Published in Curr Biol on January 08, 2002
Conserved pathways within bacteria and yeast as revealed by global protein network alignment. Proc Natl Acad Sci U S A (2003) 4.68
Synthetic multivalent ligands as probes of signal transduction. Angew Chem Int Ed Engl (2006) 3.29
G2 arrest in Xenopus oocytes depends on phosphorylation of cdc25 by protein kinase A. Proc Natl Acad Sci U S A (2002) 2.27
Rab32 is an A-kinase anchoring protein and participates in mitochondrial dynamics. J Cell Biol (2002) 1.93
Mapping the protein phosphatase-2B anchoring site on AKAP79. Binding and inhibition of phosphatase activity are mediated by residues 315-360. J Biol Chem (2002) 1.86
Bioinformatic design of A-kinase anchoring protein-in silico: a potent and selective peptide antagonist of type II protein kinase A anchoring. Proc Natl Acad Sci U S A (2003) 1.80
Imaging kinase--AKAP79--phosphatase scaffold complexes at the plasma membrane in living cells using FRET microscopy. J Cell Biol (2002) 1.67
Anchoring of both PKA and 14-3-3 inhibits the Rho-GEF activity of the AKAP-Lbc signaling complex. EMBO J (2004) 1.58
Signaling in small subcellular volumes. I. Stochastic and diffusion effects on individual pathways. Biophys J (2004) 1.36
Protein kinase A, Ca2+/calmodulin-dependent kinase II, and calcineurin regulate the intracellular trafficking of myopodin between the Z-disc and the nucleus of cardiac myocytes. Mol Cell Biol (2007) 1.30
A theoretical framework for specificity in cell signaling. Mol Syst Biol (2005) 1.27
Association of an A-kinase-anchoring protein signaling scaffold with cadherin adhesion molecules in neurons and epithelial cells. Mol Biol Cell (2005) 1.24
BLNK: molecular scaffolding through 'cis'-mediated organization of signaling proteins. EMBO J (2002) 1.21
Homer 2 tunes G protein-coupled receptors stimulus intensity by regulating RGS proteins and PLCbeta GAP activities. J Cell Biol (2003) 1.20
Convergence of signaling pathways induced by systemin, oligosaccharide elicitors, and ultraviolet-B radiation at the level of mitogen-activated protein kinases in Lycopersicon peruvianum suspension-cultured cells. Plant Physiol (2003) 1.19
Association of diacylglycerol kinase zeta with protein kinase C alpha: spatial regulation of diacylglycerol signaling. J Cell Biol (2003) 1.11
Modular construction of a signaling scaffold: MORG1 interacts with components of the ERK cascade and links ERK signaling to specific agonists. Proc Natl Acad Sci U S A (2004) 1.11
The Galpha12-RGS RhoGEF-RhoA signalling pathway regulates neurotransmitter release in C. elegans. EMBO J (2006) 1.07
Kidins220/ARMS is transported by a kinesin-1-based mechanism likely to be involved in neuronal differentiation. Mol Biol Cell (2006) 1.05
Binding specificity of SH2 domains: insight from free energy simulations. Proteins (2009) 1.02
Direct and indirect control of mitogen-activated protein kinase pathway-associated components, BRAP/IMP E3 ubiquitin ligase and CRAF/RAF1 kinase, by the deubiquitylating enzyme USP15. J Biol Chem (2012) 0.97
Stimulation of NeuroD activity by huntingtin and huntingtin-associated proteins HAP1 and MLK2. Proc Natl Acad Sci U S A (2003) 0.92
An optimal number of molecules for signal amplification and discrimination in a chemical cascade. Biophys J (2006) 0.91
Using FRET-based reporters to visualize subcellular dynamics of protein kinase A activity. Methods Mol Biol (2011) 0.81
The "acrosomal synapse": Subcellular organization by lipid rafts and scaffolding proteins exhibits high similarities in neurons and mammalian spermatozoa. Commun Integr Biol (2010) 0.80
Polypeptide modulators of caspase recruitment domain (CARD)-CARD-mediated protein-protein interactions. J Biol Chem (2011) 0.76
Suppression of chemotaxis by SSeCKS via scaffolding of phosphoinositol phosphates and the recruitment of the Cdc42 GEF, Frabin, to the leading edge. PLoS One (2014) 0.76
Neuronal activity-regulated gene transcription: how are distant synaptic signals conveyed to the nucleus? F1000Res (2012) 0.75
AKAP signalling complexes: focal points in space and time. Nat Rev Mol Cell Biol (2004) 6.97
The protein kinase A anchoring protein mAKAP coordinates two integrated cAMP effector pathways. Nature (2005) 3.82
Ubiquitination regulates PSD-95 degradation and AMPA receptor surface expression. Neuron (2003) 3.62
Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization. Curr Biol (2004) 3.45
Protein phosphorylation in signaling--50 years and counting. Trends Biochem Sci (2005) 3.19
The prevalence of cirrhosis and hepatocellular carcinoma in patients with human immunodeficiency virus infection. Hepatology (2013) 2.98
Distinct enzyme combinations in AKAP signalling complexes permit functional diversity. Nat Cell Biol (2005) 2.84
Phosphorylation of WAVE1 regulates actin polymerization and dendritic spine morphology. Nature (2006) 2.77
Molecular basis of AKAP specificity for PKA regulatory subunits. Mol Cell (2006) 2.33
Regulation of GluR1 by the A-kinase anchoring protein 79 (AKAP79) signaling complex shares properties with long-term depression. J Neurosci (2002) 2.31
AKAP signaling complexes: getting to the heart of the matter. Trends Mol Med (2006) 2.29
AKAP mediated signal transduction. Annu Rev Pharmacol Toxicol (2002) 2.26
Interaction with AKAP79 modifies the cellular pharmacology of PKC. Mol Cell (2010) 2.22
Cost-effectiveness and population outcomes of general population screening for hepatitis C. Clin Infect Dis (2012) 2.19
AKAP150 signaling complex promotes suppression of the M-current by muscarinic agonists. Nat Neurosci (2003) 2.08
Dynamic regulation of cAMP synthesis through anchored PKA-adenylyl cyclase V/VI complexes. Mol Cell (2006) 2.05
A-kinase anchoring proteins take shape. Curr Opin Cell Biol (2007) 2.03
An anchored PKA and PDE4 complex regulates subplasmalemmal cAMP dynamics. EMBO J (2006) 1.99
A WAVE-1 and WRP signaling complex regulates spine density, synaptic plasticity, and memory. J Neurosci (2007) 1.97
Loss of AKAP150 perturbs distinct neuronal processes in mice. Proc Natl Acad Sci U S A (2008) 1.96
Retinal detachment and prophylaxis in type 1 Stickler syndrome. Ophthalmology (2007) 1.95
Rab32 is an A-kinase anchoring protein and participates in mitochondrial dynamics. J Cell Biol (2002) 1.93
A-kinase anchoring proteins: from protein complexes to physiology and disease. IUBMB Life (2009) 1.89
Mapping the protein phosphatase-2B anchoring site on AKAP79. Binding and inhibition of phosphatase activity are mediated by residues 315-360. J Biol Chem (2002) 1.86
Loss of WAVE-1 causes sensorimotor retardation and reduced learning and memory in mice. Proc Natl Acad Sci U S A (2003) 1.86
The where's and when's of kinase anchoring. Trends Biochem Sci (2006) 1.83
AKAP-Lbc nucleates a protein kinase D activation scaffold. Mol Cell (2004) 1.81
Bioinformatic design of A-kinase anchoring protein-in silico: a potent and selective peptide antagonist of type II protein kinase A anchoring. Proc Natl Acad Sci U S A (2003) 1.80
The WRP component of the WAVE-1 complex attenuates Rac-mediated signalling. Nat Cell Biol (2002) 1.77
Networking with AKAPs: context-dependent regulation of anchored enzymes. Mol Interv (2010) 1.69
Compartmentalisation of phosphodiesterases and protein kinase A: opposites attract. FEBS Lett (2005) 1.66
AKAP-Lbc enhances cyclic AMP control of the ERK1/2 cascade. Nat Cell Biol (2010) 1.64
AKAP150 contributes to enhanced vascular tone by facilitating large-conductance Ca2+-activated K+ channel remodeling in hyperglycemia and diabetes mellitus. Circ Res (2013) 1.59
Trafficking of L-type calcium channels mediated by the postsynaptic scaffolding protein AKAP79. J Biol Chem (2002) 1.58
AKAP-Lbc mobilizes a cardiac hypertrophy signaling pathway. Mol Cell (2008) 1.57
Prolonged incubation and extensive subculturing do not increase recovery of clinically significant microorganisms from standard automated blood cultures. Clin Infect Dis (2005) 1.57
Increased coupled gating of L-type Ca2+ channels during hypertension and Timothy syndrome. Circ Res (2010) 1.55
Integrating cardiac PIP3 and cAMP signaling through a PKA anchoring function of p110γ. Mol Cell (2011) 1.52
Delineation of type I protein kinase A-selective signaling events using an RI anchoring disruptor. J Biol Chem (2006) 1.48
Compartmentation of cyclic nucleotide signaling in the heart: the role of A-kinase anchoring proteins. Circ Res (2006) 1.48
PKA-phosphorylation of PDE4D3 facilitates recruitment of the mAKAP signalling complex. Biochem J (2004) 1.47
Full-length cardiac Na+/Ca2+ exchanger 1 protein is not phosphorylated by protein kinase A. Am J Physiol Cell Physiol (2011) 1.46
AKAP18 contains a phosphoesterase domain that binds AMP. J Mol Biol (2007) 1.31
Spatial restriction of PDK1 activation cascades by anchoring to mAKAPalpha. Mol Cell (2005) 1.29
AKAP79-mediated targeting of the cyclic AMP-dependent protein kinase to the beta1-adrenergic receptor promotes recycling and functional resensitization of the receptor. J Biol Chem (2006) 1.28
An entirely specific type I A-kinase anchoring protein that can sequester two molecules of protein kinase A at mitochondria. Proc Natl Acad Sci U S A (2011) 1.27
Kinase- and phosphatase-anchoring proteins: harnessing the dynamic duo. Nat Cell Biol (2002) 1.27
The A-kinase anchoring protein Yotiao binds and regulates adenylyl cyclase in brain. Proc Natl Acad Sci U S A (2008) 1.27
Association of an A-kinase-anchoring protein signaling scaffold with cadherin adhesion molecules in neurons and epithelial cells. Mol Biol Cell (2005) 1.24
A-kinase anchoring protein 79/150 facilitates the phosphorylation of GABA(A) receptors by cAMP-dependent protein kinase via selective interaction with receptor beta subunits. Mol Cell Neurosci (2003) 1.23
Architecture and dynamics of an A-kinase anchoring protein 79 (AKAP79) signaling complex. Proc Natl Acad Sci U S A (2011) 1.23
Orchestration of synaptic plasticity through AKAP signaling complexes. Neuropharmacology (2004) 1.20
AKAP79 interacts with multiple adenylyl cyclase (AC) isoforms and scaffolds AC5 and -6 to alpha-amino-3-hydroxyl-5-methyl-4-isoxazole-propionate (AMPA) receptors. J Biol Chem (2010) 1.19
Migratory songbirds disperse ticks across Canada, and first isolation of the Lyme disease spirochete, Borrelia burgdorferi, from the avian tick, Ixodes auritulus. J Parasitol (2005) 1.19
Rab32 modulates apoptosis onset and mitochondria-associated membrane (MAM) properties. J Biol Chem (2010) 1.19
mAKAP compartmentalizes oxygen-dependent control of HIF-1alpha. Sci Signal (2008) 1.16
Restoration of normal L-type Ca2+ channel function during Timothy syndrome by ablation of an anchoring protein. Circ Res (2011) 1.16
Intrinsic disorder within an AKAP-protein kinase A complex guides local substrate phosphorylation. Elife (2013) 1.15
E2~Ub conjugates regulate the kinase activity of Shigella effector OspG during pathogenesis. EMBO J (2014) 1.14
Local control of TRPV4 channels by AKAP150-targeted PKC in arterial smooth muscle. J Gen Physiol (2014) 1.10
Spatial distribution of protein kinase A activity during cell migration is mediated by A-kinase anchoring protein AKAP Lbc. J Biol Chem (2008) 1.08
Signal integration through blending, bolstering and bifurcating of intracellular information. Nat Struct Mol Biol (2010) 1.07
Intracellular targeting of protein kinases and phosphatases. Diabetes (2002) 1.06
Targeting of protein kinase A by muscle A kinase-anchoring protein (mAKAP) regulates phosphorylation and function of the skeletal muscle ryanodine receptor. J Biol Chem (2003) 1.05
AKAP2 anchors PKA with aquaporin-0 to support ocular lens transparency. EMBO Mol Med (2011) 1.05
High-affinity AKAP7delta-protein kinase A interaction yields novel protein kinase A-anchoring disruptor peptides. Biochem J (2006) 1.04
Coordinated signal integration at the M-type potassium channel upon muscarinic stimulation. EMBO J (2012) 1.02
Bariatric surgery is associated with a reduction in major macrovascular and microvascular complications in moderately to severely obese patients with type 2 diabetes mellitus. J Am Coll Surg (2013) 1.02
A-kinase anchoring proteins and neuronal signaling mechanisms. Genes Dev (2003) 1.01
The A-kinase-anchoring protein AKAP-Lbc facilitates cardioprotective PKA phosphorylation of Hsp20 on Ser(16). Biochem J (2012) 1.01
Induction of flexibility through protein-protein interactions. J Biol Chem (2003) 0.99
Dual specificity A-kinase anchoring proteins (AKAPs) contain an additional binding region that enhances targeting of protein kinase A type I. J Biol Chem (2008) 0.99
Anchored protein kinase A recruitment of active Rac GTPase. J Biol Chem (2011) 0.99
MyRIP anchors protein kinase A to the exocyst complex. J Biol Chem (2007) 0.98
Cardiomyocytes from AKAP7 knockout mice respond normally to adrenergic stimulation. Proc Natl Acad Sci U S A (2012) 0.98
Anchored phosphatases modulate glucose homeostasis. EMBO J (2012) 0.98
AKAP signaling complexes: pointing towards the next generation of therapeutic targets? Trends Pharmacol Sci (2013) 0.98
Characterization of A-kinase-anchoring disruptors using a solution-based assay. Biochem J (2006) 0.98
Patient acceptance of universal screening for hepatitis C virus infection. BMC Infect Dis (2011) 0.97
Clinical characterisation and molecular analysis of Wagner syndrome. Br J Ophthalmol (2006) 0.96
Gravin is a transitory effector of polo-like kinase 1 during cell division. Mol Cell (2012) 0.96
High efficiency of mutation detection in type 1 stickler syndrome using a two-stage approach: vitreoretinal assessment coupled with exon sequencing for screening COL2A1. Hum Mutat (2006) 0.94
Gravin orchestrates protein kinase A and β2-adrenergic receptor signaling critical for synaptic plasticity and memory. J Neurosci (2012) 0.94
CK2 phosphorylates SSRP1 and inhibits its DNA-binding activity. J Biol Chem (2005) 0.93
Alpha-dystrobrevin-1 recruits alpha-catulin to the alpha1D-adrenergic receptor/dystrophin-associated protein complex signalosome. Proc Natl Acad Sci U S A (2010) 0.93
A-kinase-anchoring proteins. J Cell Sci (2005) 0.93
Discovery of cellular substrates for protein kinase A using a peptide array screening protocol. Biochem J (2011) 0.93
Calcineurin anchoring and cell signaling. Biochem Biophys Res Commun (2003) 0.92
Engineering A-kinase anchoring protein (AKAP)-selective regulatory subunits of protein kinase A (PKA) through structure-based phage selection. J Biol Chem (2013) 0.92
Anchored cAMP signaling: onward and upward - a short history of compartmentalized cAMP signal transduction. Eur J Cell Biol (2006) 0.92
Cost-effectiveness of Bariatric Surgery: Increasing the Economic Viability of the Most Effective Treatment for Type II Diabetes Mellitus. Am Surg (2015) 0.91
Ezrin-anchored protein kinase A coordinates phosphorylation-dependent disassembly of a NHERF1 ternary complex to regulate hormone-sensitive phosphate transport. J Biol Chem (2012) 0.91
PKA phosphorylation of the small heat-shock protein Hsp20 enhances its cardioprotective effects. Biochem Soc Trans (2012) 0.90
Alternative splicing modifies the effect of mutations in COL11A1 and results in recessive type 2 Stickler syndrome with profound hearing loss. J Med Genet (2013) 0.90
Bariatric surgery is associated with a reduced risk of mortality in morbidly obese patients with a history of major cardiovascular events. Am Surg (2012) 0.89
Isoform-specific targeting of PKA to multivesicular bodies. J Cell Biol (2011) 0.89
Anchoring proteins as regulators of signaling pathways. Circ Res (2012) 0.89
AKAP220 protein organizes signaling elements that impact cell migration. J Biol Chem (2011) 0.89
Organizing signal transduction through A-kinase anchoring proteins (AKAPs). FEBS J (2010) 0.88
Local cAMP signaling in disease at a glance. J Cell Sci (2013) 0.87