1
|
Statins and the risk of colorectal cancer.
|
N Engl J Med
|
2005
|
6.86
|
2
|
Genome-wide association scan identifies a colorectal cancer susceptibility locus on 11q23 and replicates risk loci at 8q24 and 18q21.
|
Nat Genet
|
2008
|
6.75
|
3
|
A locus on 19p13 modifies risk of breast cancer in BRCA1 mutation carriers and is associated with hormone receptor-negative breast cancer in the general population.
|
Nat Genet
|
2010
|
4.96
|
4
|
Network modeling links breast cancer susceptibility and centrosome dysfunction.
|
Nat Genet
|
2007
|
4.69
|
5
|
RAD51 135G-->C modifies breast cancer risk among BRCA2 mutation carriers: results from a combined analysis of 19 studies.
|
Am J Hum Genet
|
2007
|
3.63
|
6
|
Common breast cancer-predisposition alleles are associated with breast cancer risk in BRCA1 and BRCA2 mutation carriers.
|
Am J Hum Genet
|
2008
|
3.41
|
7
|
Oral contraceptives and the risk of breast cancer in BRCA1 and BRCA2 mutation carriers.
|
J Natl Cancer Inst
|
2002
|
3.25
|
8
|
Replication of lung cancer susceptibility loci at chromosomes 15q25, 5p15, and 6p21: a pooled analysis from the International Lung Cancer Consortium.
|
J Natl Cancer Inst
|
2010
|
3.18
|
9
|
Hormone therapy and the risk of breast cancer in BRCA1 mutation carriers.
|
J Natl Cancer Inst
|
2008
|
2.78
|
10
|
Genome-wide association study in BRCA1 mutation carriers identifies novel loci associated with breast and ovarian cancer risk.
|
PLoS Genet
|
2013
|
2.39
|
11
|
Meta-analysis of new genome-wide association studies of colorectal cancer risk.
|
Hum Genet
|
2011
|
2.35
|
12
|
Genetic variation in 8q24 associated with risk of colorectal cancer.
|
Cancer Biol Ther
|
2007
|
2.32
|
13
|
A novel founder mutation in the RNASEL gene, 471delAAAG, is associated with prostate cancer in Ashkenazi Jews.
|
Am J Hum Genet
|
2002
|
2.24
|
14
|
Common variants in LSP1, 2q35 and 8q24 and breast cancer risk for BRCA1 and BRCA2 mutation carriers.
|
Hum Mol Genet
|
2009
|
2.13
|
15
|
Vitamin D status in primary hyperparathyroidism.
|
Eur J Intern Med
|
2011
|
2.05
|
16
|
Tests for gene-environment interaction from case-control data: a novel study of type I error, power and designs.
|
Genet Epidemiol
|
2008
|
2.04
|
17
|
BLM heterozygosity and the risk of colorectal cancer.
|
Science
|
2002
|
2.03
|
18
|
Clinical phenotype of families with longevity.
|
J Am Geriatr Soc
|
2004
|
2.03
|
19
|
Phenotype of microsatellite unstable colorectal carcinomas: Well-differentiated and focally mucinous tumors and the absence of dirty necrosis correlate with microsatellite instability.
|
Am J Surg Pathol
|
2003
|
1.97
|
20
|
Common breast cancer susceptibility alleles and the risk of breast cancer for BRCA1 and BRCA2 mutation carriers: implications for risk prediction.
|
Cancer Res
|
2010
|
1.90
|
21
|
Identification of a BRCA2-specific modifier locus at 6p24 related to breast cancer risk.
|
PLoS Genet
|
2013
|
1.88
|
22
|
Accurate classification of MLH1/MSH2 missense variants with multivariate analysis of protein polymorphisms-mismatch repair (MAPP-MMR).
|
Hum Mutat
|
2008
|
1.76
|
23
|
BRCA1 and BRCA2 founder mutations and the risk of colorectal cancer.
|
J Natl Cancer Inst
|
2004
|
1.76
|
24
|
The relationship between serum 25(OH)D and parathyroid hormone levels.
|
Am J Med
|
2011
|
1.70
|
25
|
MRE11 deficiency increases sensitivity to poly(ADP-ribose) polymerase inhibition in microsatellite unstable colorectal cancers.
|
Cancer Res
|
2011
|
1.68
|
26
|
Common genetic variants and modification of penetrance of BRCA2-associated breast cancer.
|
PLoS Genet
|
2010
|
1.56
|
27
|
Effect of pregnancy as a risk factor for breast cancer in BRCA1/BRCA2 mutation carriers.
|
Int J Cancer
|
2005
|
1.48
|
28
|
Genetic variation in 3-hydroxy-3-methylglutaryl CoA reductase modifies the chemopreventive activity of statins for colorectal cancer.
|
Cancer Prev Res (Phila)
|
2010
|
1.45
|
29
|
Higher risk of venous thrombosis associated with drospirenone-containing oral contraceptives: a population-based cohort study.
|
CMAJ
|
2011
|
1.38
|
30
|
Smoking, gender, and ethnicity predict somatic BRAF mutations in colorectal cancer.
|
Cancer Epidemiol Biomarkers Prev
|
2010
|
1.31
|
31
|
The MLH1 D132H variant is associated with susceptibility to sporadic colorectal cancer.
|
Nat Genet
|
2004
|
1.25
|
32
|
Pathologic predictors of microsatellite instability in colorectal cancer.
|
Am J Surg Pathol
|
2009
|
1.23
|
33
|
FGFR2 is a breast cancer susceptibility gene in Jewish and Arab Israeli populations.
|
Cancer Epidemiol Biomarkers Prev
|
2008
|
1.22
|
34
|
The public prefers fecal occult blood test over colonoscopy for colorectal cancer screening.
|
Eur J Cancer Prev
|
2008
|
1.22
|
35
|
Beyond aspirin-cancer prevention with statins, metformin and bisphosphonates.
|
Nat Rev Clin Oncol
|
2013
|
1.20
|
36
|
Accurate molecular classification of human cancers based on gene expression using a simple classifier with a pathological tree-based framework.
|
Am J Pathol
|
2003
|
1.20
|
37
|
Genetic anthropology of the colorectal cancer-susceptibility allele APC I1307K: evidence of genetic drift within the Ashkenazim.
|
Am J Hum Genet
|
2003
|
1.16
|
38
|
Gene expression patterns in mismatch repair-deficient colorectal cancers highlight the potential therapeutic role of inhibitors of the phosphatidylinositol 3-kinase-AKT-mammalian target of rapamycin pathway.
|
Clin Cancer Res
|
2009
|
1.15
|
39
|
BRCA germline mutations in Jewish women with uterine serous papillary carcinoma.
|
Gynecol Oncol
|
2004
|
1.14
|
40
|
Interplay between BRCA1 and RHAMM regulates epithelial apicobasal polarization and may influence risk of breast cancer.
|
PLoS Biol
|
2011
|
1.12
|
41
|
Increased risk of lung cancer in individuals with a family history of the disease: a pooled analysis from the International Lung Cancer Consortium.
|
Eur J Cancer
|
2012
|
1.07
|
42
|
Clinical implications of UGT1A1*28 genotype testing in colorectal cancer patients.
|
Cancer
|
2011
|
1.03
|
43
|
Gene expression differences between colon and rectum tumors.
|
Clin Cancer Res
|
2011
|
1.03
|
44
|
The effect of statins on risk and survival of gynecological malignancies.
|
Gynecol Oncol
|
2013
|
1.03
|
45
|
Spontaneous and therapeutic abortions and the risk of breast cancer among BRCA mutation carriers.
|
Breast Cancer Res
|
2006
|
1.01
|
46
|
Human papillomavirus is not associated with colorectal cancer in a large international study.
|
Cancer Causes Control
|
2010
|
0.98
|
47
|
K-ras mutations in sporadic colorectal tumors in Israel: unusual high frequency of codon 13 mutations and evidence for nonhomogeneous representation of mutation subtypes.
|
Dig Dis Sci
|
2002
|
0.97
|
48
|
Vascular disorders preceding diagnosis of cancer: distinguishing the causal relationship based on Bradford-Hill guidelines.
|
Angiology
|
2003
|
0.95
|
49
|
The risk of all-cause mortality is inversely related to serum 25(OH)D levels.
|
J Clin Endocrinol Metab
|
2012
|
0.94
|
50
|
CDX2 polymorphisms, RNA expression, and risk of colorectal cancer.
|
Cancer Res
|
2005
|
0.91
|
51
|
BRCA2 Polymorphic Stop Codon K3326X and the Risk of Breast, Prostate, and Ovarian Cancers.
|
J Natl Cancer Inst
|
2015
|
0.90
|
52
|
Associated Links Among Smoking, Chronic Obstructive Pulmonary Disease, and Small Cell Lung Cancer: A Pooled Analysis in the International Lung Cancer Consortium.
|
EBioMedicine
|
2015
|
0.90
|
53
|
Aspirin and NSAID use and lung cancer risk: a pooled analysis in the International Lung Cancer Consortium (ILCCO).
|
Cancer Causes Control
|
2011
|
0.89
|
54
|
Associations of common breast cancer susceptibility alleles with risk of breast cancer subtypes in BRCA1 and BRCA2 mutation carriers.
|
Breast Cancer Res
|
2014
|
0.89
|
55
|
RNASEL mutation screening and association study in Ashkenazi and non-Ashkenazi prostate cancer patients.
|
Cancer Epidemiol Biomarkers Prev
|
2006
|
0.88
|
56
|
Age at first birth and the risk of breast cancer in BRCA1 and BRCA2 mutation carriers.
|
Breast Cancer Res Treat
|
2007
|
0.88
|
57
|
Fecal DNA biomarkers for the detection of colorectal neoplasia: attractive, but is it feasible?
|
J Natl Cancer Inst
|
2005
|
0.88
|
58
|
FOXP3 germline polymorphisms are not associated with risk of breast cancer.
|
Cancer Genet Cytogenet
|
2009
|
0.87
|
59
|
Haplotype structure in Ashkenazi Jewish BRCA1 and BRCA2 mutation carriers.
|
Hum Genet
|
2011
|
0.87
|
60
|
The association between obesity and urinary tract infection.
|
Eur J Intern Med
|
2012
|
0.86
|
61
|
Clustering women's health behaviors.
|
Health Educ Behav
|
2002
|
0.86
|
62
|
Excellent performance of Hemoccult Sensa in organised colorectal cancer screening.
|
Eur J Cancer
|
2012
|
0.86
|
63
|
The longitudinal variability of serum 25(OH)D levels.
|
Eur J Intern Med
|
2012
|
0.85
|
64
|
Risk of colorectal cancer in self-reported inflammatory bowel disease and modification of risk by statin and NSAID use.
|
Cancer
|
2010
|
0.85
|
65
|
Calcium supplementation provides an extended window of opportunity for bone mass accretion after menarche.
|
Am J Clin Nutr
|
2003
|
0.84
|
66
|
Quality control in a National Program for the Early Detection of Breast Cancer: women's satisfaction with the mammography process.
|
Womens Health Issues
|
2008
|
0.84
|
67
|
Low integrated DNA repair score and lung cancer risk.
|
Cancer Prev Res (Phila)
|
2013
|
0.83
|
68
|
The use of exercise stress testing for the management of low-risk patients with chest pain.
|
Am J Emerg Med
|
2009
|
0.83
|
69
|
N-methylpurine DNA glycosylase and OGG1 DNA repair activities: opposite associations with lung cancer risk.
|
J Natl Cancer Inst
|
2012
|
0.83
|
70
|
Polymorphisms in alcohol metabolism genes ADH1B and ALDH2, alcohol consumption and colorectal cancer.
|
PLoS One
|
2013
|
0.82
|
71
|
High risk of colorectal and endometrial cancer in Ashkenazi families with the MSH2 A636P founder mutation.
|
Gastroenterology
|
2011
|
0.81
|
72
|
Dietary intake of carotenoid isomers in Israel.
|
Int J Vitam Nutr Res
|
2007
|
0.81
|
73
|
International collaborations in cancer control and the Third International Cancer Control Congress.
|
Tumori
|
2009
|
0.81
|
74
|
Maternal mosaicism for a second mutational event--a novel deletion--in a familial adenomatous polyposis family harboring a new germ-line mutation in the alternatively spliced-exon 9 region of APC.
|
Hum Mutat
|
2002
|
0.81
|
75
|
Low allele frequency of MLH1 D132H in American colorectal and endometrial cancer patients.
|
Dis Colon Rectum
|
2005
|
0.81
|
76
|
BRCA1 breast cancer risk is modified by CYP19 polymorphisms in Ashkenazi Jews.
|
Cancer Epidemiol Biomarkers Prev
|
2009
|
0.80
|
77
|
APC E1317Q is not associated with Colorectal Cancer in a population-based case-control study in Northern Israel.
|
Cancer Epidemiol Biomarkers Prev
|
2006
|
0.80
|
78
|
Sustained effect of short-term calcium supplementation on bone mass in adolescent girls with low calcium intake.
|
Am J Clin Nutr
|
2005
|
0.80
|
79
|
Recreational physical activity modifies the association between a common GH1 polymorphism and colorectal cancer risk.
|
Cancer Epidemiol Biomarkers Prev
|
2008
|
0.80
|
80
|
Vitamin D Status in Israeli subjects before the initiation and after the cessation of vitamin D supplements.
|
Calcif Tissue Int
|
2011
|
0.79
|
81
|
Common MUTYH mutations and colorectal cancer risk in multiethnic populations.
|
Fam Cancer
|
2012
|
0.78
|
82
|
PTPRJ haplotypes and colorectal cancer risk.
|
Cancer Epidemiol Biomarkers Prev
|
2008
|
0.78
|
83
|
Unraveling seasonality in population averages: an examination of seasonal variation in glucose levels in diabetes patients using a large population-based data set.
|
Chronobiol Int
|
2011
|
0.78
|
84
|
Fecal occult blood test performance indicators in warfarin-treated patients.
|
Dis Colon Rectum
|
2010
|
0.78
|
85
|
The evaluation of vitamin D status in normocalcemic primary hyperparathyroidism.
|
Eur J Intern Med
|
2012
|
0.78
|
86
|
Genetic variation in IGF-1 and breast cancer risk in Ashkenazi carriers and noncarriers of BRCA1/2 mutations.
|
Eur J Cancer Prev
|
2009
|
0.78
|
87
|
The rationale for delaying aging and the prevention of age-related diseases.
|
Rambam Maimonides Med J
|
2012
|
0.78
|
88
|
Self-rated health is prospectively associated with uptake of screening for the early detection of colorectal cancer, not vice versa.
|
Eur J Cancer Prev
|
2016
|
0.78
|
89
|
APC I1307K and the risk of prostate cancer.
|
Cancer Epidemiol Biomarkers Prev
|
2006
|
0.77
|
90
|
Gynecologic malignancies in Ashkenazi families with the MSH2 A636P founder mutation.
|
Am J Obstet Gynecol
|
2008
|
0.77
|
91
|
Statins, aspirin and risk of venous thromboembolic events in breast cancer patients.
|
J Thromb Thrombolysis
|
2014
|
0.76
|
92
|
Corrigendum: Genome-wide association study of colorectal cancer identifies six new susceptibility loci.
|
Nat Commun
|
2015
|
0.76
|
93
|
BRCA2 germline mutation in a woman with uterine serous papillary carcinoma--case report.
|
Gynecol Oncol
|
2005
|
0.76
|
94
|
Bisphosphonates: beyond prevention of bone metastases.
|
J Natl Cancer Inst
|
2011
|
0.75
|
95
|
Are we getting closer to molecular population screening for colorectal cancer?
|
J Natl Cancer Inst
|
2009
|
0.75
|
96
|
Inference of the haplotype effect in a matched case-control study using unphased genotype data.
|
Int J Biostat
|
2008
|
0.75
|
97
|
Evaluation of Polygenic Risk Scores for Breast and Ovarian Cancer Risk Prediction in BRCA1 and BRCA2 Mutation Carriers.
|
J Natl Cancer Inst
|
2017
|
0.75
|
98
|
BRCA1/2 mutation carriers: living with susceptibility.
|
Community Genet
|
2003
|
0.75
|
99
|
Evaluation of chest pain in the ED: factors affecting triage decisions.
|
Am J Emerg Med
|
2003
|
0.75
|
100
|
Obesity and association of serum 25(OH)D levels with all-cause mortality.
|
Calcif Tissue Int
|
2014
|
0.75
|
101
|
Cancer prevention: from public health interventions to individual tailoring.
|
Eur J Cancer Prev
|
2007
|
0.75
|
102
|
Ethnic differences in the epidemiological characteristics of severe trauma due to falls from heights among children in northern Israel.
|
Isr Med Assoc J
|
2007
|
0.75
|
103
|
Antithrombotic therapy for prevention of stroke in clinical practice in the ED.
|
Am J Emerg Med
|
2007
|
0.75
|