Published in J Neurosci on August 23, 2006
Identification of the alpha2-delta-1 subunit of voltage-dependent calcium channels as a molecular target for pain mediating the analgesic actions of pregabalin. Proc Natl Acad Sci U S A (2006) 2.37
The ß subunit of voltage-gated Ca2+ channels. Physiol Rev (2010) 2.30
Pharmacological disruption of calcium channel trafficking by the alpha2delta ligand gabapentin. Proc Natl Acad Sci U S A (2008) 2.04
α2δ expression sets presynaptic calcium channel abundance and release probability. Nature (2012) 1.90
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Retracted Comparison of central versus peripheral delivery of pregabalin in neuropathic pain states. Mol Pain (2012) 1.41
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The alpha2delta subunits of voltage-gated calcium channels form GPI-anchored proteins, a posttranslational modification essential for function. Proc Natl Acad Sci U S A (2010) 1.29
Liver X receptor beta (LXRbeta): a link between beta-sitosterol and amyotrophic lateral sclerosis-Parkinson's dementia. Proc Natl Acad Sci U S A (2008) 1.26
BK Channels: mediators and models for alcohol tolerance. Trends Neurosci (2009) 1.26
Voltage-activated calcium channel expression profiles in mouse brain and cultured hippocampal neurons. Neuroscience (2010) 1.15
Endogenous voltage gradients as mediators of cell-cell communication: strategies for investigating bioelectrical signals during pattern formation. Cell Tissue Res (2012) 1.09
Genetic effects at pleiotropic loci are context-dependent with consequences for the maintenance of genetic variation in populations. PLoS Genet (2011) 1.05
Clustering of neuronal K+-Cl- cotransporters in lipid rafts by tyrosine phosphorylation. J Biol Chem (2009) 1.04
Lateral mobility of presynaptic L-type calcium channels at photoreceptor ribbon synapses. J Neurosci (2011) 1.02
Pathophysiological actions of neuropathy-related anti-ganglioside antibodies at the neuromuscular junction. J Physiol (2009) 1.01
Functional exofacially tagged N-type calcium channels elucidate the interaction with auxiliary α2δ-1 subunits. Proc Natl Acad Sci U S A (2014) 0.97
Mutant PrP suppresses glutamatergic neurotransmission in cerebellar granule neurons by impairing membrane delivery of VGCC α(2)δ-1 Subunit. Neuron (2012) 0.96
The ducky(2J) mutation in Cacna2d2 results in reduced spontaneous Purkinje cell activity and altered gene expression. J Neurosci (2006) 0.95
The dynamic architecture of photoreceptor ribbon synapses: cytoskeletal, extracellular matrix, and intramembrane proteins. Vis Neurosci (2011) 0.93
Regulation of high-voltage-activated Ca(2+) channel function, trafficking, and membrane stability by auxiliary subunits. Wiley Interdiscip Rev Membr Transp Signal (2013) 0.89
Chronic pregabalin inhibits synaptic transmission between rat dorsal root ganglion and dorsal horn neurons in culture. Channels (Austin) (2012) 0.89
Calcium currents are enhanced by α2δ-1 lacking its membrane anchor. J Biol Chem (2012) 0.88
Differential upregulation in DRG neurons of an α2δ-1 splice variant with a lower affinity for gabapentin after peripheral sensory nerve injury. Pain (2013) 0.86
The pre-synaptic motor nerve terminal as a site for antibody-mediated neurotoxicity in autoimmune neuropathies and synaptopathies. J Anat (2013) 0.84
Plasma membrane sphingomyelin hydrolysis increases hippocampal neuron excitability by sphingosine-1-phosphate mediated mechanisms. J Neurochem (2010) 0.84
Targeting of voltage-gated calcium channel α2δ-1 subunit to lipid rafts is independent from a GPI-anchoring motif. PLoS One (2011) 0.84
Regulation of presynaptic strength by controlling Ca2+ channel mobility: effects of cholesterol depletion on release at the cone ribbon synapse. J Neurophysiol (2012) 0.83
Voltage-gated calcium channels and their auxiliary subunits: physiology and pathophysiology and pharmacology. J Physiol (2016) 0.82
Mechanisms of the gabapentinoids and α 2 δ-1 calcium channel subunit in neuropathic pain. Pharmacol Res Perspect (2016) 0.82
Down-regulation of CaV1.2 channels during hypertension: how fewer CaV1.2 channels allow more Ca(2+) into hypertensive arterial smooth muscle. J Physiol (2013) 0.82
Directing traffic in neural cells: determinants of receptor tyrosine kinase localization and cellular responses. J Neurochem (2008) 0.81
In vivo single-molecule imaging identifies altered dynamics of calcium channels in dystrophin-mutant C. elegans. Nat Commun (2014) 0.81
Membrane stiffening by STOML3 facilitates mechanosensation in sensory neurons. Nat Commun (2015) 0.81
Altered expression of the voltage-gated calcium channel subunit α₂δ-1: a comparison between two experimental models of epilepsy and a sensory nerve ligation model of neuropathic pain. Neuroscience (2014) 0.79
Lipid modulation of calcium flux through CaV2.3 regulates acrosome exocytosis and fertilization. Dev Cell (2014) 0.79
Thrombospondin-4 reduces binding affinity of [(3)H]-gabapentin to calcium-channel α2δ-1-subunit but does not interact with α2δ-1 on the cell-surface when co-expressed. Sci Rep (2016) 0.78
Identification of Glycosylation Sites Essential for Surface Expression of the CaVα2δ1 Subunit and Modulation of the Cardiac CaV1.2 Channel Activity. J Biol Chem (2016) 0.77
Alternative Splicing in CaV2.2 Regulates Neuronal Trafficking via Adaptor Protein Complex-1 Adaptor Protein Motifs. J Neurosci (2015) 0.77
Modulation of voltage-gated Ca2+ channels in rat retinal ganglion cells by gabapentin. Vis Neurosci (2014) 0.77
Proteolytic maturation of α2δ represents a checkpoint for activation and neuronal trafficking of latent calcium channels. Elife (2016) 0.76
Cholesterol regulates multiple forms of vesicle endocytosis at a mammalian central synapse. J Neurochem (2015) 0.76
LRP1 influences trafficking of N-type calcium channels via interaction with the auxiliary α2δ-1 subunit. Sci Rep (2017) 0.75
Effects of IgG anti-GM1 monoclonal antibodies on neuromuscular transmission and calcium channel binding in rat neuromuscular junctions. Exp Ther Med (2015) 0.75
Age of quantitative proteomics hits voltage-gated calcium channels. Proc Natl Acad Sci U S A (2010) 0.75
The inhibition of functional expression of calcium channels by prion protein demonstrates competition with α2δ for GPI-anchoring pathways. Biochem J (2014) 0.75
The protofilament structure of insulin amyloid fibrils. Proc Natl Acad Sci U S A (2002) 4.08
Structural basis of pore formation by the bacterial toxin pneumolysin. Cell (2005) 2.87
Somatic mutations in ATP1A1 and CACNA1D underlie a common subtype of adrenal hypertension. Nat Genet (2013) 2.63
Structure of an Hsp90-Cdc37-Cdk4 complex. Mol Cell (2006) 2.62
Structural basis for the regulated protease and chaperone function of DegP. Nature (2008) 2.56
Identification of the alpha2-delta-1 subunit of voltage-dependent calcium channels as a molecular target for pain mediating the analgesic actions of pregabalin. Proc Natl Acad Sci U S A (2006) 2.37
Structure of a type IV secretion system core complex. Science (2009) 2.36
The structural basis for membrane binding and pore formation by lymphocyte perforin. Nature (2010) 2.23
Functional biology of the alpha(2)delta subunits of voltage-gated calcium channels. Trends Pharmacol Sci (2007) 2.13
Pharmacological disruption of calcium channel trafficking by the alpha2delta ligand gabapentin. Proc Natl Acad Sci U S A (2008) 2.04
The TatA component of the twin-arginine protein transport system forms channel complexes of variable diameter. Proc Natl Acad Sci U S A (2005) 2.02
Friend or foe: the same fold for attack and defense. Trends Immunol (2008) 1.99
Interaction between prion protein and toxic amyloid β assemblies can be therapeutically targeted at multiple sites. Nat Commun (2011) 1.96
Allosteric signaling of ATP hydrolysis in GroEL-GroES complexes. Nat Struct Mol Biol (2006) 1.94
PI3K promotes voltage-dependent calcium channel trafficking to the plasma membrane. Nat Neurosci (2004) 1.93
α2δ expression sets presynaptic calcium channel abundance and release probability. Nature (2012) 1.90
Atomic structure and hierarchical assembly of a cross-β amyloid fibril. Proc Natl Acad Sci U S A (2013) 1.75
The increased trafficking of the calcium channel subunit alpha2delta-1 to presynaptic terminals in neuropathic pain is inhibited by the alpha2delta ligand pregabalin. J Neurosci (2009) 1.73
The mechanism of pore formation by bacterial toxins. Curr Opin Struct Biol (2006) 1.61
Atypical AAA+ subunit packing creates an expanded cavity for disaggregation by the protein-remodeling factor Hsp104. Cell (2007) 1.56
Perforin forms transient pores on the target cell plasma membrane to facilitate rapid access of granzymes during killer cell attack. Blood (2013) 1.53
Topologies of a substrate protein bound to the chaperonin GroEL. Mol Cell (2007) 1.52
Recognition and separation of single particles with size variation by statistical analysis of their images. J Mol Biol (2004) 1.45
Detection and separation of heterogeneity in molecular complexes by statistical analysis of their two-dimensional projections. J Struct Biol (2007) 1.45
ATP-triggered conformational changes delineate substrate-binding and -folding mechanics of the GroEL chaperonin. Cell (2012) 1.41
Ca2+ channel beta-subunits: structural insights AID our understanding. Trends Pharmacol Sci (2004) 1.36
Visualization of macromolecular structures. Nat Methods (2010) 1.34
Motor mechanism for protein threading through Hsp104. Mol Cell (2009) 1.33
Beta-subunits promote the expression of Ca(V)2.2 channels by reducing their proteasomal degradation. J Biol Chem (2011) 1.32
Presynaptic HCN1 channels regulate Cav3.2 activity and neurotransmission at select cortical synapses. Nat Neurosci (2011) 1.30
The alpha2delta ligand gabapentin inhibits the Rab11-dependent recycling of the calcium channel subunit alpha2delta-2. J Neurosci (2010) 1.29
Structural analysis of substrate binding by the TatBC component of the twin-arginine protein transport system. Proc Natl Acad Sci U S A (2009) 1.29
The alpha2delta subunits of voltage-gated calcium channels form GPI-anchored proteins, a posttranslational modification essential for function. Proc Natl Acad Sci U S A (2010) 1.29
Dominant-negative calcium channel suppression by truncated constructs involves a kinase implicated in the unfolded protein response. J Neurosci (2004) 1.25
Dodecameric structure of the small heat shock protein Acr1 from Mycobacterium tuberculosis. J Biol Chem (2005) 1.24
Direct three-dimensional visualization of membrane disruption by amyloid fibrils. Proc Natl Acad Sci U S A (2012) 1.24
Globular tetramers of beta(2)-microglobulin assemble into elaborate amyloid fibrils. J Mol Biol (2009) 1.21
The ducky mutation in Cacna2d2 results in altered Purkinje cell morphology and is associated with the expression of a truncated alpha 2 delta-2 protein with abnormal function. J Biol Chem (2001) 1.21
Pregabalin suppresses spinal neuronal hyperexcitability and visceral hypersensitivity in the absence of peripheral pathophysiology. Anesthesiology (2011) 1.21
Descending serotonergic facilitation and the antinociceptive effects of pregabalin in a rat model of osteoarthritic pain. Mol Pain (2009) 1.21
The three-dimensional structure of the cardiac L-type voltage-gated calcium channel: comparison with the skeletal muscle form reveals a common architectural motif. J Biol Chem (2003) 1.20
A new look at calcium channel α2δ subunits. Curr Opin Neurobiol (2010) 1.19
RNA channelling by the eukaryotic exosome. EMBO Rep (2010) 1.16
Intrinsically disordered protein threads through the bacterial outer-membrane porin OmpF. Science (2013) 1.13
N terminus is key to the dominant negative suppression of Ca(V)2 calcium channels: implications for episodic ataxia type 2. J Biol Chem (2009) 1.11
Multiple states of a nucleotide-bound group 2 chaperonin. Structure (2008) 1.11
Elongated oligomers assemble into mammalian PrP amyloid fibrils. J Mol Biol (2006) 1.10
Chlamydiae assemble a pathogen synapse to hijack the host endoplasmic reticulum. Traffic (2012) 1.09
Recruitment of the actin-binding protein HIP-55 to the immunological synapse regulates T cell receptor signaling and endocytosis. J Biol Chem (2004) 1.09
3D structure of the skeletal muscle dihydropyridine receptor. J Mol Biol (2002) 1.08
Multiple distinct assemblies reveal conformational flexibility in the small heat shock protein Hsp26. Structure (2006) 1.06
Structure determination of macromolecular assemblies by single-particle analysis of cryo-electron micrographs. Curr Opin Struct Biol (2004) 1.06
Convergent functional genomics of oligodendrocyte differentiation identifies multiple autoinhibitory signaling circuits. Mol Cell Biol (2009) 1.05
A mutant chaperonin with rearranged inter-ring electrostatic contacts and temperature-sensitive dissociation. Nat Struct Mol Biol (2004) 1.05
Go hybrid: EM, crystallography, and beyond. Curr Opin Struct Biol (2012) 1.01
Folding with and without encapsulation by cis- and trans-only GroEL-GroES complexes. EMBO J (2003) 1.01
Amyloid-β nanotubes are associated with prion protein-dependent synaptotoxicity. Nat Commun (2013) 1.00
Vesicular apparatus, including functional calcium channels, are present in developing rodent optic nerve axons and are required for normal node of Ranvier formation. J Physiol (2008) 0.98
Time course and specificity of the pharmacological disruption of the trafficking of voltage-gated calcium channels by gabapentin. Channels (Austin) (2008) 0.98
The novel product of a five-exon stargazin-related gene abolishes Ca(V)2.2 calcium channel expression. EMBO J (2002) 0.98
α2δ-1 gene deletion affects somatosensory neuron function and delays mechanical hypersensitivity in response to peripheral nerve damage. J Neurosci (2013) 0.98
The importance of occupancy rather than affinity of CaV(beta) subunits for the calcium channel I-II linker in relation to calcium channel function. J Physiol (2006) 0.97
Human neuronal stargazin-like proteins, gamma2, gamma3 and gamma4; an investigation of their specific localization in human brain and their influence on CaV2.1 voltage-dependent calcium channels expressed in Xenopus oocytes. BMC Neurosci (2003) 0.96
Mutant PrP suppresses glutamatergic neurotransmission in cerebellar granule neurons by impairing membrane delivery of VGCC α(2)δ-1 Subunit. Neuron (2012) 0.96
Three-dimensional structure of CaV3.1: comparison with the cardiac L-type voltage-gated calcium channel monomer architecture. J Biol Chem (2009) 0.95
The ducky(2J) mutation in Cacna2d2 results in reduced spontaneous Purkinje cell activity and altered gene expression. J Neurosci (2006) 0.95
Methods for three-dimensional reconstruction of heterogeneous assemblies. Methods Enzymol (2010) 0.95
Chemical inducers and transcriptional markers of oligodendrocyte differentiation. J Neurosci Res (2010) 0.94
The HOOK-domain between the SH3 and the GK domains of Cavbeta subunits contains key determinants controlling calcium channel inactivation. Channels (Austin) (2007) 0.94
The anti-allodynic alpha(2)delta ligand pregabalin inhibits the trafficking of the calcium channel alpha(2)delta-1 subunit to presynaptic terminals in vivo. Biochem Soc Trans (2010) 0.93
Abl-SH3 binding protein 2, 3BP2, interacts with CIN85 and HIP-55. FEBS Lett (2007) 0.93
The stargazin-related protein gamma 7 interacts with the mRNA-binding protein heterogeneous nuclear ribonucleoprotein A2 and regulates the stability of specific mRNAs, including CaV2.2. J Neurosci (2008) 0.93
Newly folded substrates inside the molecular cage of the HtrA chaperone DegQ. Nat Struct Mol Biol (2012) 0.93
An expanded and flexible form of the vacuolar ATPase membrane sector. Structure (2006) 0.92
Pathogen-host reorganization during Chlamydia invasion revealed by cryo-electron tomography. Cell Microbiol (2014) 0.91
Location of auxilin within a clathrin cage. J Mol Biol (2004) 0.90
An expanded protein folding cage in the GroEL-gp31 complex. J Mol Biol (2006) 0.90
Chronic pregabalin inhibits synaptic transmission between rat dorsal root ganglion and dorsal horn neurons in culture. Channels (Austin) (2012) 0.89
Cryo electron microscopy structures of Hsp100 proteins: crowbars in or out? Biochem Cell Biol (2010) 0.88
Calcium currents are enhanced by α2δ-1 lacking its membrane anchor. J Biol Chem (2012) 0.88