PubRank

Timothy M Frayling

Author PubWeight™ 484.75‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes. Nat Genet 2008 35.06
2 Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes. Science 2007 32.97
3 Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. Nat Genet 2010 23.08
4 Six new loci associated with body mass index highlight a neuronal influence on body weight regulation. Nat Genet 2008 22.35
5 Hundreds of variants clustered in genomic loci and biological pathways affect human height. Nature 2010 20.01
6 New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. Nat Genet 2010 17.89
7 Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis. Nat Genet 2010 16.96
8 Genome-wide association analysis identifies 20 loci that influence adult height. Nat Genet 2008 16.92
9 Common variants near MC4R are associated with fat mass, weight and risk of obesity. Nat Genet 2008 15.94
10 Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk. Nature 2011 13.25
11 Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants. Nat Genet 2007 12.62
12 Genome-wide association study of CNVs in 16,000 cases of eight common diseases and 3,000 shared controls. Nature 2010 12.27
13 Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes. Nat Genet 2012 11.09
14 Activating mutations in the gene encoding the ATP-sensitive potassium-channel subunit Kir6.2 and permanent neonatal diabetes. N Engl J Med 2004 8.62
15 Large-scale association studies of variants in genes encoding the pancreatic beta-cell KATP channel subunits Kir6.2 (KCNJ11) and SUR1 (ABCC8) confirm that the KCNJ11 E23K variant is associated with type 2 diabetes. Diabetes 2003 8.19
16 Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution. Nat Genet 2010 7.94
17 A common variant of HMGA2 is associated with adult and childhood height in the general population. Nat Genet 2007 6.87
18 Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge. Nat Genet 2010 6.66
19 The metabochip, a custom genotyping array for genetic studies of metabolic, cardiovascular, and anthropometric traits. PLoS Genet 2012 6.15
20 Genome-wide association scan meta-analysis identifies three Loci influencing adiposity and fat distribution. PLoS Genet 2009 5.81
21 Conditional and joint multiple-SNP analysis of GWAS summary statistics identifies additional variants influencing complex traits. Nat Genet 2012 5.55
22 Genomic inflation factors under polygenic inheritance. Eur J Hum Genet 2011 4.89
23 A genome-wide association study identifies protein quantitative trait loci (pQTLs). PLoS Genet 2008 4.75
24 Population-based genome-wide association studies reveal six loci influencing plasma levels of liver enzymes. Am J Hum Genet 2008 4.69
25 Assessing the combined impact of 18 common genetic variants of modest effect sizes on type 2 diabetes risk. Diabetes 2008 4.57
26 A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance. Nat Genet 2012 4.37
27 Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility. Nat Genet 2014 4.13
28 Evaluation of common variants in the six known maturity-onset diabetes of the young (MODY) genes for association with type 2 diabetes. Diabetes 2007 3.84
29 Association analysis of 6,736 U.K. subjects provides replication and confirms TCF7L2 as a type 2 diabetes susceptibility gene with a substantial effect on individual risk. Diabetes 2006 3.79
30 Common variation in the FTO gene alters diabetes-related metabolic traits to the extent expected given its effect on BMI. Diabetes 2008 3.76
31 Combining information from common type 2 diabetes risk polymorphisms improves disease prediction. PLoS Med 2006 3.75
32 No evidence of association of ENPP1 variants with type 2 diabetes or obesity in a study of 8,089 U.K. Caucasians. Diabetes 2006 3.58
33 Common variants in WFS1 confer risk of type 2 diabetes. Nat Genet 2007 3.58
34 Genome-wide association study in individuals of South Asian ancestry identifies six new type 2 diabetes susceptibility loci. Nat Genet 2011 3.46
35 Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals. PLoS Genet 2012 3.21
36 The fat mass- and obesity-associated locus and dietary intake in children. Am J Clin Nutr 2008 3.18
37 Reaching new heights: insights into the genetics of human stature. Trends Genet 2008 2.89
38 Interrogating type 2 diabetes genome-wide association data using a biological pathway-based approach. Diabetes 2009 2.85
39 FTO genotype is associated with phenotypic variability of body mass index. Nature 2012 2.77
40 Common variants of the novel type 2 diabetes genes CDKAL1 and HHEX/IDE are associated with decreased pancreatic beta-cell function. Diabetes 2007 2.73
41 Causal relationship between obesity and vitamin D status: bi-directional Mendelian randomization analysis of multiple cohorts. PLoS Med 2013 2.73
42 Variants in the aromatase gene and on the Y-chromosome are not associated with adult height or insulin resistance in a UK population. Clin Endocrinol (Oxf) 2003 2.65
43 Stratifying type 2 diabetes cases by BMI identifies genetic risk variants in LAMA1 and enrichment for risk variants in lean compared to obese cases. PLoS Genet 2012 2.34
44 Common variation in the DIO2 gene predicts baseline psychological well-being and response to combination thyroxine plus triiodothyronine therapy in hypothyroid patients. J Clin Endocrinol Metab 2009 2.31
45 Variants in ADCY5 and near CCNL1 are associated with fetal growth and birth weight. Nat Genet 2010 2.30
46 Genome-wide association identifies nine common variants associated with fasting proinsulin levels and provides new insights into the pathophysiology of type 2 diabetes. Diabetes 2011 2.21
47 Exploring the developmental overnutrition hypothesis using parental-offspring associations and FTO as an instrumental variable. PLoS Med 2008 2.16
48 A genome-wide association study reveals variants in ARL15 that influence adiponectin levels. PLoS Genet 2009 2.09
49 A common genetic variant in the 15q24 nicotinic acetylcholine receptor gene cluster (CHRNA5-CHRNA3-CHRNB4) is associated with a reduced ability of women to quit smoking in pregnancy. Hum Mol Genet 2009 2.02
50 Integrated genetic and epigenetic analysis identifies haplotype-specific methylation in the FTO type 2 diabetes and obesity susceptibility locus. PLoS One 2010 1.93
51 New loci associated with birth weight identify genetic links between intrauterine growth and adult height and metabolism. Nat Genet 2012 1.90
52 Allelic heterogeneity and more detailed analyses of known loci explain additional phenotypic variation and reveal complex patterns of association. Hum Mol Genet 2011 1.83
53 Common variation in the beta-carotene 15,15'-monooxygenase 1 gene affects circulating levels of carotenoids: a genome-wide association study. Am J Hum Genet 2009 1.81
54 Clear detection of ADIPOQ locus as the major gene for plasma adiponectin: results of genome-wide association analyses including 4659 European individuals. Atherosclerosis 2009 1.78
55 A genome-wide association search for type 2 diabetes genes in African Americans. PLoS One 2012 1.72
56 Multiple loci are associated with white blood cell phenotypes. PLoS Genet 2011 1.65
57 Adiposity-related heterogeneity in patterns of type 2 diabetes susceptibility observed in genome-wide association data. Diabetes 2008 1.64
58 Genetic evidence that raised sex hormone binding globulin (SHBG) levels reduce the risk of type 2 diabetes. Hum Mol Genet 2009 1.61
59 Genetic variation at CHRNA5-CHRNA3-CHRNB4 interacts with smoking status to influence body mass index. Int J Epidemiol 2011 1.61
60 Underlying genetic models of inheritance in established type 2 diabetes associations. Am J Epidemiol 2009 1.60
61 People of the British Isles: preliminary analysis of genotypes and surnames in a UK-control population. Eur J Hum Genet 2011 1.58
62 Type 2 diabetes risk alleles are associated with reduced size at birth. Diabetes 2009 1.58
63 Type 2 diabetes TCF7L2 risk genotypes alter birth weight: a study of 24,053 individuals. Am J Hum Genet 2007 1.52
64 FTO gene variation and measures of body mass in an African population. BMC Med Genet 2009 1.49
65 Biomarkers for type 2 diabetes and impaired fasting glucose using a nontargeted metabolomics approach. Diabetes 2013 1.44
66 New gene variants alter type 2 diabetes risk predominantly through reduced beta-cell function. Curr Opin Clin Nutr Metab Care 2008 1.43
67 A common variant of the p16(INK4a) genetic region is associated with physical function in older people. Mech Ageing Dev 2007 1.39
68 Intrauterine hyperglycemia is associated with an earlier diagnosis of diabetes in HNF-1alpha gene mutation carriers. Diabetes Care 2002 1.38
69 Genetic regulation of birth weight and fasting glucose by a common polymorphism in the islet cell promoter of the glucokinase gene. Diabetes 2005 1.38
70 Association studies of genetic variation in the WFS1 gene and type 2 diabetes in U.K. populations. Diabetes 2002 1.37
71 Human aging is characterized by focused changes in gene expression and deregulation of alternative splicing. Aging Cell 2011 1.37
72 Population-specific risk of type 2 diabetes conferred by HNF4A P2 promoter variants: a lesson for replication studies. Diabetes 2008 1.33
73 Evidence for linkage of stature to chromosome 3p26 in a large U.K. Family data set ascertained for type 2 diabetes. Am J Hum Genet 2001 1.32
74 Eight common genetic variants associated with serum DHEAS levels suggest a key role in ageing mechanisms. PLoS Genet 2011 1.30
75 Discovery and fine mapping of serum protein loci through transethnic meta-analysis. Am J Hum Genet 2012 1.29
76 Mendelian randomization studies do not support a role for raised circulating triglyceride levels influencing type 2 diabetes, glucose levels, or insulin resistance. Diabetes 2011 1.29
77 The 9p21 myocardial infarction risk allele increases risk of peripheral artery disease in older people. Circ Cardiovasc Genet 2009 1.27
78 Common variants of the hepatocyte nuclear factor-4alpha P2 promoter are associated with type 2 diabetes in the U.K. population. Diabetes 2004 1.25
79 Mendelian randomization studies do not support a causal role for reduced circulating adiponectin levels in insulin resistance and type 2 diabetes. Diabetes 2013 1.25
80 Meta-analysis and a large association study confirm a role for calpain-10 variation in type 2 diabetes susceptibility. Am J Hum Genet 2003 1.24
81 A genome-wide association meta-analysis of circulating sex hormone-binding globulin reveals multiple Loci implicated in sex steroid hormone regulation. PLoS Genet 2012 1.23
82 A large-scale association analysis of common variation of the HNF1alpha gene with type 2 diabetes in the U.K. Caucasian population. Diabetes 2005 1.18
83 A powerful approach to sub-phenotype analysis in population-based genetic association studies. Genet Epidemiol 2010 1.16
84 A common variation in deiodinase 1 gene DIO1 is associated with the relative levels of free thyroxine and triiodothyronine. J Clin Endocrinol Metab 2008 1.15
85 Effects of the diabetes linked TCF7L2 polymorphism in a representative older population. BMC Med 2006 1.15
86 Association of the calpain-10 gene with type 2 diabetes in Europeans: results of pooled and meta-analyses. Mol Genet Metab 2006 1.14
87 Novel biological insights emerging from genetic studies of type 2 diabetes and related metabolic traits. Curr Opin Lipidol 2010 1.13
88 Hyperglycemia and Adverse Pregnancy Outcome (HAPO) study: common genetic variants in GCK and TCF7L2 are associated with fasting and postchallenge glucose levels in pregnancy and with the new consensus definition of gestational diabetes mellitus from the International Association of Diabetes and Pregnancy Study Groups. Diabetes 2010 1.12
89 A meta-analysis of thyroid-related traits reveals novel loci and gender-specific differences in the regulation of thyroid function. PLoS Genet 2013 1.12
90 Triglyceride associated polymorphisms of the APOA5 gene have very different allele frequencies in Pune, India compared to Europeans. BMC Med Genet 2006 1.11
91 Adult height variants affect birth length and growth rate in children. Hum Mol Genet 2011 1.11
92 Association studies of insulin receptor substrate 1 gene (IRS1) variants in type 2 diabetes samples enriched for family history and early age of onset. Diabetes 2004 1.07
93 Genetic variants associated with glycine metabolism and their role in insulin sensitivity and type 2 diabetes. Diabetes 2013 1.06
94 Imputation of variants from the 1000 Genomes Project modestly improves known associations and can identify low-frequency variant-phenotype associations undetected by HapMap based imputation. PLoS One 2013 1.05
95 Genetic variation associated with circulating monocyte count in the eMERGE Network. Hum Mol Genet 2013 1.05
96 Genetic variation in the 15q25 nicotinic acetylcholine receptor gene cluster (CHRNA5-CHRNA3-CHRNB4) interacts with maternal self-reported smoking status during pregnancy to influence birth weight. Hum Mol Genet 2012 1.01
97 Deep resequencing unveils genetic architecture of ADIPOQ and identifies a novel low-frequency variant strongly associated with adiponectin variation. Diabetes 2012 1.00
98 The role of transcription factors in maturity-onset diabetes of the young. Mol Genet Metab 2002 0.98
99 Parental diabetes and birthweight in 236 030 individuals in the UK biobank study. Int J Epidemiol 2013 0.96
100 Variation in the calpain-10 gene affects blood glucose levels in the British population. Diabetes 2002 0.96
101 Phosphodiesterase 8B gene polymorphism is associated with subclinical hypothyroidism in pregnancy. J Clin Endocrinol Metab 2009 0.95
102 Linkage disequilibrium mapping of the replicated type 2 diabetes linkage signal on chromosome 1q. Diabetes 2009 0.95
103 Evidence from a large U.K. family collection that genes influencing age of onset of type 2 diabetes map to chromosome 12p and to the MODY3/NIDDM2 locus on 12q24. Diabetes 2004 0.94
104 Common variants show predicted polygenic effects on height in the tails of the distribution, except in extremely short individuals. PLoS Genet 2011 0.94
105 Genetic variation in the small heterodimer partner gene and young-onset type 2 diabetes, obesity, and birth weight in U.K. subjects. Diabetes 2003 0.93
106 Genome-wide association scan allowing for epistasis in type 2 diabetes. Ann Hum Genet 2010 0.93
107 Association and haplotype analysis of the insulin-degrading enzyme (IDE) gene, a strong positional and biological candidate for type 2 diabetes susceptibility. Diabetes 2003 0.91
108 Large-scale association analysis of TNF/LTA gene region polymorphisms in type 2 diabetes. BMC Med Genet 2010 0.90
109 Identification and validation of N-acetyltransferase 2 as an insulin sensitivity gene. J Clin Invest 2015 0.90
110 Insights on pathogenesis of type 2 diabetes from MODY genetics. Curr Diab Rep 2007 0.89
111 Genetic variants in Apolipoprotein AV alter triglyceride concentrations in pregnancy. Lipids Health Dis 2003 0.89
112 The functional "KL-VS" variant of KLOTHO is not associated with type 2 diabetes in 5028 UK Caucasians. BMC Med Genet 2006 0.89
113 Genome-wide meta-analysis of common variant differences between men and women. Hum Mol Genet 2012 0.88
114 Variation within the type 2 diabetes susceptibility gene calpain-10 and polycystic ovary syndrome. J Clin Endocrinol Metab 2002 0.87
115 A genetic variant in the seed region of miR-4513 shows pleiotropic effects on lipid and glucose homeostasis, blood pressure, and coronary artery disease. Hum Mutat 2014 0.85
116 Common variation in the LMNA gene (encoding lamin A/C) and type 2 diabetes: association analyses in 9,518 subjects. Diabetes 2007 0.84
117 Recent progress in the use of genetics to understand links between type 2 diabetes and related metabolic traits. Genome Biol 2013 0.83
118 Allelic drop-out may occur with a primer binding site polymorphism for the commonly used RFLP assay for the -1131T>C polymorphism of the Apolipoprotein AV gene. Lipids Health Dis 2006 0.83
119 Low frequency variants in the exons only encoding isoform A of HNF1A do not contribute to susceptibility to type 2 diabetes. PLoS One 2009 0.83
120 Lack of support for a role of the insulin gene variable number of tandem repeats minisatellite (INS-VNTR) locus in fetal growth or type 2 diabetes-related intermediate traits in United Kingdom populations. J Clin Endocrinol Metab 2004 0.82
121 The role of the HNF4alpha enhancer in type 2 diabetes. Mol Genet Metab 2002 0.82
122 Polygenic risk variants for type 2 diabetes susceptibility modify age at diagnosis in monogenic HNF1A diabetes. Diabetes 2009 0.82
123 Filaggrin gene mutations are associated with asthma and eczema in later life. J Allergy Clin Immunol 2008 0.80
124 Functional variation in VEGF is not associated with type 2 diabetes in a United Kingdom Caucasian population. JOP 2006 0.80
125 Assessment of the role of common genetic variation in the transient neonatal diabetes mellitus (TNDM) region in type 2 diabetes: a comparative genomic and tagging single nucleotide polymorphism approach. Diabetes 2006 0.79
126 In silico searching of human and mouse genome data identifies known and unknown HNF1 binding sites upstream of beta-cell genes. Mol Genet Metab 2003 0.78
127 The longitudinal association of common susceptibility variants for type 2 diabetes and obesity with fasting glucose level and BMI. BMC Med Genet 2010 0.78
128 A study of association between common variation in the growth hormone-chorionic somatomammotropin hormone gene cluster and adult fasting insulin in a UK Caucasian population. J Negat Results Biomed 2006 0.76
129 Identification and validation of N-acetyltransferase 2 as an insulin sensitivity gene. J Clin Invest 2016 0.76
130 The impact of the angiotensin-converting enzyme insertion/deletion polymorphism on severe hypoglycemia in Type 2 diabetes. Rev Diabet Stud 2006 0.75
131 Interleukin-18 polymorphism and physical functioning in older people: a replication study and meta-analysis. J Gerontol A Biol Sci Med Sci 2009 0.75
132 Genome-wide association study to identify common variants associated with brachial circumference: a meta-analysis of 14 cohorts. PLoS One 2012 0.75
133 Polymorphisms in LMNA and near a SERPINA gene cluster are associated with cognitive function in older people. Neurobiol Aging 2008 0.75
134 Tall stories: the fundamental difficulties of genetic association studies. Clin Endocrinol (Oxf) 2004 0.75
135 Combining genome and mouse knockout expression data to highlight binding sites for the transcription factor HNF1alpha. In Silico Biol 2002 0.75
136 Correction: Genome-wide physical activity interactions in adiposity - A meta-analysis of 200,452 adults. PLoS Genet 2017 0.75