Increased filamin binding to beta-integrin cytoplasmic domains inhibits cell migration.

PubWeight™: 2.29‹?› | Rank: Top 2%

🔗 View Article (PMID 11781567)

Published in Nat Cell Biol on December 01, 2001

Authors

D A Calderwood1, A Huttenlocher, W B Kiosses, D M Rose, D G Woodside, M A Schwartz, M H Ginsberg

Author Affiliations

1: Department of Vascular Biology, The Scripps Research Institute, 10550 N. Torrey Pines Rd, La Jolla, California 92037, USA.

Articles citing this

Structural basis of integrin regulation and signaling. Annu Rev Immunol (2007) 8.60

Integrin beta cytoplasmic domain interactions with phosphotyrosine-binding domains: a structural prototype for diversity in integrin signaling. Proc Natl Acad Sci U S A (2003) 2.89

Stretchy proteins on stretchy substrates: the important elements of integrin-mediated rigidity sensing. Dev Cell (2010) 2.65

The filamins: organizers of cell structure and function. Cell Adh Migr (2011) 2.50

Mammary gland ECM remodeling, stiffness, and mechanosignaling in normal development and tumor progression. Cold Spring Harb Perspect Biol (2011) 2.48

Structure and mechanics of integrin-based cell adhesion. Curr Opin Cell Biol (2007) 2.48

The integrin-actin connection, an eternal love affair. EMBO J (2003) 2.26

Mechanical strain in actin networks regulates FilGAP and integrin binding to filamin A. Nature (2011) 2.22

Structure of three tandem filamin domains reveals auto-inhibition of ligand binding. EMBO J (2007) 1.85

MULTISCALE TWO-DIMENSIONAL MODELING OF A MOTILE SIMPLE-SHAPED CELL. Multiscale Model Simul (2005) 1.83

Guiding neuronal cell migrations. Cold Spring Harb Perspect Biol (2010) 1.82

Ribosomal S6 kinase (RSK) regulates phosphorylation of filamin A on an important regulatory site. Mol Cell Biol (2004) 1.81

Absence of filamin A prevents cells from responding to stiffness gradients on gels coated with collagen but not fibronectin. Biophys J (2009) 1.70

Migfilin, a molecular switch in regulation of integrin activation. J Biol Chem (2008) 1.68

The tail of integrin activation. Trends Biochem Sci (2011) 1.62

Structural basis of the migfilin-filamin interaction and competition with integrin beta tails. J Biol Chem (2008) 1.54

Regulation of integrin activity and signalling. Biochim Biophys Acta (2009) 1.51

Structural mechanism of integrin inactivation by filamin. Nat Struct Mol Biol (2015) 1.50

Prostate-specific membrane antigen regulates angiogenesis by modulating integrin signal transduction. Mol Cell Biol (2006) 1.48

Filamin A-beta1 integrin complex tunes epithelial cell response to matrix tension. Mol Biol Cell (2009) 1.47

Integrin inactivators: balancing cellular functions in vitro and in vivo. Nat Rev Mol Cell Biol (2013) 1.45

Filamin A regulates focal adhesion disassembly and suppresses breast cancer cell migration and invasion. J Exp Med (2010) 1.43

Filamin A is essential for active cell stiffening but not passive stiffening under external force. Biophys J (2009) 1.39

MEKK4 signaling regulates filamin expression and neuronal migration. Neuron (2006) 1.37

Filamins regulate cell spreading and initiation of cell migration. PLoS One (2009) 1.36

Loss of PIP5KIgamma, unlike other PIP5KI isoforms, impairs the integrity of the membrane cytoskeleton in murine megakaryocytes. J Clin Invest (2008) 1.33

Identification and characterization of multiple similar ligand-binding repeats in filamin: implication on filamin-mediated receptor clustering and cross-talk. J Biol Chem (2009) 1.28

Specific integrin alpha and beta chain phosphorylations regulate LFA-1 activation through affinity-dependent and -independent mechanisms. J Cell Biol (2005) 1.25

The structure of the N-terminus of kindlin-1: a domain important for alphaiibbeta3 integrin activation. J Mol Biol (2009) 1.25

A meckelin-filamin A interaction mediates ciliogenesis. Hum Mol Genet (2011) 1.12

The NPIY motif in the integrin beta1 tail dictates the requirement for talin-1 in outside-in signaling. J Cell Sci (2010) 1.10

Beta4 integrin promotes osteosarcoma metastasis and interacts with ezrin. Oncogene (2009) 1.09

Talin and signaling through integrins. Methods Mol Biol (2012) 1.07

Two distinct cytoplasmic regions of the beta2 integrin chain regulate RhoA function during phagocytosis. J Cell Biol (2006) 1.07

Migfilin and filamin as regulators of integrin activation in endothelial cells and neutrophils. PLoS One (2011) 1.06

The E3 ubiquitin ligase specificity subunit ASB2beta is a novel regulator of muscle differentiation that targets filamin B to proteasomal degradation. Cell Death Differ (2009) 1.06

Functional characterization of filamin a interacting protein 1-like, a novel candidate for antivascular cancer therapy. Cancer Res (2008) 1.04

Mechanisms of talin-dependent integrin signaling and crosstalk. Biochim Biophys Acta (2013) 1.03

Filamin A modulates kinase activation and intracellular trafficking of epidermal growth factor receptors in human melanoma cells. Endocrinology (2009) 1.03

Novel anti-filamin-A antibody detects a secreted variant of filamin-A in plasma from patients with breast carcinoma and high-grade astrocytoma. Cancer Sci (2009) 1.02

Phosphorylation facilitates the integrin binding of filamin under force. Biophys J (2009) 0.99

Rac1 is deactivated at integrin activation sites through an IQGAP1-filamin-A-RacGAP1 pathway. J Cell Sci (2013) 0.97

A conserved lipid-binding loop in the kindlin FERM F1 domain is required for kindlin-mediated αIIbβ3 integrin coactivation. J Biol Chem (2012) 0.97

Periventricular heterotopia: new insights into Ehlers-Danlos syndrome. Clin Med Res (2005) 0.96

Stretch activates human myometrium via ERK, caldesmon and focal adhesion signaling. PLoS One (2009) 0.96

Pro-prion binds filamin A, facilitating its interaction with integrin beta1, and contributes to melanomagenesis. J Biol Chem (2010) 0.95

RSK2 protein suppresses integrin activation and fibronectin matrix assembly and promotes cell migration. J Biol Chem (2012) 0.95

Complex roles of filamin-A mediated cytoskeleton network in cancer progression. Cell Biosci (2013) 0.95

Macrophage mesenchymal migration requires podosome stabilization by filamin A. J Biol Chem (2012) 0.94

Regulation of the actin cytoskeleton by an interaction of IQGAP related protein GAPA with filamin and cortexillin I. PLoS One (2010) 0.94

Integrin alpha5beta1 is necessary for regulation of radial migration of cortical neurons during mouse brain development. Eur J Neurosci (2010) 0.94

FLN-1/filamin is required for maintenance of actin and exit of fertilized oocytes from the spermatheca in C. elegans. Dev Biol (2010) 0.93

Epidermal growth factor (EGF) regulates α5β1 integrin activation state in human cancer cell lines through the p90RSK-dependent phosphorylation of filamin A. J Biol Chem (2012) 0.93

Evidence for multisite ligand binding and stretching of filamin by integrin and migfilin. Biochemistry (2011) 0.92

Mechanotransduction at focal adhesions: integrating cytoskeletal mechanics in migrating cells. J Cell Mol Med (2013) 0.92

Cytoskeletal proteins in cortical development and disease: actin associated proteins in periventricular heterotopia. Front Cell Neurosci (2015) 0.86

Combining mechanical and optical approaches to dissect cellular mechanobiology. J Biomech (2009) 0.86

Insulin-like growth factor-binding protein-5-induced laminin gamma1 transcription requires filamin A. J Biol Chem (2010) 0.85

Filamin A controls matrix metalloproteinase activity and regulates cell invasion in human fibrosarcoma cells. J Cell Sci (2012) 0.84

Filamin B regulates chondrocyte proliferation and differentiation through Cdk1 signaling. PLoS One (2014) 0.83

Distinct regional and subcellular localization of the actin-binding protein filamin A in the mature rat brain. J Comp Neurol (2012) 0.82

Characterization of 14-3-3-ζ Interactions with integrin tails. J Mol Biol (2013) 0.82

RNase L interacts with Filamin A to regulate actin dynamics and barrier function for viral entry. MBio (2014) 0.79

Formin 1 and filamin B physically interact to coordinate chondrocyte proliferation and differentiation in the growth plate. Hum Mol Genet (2014) 0.78

Binding of pro-prion to filamin A: by design or an unfortunate blunder. Oncogene (2010) 0.78

T Lymphocyte Migration: An Action Movie Starring the Actin and Associated Actors. Front Immunol (2015) 0.77

Quantitative measurement of cell migration using time-lapse videomicroscopy and non-linear system analysis. Histochem Cell Biol (2003) 0.77

Structurally governed cell mechanotransduction through multiscale modeling. Sci Rep (2015) 0.77

Cellular mechanotransduction: filamin A strains to regulate motility. Curr Biol (2011) 0.77

Filamin A-hinge region 1-EGFP: a novel tool for tracking the cellular functions of filamin A in real-time. PLoS One (2012) 0.76

Filamin-a increases the stability and plasma membrane expression of polycystin-2. PLoS One (2015) 0.76

The β isoform of the catalytic subunit of protein phosphatase 2B restrains platelet function by suppressing outside-in αII b β3 integrin signaling. J Thromb Haemost (2014) 0.76

Structural and mechanical functions of integrins. Biophys Rev (2013) 0.75

Filamin A and Big2: a shared endocytic pathway. Bioarchitecture (2014) 0.75

Filamin structure, function and mechanics: are altered filamin-mediated force responses associated with human disease? Biophys Rev (2011) 0.75

Comparative Proteomic Analysis of Three Chinese Hamster Ovary (CHO) Host Cells. Biochem Eng J (2017) 0.75

Periventricular heterotopia with complete agenesis of the corpus callosum : a case report. J Neurol (2006) 0.75

Articles by these authors

Regulation of the small GTP-binding protein Rho by cell adhesion and the cytoskeleton. EMBO J (1999) 9.76

Integrins: emerging paradigms of signal transduction. Annu Rev Cell Dev Biol (1995) 8.88

Integrin-ligand binding properties govern cell migration speed through cell-substratum adhesiveness. Nature (1997) 8.52

Localized Rac activation dynamics visualized in living cells. Science (2000) 7.00

The extracellular matrix as a cell survival factor. Mol Biol Cell (1993) 6.32

A receptor for phosphatidylserine-specific clearance of apoptotic cells. Nature (2000) 6.12

Platelet membrane glycoprotein IIb/IIIa: member of a family of Arg-Gly-Asp--specific adhesion receptors. Science (1986) 5.58

Activation of Rac and Cdc42 by integrins mediates cell spreading. Mol Biol Cell (1998) 5.00

The Talin head domain binds to integrin beta subunit cytoplasmic tails and regulates integrin activation. J Biol Chem (1999) 4.92

The small GTP-binding protein Rho regulates a phosphatidylinositol 4-phosphate 5-kinase in mammalian cells. Cell (1994) 4.80

Breaking the integrin hinge. A defined structural constraint regulates integrin signaling. J Biol Chem (1996) 4.45

Adhesion to the extracellular matrix regulates the coupling of the small GTPase Rac to its effector PAK. EMBO J (2000) 4.39

Integrin cytoplasmic domains mediate inside-out signal transduction. J Cell Biol (1994) 4.07

Timing of cyclin D1 expression within G1 phase is controlled by Rho. Nat Cell Biol (2001) 3.63

Focal adhesion kinase suppresses Rho activity to promote focal adhesion turnover. J Cell Sci (2000) 3.31

Activation of integrins in endothelial cells by fluid shear stress mediates Rho-dependent cytoskeletal alignment. EMBO J (2001) 3.22

Modulation of cell migration by integrin-mediated cytoskeletal linkages and ligand-binding affinity. J Cell Biol (1996) 3.18

Integrin cytoplasmic domain-binding proteins. J Cell Sci (2000) 3.17

Integrin activation controls metastasis in human breast cancer. Proc Natl Acad Sci U S A (2001) 3.07

Determination of GTP loading on Rho. Methods Enzymol (2000) 2.97

Suppression of integrin activation: a novel function of a Ras/Raf-initiated MAP kinase pathway. Cell (1997) 2.84

Ligands "activate" integrin alpha IIb beta 3 (platelet GPIIb-IIIa). Cell (1991) 2.81

PEA-15 mediates cytoplasmic sequestration of ERK MAP kinase. Dev Cell (2001) 2.73

The effect of Arg-Gly-Asp-containing peptides on fibrinogen and von Willebrand factor binding to platelets. Proc Natl Acad Sci U S A (1985) 2.64

Association of Mycoplasma genitalium with nongonococcal urethritis in heterosexual men. J Infect Dis (2000) 2.63

Arginyl-glycyl-aspartic acid (RGD): a cell adhesion motif. Trends Biochem Sci (1991) 2.62

Complementation of dominant suppression implicates CD98 in integrin activation. Nature (1997) 2.62

Adhesion to fibronectin stimulates inositol lipid synthesis and enhances PDGF-induced inositol lipid breakdown. J Cell Biol (1993) 2.59

Binding of paxillin to alpha4 integrins modifies integrin-dependent biological responses. Nature (1999) 2.59

Modulation of the affinity of integrin alpha IIb beta 3 (GPIIb-IIIa) by the cytoplasmic domain of alpha IIb. Science (1991) 2.57

beta3 Integrins mediate the cellular entry of hantaviruses that cause respiratory failure. Proc Natl Acad Sci U S A (1998) 2.54

Integrin-mediated adhesion regulates cell polarity and membrane protrusion through the Rho family of GTPases. Mol Biol Cell (2001) 2.53

Integrins and actin filaments: reciprocal regulation of cell adhesion and signaling. J Biol Chem (2000) 2.52

Regulation of cell migration by the calcium-dependent protease calpain. J Biol Chem (1997) 2.52

Radiofrequency ablation of 231 unresectable hepatic tumors: indications, limitations, and complications. Ann Surg Oncol (2000) 2.51

Growth factor activation of MAP kinase requires cell adhesion. EMBO J (1997) 2.47

A beta 3 integrin mutation abolishes ligand binding and alters divalent cation-dependent conformation. Science (1990) 2.42

Control of intracellular pH and growth by fibronectin in capillary endothelial cells. J Cell Biol (1990) 2.41

Integrin-mediated mechanotransduction requires its dynamic interaction with specific extracellular matrix (ECM) ligands. Proc Natl Acad Sci U S A (2001) 2.40

Integrin beta 1- and beta 3-mediated endothelial cell migration is triggered through distinct signaling mechanisms. J Cell Biol (1993) 2.38

Integrin activation and cytoskeletal interaction are essential for the assembly of a fibronectin matrix. Cell (1995) 2.36

A role for p21-activated kinase in endothelial cell migration. J Cell Biol (1999) 2.35

Monoclonal antibodies to ligand-occupied conformers of integrin alpha IIb beta 3 (glycoprotein IIb-IIIa) alter receptor affinity, specificity, and function. J Biol Chem (1991) 2.34

Specific and saturable binding of plasma fibronectin to thrombin-stimulated human platelets. J Biol Chem (1981) 2.31

Affinity modulation of the alpha IIb beta 3 integrin (platelet GPIIb-IIIa) is an intrinsic property of the receptor. Cell Regul (1990) 2.29

Physical and biochemical regulation of integrin release during rear detachment of migrating cells. J Cell Sci (1998) 2.23

Coordinate signaling by integrins and receptor tyrosine kinases in the regulation of G1 phase cell-cycle progression. Curr Opin Genet Dev (2001) 2.22

Integrin beta cytoplasmic domains differentially bind to cytoskeletal proteins. J Biol Chem (1998) 2.19

Integrin regulation of c-Abl tyrosine kinase activity and cytoplasmic-nuclear transport. Proc Natl Acad Sci U S A (1996) 2.19

Selective inhibition of integrin function by antibodies specific for ligand-occupied receptor conformers. J Biol Chem (1990) 2.16

A platelet alpha granule membrane protein that is associated with the plasma membrane after activation. Characterization and subcellular localization of platelet activation-dependent granule-external membrane protein. J Clin Invest (1986) 2.13

Rac recruits high-affinity integrin alphavbeta3 to lamellipodia in endothelial cell migration. Nat Cell Biol (2001) 2.11

Apparent effect of probenecid on the distribution of penicillins in man. Clin Pharmacol Ther (1968) 2.09

Distinct functions of integrin alpha and beta subunit cytoplasmic domains in cell spreading and formation of focal adhesions. J Cell Biol (1993) 2.08

Cellular entry of hantaviruses which cause hemorrhagic fever with renal syndrome is mediated by beta3 integrins. J Virol (1999) 2.03

Integrin activation takes shape. J Cell Biol (2002) 2.02

Localization of an Arg-Gly-Asp recognition site within an integrin adhesion receptor. Science (1988) 1.98

Analysis of platelet adhesion with a radioactive chemical crosslinking reagent: interaction of thrombospondin with fibronectin and collagen. Cell (1982) 1.96

Related binding mechanisms for fibrinogen, fibronectin, von Willebrand factor, and thrombospondin on thrombin-stimulated human platelets. Blood (1985) 1.95

Regulation of the protein tyrosine kinase pp72syk by platelet agonists and the integrin alpha IIb beta 3. J Biol Chem (1994) 1.93

Trans-dominant inhibition of integrin function. Mol Biol Cell (1996) 1.92

Reduced cell migration and disruption of the actin cytoskeleton in calpain-deficient embryonic fibroblasts. J Biol Chem (2001) 1.91

Affinity modulation of integrin alpha 5 beta 1: regulation of the functional response by soluble fibronectin. J Cell Biol (1993) 1.86

Evidence that three adhesive proteins interact with a common recognition site on activated platelets. J Biol Chem (1984) 1.83

Involvement of the small GTPase rho in integrin-mediated activation of mitogen-activated protein kinase. J Biol Chem (1996) 1.82

Immunochemical and amino-terminal sequence comparison of two cytoadhesins indicates they contain similar or identical beta subunits and distinct alpha subunits. J Biol Chem (1987) 1.82

Calpain cleavage promotes talin binding to the beta 3 integrin cytoplasmic domain. J Biol Chem (2001) 1.80

The conserved membrane-proximal region of an integrin cytoplasmic domain specifies ligand binding affinity. J Biol Chem (1995) 1.80

Regulation of the pp72syk protein tyrosine kinase by platelet integrin alpha IIb beta 3. EMBO J (1997) 1.79

NMR analysis of structure and dynamics of the cytosolic tails of integrin alpha IIb beta 3 in aqueous solution. Biochemistry (2001) 1.76

Calpain regulates neutrophil chemotaxis. Proc Natl Acad Sci U S A (2003) 1.73

Long range propagation of conformational changes in integrin alpha IIb beta 3. J Biol Chem (1993) 1.73

Integrins, adhesion and apoptosis. Trends Cell Biol (1997) 1.72

A point mutation in the integrin beta 3 cytoplasmic domain (S752-->P) impairs bidirectional signaling through alpha IIb beta 3 (platelet glycoprotein IIb-IIIa). Blood (1994) 1.71

Radiofrequency ablation: a minimally invasive technique with multiple applications. Cancer J Sci Am (1999) 1.70

Metabolism of diazepam in rat, dog, and man. J Pharmacol Exp Ther (1965) 1.69

Effect of platelet activation on the conformation of the plasma membrane glycoprotein IIb-IIIa complex. J Biol Chem (1991) 1.67

The ligand binding site of the platelet integrin receptor GPIIb-IIIa is proximal to the second calcium binding domain of its alpha subunit. J Biol Chem (1990) 1.66

Integrin-mediated cell adhesion: the extracellular face. J Biol Chem (1994) 1.66

Physical association of the small GTPase Rho with a 68-kDa phosphatidylinositol 4-phosphate 5-kinase in Swiss 3T3 cells. Mol Biol Cell (1996) 1.66

Identification of a novel integrin binding site in fibronectin. Differential utilization by beta 3 integrins. J Biol Chem (1994) 1.60

Activation of Syk protein tyrosine kinase through interaction with integrin beta cytoplasmic domains. Curr Biol (2001) 1.59

Differing structural requirements for GTPase-activating protein responsiveness and NADPH oxidase activation by Rac. J Biol Chem (1994) 1.59

Calpain cleavage of the cytoplasmic domain of the integrin beta 3 subunit. J Biol Chem (1995) 1.59

Effects of OKM5, a monoclonal antibody to glycoprotein IV, on platelet aggregation and thrombospondin surface expression. Blood (1990) 1.58

Does complete resection of melanoma metastatic to solid intra-abdominal organs improve survival? Ann Surg Oncol (2001) 1.57

Insulin-like growth factor receptor cooperates with integrin alpha v beta 5 to promote tumor cell dissemination in vivo. J Clin Invest (1997) 1.53

Cellular adhesion: GPIIb-IIIa as a prototypic adhesion receptor. Prog Hemost Thromb (1989) 1.53

Stimulation of fascin spikes by thrombospondin-1 is mediated by the GTPases Rac and Cdc42. J Cell Biol (2000) 1.53

Tyrosine phosphorylation of pp125FAK in platelets requires coordinated signaling through integrin and agonist receptors. J Biol Chem (1994) 1.53

Focal adhesion kinase mediates the integrin signaling requirement for growth factor activation of MAP kinase. J Cell Biol (1999) 1.52

Isoform specific function of calpain 2 in regulating membrane protrusion. Exp Cell Res (2004) 1.52

Long-term survival with partial left heart bypass following perioperative myocardial infarction and shock. J Thorac Cardiovasc Surg (1982) 1.51

Calpain. Int J Biochem Cell Biol (2002) 1.51