Published in J Biol Chem on January 10, 2002
Prostaglandins and inflammation. Arterioscler Thromb Vasc Biol (2011) 4.67
Cellular mechanisms of redox cell signalling: role of cysteine modification in controlling antioxidant defences in response to electrophilic lipid oxidation products. Biochem J (2004) 3.15
Protein damage by reactive electrophiles: targets and consequences. Chem Res Toxicol (2007) 2.31
Biosynthesis of 15-deoxy-delta12,14-PGJ2 and the ligation of PPARgamma. J Clin Invest (2003) 2.27
Transcription factor Nrf2 regulates inflammation by mediating the effect of 15-deoxy-Delta(12,14)-prostaglandin j(2). Mol Cell Biol (2004) 2.25
Δ12-prostaglandin J3, an omega-3 fatty acid-derived metabolite, selectively ablates leukemia stem cells in mice. Blood (2011) 2.22
15-deoxy-Δ¹²,¹⁴-PGJ₂ promotes inflammation and apoptosis in cardiomyocytes via the DP2/MAPK/TNFα axis. Int J Cardiol (2014) 2.06
Production of adiponectin, an anti-inflammatory protein, in mesenteric adipose tissue in Crohn's disease. Gut (2005) 2.03
Fatty acid binding proteins--the evolutionary crossroads of inflammatory and metabolic responses. J Nutr (2004) 2.00
Thy-1 expression in human fibroblast subsets defines myofibroblastic or lipofibroblastic phenotypes. Am J Pathol (2003) 1.75
Cox-dependent fatty acid metabolites cause pain through activation of the irritant receptor TRPA1. Proc Natl Acad Sci U S A (2008) 1.59
The role of fatty acid binding proteins in metabolic syndrome and atherosclerosis. Curr Opin Lipidol (2005) 1.53
Accumulation of 15-deoxy-delta(12,14)-prostaglandin J2 adduct formation with Keap1 over time: effects on potency for intracellular antioxidant defence induction. Biochem J (2008) 1.44
Anti-inflammatory lipid mediator 15d-PGJ2 inhibits translation through inactivation of eIF4A. EMBO J (2007) 1.42
Isoprostane generation and function. Chem Rev (2011) 1.41
Involvement of cyclooxygenase-2 and prostaglandins in the molecular pathogenesis of inflammatory lung diseases. Am J Physiol Lung Cell Mol Physiol (2006) 1.40
Cutaneous nociception evoked by 15-delta PGJ2 via activation of ion channel TRPA1. Mol Pain (2008) 1.33
Activated human T lymphocytes express cyclooxygenase-2 and produce proadipogenic prostaglandins that drive human orbital fibroblast differentiation to adipocytes. Am J Pathol (2006) 1.32
15-Deoxy-Delta(12,14)-prostaglandin J(2): the endogenous electrophile that induces neuronal apoptosis. Proc Natl Acad Sci U S A (2002) 1.28
The cyclopentenone 15-deoxy-delta 12,14-prostaglandin J2 binds to and activates H-Ras. Proc Natl Acad Sci U S A (2003) 1.23
Mitochondrial targeting of the electrophilic lipid 15-deoxy-Delta12,14-prostaglandin J2 increases apoptotic efficacy via redox cell signalling mechanisms. Biochem J (2010) 1.18
Redox signaling, alkylation (carbonylation) of conserved cysteines inactivates class I histone deacetylases 1, 2, and 3 and antagonizes their transcriptional repressor function. J Biol Chem (2010) 1.13
Molecular pharmacology of the human prostaglandin D2 receptor, CRTH2. Br J Pharmacol (2002) 1.13
Glucocorticoid protects rodent hearts from ischemia/reperfusion injury by activating lipocalin-type prostaglandin D synthase-derived PGD2 biosynthesis. J Clin Invest (2009) 1.12
15-Deoxy-delta12,14-PGJ2: endogenous PPARgamma ligand or minor eicosanoid degradation product? J Clin Invest (2003) 1.08
PPARs and lipid ligands in inflammation and metabolism. Chem Rev (2011) 1.06
Immune mechanisms in thyroid eye disease. Thyroid (2008) 1.05
Subchronic infusion of the product of inflammation prostaglandin J2 models sporadic Parkinson's disease in mice. J Neuroinflammation (2009) 1.05
Redox-dependent anti-inflammatory signaling actions of unsaturated fatty acids. Annu Rev Physiol (2013) 1.05
Combined bezafibrate and medroxyprogesterone acetate: potential novel therapy for acute myeloid leukaemia. PLoS One (2009) 1.03
Modification of ubiquitin-C-terminal hydrolase-L1 by cyclopentenone prostaglandins exacerbates hypoxic injury. Neurobiol Dis (2010) 1.02
Alkylation of the tumor suppressor PTEN activates Akt and β-catenin signaling: a mechanism linking inflammation and oxidative stress with cancer. PLoS One (2010) 1.00
Cyclooxygenase-2 deficiency attenuates adipose tissue differentiation and inflammation in mice. J Biol Chem (2010) 1.00
Changes in the Th1:Th2 cytokine bias in pregnancy and the effects of the anti-inflammatory cyclopentenone prostaglandin 15-deoxy-Δ(12,14)-prostaglandin J2. Mediators Inflamm (2012) 1.00
Cyclopentenone prostaglandin-induced unfolding and aggregation of the Parkinson disease-associated UCH-L1. Proc Natl Acad Sci U S A (2010) 0.99
Proteasome-caspase-cathepsin sequence leading to tau pathology induced by prostaglandin J2 in neuronal cells. J Neurochem (2009) 0.98
PPAR and immune system--what do we know? Int Immunopharmacol (2002) 0.97
Peroxisome proliferator-activated receptor gamma ligands enhance human B cell antibody production and differentiation. J Immunol (2009) 0.95
Inhibition of interleukin-1beta-induced matrix metalloproteinases 1 and 13 production in human osteoarthritic chondrocytes by prostaglandin D2. Arthritis Rheum (2008) 0.95
Preventive effect of the flavonoid, wogonin, against ethanol-induced gastric mucosal damage in rats. Dig Dis Sci (2004) 0.93
The eicosapentaenoic acid metabolite 15-deoxy-δ(12,14)-prostaglandin J3 increases adiponectin secretion by adipocytes partly via a PPARγ-dependent mechanism. PLoS One (2013) 0.92
Increased generation of cyclopentenone prostaglandins after brain ischemia and their role in aggregation of ubiquitinated proteins in neurons. Neurotox Res (2013) 0.92
Regulation of Lymphocyte Function by PPARgamma: Relevance to Thyroid Eye Disease-Related Inflammation. PPAR Res (2008) 0.90
15-Deoxy- γ 12,14-prostaglandin J2 Reduces Liver Impairment in a Model of ConA-Induced Acute Hepatic Inflammation by Activation of PPAR γ and Reduction in NF- κ B Activity. PPAR Res (2014) 0.89
Changes in peroxisome proliferator-activated receptor-gamma activity in children with septic shock. Intensive Care Med (2009) 0.88
Aldo-keto reductase 1C3 is expressed in differentiated human epidermis, affects keratinocyte differentiation, and is upregulated in atopic dermatitis. J Invest Dermatol (2011) 0.88
The anti-inflammatory prostaglandin 15d-PGJ2 decreases oxidative/nitrosative mediators in brain after acute stress in rats. Psychopharmacology (Berl) (2005) 0.87
The point mutation UCH-L1 C152A protects primary neurons against cyclopentenone prostaglandin-induced cytotoxicity: implications for post-ischemic neuronal injury. Cell Death Dis (2015) 0.86
15-deoxy-Delta12,14 prostaglandin J2-induced heme oxygenase-1 in megakaryocytes regulates thrombopoiesis. J Thromb Haemost (2008) 0.86
CXCR4 in Cancer and Its Regulation by PPARgamma. PPAR Res (2008) 0.85
15-deoxy-Delta12,14-prostaglandin J2 impairs phosphatidylcholine synthesis and induces nuclear accumulation of thiol-modified cytidylyltransferase. J Biol Chem (2008) 0.85
Neuroinflammation and J2 prostaglandins: linking impairment of the ubiquitin-proteasome pathway and mitochondria to neurodegeneration. Front Mol Neurosci (2015) 0.84
Prostaglandin D2 and J2-series (PGJ2, Delta12-PGJ2) prostaglandins stimulate IL-6 and MCP-1, but inhibit leptin, expression and secretion by 3T3-L1 adipocytes. Pflugers Arch (2006) 0.84
Resolution of inflammation as a novel chemopreventive strategy. Semin Immunopathol (2013) 0.84
Resolution of Inflammation: What Controls Its Onset? Front Immunol (2016) 0.84
Nonenzymatic free radical-catalyzed generation of 15-deoxy-Δ(12,14)-prostaglandin J₂-like compounds (deoxy-J₂-isoprostanes) in vivo. J Lipid Res (2010) 0.82
15-Lipoxygenase metabolites of α-linolenic acid, [13-(S)-HPOTrE and 13-(S)-HOTrE], mediate anti-inflammatory effects by inactivating NLRP3 inflammasome. Sci Rep (2016) 0.80
Prostaglandin D2 toxicity in primary neurons is mediated through its bioactive cyclopentenone metabolites. Neurotoxicology (2013) 0.80
The immunobiology of prostanoid receptor signaling in connecting innate and adaptive immunity. Biomed Res Int (2013) 0.80
Novel Therapeutic Agents in Pediatric Sepsis: Peroxisome Proliferator Receptor γ (PPAR γ) Agonists. Open Inflamm J (2011) 0.80
Dexamethasone protects neonatal hypoxic-ischemic brain injury via L-PGDS-dependent PGD2-DP1-pERK signaling pathway. PLoS One (2014) 0.80
UVB light upregulates prostaglandin synthases and prostaglandin receptors in mouse keratinocytes. Toxicol Appl Pharmacol (2008) 0.79
Protein lipoxidation: Detection strategies and challenges. Redox Biol (2015) 0.79
Aldo-keto reductase 1C3 is overexpressed in skin squamous cell carcinoma (SCC) and affects SCC growth via prostaglandin metabolism. Exp Dermatol (2014) 0.79
Early increase in alveolar macrophage prostaglandin 15d-PGJ2 precedes neutrophil recruitment into lungs of cytokine-insufflated rats. Inflammation (2013) 0.78
Rac1 modification by an electrophilic 15-deoxy Δ(12,14)-prostaglandin J2 analog. Redox Biol (2015) 0.77
Identification of a prostaglandin D2 metabolite as a neuritogenesis enhancer targeting the TRPV1 ion channel. Sci Rep (2016) 0.77
Receptors involved in the modulation of guinea pig urinary bladder motility by prostaglandin D2. Br J Pharmacol (2015) 0.77
15-deoxy-Delta 12,14-ProstaglandinJ2 regulates dedifferentiation through peroxisome proliferator-activated receptor-gamma-dependent pathway but not COX-2 expression in articular chondrocytes. J Korean Med Sci (2007) 0.76
Synergistic effects of atorvastatin and rosiglitazone on endothelium protection in rats with dyslipidemia. Lipids Health Dis (2014) 0.75
Chemoattractant receptor homologous to the T helper 2 cell (CRTH2) is not expressed in human amniocytes and myocytes. PLoS One (2012) 0.75
15-Deoxy-Δ(12,14)-Prostaglandin J2 Modifies Components of the Proteasome and Inhibits Inflammatory Responses in Human Endothelial Cells. Front Immunol (2016) 0.75
15-Deoxy-Δ(12,14)-prostaglandin J2 Exerts Antioxidant Effects While Exacerbating Inflammation in Mice Subjected to Ureteral Obstruction. Mediators Inflamm (2017) 0.75
Activation of the MAPK/Akt/Nrf2-Egr1/HO-1-GCLc axis protects MG-63 osteosarcoma cells against 15d-PGJ2-mediated cell death. Biochem Pharmacol (2016) 0.75
Inflammatory Pathways in Knee Osteoarthritis: Potential Targets for Treatment. Curr Rheumatol Rev (2015) 0.75
Oxidative and electrophilic stresses activate Nrf2 through inhibition of ubiquitination activity of Keap1. Mol Cell Biol (2006) 3.97
Transcription factor Nrf2 regulates inflammation by mediating the effect of 15-deoxy-Delta(12,14)-prostaglandin j(2). Mol Cell Biol (2004) 2.25
Whole-exome sequencing uncovers frequent GNAS mutations in intraductal papillary mucinous neoplasms of the pancreas. Sci Rep (2011) 2.09
Dietary cyanidin 3-O-beta-D-glucoside-rich purple corn color prevents obesity and ameliorates hyperglycemia in mice. J Nutr (2003) 2.00
Short-chain fatty acids and ketones directly regulate sympathetic nervous system via G protein-coupled receptor 41 (GPR41). Proc Natl Acad Sci U S A (2011) 1.97
Role of 15-deoxy delta(12,14) prostaglandin J2 and Nrf2 pathways in protection against acute lung injury. Am J Respir Crit Care Med (2005) 1.94
Clinicopathological differentiation between sclerosing cholangitis with autoimmune pancreatitis and primary sclerosing cholangitis. J Gastroenterol (2007) 1.87
Bilirubin rinse: A simple protectant against the rat liver graft injury mimicking heme oxygenase-1 preconditioning. Hepatology (2003) 1.69
Molecular characterization of TRPA1 channel activation by cysteine-reactive inflammatory mediators. Channels (Austin) (2008) 1.59
Differential responses of the Nrf2-Keap1 system to laminar and oscillatory shear stresses in endothelial cells. J Biol Chem (2005) 1.54
Thioredoxin as a molecular target of cyclopentenone prostaglandins. J Biol Chem (2003) 1.45
Zerumbone, a tropical ginger sesquiterpene, activates phase II drug metabolizing enzymes. FEBS Lett (2004) 1.42
Macrophage as a target of quercetin glucuronides in human atherosclerotic arteries: implication in the anti-atherosclerotic mechanism of dietary flavonoids. J Biol Chem (2008) 1.39
Prognostic relevance of morphological types of intraductal papillary mucinous neoplasms of the pancreas. Gut (2010) 1.35
Oxidative modification of proteasome: identification of an oxidation-sensitive subunit in 26 S proteasome. Biochemistry (2005) 1.35
A sulforaphane analogue that potently activates the Nrf2-dependent detoxification pathway. J Biol Chem (2001) 1.34
Biliary tract involvement in autoimmune pancreatitis. Pancreas (2005) 1.32
Hydrogen sulfide anion regulates redox signaling via electrophile sulfhydration. Nat Chem Biol (2012) 1.32
Molecular basis of enzyme inactivation by an endogenous electrophile 4-hydroxy-2-nonenal: identification of modification sites in glyceraldehyde-3-phosphate dehydrogenase. Biochemistry (2003) 1.30
15-Deoxy-Delta(12,14)-prostaglandin J(2): the endogenous electrophile that induces neuronal apoptosis. Proc Natl Acad Sci U S A (2002) 1.28
Dihydrochalcones: evaluation as novel radical scavenging antioxidants. J Agric Food Chem (2003) 1.27
Acrolein impairs ATP binding cassette transporter A1-dependent cholesterol export from cells through site-specific modification of apolipoprotein A-I. J Biol Chem (2005) 1.27
Ebselen, a seleno-organic antioxidant, as an electrophile. Chem Res Toxicol (2006) 1.25
Cyanidin 3-O-beta-D-glucoside suppresses nitric oxide production during a zymosan treatment in rats. J Nutr Sci Vitaminol (Tokyo) (2002) 1.24
A lipid peroxidation-derived inflammatory mediator: identification of 4-hydroxy-2-nonenal as a potential inducer of cyclooxygenase-2 in macrophages. J Biol Chem (2004) 1.22
Anthocyanin enhances adipocytokine secretion and adipocyte-specific gene expression in isolated rat adipocytes. Biochem Biophys Res Commun (2004) 1.20
Intraductal tubulopapillary neoplasms of the pancreas distinct from pancreatic intraepithelial neoplasia and intraductal papillary mucinous neoplasms. Am J Surg Pathol (2009) 1.18
A link between benzyl isothiocyanate-induced cell cycle arrest and apoptosis: involvement of mitogen-activated protein kinases in the Bcl-2 phosphorylation. Cancer Res (2004) 1.18
Critical role of acrolein in secondary injury following ex vivo spinal cord trauma. J Neurochem (2008) 1.15
Osteopontin expression in pulmonary tumor thrombotic microangiopathy caused by gastric carcinoma. Pathol Int (2009) 1.14
An inhibitor of mitochondrial complex I, rotenone, inactivates proteasome by oxidative modification and induces aggregation of oxidized proteins in SH-SY5Y cells. J Neurosci Res (2003) 1.13
An endogenous electrophile that modulates the regulatory mechanism of protein turnover: inhibitory effects of 15-deoxy-Delta 12,14-prostaglandin J2 on proteasome. Biochemistry (2003) 1.13
Accumulation of acrolein-protein adducts after traumatic spinal cord injury. Neurochem Res (2005) 1.11
Involvement of the mitochondrial death pathway in chemopreventive benzyl isothiocyanate-induced apoptosis. J Biol Chem (2001) 1.09
Structures of (-)-epicatechin glucuronide identified from plasma and urine after oral ingestion of (-)-epicatechin: differences between human and rat. Free Radic Biol Med (2003) 1.09
Identification of actin as a 15-deoxy-Delta12,14-prostaglandin J2 target in neuroblastoma cells: mass spectrometric, computational, and functional approaches to investigate the effect on cytoskeletal derangement. Biochemistry (2007) 1.08
N(epsilon)-(3-methylpyridinium)lysine, a major antigenic adduct generated in acrolein-modified protein. J Biol Chem (2003) 1.07
Inhibition of protein kinase CK2 prevents the progression of glomerulonephritis. Proc Natl Acad Sci U S A (2005) 1.06
Carbonyl scavenger and antiatherogenic effects of hydrazine derivatives. Free Radic Biol Med (2008) 1.05
[The role for oxidative stress in neurodegenerative diseases]. Brain Nerve (2008) 1.03
Lysophosphatidylcholine enhances cytokine production of endothelial cells via induction of L-type amino acid transporter 1 and cell surface antigen 4F2. Arterioscler Thromb Vasc Biol (2004) 1.03
Identification of a lipid peroxidation product as a potential trigger of the p53 pathway. J Biol Chem (2005) 1.03
Albumin is the main nucleophilic target of human plasma: a protective role against pro-atherogenic electrophilic reactive carbonyl species? Chem Res Toxicol (2008) 1.03
Structural basis of protein-bound endogenous aldehydes. Chemical and immunochemical characterizations of configurational isomers of a 4-hydroxy-2-nonenal-histidine adduct. J Biol Chem (2002) 1.02
Dietary ginger constituents, galanals A and B, are potent apoptosis inducers in Human T lymphoma Jurkat cells. Cancer Lett (2003) 1.01
Astaxanthin inhibits reactive oxygen species-mediated cellular toxicity in dopaminergic SH-SY5Y cells via mitochondria-targeted protective mechanism. Brain Res (2008) 1.01
Chemical knockdown of protein-tyrosine phosphatase 1B by 1,2-naphthoquinone through covalent modification causes persistent transactivation of epidermal growth factor receptor. J Biol Chem (2007) 1.01
Microarray profiling of gene expression in human adipocytes in response to anthocyanins. Biochem Pharmacol (2006) 1.00
Somatic mutations in PIK3CA and activation of AKT in intraductal tubulopapillary neoplasms of the pancreas. Am J Surg Pathol (2011) 1.00
GLO1 overexpression in human malignant melanoma. Melanoma Res (2010) 0.99
Cytokines and peroxisome proliferator-activated receptor gamma ligand regulate phagocytosis by pancreatic stellate cells. Gastroenterology (2005) 0.99
Expression and quantitative analysis of matrix metalloproteinase-2 and -9 in human gliomas. Brain Tumor Pathol (2004) 0.99
The effects of tetrahydrocurcumin and green tea polyphenol on the survival of male C57BL/6 mice. Biogerontology (2007) 0.99
Benzyl isothiocyanate inhibits excessive superoxide generation in inflammatory leukocytes: implication for prevention against inflammation-related carcinogenesis. Carcinogenesis (2003) 0.99
Astaxanthin improves muscle lipid metabolism in exercise via inhibitory effect of oxidative CPT I modification. Biochem Biophys Res Commun (2007) 0.99
Bilateral massive bloody pleurisy complicated by angiosarcoma. Intern Med (2007) 0.98
Rosmarinic acid, a major polyphenolic component of Perilla frutescens, reduces lipopolysaccharide (LPS)-induced liver injury in D-galactosamine (D-GalN)-sensitized mice. Free Radic Biol Med (2002) 0.98
Lemon flavonoid, eriocitrin, suppresses exercise-induced oxidative damage in rat liver. Life Sci (2003) 0.98
Sesamin, a lignan of sesame, down-regulates cyclin D1 protein expression in human tumor cells. Cancer Sci (2007) 0.98
RET gene rearrangements (RET/PTC1 and RET/PTC3) in papillary thyroid carcinomas from an iodine-rich country (Japan). Cancer (2005) 0.98
Pathological and immunohistochemical findings of an autopsy case of adult moyamoya disease. Neuropathology (2004) 0.97
Thiolation of protein-bound carcinogenic aldehyde. An electrophilic acrolein-lysine adduct that covalently binds to thiols. J Biol Chem (2002) 0.97
Epigenetic silencing of TTF-1/NKX2-1 through DNA hypermethylation and histone H3 modulation in thyroid carcinomas. Lab Invest (2009) 0.97
Functional parathyroid carcinoma: Long-term treatment outcome and risk factor analysis. Surgery (2007) 0.96
Rosmarinic acid inhibits lung injury induced by diesel exhaust particles. Free Radic Biol Med (2003) 0.96
Stereochemical configuration of 4-hydroxy-2-nonenal-cysteine adducts and their stereoselective formation in a redox-regulated protein. J Biol Chem (2009) 0.96
Ebselen, a glutathione peroxidase mimetic seleno-organic compound, as a multifunctional antioxidant. Implication for inflammation-associated carcinogenesis. J Biol Chem (2001) 0.95
Isothiocyanates reduce mercury accumulation via an Nrf2-dependent mechanism during exposure of mice to methylmercury. Environ Health Perspect (2011) 0.95
Increase in oxidative stress in kidneys of diabetic Akita mice. Biosci Biotechnol Biochem (2002) 0.95
Reappraisal of short-term low-volume hydration in cisplatin-based chemotherapy: results of a prospective feasibility study in advanced lung cancer in the Okayama Lung Cancer Study Group Trial 1002. Jpn J Clin Oncol (2013) 0.95
Dose-dependent differential regulation of cytokine secretion from macrophages by fractalkine. J Immunol (2007) 0.95
Formation of dopamine adducts derived from brain polyunsaturated fatty acids: mechanism for Parkinson disease. J Biol Chem (2008) 0.94
Effect of sesame lignans on TNF-alpha-induced expression of adhesion molecules in endothelial cells. Biosci Biotechnol Biochem (2010) 0.94
Roles of oxidative stress and Akt signaling in doxorubicin cardiotoxicity. Biochem Biophys Res Commun (2007) 0.93
Blood vessel invasion as a predictor of long-term survival for Japanese patients with breast cancer. Breast Cancer Res Treat (2002) 0.93
Effects of the PPARgamma activator pioglitazone on p38 MAP kinase and IkappaBalpha in the spinal cord of a transgenic mouse model of amyotrophic lateral sclerosis. Neuropathology (2008) 0.93
Astaxanthin protects neuronal cells against oxidative damage and is a potent candidate for brain food. Forum Nutr (2009) 0.93
Immunogenicity of a brominated protein and successive establishment of a monoclonal antibody to dihalogenated tyrosine. Free Radic Biol Med (2005) 0.93
Heat-shock protein 27 is a major methylglyoxal-modified protein in endothelial cells. FEBS Lett (2006) 0.93