Published in J Biol Chem on December 26, 2001
Beta subunits of voltage-gated calcium channels. J Bioenerg Biomembr (2003) 2.96
The metal-ion-dependent adhesion site in the Von Willebrand factor-A domain of alpha2delta subunits is key to trafficking voltage-gated Ca2+ channels. Proc Natl Acad Sci U S A (2005) 1.65
Calcium channel alpha2delta subunits: differential expression, function, and drug binding. J Bioenerg Biomembr (2003) 1.49
The Physiology, Pathology, and Pharmacology of Voltage-Gated Calcium Channels and Their Future Therapeutic Potential. Pharmacol Rev (2015) 1.38
Presynaptic alpha2delta-3 is required for synaptic morphogenesis independent of its Ca2+-channel functions. Nat Neurosci (2009) 1.35
KCa channels as therapeutic targets in episodic ataxia type-2. J Neurosci (2010) 1.27
Voltage-activated calcium channel expression profiles in mouse brain and cultured hippocampal neurons. Neuroscience (2010) 1.15
Role of voltage-gated calcium channels in epilepsy. Pflugers Arch (2009) 1.08
Distinct ontogenic and regional expressions of newly identified Cajal-Retzius cell-specific genes during neocorticogenesis. Proc Natl Acad Sci U S A (2004) 1.04
Cerebellar ataxia, seizures, premature death, and cardiac abnormalities in mice with targeted disruption of the Cacna2d2 gene. Am J Pathol (2004) 1.00
Vesicular apparatus, including functional calcium channels, are present in developing rodent optic nerve axons and are required for normal node of Ranvier formation. J Physiol (2008) 0.98
Functional exofacially tagged N-type calcium channels elucidate the interaction with auxiliary α2δ-1 subunits. Proc Natl Acad Sci U S A (2014) 0.97
The ducky(2J) mutation in Cacna2d2 results in reduced spontaneous Purkinje cell activity and altered gene expression. J Neurosci (2006) 0.95
Proteolytic cleavage of the voltage-gated Ca2+ channel alpha2delta subunit: structural and functional features. Eur J Neurosci (2007) 0.95
The stargazin-related protein gamma 7 interacts with the mRNA-binding protein heterogeneous nuclear ribonucleoprotein A2 and regulates the stability of specific mRNAs, including CaV2.2. J Neurosci (2008) 0.93
Delayed postnatal loss of P/Q-type calcium channels recapitulates the absence epilepsy, dyskinesia, and ataxia phenotypes of genomic Cacna1a mutations. J Neurosci (2011) 0.92
Targeting mechanisms of high voltage-activated Ca2+ channels. J Bioenerg Biomembr (2003) 0.89
A novel null homozygous mutation confirms CACNA2D2 as a gene mutated in epileptic encephalopathy. PLoS One (2013) 0.87
Voltage-gated calcium channels and their auxiliary subunits: physiology and pathophysiology and pharmacology. J Physiol (2016) 0.82
Insights from mouse models of absence epilepsy into Ca2+ channel physiology and disease etiology. Cell Mol Neurobiol (2002) 0.82
The hemiplegic migraine-associated Y1245C mutation in CACNA1A results in a gain of channel function due to its effect on the voltage sensor and G-protein-mediated inhibition. Pflugers Arch (2009) 0.82
Expression of voltage-gated calcium channel α(2)δ(4) subunits in the mouse and rat retina. J Comp Neurol (2013) 0.82
Structure-function of proteins interacting with the α1 pore-forming subunit of high-voltage-activated calcium channels. Front Physiol (2014) 0.81
Altered expression of the voltage-gated calcium channel subunit α₂δ-1: a comparison between two experimental models of epilepsy and a sensory nerve ligation model of neuropathic pain. Neuroscience (2014) 0.79
Emerging evidence for specific neuronal functions of auxiliary calcium channel α₂δ subunits. Gen Physiol Biophys (2014) 0.78
Does modulation of the endocannabinoid system have potential therapeutic utility in cerebellar ataxia? J Physiol (2016) 0.78
Calcium current homeostasis and synaptic deficits in hippocampal neurons from Kelch-like 1 knockout mice. Front Cell Neurosci (2015) 0.78
Functional properties of the CaV1.2 calcium channel activated by calmodulin in the absence of alpha2delta subunits. Channels (Austin) (2009) 0.78
Expression and cellular localization of the voltage-gated calcium channel α2δ3 in the rodent retina. J Comp Neurol (2015) 0.77
Transsynaptic channelosomes: non-conducting roles of ion channels in synapse formation. Channels (Austin) (2011) 0.77
The du(2J) mouse model of ataxia and absence epilepsy has deficient cannabinoid CB₁ receptor-mediated signalling. J Physiol (2013) 0.76
How to button a bouton with alpha2deltas. Nat Neurosci (2009) 0.76
Proteolytic maturation of α2δ represents a checkpoint for activation and neuronal trafficking of latent calcium channels. Elife (2016) 0.76
The inhibition of functional expression of calcium channels by prion protein demonstrates competition with α2δ for GPI-anchoring pathways. Biochem J (2014) 0.75
Loss of the calcium channel β4 subunit impairs parallel fibre volley and Purkinje cell firing in cerebellum of adult ataxic mice. Eur J Neurosci (2016) 0.75
Isolation and characterization of the 5´-upstream region of the human voltage-gated Ca(2+) channel α 2δ-1 auxiliary subunit gene: promoter analysis and regulation by transcription factor Sp1. Pflugers Arch (2012) 0.75
SCN9A mutations in paroxysmal extreme pain disorder: allelic variants underlie distinct channel defects and phenotypes. Neuron (2006) 3.96
Somatic mutations in ATP1A1 and CACNA1D underlie a common subtype of adrenal hypertension. Nat Genet (2013) 2.63
Gene regulatory logic for reading the Sonic Hedgehog signaling gradient in the vertebrate neural tube. Cell (2012) 2.54
Identification of the alpha2-delta-1 subunit of voltage-dependent calcium channels as a molecular target for pain mediating the analgesic actions of pregabalin. Proc Natl Acad Sci U S A (2006) 2.37
Functional biology of the alpha(2)delta subunits of voltage-gated calcium channels. Trends Pharmacol Sci (2007) 2.13
Pharmacological disruption of calcium channel trafficking by the alpha2delta ligand gabapentin. Proc Natl Acad Sci U S A (2008) 2.04
siRNA relieves chronic neuropathic pain. Nucleic Acids Res (2004) 1.96
PI3K promotes voltage-dependent calcium channel trafficking to the plasma membrane. Nat Neurosci (2004) 1.93
α2δ expression sets presynaptic calcium channel abundance and release probability. Nature (2012) 1.90
The increased trafficking of the calcium channel subunit alpha2delta-1 to presynaptic terminals in neuropathic pain is inhibited by the alpha2delta ligand pregabalin. J Neurosci (2009) 1.73
Complement fragment C3a controls mutual cell attraction during collective cell migration. Dev Cell (2011) 1.54
Nicotine up-regulates alpha4beta2 nicotinic receptors and ER exit sites via stoichiometry-dependent chaperoning. J Gen Physiol (2011) 1.46
The calcium channel alpha2delta-2 subunit partitions with CaV2.1 into lipid rafts in cerebellum: implications for localization and function. J Neurosci (2006) 1.42
Nonfunctionalized nanocrystals can exploit a cell's active transport machinery delivering them to specific nuclear and cytoplasmic compartments. Nano Lett (2007) 1.37
Ca2+ channel beta-subunits: structural insights AID our understanding. Trends Pharmacol Sci (2004) 1.36
Efficient generation and cryopreservation of cardiomyocytes derived from human embryonic stem cells. Regen Med (2011) 1.35
Beta-subunits promote the expression of Ca(V)2.2 channels by reducing their proteasomal degradation. J Biol Chem (2011) 1.32
Presynaptic HCN1 channels regulate Cav3.2 activity and neurotransmission at select cortical synapses. Nat Neurosci (2011) 1.30
The alpha2delta ligand gabapentin inhibits the Rab11-dependent recycling of the calcium channel subunit alpha2delta-2. J Neurosci (2010) 1.29
The alpha2delta subunits of voltage-gated calcium channels form GPI-anchored proteins, a posttranslational modification essential for function. Proc Natl Acad Sci U S A (2010) 1.29
Dominant-negative calcium channel suppression by truncated constructs involves a kinase implicated in the unfolded protein response. J Neurosci (2004) 1.25
What can we learn from the population incidence of cancer? Armitage and Doll revisited. Lancet Oncol (2007) 1.22
Pregabalin suppresses spinal neuronal hyperexcitability and visceral hypersensitivity in the absence of peripheral pathophysiology. Anesthesiology (2011) 1.21
Descending serotonergic facilitation and the antinociceptive effects of pregabalin in a rat model of osteoarthritic pain. Mol Pain (2009) 1.21
The three-dimensional structure of the cardiac L-type voltage-gated calcium channel: comparison with the skeletal muscle form reveals a common architectural motif. J Biol Chem (2003) 1.20
A new look at calcium channel α2δ subunits. Curr Opin Neurobiol (2010) 1.19
Evaluation of the positional candidate gene CHRNA7 at the juvenile myoclonic epilepsy locus (EJM2) on chromosome 15q13-14. Epilepsy Res (2002) 1.14
N terminus is key to the dominant negative suppression of Ca(V)2 calcium channels: implications for episodic ataxia type 2. J Biol Chem (2009) 1.11
3D structure of the skeletal muscle dihydropyridine receptor. J Mol Biol (2002) 1.08
Breast cancer dormancy can be maintained by small numbers of micrometastases. Cancer Res (2010) 1.06
Nicotine normalizes intracellular subunit stoichiometry of nicotinic receptors carrying mutations linked to autosomal dominant nocturnal frontal lobe epilepsy. Mol Pharmacol (2009) 1.05
L-plastin regulates polarization and migration in chemokine-stimulated human T lymphocytes. J Immunol (2012) 1.05
Module dynamics of the GnRH signal transduction network. J Theor Biol (2002) 1.01
Time course and specificity of the pharmacological disruption of the trafficking of voltage-gated calcium channels by gabapentin. Channels (Austin) (2008) 0.98
The novel product of a five-exon stargazin-related gene abolishes Ca(V)2.2 calcium channel expression. EMBO J (2002) 0.98
Vesicular apparatus, including functional calcium channels, are present in developing rodent optic nerve axons and are required for normal node of Ranvier formation. J Physiol (2008) 0.98
α2δ-1 gene deletion affects somatosensory neuron function and delays mechanical hypersensitivity in response to peripheral nerve damage. J Neurosci (2013) 0.98
The importance of occupancy rather than affinity of CaV(beta) subunits for the calcium channel I-II linker in relation to calcium channel function. J Physiol (2006) 0.97
Effectiveness and safety of tapentadol prolonged release for severe, chronic low back pain with or without a neuropathic pain component: results of an open-label, phase 3b study. Curr Med Res Opin (2012) 0.97
Human neuronal stargazin-like proteins, gamma2, gamma3 and gamma4; an investigation of their specific localization in human brain and their influence on CaV2.1 voltage-dependent calcium channels expressed in Xenopus oocytes. BMC Neurosci (2003) 0.96
Mutant PrP suppresses glutamatergic neurotransmission in cerebellar granule neurons by impairing membrane delivery of VGCC α(2)δ-1 Subunit. Neuron (2012) 0.96
Diversity, dilemmas, and monopolies of niche construction. Am Nat (2009) 0.95
Three-dimensional structure of CaV3.1: comparison with the cardiac L-type voltage-gated calcium channel monomer architecture. J Biol Chem (2009) 0.95
The ducky(2J) mutation in Cacna2d2 results in reduced spontaneous Purkinje cell activity and altered gene expression. J Neurosci (2006) 0.95
"Jelly dots": synthesis and cytotoxicity studies of CdTe quantum dot-gelatin nanocomposites. Small (2007) 0.94
The HOOK-domain between the SH3 and the GK domains of Cavbeta subunits contains key determinants controlling calcium channel inactivation. Channels (Austin) (2007) 0.94
The stargazin-related protein gamma 7 interacts with the mRNA-binding protein heterogeneous nuclear ribonucleoprotein A2 and regulates the stability of specific mRNAs, including CaV2.2. J Neurosci (2008) 0.93
The anti-allodynic alpha(2)delta ligand pregabalin inhibits the trafficking of the calcium channel alpha(2)delta-1 subunit to presynaptic terminals in vivo. Biochem Soc Trans (2010) 0.93
The value of pre-operative treatment with GnRH analogues in women with submucous fibroids: a double-blind, placebo-controlled randomized trial. Hum Reprod (2010) 0.92
CdTe nanoparticles display tropism to core histones and histone-rich cell organelles. Small (2008) 0.92
Leukocyte function-associated antigen-1/intercellular adhesion molecule-1 interaction induces a novel genetic signature resulting in T-cells refractory to transforming growth factor-β signaling. J Biol Chem (2012) 0.91
Chronic pregabalin inhibits synaptic transmission between rat dorsal root ganglion and dorsal horn neurons in culture. Channels (Austin) (2012) 0.89
Förster resonance energy transfer (FRET) correlates of altered subunit stoichiometry in cys-loop receptors, exemplified by nicotinic α4β2. Int J Mol Sci (2012) 0.88
Calcium currents are enhanced by α2δ-1 lacking its membrane anchor. J Biol Chem (2012) 0.88
The in vivo rate of somatic adenomatous polyposis coli mutation. Am J Pathol (2008) 0.88
Kinetics and Gbetagamma modulation of Ca(v)2.2 channels with different auxiliary beta subunits. Pflugers Arch (2002) 0.87
Bile acids modulate the Golgi membrane fission process via a protein kinase Ceta and protein kinase D-dependent pathway in colonic epithelial cells. Carcinogenesis (2010) 0.86
Workflow-based software environment for large-scale biological experiments. J Biomol Screen (2010) 0.86
A gene regulatory motif that generates oscillatory or multiway switch outputs. J R Soc Interface (2012) 0.86
Evaluation of CACNA1H in European patients with childhood absence epilepsy. Epilepsy Res (2006) 0.86
Ezrin mediates tethering of the gamma-aminobutyric acid transporter GAT1 to actin filaments via a C-terminal PDZ-interacting domain. Biophys J (2009) 0.86
Linkage and association analysis of CACNG3 in childhood absence epilepsy. Eur J Hum Genet (2007) 0.86
Using antibodies against P2Y and P2X receptors in purinergic signaling research. Purinergic Signal (2011) 0.86
Determinants of the voltage dependence of G protein modulation within calcium channel beta subunits. Pflugers Arch (2008) 0.84
Generalized, switch-like competitive heterodimerization networks. Bull Math Biol (2007) 0.84
A high-content analysis toolbox permits dissection of diverse signaling pathways for T lymphocyte polarization. J Biomol Screen (2010) 0.84
Linkage analysis between childhood absence epilepsy and genes encoding GABAA and GABAB receptors, voltage-dependent calcium channels, and the ECA1 region on chromosome 8q. Epilepsy Res (2002) 0.83
Stochastic models of receptor oligomerization by bivalent ligand. J R Soc Interface (2006) 0.83
Mathematical models of the VEGF receptor and its role in cancer therapy. J R Soc Interface (2007) 0.82
Pre-Treatment of platinum resistant ovarian cancer cells with an MMP-9/MMP-2 inhibitor prior to cisplatin enhances cytotoxicity as determined by high content screening. Int J Mol Sci (2013) 0.82
Current approaches and future role of high content imaging in safety sciences and drug discovery. ALTEX (2014) 0.81
What can be learnt about disease progression in breast cancer dormancy from relapse data? PLoS One (2013) 0.80
Mathematical models of the fate of lymphoma B cells after antigen receptor ligation with specific antibodies. J Theor Biol (2005) 0.80