Published in J Biol Chem on September 23, 1994
The Ras-related protein Cdc42Hs and bradykinin promote formation of peripheral actin microspikes and filopodia in Swiss 3T3 fibroblasts. Mol Cell Biol (1995) 7.23
Rho family GTPases and neuronal growth cone remodelling: relationship between increased complexity induced by Cdc42Hs, Rac1, and acetylcholine and collapse induced by RhoA and lysophosphatidic acid. Mol Cell Biol (1997) 3.44
Requirements for both Rac1 and Cdc42 in membrane ruffling and phagocytosis in leukocytes. J Exp Med (1997) 3.32
Induction of protein-protein interactions in live cells using light. Nat Biotechnol (2009) 3.16
Regulation of actin polymerization in cell-free systems by GTPgammaS and Cdc42. J Cell Biol (1997) 2.14
Identification of a novel human Rho protein with unusual properties: GTPase deficiency and in vivo farnesylation. Mol Cell Biol (1996) 1.98
Rac GTPase interacts specifically with phosphatidylinositol 3-kinase. Biochem J (1996) 1.78
Human immunodeficiency virus type 1 Nef associates with a member of the p21-activated kinase family. J Virol (1996) 1.69
Antagonism of glucocorticoid receptor transcriptional activation by the c-Jun N-terminal kinase. Proc Natl Acad Sci U S A (1998) 1.66
Mechanism of Cdc42-induced actin polymerization in neutrophil extracts. J Cell Biol (1998) 1.51
Functions and functional domains of the GTPase Cdc42p. Mol Biol Cell (2000) 1.45
Abr and Bcr are multifunctional regulators of the Rho GTP-binding protein family. Proc Natl Acad Sci U S A (1995) 1.38
Rac GTPase interacts with GAPs and target proteins through multiple effector sites. EMBO J (1995) 1.25
Multiple p21ras effector pathways regulate nuclear factor of activated T cells. EMBO J (1996) 1.24
Profilin enhances Cdc42-induced nucleation of actin polymerization. J Cell Biol (2000) 1.21
The hematopoiesis-specific GTP-binding protein RhoH is GTPase deficient and modulates activities of other Rho GTPases by an inhibitory function. Mol Cell Biol (2002) 1.20
An actin cytoskeleton with evolutionarily conserved functions in the absence of canonical actin-binding proteins. Proc Natl Acad Sci U S A (2011) 1.05
Convergent use of RhoGAP toxins by eukaryotic parasites and bacterial pathogens. PLoS Pathog (2007) 0.97
Deconstructing signal transduction pathways that regulate the actin cytoskeleton in dendritic spines. Cytoskeleton (Hoboken) (2012) 0.93
Expression and translocation of Rac2 in eosinophils during superoxide generation. Immunology (1999) 0.87
Role of the Rho GTPase Rac in the activation of the phagocyte NADPH oxidase: outsourcing a key task. Small GTPases (2014) 0.84
The crystal structure of the plant small GTPase OsRac1 reveals its mode of binding to NADPH oxidase. J Biol Chem (2014) 0.80
Modified SH2 domain to phototrap and identify phosphotyrosine proteins from subcellular sites within cells. Proc Natl Acad Sci U S A (2012) 0.79
Simultaneous and independent tuning of RhoA and Rac1 activity with orthogonally inducible promoters. Integr Biol (Camb) (2014) 0.76
Transcriptomic and Expression Analysis of the Salivary Glands in White-Backed Planthoppers, Sogatella furcifera. PLoS One (2016) 0.75
Regulation of the small GTP-binding protein Rho by cell adhesion and the cytoskeleton. EMBO J (1999) 9.76
EMT, cancer stem cells and drug resistance: an emerging axis of evil in the war on cancer. Oncogene (2010) 9.66
Localized Rac activation dynamics visualized in living cells. Science (2000) 7.00
The extracellular matrix as a cell survival factor. Mol Biol Cell (1993) 6.32
Activation of LIM-kinase by Pak1 couples Rac/Cdc42 GTPase signalling to actin cytoskeletal dynamics. Nat Cell Biol (1999) 6.18
Characterization of rac and cdc42 activation in chemoattractant-stimulated human neutrophils using a novel assay for active GTPases. J Biol Chem (1999) 5.80
Inhibition of myosin light chain kinase by p21-activated kinase. Science (1999) 5.41
Activation of Rac and Cdc42 by integrins mediates cell spreading. Mol Biol Cell (1998) 5.00
Human p21-activated kinase (Pak1) regulates actin organization in mammalian cells. Curr Biol (1997) 4.91
Normal and oncogenic p21ras proteins bind to the amino-terminal regulatory domain of c-Raf-1. Nature (1993) 4.88
The small GTP-binding protein Rho regulates a phosphatidylinositol 4-phosphate 5-kinase in mammalian cells. Cell (1994) 4.80
Thrombin receptor ligation and activated Rac uncap actin filament barbed ends through phosphoinositide synthesis in permeabilized human platelets. Cell (1995) 4.39
Adhesion to the extracellular matrix regulates the coupling of the small GTPase Rac to its effector PAK. EMBO J (2000) 4.39
Rho family GTPases regulate p38 mitogen-activated protein kinase through the downstream mediator Pak1. J Biol Chem (1995) 4.36
Regulation of phagocyte oxygen radical production by the GTP-binding protein Rac 2. Science (1991) 3.87
Timing of cyclin D1 expression within G1 phase is controlled by Rho. Nat Cell Biol (2001) 3.63
Requirements for both Rac1 and Cdc42 in membrane ruffling and phagocytosis in leukocytes. J Exp Med (1997) 3.32
Focal adhesion kinase suppresses Rho activity to promote focal adhesion turnover. J Cell Sci (2000) 3.31
Activation of integrins in endothelial cells by fluid shear stress mediates Rho-dependent cytoskeletal alignment. EMBO J (2001) 3.22
rac, a novel ras-related family of proteins that are botulinum toxin substrates. J Biol Chem (1989) 3.21
Identification of the predominant substrate for ADP-ribosylation by islet activating protein. J Biol Chem (1983) 3.11
Membrane and morphological changes in apoptotic cells regulated by caspase-mediated activation of PAK2. Science (1997) 3.07
Determination of GTP loading on Rho. Methods Enzymol (2000) 2.97
Inhibition of receptor-mediated release of arachidonic acid by pertussis toxin. Cell (1984) 2.96
Regulation of human leukocyte p21-activated kinases through G protein--coupled receptors. Science (1995) 2.87
Regulation of receptor-mediated endocytosis by Rho and Rac. Nature (1996) 2.84
Suppression of integrin activation: a novel function of a Ras/Raf-initiated MAP kinase pathway. Cell (1997) 2.84
Association of Mycoplasma genitalium with nongonococcal urethritis in heterosexual men. J Infect Dis (2000) 2.63
The Rho GTPase and a putative RhoGEF mediate a signaling pathway for the cell shape changes in Drosophila gastrulation. Cell (1997) 2.62
Adhesion to fibronectin stimulates inositol lipid synthesis and enhances PDGF-induced inositol lipid breakdown. J Cell Biol (1993) 2.59
Purification and properties of the inhibitory guanine nucleotide-binding regulatory component of adenylate cyclase. J Biol Chem (1984) 2.56
Growth factor activation of MAP kinase requires cell adhesion. EMBO J (1997) 2.47
Molecular basis for Rac2 regulation of phagocyte NADPH oxidase. Nat Immunol (2001) 2.45
p21-activated kinase 1 phosphorylates the death agonist bad and protects cells from apoptosis. Mol Cell Biol (2000) 2.42
Control of intracellular pH and growth by fibronectin in capillary endothelial cells. J Cell Biol (1990) 2.41
Integrin-mediated mechanotransduction requires its dynamic interaction with specific extracellular matrix (ECM) ligands. Proc Natl Acad Sci U S A (2001) 2.40
Integrin beta 1- and beta 3-mediated endothelial cell migration is triggered through distinct signaling mechanisms. J Cell Biol (1993) 2.38
Localization of p21-activated kinase 1 (PAK1) to pinocytic vesicles and cortical actin structures in stimulated cells. J Cell Biol (1997) 2.37
Identification of a central phosphorylation site in p21-activated kinase regulating autoinhibition and kinase activity. J Biol Chem (1999) 2.36
A role for p21-activated kinase in endothelial cell migration. J Cell Biol (1999) 2.35
Signal transduction and cytoskeletal activation in the neutrophil. Physiol Rev (1987) 2.34
Increased filamin binding to beta-integrin cytoplasmic domains inhibits cell migration. Nat Cell Biol (2001) 2.29
Coordinate signaling by integrins and receptor tyrosine kinases in the regulation of G1 phase cell-cycle progression. Curr Opin Genet Dev (2001) 2.22
Integrin regulation of c-Abl tyrosine kinase activity and cytoplasmic-nuclear transport. Proc Natl Acad Sci U S A (1996) 2.19
Membrane targeting of p21-activated kinase 1 (PAK1) induces neurite outgrowth from PC12 cells. EMBO J (1998) 2.18
Regulation of macropinocytosis by p21-activated kinase-1. Mol Biol Cell (2000) 2.16
Regulation of actin polymerization in cell-free systems by GTPgammaS and Cdc42. J Cell Biol (1997) 2.14
Translocation of Rac correlates with NADPH oxidase activation. Evidence for equimolar translocation of oxidase components. J Biol Chem (1993) 2.13
Rho family proteins modulate rapid apoptosis induced by cytotoxic T lymphocytes and Fas. J Biol Chem (2000) 2.12
Rac recruits high-affinity integrin alphavbeta3 to lamellipodia in endothelial cell migration. Nat Cell Biol (2001) 2.11
Apparent effect of probenecid on the distribution of penicillins in man. Clin Pharmacol Ther (1968) 2.09
c-Src regulates the simultaneous rearrangement of actin cytoskeleton, p190RhoGAP, and p120RasGAP following epidermal growth factor stimulation. J Cell Biol (1995) 2.06
The inhibitory guanine nucleotide-binding regulatory component of adenylate cyclase. Properties and function of the purified protein. J Biol Chem (1984) 2.05
The p21Rac/Cdc42-activated kinases (PAKs). Int J Biochem Cell Biol (1998) 2.00
Adenovirus endocytosis requires actin cytoskeleton reorganization mediated by Rho family GTPases. J Virol (1998) 1.99
Identification of a novel human Rho protein with unusual properties: GTPase deficiency and in vivo farnesylation. Mol Cell Biol (1996) 1.98
Myoblast city, the Drosophila homolog of DOCK180/CED-5, is required in a Rac signaling pathway utilized for multiple developmental processes. Genes Dev (1998) 1.97
Analysis of platelet adhesion with a radioactive chemical crosslinking reagent: interaction of thrombospondin with fibronectin and collagen. Cell (1982) 1.96
p21-activated protein kinase: a crucial component of morphological signaling? Trends Biochem Sci (1999) 1.94
Inhibition of cervical carcinoma cell line proliferation by the introduction of a bovine papillomavirus regulatory gene. J Virol (1993) 1.92
The N-terminal region of GAP regulates cytoskeletal structure and cell adhesion. EMBO J (1993) 1.91
Bovine papillomavirus mutant temperature sensitive for transformation, replication and transactivation. EMBO J (1988) 1.89
Involvement of the small GTPase rho in integrin-mediated activation of mitogen-activated protein kinase. J Biol Chem (1996) 1.82
Molecular targeted therapy of lung cancer: EGFR mutations and response to EGFR inhibitors. Cold Spring Harb Symp Quant Biol (2005) 1.78
The PRK2 kinase is a potential effector target of both Rho and Rac GTPases and regulates actin cytoskeletal organization. Mol Cell Biol (1997) 1.78
D4-GDI, a substrate of CPP32, is proteolyzed during Fas-induced apoptosis. J Biol Chem (1996) 1.74
The adhesion signaling molecule p190 RhoGAP is required for morphogenetic processes in neural development. Development (2000) 1.74
Rac translocates independently of the neutrophil NADPH oxidase components p47phox and p67phox. Evidence for its interaction with flavocytochrome b558. J Biol Chem (1994) 1.74
Identification of a human rasGAP-related protein containing calmodulin-binding motifs. J Biol Chem (1994) 1.73
p190 RhoGAP is the principal Src substrate in brain and regulates axon outgrowth, guidance and fasciculation. Nat Cell Biol (2001) 1.72
Integrins, adhesion and apoptosis. Trends Cell Biol (1997) 1.72
Purification and characterization of Rac 2. A cytosolic GTP-binding protein that regulates human neutrophil NADPH oxidase. J Biol Chem (1992) 1.69
The inhibitory guanine nucleotide-binding regulatory component of adenylate cyclase. Subunit dissociation and guanine nucleotide-dependent hormonal inhibition. J Biol Chem (1984) 1.69
Metabolism of diazepam in rat, dog, and man. J Pharmacol Exp Ther (1965) 1.69
Physical association of the small GTPase Rho with a 68-kDa phosphatidylinositol 4-phosphate 5-kinase in Swiss 3T3 cells. Mol Biol Cell (1996) 1.66
Stimulation of arachidonic acid metabolism in the polymorphonuclear leukocyte by an N-formylated peptide. Comparison with ionophore A23187. J Biol Chem (1980) 1.65
The inhibitory guanine nucleotide-binding regulatory component of adenylate cyclase. Subunit dissociation and the inhibition of adenylate cyclase in S49 lymphoma cyc- and wild type membranes. J Biol Chem (1984) 1.62
Biologically active lipids are regulators of Rac.GDI complexation. J Biol Chem (1993) 1.62
p21-activated kinase (PAK1) is phosphorylated and activated by 3-phosphoinositide-dependent kinase-1 (PDK1). J Biol Chem (2000) 1.61
Rho family GTPases: more than simple switches. Trends Cell Biol (2000) 1.60
Insulin-like growth factor receptor cooperates with integrin alpha v beta 5 to promote tumor cell dissemination in vivo. J Clin Invest (1997) 1.53
Stimulation of fascin spikes by thrombospondin-1 is mediated by the GTPases Rac and Cdc42. J Cell Biol (2000) 1.53
Multiple GTP-binding proteins regulate vesicular transport from the ER to Golgi membranes. J Cell Biol (1992) 1.52
The COOH-terminal domain of the Rap1A (Krev-1) protein is isoprenylated and supports transformation by an H-Ras:Rap1A chimeric protein. Mol Cell Biol (1991) 1.52
Focal adhesion kinase mediates the integrin signaling requirement for growth factor activation of MAP kinase. J Cell Biol (1999) 1.52
Protein kinase C regulates alpha v beta 5-dependent cytoskeletal associations and focal adhesion kinase phosphorylation. J Cell Biol (1996) 1.48
Characterization of rho GTPase family homologues in Drosophila melanogaster: overexpressing Rho1 in retinal cells causes a late developmental defect. EMBO J (1995) 1.48
The Rac1/p38 mitogen-activated protein kinase pathway is required for interferon alpha-dependent transcriptional activation but not serine phosphorylation of Stat proteins. J Biol Chem (2000) 1.47
alphaPix stimulates p21-activated kinase activity through exchange factor-dependent and -independent mechanisms. J Biol Chem (1999) 1.47
Tandem SH2 binding sites mediate the RasGAP-RhoGAP interaction: a conformational mechanism for SH3 domain regulation. EMBO J (1997) 1.45
Rap1A is a substrate for cyclic AMP-dependent protein kinase in human neutrophils. J Immunol (1991) 1.43
The molecular adapter SLP-76 relays signals from platelet integrin alphaIIbbeta3 to the actin cytoskeleton. J Biol Chem (2000) 1.43
Bovine papillomavirus E2 gene regulates expression of the viral E5 transforming gene. J Virol (1988) 1.40
Venlafaxine in adults with attention-deficit/hyperactivity disorder: an open clinical trial. J Clin Psychiatry (1996) 1.39