Published in Annu Rev Pharmacol Toxicol on January 01, 2002
Protein kinase CK2: structure, regulation and role in cellular decisions of life and death. Biochem J (2003) 5.11
Regulation of the ABC kinases by phosphorylation: protein kinase C as a paradigm. Biochem J (2003) 4.65
CaM kinase II selectively signals to histone deacetylase 4 during cardiomyocyte hypertrophy. J Clin Invest (2006) 3.53
Fluorescent indicators of cAMP and Epac activation reveal differential dynamics of cAMP signaling within discrete subcellular compartments. Proc Natl Acad Sci U S A (2004) 3.31
The evolving role of lipid rafts and caveolae in G protein-coupled receptor signaling: implications for molecular pharmacology. Br J Pharmacol (2004) 2.70
Genome-wide analysis of cancer/testis gene expression. Proc Natl Acad Sci U S A (2008) 2.66
Supramolecular assemblies and localized regulation of voltage-gated ion channels. Physiol Rev (2009) 2.53
A dynamic mechanism for AKAP binding to RII isoforms of cAMP-dependent protein kinase. Mol Cell (2006) 2.27
Targeting of calcium/calmodulin-dependent protein kinase II. Biochem J (2004) 2.08
Age-dependent requirement of AKAP150-anchored PKA and GluR2-lacking AMPA receptors in LTP. EMBO J (2007) 1.88
Regulation and organization of adenylyl cyclases and cAMP. Biochem J (2003) 1.73
Bicarbonate-responsive "soluble" adenylyl cyclase defines a nuclear cAMP microdomain. J Cell Biol (2004) 1.68
Anchoring of both PKA and 14-3-3 inhibits the Rho-GEF activity of the AKAP-Lbc signaling complex. EMBO J (2004) 1.58
Sperm-specific protein kinase A catalytic subunit Calpha2 orchestrates cAMP signaling for male fertility. Proc Natl Acad Sci U S A (2004) 1.54
Intrinsic disorder in scaffold proteins: getting more from less. Prog Biophys Mol Biol (2008) 1.49
Protein kinase A regulates AKAP250 (gravin) scaffold binding to the beta2-adrenergic receptor. EMBO J (2003) 1.43
AKAPs (A-kinase anchoring proteins) and molecules that compose their G-protein-coupled receptor signalling complexes. Biochem J (2004) 1.36
Mitochondrial AKAP121 binds and targets protein tyrosine phosphatase D1, a novel positive regulator of src signaling. Mol Cell Biol (2004) 1.33
Spatial regulation of the cAMP-dependent protein kinase during chemotactic cell migration. Proc Natl Acad Sci U S A (2005) 1.32
Protein kinase A-anchoring (AKAP) domains in brefeldin A-inhibited guanine nucleotide-exchange protein 2 (BIG2). Proc Natl Acad Sci U S A (2003) 1.32
Signaling defects in anti-tumor T cells. Immunol Rev (2008) 1.28
Regulatory actions of the A-kinase anchoring protein Yotiao on a heart potassium channel downstream of PKA phosphorylation. Proc Natl Acad Sci U S A (2004) 1.26
Insulin regulates adipocyte lipolysis via an Akt-independent signaling pathway. Mol Cell Biol (2010) 1.21
Regulation of nuclear PKA revealed by spatiotemporal manipulation of cyclic AMP. Nat Chem Biol (2012) 1.20
Differential phosphorylation and dephosphorylation of beta2-adrenoceptor sites Ser262 and Ser355,356. Br J Pharmacol (2006) 1.20
A transforming growth factor beta-induced Smad3/Smad4 complex directly activates protein kinase A. Mol Cell Biol (2004) 1.19
Rab32 modulates apoptosis onset and mitochondria-associated membrane (MAM) properties. J Biol Chem (2010) 1.19
Cancer/testis (CT) antigens, carcinogenesis and spermatogenesis. Spermatogenesis (2011) 1.16
Turning off AKT: PHLPP as a drug target. Annu Rev Pharmacol Toxicol (2014) 1.12
Tankyrase polymerization is controlled by its sterile alpha motif and poly(ADP-ribose) polymerase domains. Mol Cell Biol (2004) 1.09
Optic atrophy 1 is an A-kinase anchoring protein on lipid droplets that mediates adrenergic control of lipolysis. EMBO J (2011) 1.06
Gene-trapped mouse embryonic stem cell-derived cardiac myocytes and human genetics implicate AKAP10 in heart rhythm regulation. Proc Natl Acad Sci U S A (2007) 1.04
GISP: a novel brain-specific protein that promotes surface expression and function of GABA(B) receptors. J Neurochem (2007) 1.03
AKAP79/150 interacts with AC8 and regulates Ca2+-dependent cAMP synthesis in pancreatic and neuronal systems. J Biol Chem (2010) 1.03
Efficient trafficking of MDR1/P-glycoprotein to apical canalicular plasma membranes in HepG2 cells requires PKA-RIIalpha anchoring and glucosylceramide. Mol Biol Cell (2006) 1.02
Localization and quaternary structure of the PKA RIβ holoenzyme. Proc Natl Acad Sci U S A (2012) 1.02
Prostaglandin E2-induced masculinization of brain and behavior requires protein kinase A, AMPA/kainate, and metabotropic glutamate receptor signaling. J Neurosci (2009) 1.00
Regulation of cardiac inward rectifier potassium current (I(K1)) by synapse-associated protein-97. J Biol Chem (2010) 0.97
Phosphodiesterase type 3A regulates basal myocardial contractility through interacting with sarcoplasmic reticulum calcium ATPase type 2a signaling complexes in mouse heart. Circ Res (2012) 0.95
Cardiac troponin T, a sarcomeric AKAP, tethers protein kinase A at the myofilaments. J Biol Chem (2010) 0.95
The PKARIalpha subunit of protein kinase A modulates the activation of p90RSK1 and its function. J Biol Chem (2009) 0.94
Human bronchial smooth muscle cells express adenylyl cyclase isoforms 2, 4, and 6 in distinct membrane microdomains. J Pharmacol Exp Ther (2011) 0.93
Swiss Cheese, a protein involved in progressive neurodegeneration, acts as a noncanonical regulatory subunit for PKA-C3. J Neurosci (2008) 0.93
Quantitative phosphoproteomic analysis reveals a role for serine and threonine kinases in the cytoskeletal reorganization in early T cell receptor activation in human primary T cells. Mol Cell Proteomics (2012) 0.92
Differential gene expression in human granulosa cells from recombinant FSH versus human menopausal gonadotropin ovarian stimulation protocols. Reprod Biol Endocrinol (2010) 0.91
CaV1.2 signaling complexes in the heart. J Mol Cell Cardiol (2012) 0.90
Signalosomes as Therapeutic Targets. Prog Pediatr Cardiol (2008) 0.88
Mechanism for targeting the A-kinase anchoring protein AKAP18δ to the membrane. J Biol Chem (2012) 0.87
Neuronal microtubule-associated protein 2D is a dual a-kinase anchoring protein expressed in rat ovarian granulosa cells. J Biol Chem (2004) 0.87
Targeted disruption of PDE3B, but not PDE3A, protects murine heart from ischemia/reperfusion injury. Proc Natl Acad Sci U S A (2015) 0.86
Impact of cAMP on the T-cell response to type II collagen. Immunology (2004) 0.85
Proteomic Analysis of Vascular Endothelial Cells-Effects of Laminar Shear Stress and High Glucose. J Proteomics Bioinform (2009) 0.83
Controlling fertilization and cAMP signaling in sperm by optogenetics. Elife (2015) 0.83
Bigger, better, faster: principles and models of AKAP anchoring protein signaling. J Cardiovasc Pharmacol (2011) 0.83
Anchoring of protein kinase A-regulatory subunit IIalpha to subapically positioned centrosomes mediates apical bile canalicular lumen development in response to oncostatin M but not cAMP. Mol Biol Cell (2007) 0.83
Serotonin induces selective cleavage of the PKA RI subunit but not RII subunit in Aplysia neurons. Biochem Biophys Res Commun (2007) 0.83
AKAP-independent localization of type-II protein kinase A to dynamic actin microspikes. Cell Motil Cytoskeleton (2009) 0.82
Phosphodiesterases maintain signaling fidelity via compartmentalization of cyclic nucleotides. Physiology (Bethesda) (2014) 0.82
PKA compartmentalization via AKAP220 and AKAP12 contributes to endothelial barrier regulation. PLoS One (2014) 0.82
The protein kinase A-anchoring protein moesin is bound to pigment granules in melanophores. Traffic (2008) 0.81
Anchoring of both PKA-RIIα and 14-3-3θ regulates retinoic acid induced 16 mediated phosphorylation of heat shock protein 70. Oncotarget (2015) 0.81
A dynamic interface between ubiquitylation and cAMP signaling. Front Pharmacol (2015) 0.80
Using computational modeling to predict arrhythmogenesis and antiarrhythmic therapy. Drug Discov Today Dis Models (2009) 0.79
Anchoring of protein kinase A by ERM (ezrin-radixin-moesin) proteins is required for proper netrin signaling through DCC (deleted in colorectal cancer). J Biol Chem (2015) 0.79
Specification of spatial relationships in directed graphs of cell signaling networks. Ann N Y Acad Sci (2009) 0.78
A-Kinase Anchoring Protein 4 (AKAP4) is an ERK1/2 substrate and a switch molecule between cAMP/PKA and PKC/ERK1/2 in human spermatozoa. Sci Rep (2016) 0.77
A timely characterization of vasopressin-sensitive adenylyl cyclase isoforms in the mouse inner medullary collecting duct. Am J Physiol Renal Physiol (2009) 0.77
Suppressor of cytokine signaling-3 is a glucagon-inducible inhibitor of PKA activity and gluconeogenic gene expression in hepatocytes. J Biol Chem (2010) 0.77
Molecular Mechanisms for cAMP-Mediated Immunoregulation in T cells - Role of Anchored Protein Kinase A Signaling Units. Front Immunol (2016) 0.77
Differential distribution of cAMP-dependent protein kinase isoforms in the mantle of the bivalve mollusc Mytilus galloprovincialis. J Mol Histol (2009) 0.76
Delocalization of Endogenous A-kinase Antagonizes Rap1-Rho-α2C-Adrenoceptor Signaling in Human Microvascular Smooth Muscle Cells. J Cytol Mol Biol (2014) 0.76
Synapse-specific compartmentalization of signaling cascades for LTP induction in CA3 interneurons. Neuroscience (2015) 0.76
Drosophila mutants of the autism candidate gene neurobeachin (rugose) exhibit neuro-developmental disorders, aberrant synaptic properties, altered locomotion, and impaired adult social behavior and activity patterns. J Neurogenet (2015) 0.76
Dissociation between AKAP3 and PKARII promotes AKAP3 degradation in sperm capacitation. PLoS One (2013) 0.75
Biochemical and molecular aspects of vascular adrenergic regulation of blood pressure in the elderly. Int J Hypertens (2011) 0.75
AKAP signalling complexes: focal points in space and time. Nat Rev Mol Cell Biol (2004) 6.97
The protein kinase A anchoring protein mAKAP coordinates two integrated cAMP effector pathways. Nature (2005) 3.82
Ubiquitination regulates PSD-95 degradation and AMPA receptor surface expression. Neuron (2003) 3.62
Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization. Curr Biol (2004) 3.45
Protein phosphorylation in signaling--50 years and counting. Trends Biochem Sci (2005) 3.19
The prevalence of cirrhosis and hepatocellular carcinoma in patients with human immunodeficiency virus infection. Hepatology (2013) 2.98
Distinct enzyme combinations in AKAP signalling complexes permit functional diversity. Nat Cell Biol (2005) 2.84
Phosphorylation of WAVE1 regulates actin polymerization and dendritic spine morphology. Nature (2006) 2.77
Molecular basis of AKAP specificity for PKA regulatory subunits. Mol Cell (2006) 2.33
Regulation of GluR1 by the A-kinase anchoring protein 79 (AKAP79) signaling complex shares properties with long-term depression. J Neurosci (2002) 2.31
AKAP signaling complexes: getting to the heart of the matter. Trends Mol Med (2006) 2.29
Interaction with AKAP79 modifies the cellular pharmacology of PKC. Mol Cell (2010) 2.22
Cost-effectiveness and population outcomes of general population screening for hepatitis C. Clin Infect Dis (2012) 2.19
AKAP150 signaling complex promotes suppression of the M-current by muscarinic agonists. Nat Neurosci (2003) 2.08
Dynamic regulation of cAMP synthesis through anchored PKA-adenylyl cyclase V/VI complexes. Mol Cell (2006) 2.05
A-kinase anchoring proteins take shape. Curr Opin Cell Biol (2007) 2.03
An anchored PKA and PDE4 complex regulates subplasmalemmal cAMP dynamics. EMBO J (2006) 1.99
A WAVE-1 and WRP signaling complex regulates spine density, synaptic plasticity, and memory. J Neurosci (2007) 1.97
Loss of AKAP150 perturbs distinct neuronal processes in mice. Proc Natl Acad Sci U S A (2008) 1.96
Retinal detachment and prophylaxis in type 1 Stickler syndrome. Ophthalmology (2007) 1.95
Rab32 is an A-kinase anchoring protein and participates in mitochondrial dynamics. J Cell Biol (2002) 1.93
A-kinase anchoring proteins: from protein complexes to physiology and disease. IUBMB Life (2009) 1.89
Loss of WAVE-1 causes sensorimotor retardation and reduced learning and memory in mice. Proc Natl Acad Sci U S A (2003) 1.86
Mapping the protein phosphatase-2B anchoring site on AKAP79. Binding and inhibition of phosphatase activity are mediated by residues 315-360. J Biol Chem (2002) 1.86
The where's and when's of kinase anchoring. Trends Biochem Sci (2006) 1.83
AKAP-Lbc nucleates a protein kinase D activation scaffold. Mol Cell (2004) 1.81
Bioinformatic design of A-kinase anchoring protein-in silico: a potent and selective peptide antagonist of type II protein kinase A anchoring. Proc Natl Acad Sci U S A (2003) 1.80
The WRP component of the WAVE-1 complex attenuates Rac-mediated signalling. Nat Cell Biol (2002) 1.77
Networking with AKAPs: context-dependent regulation of anchored enzymes. Mol Interv (2010) 1.69
Compartmentalisation of phosphodiesterases and protein kinase A: opposites attract. FEBS Lett (2005) 1.66
AKAP-Lbc enhances cyclic AMP control of the ERK1/2 cascade. Nat Cell Biol (2010) 1.64
AKAP150 contributes to enhanced vascular tone by facilitating large-conductance Ca2+-activated K+ channel remodeling in hyperglycemia and diabetes mellitus. Circ Res (2013) 1.59
Trafficking of L-type calcium channels mediated by the postsynaptic scaffolding protein AKAP79. J Biol Chem (2002) 1.58
AKAP-Lbc mobilizes a cardiac hypertrophy signaling pathway. Mol Cell (2008) 1.57
Prolonged incubation and extensive subculturing do not increase recovery of clinically significant microorganisms from standard automated blood cultures. Clin Infect Dis (2005) 1.57
Increased coupled gating of L-type Ca2+ channels during hypertension and Timothy syndrome. Circ Res (2010) 1.55
Signaling complexes: junctions on the intracellular information super highway. Curr Biol (2002) 1.54
Integrating cardiac PIP3 and cAMP signaling through a PKA anchoring function of p110γ. Mol Cell (2011) 1.52
Delineation of type I protein kinase A-selective signaling events using an RI anchoring disruptor. J Biol Chem (2006) 1.48
Compartmentation of cyclic nucleotide signaling in the heart: the role of A-kinase anchoring proteins. Circ Res (2006) 1.48
PKA-phosphorylation of PDE4D3 facilitates recruitment of the mAKAP signalling complex. Biochem J (2004) 1.47
Full-length cardiac Na+/Ca2+ exchanger 1 protein is not phosphorylated by protein kinase A. Am J Physiol Cell Physiol (2011) 1.46
AKAP18 contains a phosphoesterase domain that binds AMP. J Mol Biol (2007) 1.31
Spatial restriction of PDK1 activation cascades by anchoring to mAKAPalpha. Mol Cell (2005) 1.29
AKAP79-mediated targeting of the cyclic AMP-dependent protein kinase to the beta1-adrenergic receptor promotes recycling and functional resensitization of the receptor. J Biol Chem (2006) 1.28
An entirely specific type I A-kinase anchoring protein that can sequester two molecules of protein kinase A at mitochondria. Proc Natl Acad Sci U S A (2011) 1.27
Kinase- and phosphatase-anchoring proteins: harnessing the dynamic duo. Nat Cell Biol (2002) 1.27
The A-kinase anchoring protein Yotiao binds and regulates adenylyl cyclase in brain. Proc Natl Acad Sci U S A (2008) 1.27
Association of an A-kinase-anchoring protein signaling scaffold with cadherin adhesion molecules in neurons and epithelial cells. Mol Biol Cell (2005) 1.24
A-kinase anchoring protein 79/150 facilitates the phosphorylation of GABA(A) receptors by cAMP-dependent protein kinase via selective interaction with receptor beta subunits. Mol Cell Neurosci (2003) 1.23
Architecture and dynamics of an A-kinase anchoring protein 79 (AKAP79) signaling complex. Proc Natl Acad Sci U S A (2011) 1.23
Orchestration of synaptic plasticity through AKAP signaling complexes. Neuropharmacology (2004) 1.20
AKAP79 interacts with multiple adenylyl cyclase (AC) isoforms and scaffolds AC5 and -6 to alpha-amino-3-hydroxyl-5-methyl-4-isoxazole-propionate (AMPA) receptors. J Biol Chem (2010) 1.19
Migratory songbirds disperse ticks across Canada, and first isolation of the Lyme disease spirochete, Borrelia burgdorferi, from the avian tick, Ixodes auritulus. J Parasitol (2005) 1.19
Rab32 modulates apoptosis onset and mitochondria-associated membrane (MAM) properties. J Biol Chem (2010) 1.19
mAKAP compartmentalizes oxygen-dependent control of HIF-1alpha. Sci Signal (2008) 1.16
Restoration of normal L-type Ca2+ channel function during Timothy syndrome by ablation of an anchoring protein. Circ Res (2011) 1.16
Intrinsic disorder within an AKAP-protein kinase A complex guides local substrate phosphorylation. Elife (2013) 1.15
E2~Ub conjugates regulate the kinase activity of Shigella effector OspG during pathogenesis. EMBO J (2014) 1.14
Local control of TRPV4 channels by AKAP150-targeted PKC in arterial smooth muscle. J Gen Physiol (2014) 1.10
Spatial distribution of protein kinase A activity during cell migration is mediated by A-kinase anchoring protein AKAP Lbc. J Biol Chem (2008) 1.08
Signal integration through blending, bolstering and bifurcating of intracellular information. Nat Struct Mol Biol (2010) 1.07
Intracellular targeting of protein kinases and phosphatases. Diabetes (2002) 1.06
Targeting of protein kinase A by muscle A kinase-anchoring protein (mAKAP) regulates phosphorylation and function of the skeletal muscle ryanodine receptor. J Biol Chem (2003) 1.05
AKAP2 anchors PKA with aquaporin-0 to support ocular lens transparency. EMBO Mol Med (2011) 1.05
High-affinity AKAP7delta-protein kinase A interaction yields novel protein kinase A-anchoring disruptor peptides. Biochem J (2006) 1.04
Coordinated signal integration at the M-type potassium channel upon muscarinic stimulation. EMBO J (2012) 1.02
Bariatric surgery is associated with a reduction in major macrovascular and microvascular complications in moderately to severely obese patients with type 2 diabetes mellitus. J Am Coll Surg (2013) 1.02
A-kinase anchoring proteins and neuronal signaling mechanisms. Genes Dev (2003) 1.01
The A-kinase-anchoring protein AKAP-Lbc facilitates cardioprotective PKA phosphorylation of Hsp20 on Ser(16). Biochem J (2012) 1.01
Induction of flexibility through protein-protein interactions. J Biol Chem (2003) 0.99
Dual specificity A-kinase anchoring proteins (AKAPs) contain an additional binding region that enhances targeting of protein kinase A type I. J Biol Chem (2008) 0.99
Anchored protein kinase A recruitment of active Rac GTPase. J Biol Chem (2011) 0.99
MyRIP anchors protein kinase A to the exocyst complex. J Biol Chem (2007) 0.98
Cardiomyocytes from AKAP7 knockout mice respond normally to adrenergic stimulation. Proc Natl Acad Sci U S A (2012) 0.98
Anchored phosphatases modulate glucose homeostasis. EMBO J (2012) 0.98
AKAP signaling complexes: pointing towards the next generation of therapeutic targets? Trends Pharmacol Sci (2013) 0.98
Characterization of A-kinase-anchoring disruptors using a solution-based assay. Biochem J (2006) 0.98
Patient acceptance of universal screening for hepatitis C virus infection. BMC Infect Dis (2011) 0.97
Clinical characterisation and molecular analysis of Wagner syndrome. Br J Ophthalmol (2006) 0.96
Gravin is a transitory effector of polo-like kinase 1 during cell division. Mol Cell (2012) 0.96
High efficiency of mutation detection in type 1 stickler syndrome using a two-stage approach: vitreoretinal assessment coupled with exon sequencing for screening COL2A1. Hum Mutat (2006) 0.94
Gravin orchestrates protein kinase A and β2-adrenergic receptor signaling critical for synaptic plasticity and memory. J Neurosci (2012) 0.94
CK2 phosphorylates SSRP1 and inhibits its DNA-binding activity. J Biol Chem (2005) 0.93
Alpha-dystrobrevin-1 recruits alpha-catulin to the alpha1D-adrenergic receptor/dystrophin-associated protein complex signalosome. Proc Natl Acad Sci U S A (2010) 0.93
A-kinase-anchoring proteins. J Cell Sci (2005) 0.93
Discovery of cellular substrates for protein kinase A using a peptide array screening protocol. Biochem J (2011) 0.93
Calcineurin anchoring and cell signaling. Biochem Biophys Res Commun (2003) 0.92
Engineering A-kinase anchoring protein (AKAP)-selective regulatory subunits of protein kinase A (PKA) through structure-based phage selection. J Biol Chem (2013) 0.92
Anchored cAMP signaling: onward and upward - a short history of compartmentalized cAMP signal transduction. Eur J Cell Biol (2006) 0.92
Cost-effectiveness of Bariatric Surgery: Increasing the Economic Viability of the Most Effective Treatment for Type II Diabetes Mellitus. Am Surg (2015) 0.91
Ezrin-anchored protein kinase A coordinates phosphorylation-dependent disassembly of a NHERF1 ternary complex to regulate hormone-sensitive phosphate transport. J Biol Chem (2012) 0.91
PKA phosphorylation of the small heat-shock protein Hsp20 enhances its cardioprotective effects. Biochem Soc Trans (2012) 0.90
Alternative splicing modifies the effect of mutations in COL11A1 and results in recessive type 2 Stickler syndrome with profound hearing loss. J Med Genet (2013) 0.90
Bariatric surgery is associated with a reduced risk of mortality in morbidly obese patients with a history of major cardiovascular events. Am Surg (2012) 0.89
Isoform-specific targeting of PKA to multivesicular bodies. J Cell Biol (2011) 0.89
Anchoring proteins as regulators of signaling pathways. Circ Res (2012) 0.89
AKAP220 protein organizes signaling elements that impact cell migration. J Biol Chem (2011) 0.89
Organizing signal transduction through A-kinase anchoring proteins (AKAPs). FEBS J (2010) 0.88
Local cAMP signaling in disease at a glance. J Cell Sci (2013) 0.87