Published in J Biol Chem on January 10, 2012
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Two-piconewton slip bond between fibronectin and the cytoskeleton depends on talin. Nature (2003) 3.70
The molecular basis of filamin binding to integrins and competition with talin. Mol Cell (2006) 3.64
Structural basis for vinculin activation at sites of cell adhesion. Nature (2004) 3.62
Talin depletion reveals independence of initial cell spreading from integrin activation and traction. Nat Cell Biol (2008) 3.62
The structure and regulation of vinculin. Trends Cell Biol (2006) 3.52
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Forces and bond dynamics in cell adhesion. Science (2007) 2.88
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Talins and kindlins: partners in integrin-mediated adhesion. Nat Rev Mol Cell Biol (2013) 2.14
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The Kindler syndrome protein is regulated by transforming growth factor-beta and involved in integrin-mediated adhesion. J Biol Chem (2003) 1.97
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Domain motion in cytochrome P450 reductase: conformational equilibria revealed by NMR and small-angle x-ray scattering. J Biol Chem (2009) 1.87
FAK promotes recruitment of talin to nascent adhesions to control cell motility. J Cell Biol (2012) 1.87
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Talin-dependent integrin activation is required for fibrin clot retraction by platelets. Blood (2010) 1.83
The structure of the C-terminal actin-binding domain of talin. EMBO J (2007) 1.77
Activation of a vinculin-binding site in the talin rod involves rearrangement of a five-helix bundle. EMBO J (2004) 1.73
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Characterization of an actin-binding site within the talin FERM domain. J Mol Biol (2004) 1.55
Human alpha-synemin interacts directly with vinculin and metavinculin. Biochem J (2008) 1.54
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Mechanotransduction in vivo by repeated talin stretch-relaxation events depends upon vinculin. PLoS Biol (2011) 1.52
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Filamin A-beta1 integrin complex tunes epithelial cell response to matrix tension. Mol Biol Cell (2009) 1.47
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Talin forges the links between integrins and actin. Nat Cell Biol (2003) 1.45
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Phosphatidylinositol phosphate kinase type 1gamma and beta1-integrin cytoplasmic domain bind to the same region in the talin FERM domain. J Biol Chem (2003) 1.37
Filamins regulate cell spreading and initiation of cell migration. PLoS One (2009) 1.36
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Loss of PIP5KIgamma, unlike other PIP5KI isoforms, impairs the integrity of the membrane cytoskeleton in murine megakaryocytes. J Clin Invest (2008) 1.33
Structural basis for phosphatidylinositol phosphate kinase type Igamma binding to talin at focal adhesions. J Biol Chem (2004) 1.32
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Integrin connections to the cytoskeleton through talin and vinculin. Biochem Soc Trans (2008) 1.30
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The role of FilGAP-filamin A interactions in mechanoprotection. Mol Biol Cell (2009) 1.28
The integrin binding site 2 (IBS2) in the talin rod domain is essential for linking integrin beta subunits to the cytoskeleton. J Biol Chem (2007) 1.28
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An essential role for talin during alpha(M)beta(2)-mediated phagocytosis. Mol Biol Cell (2007) 1.24
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Structural diversity in integrin/talin interactions. Structure (2010) 1.20
RIAM and vinculin binding to talin are mutually exclusive and regulate adhesion assembly and turnover. J Biol Chem (2013) 1.19
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