Published in Science on October 20, 1995
Genome sequencing in microfabricated high-density picolitre reactors. Nature (2005) 150.21
tRNAscan-SE: a program for improved detection of transfer RNA genes in genomic sequence. Nucleic Acids Res (1997) 142.55
GeneMark.hmm: new solutions for gene finding. Nucleic Acids Res (1998) 25.21
Essential Bacillus subtilis genes. Proc Natl Acad Sci U S A (2003) 14.01
Complete sequence analysis of the genome of the bacterium Mycoplasma pneumoniae. Nucleic Acids Res (1996) 10.46
Proton-dependent multidrug efflux systems. Microbiol Rev (1996) 8.81
The FunCat, a functional annotation scheme for systematic classification of proteins from whole genomes. Nucleic Acids Res (2004) 8.79
Genome sequences of Chlamydia trachomatis MoPn and Chlamydia pneumoniae AR39. Nucleic Acids Res (2000) 8.69
Short-sequence DNA repeats in prokaryotic genomes. Microbiol Mol Biol Rev (1998) 8.47
Molecular biology and pathogenicity of mycoplasmas. Microbiol Mol Biol Rev (1998) 7.89
Genome-wide analysis of integral membrane proteins from eubacterial, archaean, and eukaryotic organisms. Protein Sci (1998) 7.88
Measuring genome evolution. Proc Natl Acad Sci U S A (1998) 6.97
Genome sequence and comparative analysis of the solvent-producing bacterium Clostridium acetobutylicum. J Bacteriol (2001) 6.46
A minimal gene set for cellular life derived by comparison of complete bacterial genomes. Proc Natl Acad Sci U S A (1996) 6.38
Essential genes of a minimal bacterium. Proc Natl Acad Sci U S A (2006) 6.31
The acetate switch. Microbiol Mol Biol Rev (2005) 6.10
A whole-cell computational model predicts phenotype from genotype. Cell (2012) 5.98
Yeast microarrays for genome wide parallel genetic and gene expression analysis. Proc Natl Acad Sci U S A (1997) 5.59
Complete genome sequence of Caulobacter crescentus. Proc Natl Acad Sci U S A (2001) 5.58
Evidence for symmetric chromosomal inversions around the replication origin in bacteria. Genome Biol (2000) 5.40
Annotation transfer between genomes: protein-protein interologs and protein-DNA regulogs. Genome Res (2004) 5.26
Enzyme-specific profiles for genome annotation: PRIAM. Nucleic Acids Res (2003) 5.10
Reductive genome evolution in Buchnera aphidicola. Proc Natl Acad Sci U S A (2003) 4.88
Genome sequence and comparative microarray analysis of serotype M18 group A Streptococcus strains associated with acute rheumatic fever outbreaks. Proc Natl Acad Sci U S A (2002) 4.85
Genomics of bacteria and archaea: the emerging dynamic view of the prokaryotic world. Nucleic Acids Res (2008) 4.78
Extreme genome reduction in symbiotic bacteria. Nat Rev Microbiol (2011) 4.67
From genetic footprinting to antimicrobial drug targets: examples in cofactor biosynthetic pathways. J Bacteriol (2002) 4.66
FtsZ ring formation in fts mutants. J Bacteriol (1996) 4.60
A heuristic graph comparison algorithm and its application to detect functionally related enzyme clusters. Nucleic Acids Res (2000) 4.53
DNA Data Bank of Japan at work on genome sequence data. Nucleic Acids Res (1998) 4.43
Genome sequence of Chlamydophila caviae (Chlamydia psittaci GPIC): examining the role of niche-specific genes in the evolution of the Chlamydiaceae. Nucleic Acids Res (2003) 4.33
Macrolide resistance conferred by base substitutions in 23S rRNA. Antimicrob Agents Chemother (2001) 4.17
Determination of the core of a minimal bacterial gene set. Microbiol Mol Biol Rev (2004) 4.14
Archaea and the prokaryote-to-eukaryote transition. Microbiol Mol Biol Rev (1997) 3.94
Trends between gene content and genome size in prokaryotic species with larger genomes. Proc Natl Acad Sci U S A (2004) 3.89
The genome sequence of Blochmannia floridanus: comparative analysis of reduced genomes. Proc Natl Acad Sci U S A (2003) 3.81
Analyzing genomes with cumulative skew diagrams. Nucleic Acids Res (1998) 3.71
A phylogenomic study of DNA repair genes, proteins, and processes. Mutat Res (1999) 3.67
Genome sequence of the cyanobacterium Prochlorococcus marinus SS120, a nearly minimal oxyphototrophic genome. Proc Natl Acad Sci U S A (2003) 3.55
DNA repeats identify novel virulence genes in Haemophilus influenzae. Proc Natl Acad Sci U S A (1996) 3.38
The complete genome and proteome of Mycoplasma mobile. Genome Res (2004) 3.36
Population genetic analysis of Helicobacter pylori by multilocus enzyme electrophoresis: extensive allelic diversity and recombinational population structure. J Bacteriol (1996) 3.32
Isoprenoid biosynthesis: the evolution of two ancient and distinct pathways across genomes. Proc Natl Acad Sci U S A (2000) 3.32
Structure determination of membrane proteins by NMR spectroscopy. Chem Rev (2004) 3.25
Mycoplasmas and ureaplasmas as neonatal pathogens. Clin Microbiol Rev (2005) 3.20
Glu-tRNAGln amidotransferase: a novel heterotrimeric enzyme required for correct decoding of glutamine codons during translation. Proc Natl Acad Sci U S A (1997) 3.13
Evolutionary motif and its biological and structural significance. J Mol Evol (1997) 3.03
A primordial tRNA modification required for the evolution of life? EMBO J (2001) 3.01
Global phenotypic characterization of bacteria. FEMS Microbiol Rev (2008) 2.97
Protein phylogenies and signature sequences: A reappraisal of evolutionary relationships among archaebacteria, eubacteria, and eukaryotes. Microbiol Mol Biol Rev (1998) 2.96
Accelerated evolution associated with genome reduction in a free-living prokaryote. Genome Biol (2005) 2.95
DEG 5.0, a database of essential genes in both prokaryotes and eukaryotes. Nucleic Acids Res (2008) 2.94
Variable number of tandem repeats in clinical strains of Haemophilus influenzae. Infect Immun (1997) 2.92
The process of genome shrinkage in the obligate symbiont Buchnera aphidicola. Genome Biol (2001) 2.84
Alpha-crystallin-type heat shock proteins: socializing minichaperones in the context of a multichaperone network. Microbiol Mol Biol Rev (2002) 2.80
Re-annotating the Mycoplasma pneumoniae genome sequence: adding value, function and reading frames. Nucleic Acids Res (2000) 2.79
The complete genome sequence of the murine respiratory pathogen Mycoplasma pulmonis. Nucleic Acids Res (2001) 2.75
Pseudouridine synthases: four families of enzymes containing a putative uridine-binding motif also conserved in dUTPases and dCTP deaminases. Nucleic Acids Res (1996) 2.73
Evidence of a large novel gene pool associated with prokaryotic genomic islands. PLoS Genet (2005) 2.71
Structure-based assignment of the biochemical function of a hypothetical protein: a test case of structural genomics. Proc Natl Acad Sci U S A (1998) 2.70
Morphogenesis of Escherichia coli. Microbiol Mol Biol Rev (1998) 2.61
Predicted highly expressed genes of diverse prokaryotic genomes. J Bacteriol (2000) 2.60
Disulfide bond formation in the Escherichia coli cytoplasm: an in vivo role reversal for the thioredoxins. EMBO J (1998) 2.56
Towards synthesis of a minimal cell. Mol Syst Biol (2006) 2.55
Prediction of transcriptional terminators in Bacillus subtilis and related species. PLoS Comput Biol (2005) 2.54
The genomic tree as revealed from whole proteome comparisons. Genome Res (1999) 2.47
A diverse superfamily of enzymes with ATP-dependent carboxylate-amine/thiol ligase activity. Protein Sci (1997) 2.47
Compilation and analysis of intein sequences. Nucleic Acids Res (1997) 2.46
The PIR-International Protein Sequence Database. Nucleic Acids Res (1998) 2.45
Replicational and transcriptional selection on codon usage in Borrelia burgdorferi. Proc Natl Acad Sci U S A (1998) 2.42
Universally conserved translation initiation factors. Proc Natl Acad Sci U S A (1998) 2.41
Conserved clusters of functionally related genes in two bacterial genomes. J Mol Evol (1997) 2.39
Mycoplasma genitalium: from Chrysalis to multicolored butterfly. Clin Microbiol Rev (2011) 2.39
The genome sequence of Mycoplasma mycoides subsp. mycoides SC type strain PG1T, the causative agent of contagious bovine pleuropneumonia (CBPP). Genome Res (2004) 2.33
Genome plasticity as a paradigm of eubacteria evolution. J Mol Evol (1997) 2.29
Abundant microsatellite polymorphism in Saccharomyces cerevisiae, and the different distributions of microsatellites in eight prokaryotes and S. cerevisiae, result from strong mutation pressures and a variety of selective forces. Proc Natl Acad Sci U S A (1998) 2.28
Comparative analysis of the genomes of the bacteria Mycoplasma pneumoniae and Mycoplasma genitalium. Nucleic Acids Res (1997) 2.28
Complete resolution of the solid-state NMR spectrum of a uniformly 15N-labeled membrane protein in phospholipid bilayers. Proc Natl Acad Sci U S A (1997) 2.27
Comparative genomic analyses of the bacterial phosphotransferase system. Microbiol Mol Biol Rev (2005) 2.26
DNA sequencing: bench to bedside and beyond. Nucleic Acids Res (2007) 2.25
Identification and characterization of a new organic hydroperoxide resistance (ohr) gene with a novel pattern of oxidative stress regulation from Xanthomonas campestris pv. phaseoli. J Bacteriol (1998) 2.20
Metabolic interdependence of obligate intracellular bacteria and their insect hosts. Microbiol Mol Biol Rev (2004) 2.19
Comparing function and structure between entire proteomes. Protein Sci (2001) 2.18
Self-identification of protein-coding regions in microbial genomes. Proc Natl Acad Sci U S A (1998) 2.17
The complete genomic sequence of Mycoplasma penetrans, an intracellular bacterial pathogen in humans. Nucleic Acids Res (2002) 2.17
Comprehensive identification of essential Staphylococcus aureus genes using Transposon-Mediated Differential Hybridisation (TMDH). BMC Genomics (2009) 2.17
Probing the structure of the Escherichia coli 10Sa RNA (tmRNA). RNA (1997) 2.15
Comparative genomics and understanding of microbial biology. Emerg Infect Dis (2000) 2.14
Structural assignments to the Mycoplasma genitalium proteins show extensive gene duplications and domain rearrangements. Proc Natl Acad Sci U S A (1998) 2.08
Being pathogenic, plastic, and sexual while living with a nearly minimal bacterial genome. PLoS Genet (2007) 2.08
Large-scale transposon mutagenesis of Mycoplasma pulmonis. Mol Microbiol (2008) 2.08
Detection of Mycoplasma genitalium by PCR amplification of the 16S rRNA gene. J Clin Microbiol (2003) 2.07
Methanogenesis: genes, genomes, and who's on first? J Bacteriol (1997) 2.06
Peptide methionine sulfoxide reductase contributes to the maintenance of adhesins in three major pathogens. Proc Natl Acad Sci U S A (1996) 2.05
Sigma factors and global gene regulation in Mycobacterium tuberculosis. J Bacteriol (2004) 2.05
Imaging mass spectrometry in microbiology. Nat Rev Microbiol (2011) 2.04
The yeast gene YNL292w encodes a pseudouridine synthase (Pus4) catalyzing the formation of psi55 in both mitochondrial and cytoplasmic tRNAs. Nucleic Acids Res (1997) 2.03
A genome-scale metabolic reconstruction of Mycoplasma genitalium, iPS189. PLoS Comput Biol (2009) 2.02
Structure and assembly of large lipid-containing dsDNA viruses. Nat Struct Biol (2000) 2.00
The sequence of the human genome. Science (2001) 101.55
Nucleotide sequence of bacteriophage phi X174 DNA. Nature (1977) 95.69
The genome sequence of Drosophila melanogaster. Science (2000) 74.32
Whole-genome random sequencing and assembly of Haemophilus influenzae Rd. Science (1995) 68.34
Improved microbial gene identification with GLIMMER. Nucleic Acids Res (1999) 51.34
Complete genome sequence of the methanogenic archaeon, Methanococcus jannaschii. Science (1996) 41.35
A whole-genome assembly of Drosophila. Science (2000) 38.48
The complete genome sequence of the gastric pathogen Helicobacter pylori. Nature (1997) 34.00
A simple method for DNA restriction site mapping. Nucleic Acids Res (1976) 22.24
Complete genome sequence of a virulent isolate of Streptococcus pneumoniae. Science (2001) 21.99
TIGRFAMs: a protein family resource for the functional identification of proteins. Nucleic Acids Res (2001) 20.84
Microbial gene identification using interpolated Markov models. Nucleic Acids Res (1998) 20.26
Alignment of whole genomes. Nucleic Acids Res (1999) 20.02
DNA sequence of both chromosomes of the cholera pathogen Vibrio cholerae. Nature (2000) 19.93
A restriction enzyme from Hemophilus influenzae. I. Purification and general properties. J Mol Biol (1970) 19.69
Complementary DNA sequencing: expressed sequence tags and human genome project. Science (1991) 19.42
Genomic sequence of a Lyme disease spirochaete, Borrelia burgdorferi. Nature (1997) 19.08
Analysis of the protein-coding content of the sequence of human cytomegalovirus strain AD169. Curr Top Microbiol Immunol (1990) 16.31
Complete genome sequence of Neisseria meningitidis serogroup B strain MC58. Science (2000) 16.04
Evidence for lateral gene transfer between Archaea and bacteria from genome sequence of Thermotoga maritima. Nature (1999) 14.42
The complete genome sequence of the hyperthermophilic, sulphate-reducing archaeon Archaeoglobus fulgidus. Nature (1997) 14.38
A gene map of the human genome. Science (1996) 14.32
The nucleotide sequence of bacteriophage phiX174. J Mol Biol (1978) 13.55
Restriction endonucleases in the analysis and restructuring of dna molecules. Annu Rev Biochem (1975) 11.76
A restriction enzyme from Hemophilus influenzae. II. J Mol Biol (1970) 11.54
Global transposon mutagenesis and a minimal Mycoplasma genome. Science (1999) 11.36
The Comprehensive Microbial Resource. Nucleic Acids Res (2001) 11.19
Specific cleavage analysis of mammalian mitochondrial DNA. Proc Natl Acad Sci U S A (1975) 9.65