.87
Polyclonal B-cell activators in the study of the regulation of immunoglobulin synthesis in the human system. Adv Immunol (1982) 1.85
High throughput direct end sequencing of BAC clones. Nucleic Acids Res (1999) 1.85
Sequence-tagged connectors: a sequence approach to mapping and scanning the human genome. Proc Natl Acad Sci U S A (1999) 1.85
Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana. Nature (2000) 1.85
The construction of Arabidopsis expressed sequence tag assemblies. A new resource to facilitate gene identification. Plant Physiol (1996) 1.84
Studies on the mechanism of human immunodeficiency virus reverse transcriptase. Steady-state kinetics, processivity, and polynucleotide inhibition. J Biol Chem (1988) 1.82
Fc-receptors on human T lymphocytes. I. Transition of Tgamma to Tmu cells. J Immunol (1978) 1.79
Use of the complete genome sequence information of Haemophilus influenzae strain Rd to investigate lipopolysaccharide biosynthesis. Mol Microbiol (1996) 1.79
Disorders of suppressor immunoregulatory cells in the pathogenesis of immunodeficiency and autoimmunity. Ann Intern Med (1978) 1.78
Functional properties of antigen-specific T cells infected by human T-cell leukemia-lymphoma virus (HTLV-I). Science (1984) 1.74
Molecular structure and evolution of an alpha satellite/non-alpha satellite junction at 16p11. Hum Mol Genet (2000) 1.71
Primary structure of rat cardiac beta-adrenergic and muscarinic cholinergic receptors obtained by automated DNA sequence analysis: further evidence for a multigene family. Proc Natl Acad Sci U S A (1987) 1.70
Stepwise mechanism of HIV reverse transcriptase: primer function of phosphorothioate oligodeoxynucleotide. Biochemistry (1989) 1.70