Published in Synapse on March 01, 2002
The sodium iodide symporter (NIS) as an imaging reporter for gene, viral, and cell-based therapies. Curr Gene Ther (2012) 1.18
PET-based molecular imaging in neuroscience. Eur J Nucl Med Mol Imaging (2003) 0.95
Aging of the striatum: mechanisms and interventions. Age (Dordr) (2008) 0.93
Nonneurotropic adenovirus: a vector for gene transfer to the brain and gene therapy of neurological disorders. Int Rev Neurobiol (2003) 0.79
Resveratrol improves health and survival of mice on a high-calorie diet. Nature (2006) 20.91
Resveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending life span. Cell Metab (2008) 6.22
Impact of caloric restriction on health and survival in rhesus monkeys from the NIA study. Nature (2012) 5.00
Mitochondrial genome variation in eastern Asia and the peopling of Japan. Genome Res (2004) 3.34
AGEMAP: a gene expression database for aging in mice. PLoS Genet (2007) 3.22
Laparoscopic radical nephroureterectomy: a multicenter analysis in Japan. Eur Urol (2009) 2.97
Genome-wide association study identifies five new susceptibility loci for prostate cancer in the Japanese population. Nat Genet (2010) 2.92
Intermittent fasting dissociates beneficial effects of dietary restriction on glucose metabolism and neuronal resistance to injury from calorie intake. Proc Natl Acad Sci U S A (2003) 2.82
Calorie restriction mimetics: an emerging research field. Aging Cell (2006) 2.82
Plasma adiponectin plays an important role in improving insulin resistance with glimepiride in elderly type 2 diabetic subjects. Diabetes Care (2003) 2.71
Metformin improves healthspan and lifespan in mice. Nat Commun (2013) 2.68
Physical finding of nutcracker phenomenon. Kidney Int (2013) 2.60
Mechanisms underlying the impairment of ischemia-induced neovascularization in matrix metalloproteinase 2-deficient mice. Circ Res (2007) 2.57
Dietary deprivation extends lifespan in Caenorhabditis elegans. Aging Cell (2006) 2.54
Calorie restriction in rhesus monkeys. Exp Gerontol (2003) 2.52
A simple method of plaque rupture induction in apolipoprotein E-deficient mice. Arterioscler Thromb Vasc Biol (2006) 2.38
Aging in rhesus monkeys: relevance to human health interventions. Science (2004) 2.37
Biomarkers of caloric restriction may predict longevity in humans. Science (2002) 2.32
Salt-sensitive hypertension in circadian clock-deficient Cry-null mice involves dysregulated adrenal Hsd3b6. Nat Med (2009) 2.30
Antiandrogen bicalutamide promotes tumor growth in a novel androgen-dependent prostate cancer xenograft model derived from a bicalutamide-treated patient. Cancer Res (2005) 2.29
Cortical organization by the septin cytoskeleton is essential for structural and mechanical integrity of mammalian spermatozoa. Dev Cell (2005) 2.21
A controlled trial of reduced meal frequency without caloric restriction in healthy, normal-weight, middle-aged adults. Am J Clin Nutr (2007) 2.16
Substrate specificity of MATE1 and MATE2-K, human multidrug and toxin extrusions/H(+)-organic cation antiporters. Biochem Pharmacol (2007) 2.05
Delay of T cell senescence by caloric restriction in aged long-lived nonhuman primates. Proc Natl Acad Sci U S A (2006) 2.03
Elastolytic cathepsin induction/activation system exists in myocardium and is upregulated in hypertensive heart failure. Hypertension (2006) 2.03
Blueberry polyphenols increase lifespan and thermotolerance in Caenorhabditis elegans. Aging Cell (2006) 2.01
Transient improvement in cognitive function and synaptic plasticity in rats following cancer chemotherapy. Clin Cancer Res (2006) 1.97
Nrf2 mediates cancer protection but not prolongevity induced by caloric restriction. Proc Natl Acad Sci U S A (2008) 1.97
Radiation exposure and risk-benefit analysis in cancer screening using FDG-PET: results of a Japanese nationwide survey. Ann Nucl Med (2011) 1.95
Efficacy of nondrug lifestyle measures for the treatment of nocturia. J Urol (2010) 1.94
Development of calorie restriction mimetics as a prolongevity strategy. Ann N Y Acad Sci (2004) 1.92
Caloric restriction increases neurotrophic factor levels and attenuates neurochemical and behavioral deficits in a primate model of Parkinson's disease. Proc Natl Acad Sci U S A (2004) 1.86
Gene expression levels and immunolocalization of organic ion transporters in the human kidney. J Am Soc Nephrol (2002) 1.85
Cognitive impairment following high fat diet consumption is associated with brain inflammation. J Neuroimmunol (2009) 1.82
Effects of high fat diet on Morris maze performance, oxidative stress, and inflammation in rats: contributions of maternal diet. Neurobiol Dis (2009) 1.80
Identification and functional characterization of a new human kidney-specific H+/organic cation antiporter, kidney-specific multidrug and toxin extrusion 2. J Am Soc Nephrol (2006) 1.80
Involvement of Notch signaling in hippocampal synaptic plasticity. Proc Natl Acad Sci U S A (2004) 1.77
XIST unmethylated DNA fragments in male-derived plasma as a tumour marker for testicular cancer. Lancet (2004) 1.76
Involvement of urinary bladder Connexin43 and the circadian clock in coordination of diurnal micturition rhythm. Nat Commun (2012) 1.74
Aortic wall inflammation due to Takayasu arteritis imaged with 18F-FDG PET coregistered with enhanced CT. J Nucl Med (2005) 1.70
Impact of IGF-I and CYP19 gene polymorphisms on the survival of patients with metastatic prostate cancer. J Clin Oncol (2006) 1.68
Age and gender effects on microglia and astrocyte numbers in brains of mice. Brain Res (2002) 1.67
Outcome of different post-orchiectomy management for stage I seminoma: Japanese multi-institutional study including 425 patients. Int J Urol (2010) 1.65
Circulating adiponectin levels increase in rats on caloric restriction: the potential for insulin sensitization. Exp Gerontol (2004) 1.64
Selective butyrylcholinesterase inhibition elevates brain acetylcholine, augments learning and lowers Alzheimer beta-amyloid peptide in rodent. Proc Natl Acad Sci U S A (2005) 1.61
Effects of long-term diet restriction on aging and longevity in primates remain uncertain. J Gerontol A Biol Sci Med Sci (2004) 1.60
Common variants at 11q12, 10q26 and 3p11.2 are associated with prostate cancer susceptibility in Japanese. Nat Genet (2012) 1.59
Age-associated learning and memory deficits in two mouse versions of the Stone T-maze. Neurobiol Aging (2012) 1.55
Laparoscopic partial nephrectomy using microwave tissue coagulator for small renal tumors: usefulness and complications. Eur Urol (2004) 1.55
Regional differences in blood flow and oxygen consumption in resting muscle and their relationship during recovery from exhaustive exercise. J Appl Physiol (1985) (2003) 1.53
Validation of cardiac (123)I-MIBG scintigraphy in patients with Parkinson's disease who were diagnosed with dopamine PET. Eur J Nucl Med Mol Imaging (2010) 1.51
Clinical impact of (11)C-methionine PET on expected management of patients with brain neoplasm. Eur J Nucl Med Mol Imaging (2009) 1.50
Involvement of vertebrate polkappa in Rad18-independent postreplication repair of UV damage. J Biol Chem (2002) 1.48
Usefulness of soluble dietary fiber for the treatment of diarrhea during enteral nutrition in elderly patients. Nutrition (2002) 1.48
Regulation of connexin 43 by basic fibroblast growth factor in the bladder: transcriptional and behavioral implications. J Urol (2011) 1.48
Sigma receptor ligands: possible application as therapeutic drugs and as radiopharmaceuticals. Curr Pharm Des (2006) 1.48
Impact of age and caloric restriction on neurogenesis in the dentate gyrus of C57BL/6 mice. Neurobiol Aging (2004) 1.46
Canonical Nlrp3 inflammasome links systemic low-grade inflammation to functional decline in aging. Cell Metab (2013) 1.45
Lack of correlation between total lymphocyte count and nutritional status in the elderly. Clin Nutr (2005) 1.44
Effects of caloric restriction on inflammatory periodontal disease. Nutrition (2008) 1.43
High fat diet increases hippocampal oxidative stress and cognitive impairment in aged mice: implications for decreased Nrf2 signaling. J Neurochem (2010) 1.43
¹¹C-PiB PET imaging of encephalopathy associated with cerebral amyloid angiopathy. Intern Med (2014) 1.41
Objective patterning of uroflowmetry curves in children with daytime and nighttime wetting. J Urol (2010) 1.41
Common physical and functional changes associated with aging in dogs. J Am Vet Med Assoc (2015) 1.40
Defining healthy aging in older dogs and differentiating healthy aging from disease. J Am Vet Med Assoc (2015) 1.40
A polymorphism of the POLG2 gene is genetically associated with the invasiveness of urinary bladder cancer in Japanese males. J Hum Genet (2011) 1.39
Effect of age and caloric restriction on circadian adrenal steroid rhythms in rhesus macaques. Neurobiol Aging (2007) 1.39
Database of normal human cerebral blood flow, cerebral blood volume, cerebral oxygen extraction fraction and cerebral metabolic rate of oxygen measured by positron emission tomography with 15O-labelled carbon dioxide or water, carbon monoxide and oxygen: a multicentre study in Japan. Eur J Nucl Med Mol Imaging (2004) 1.36
Extraction of a plasma time-activity curve from dynamic brain PET images based on independent component analysis. IEEE Trans Biomed Eng (2005) 1.36
Deficiency of gelatinase a suppresses smooth muscle cell invasion and development of experimental intimal hyperplasia. Circulation (2003) 1.35
Effect of MMP-2 deficiency on atherosclerotic lesion formation in apoE-deficient mice. Arterioscler Thromb Vasc Biol (2006) 1.35
Current status of endocrine therapy for prostate cancer in Japan analysis of primary androgen deprivation therapy on the basis of data collected by J-CaP. Jpn J Clin Oncol (2007) 1.34
High occupancy of sigma-1 receptors in the human brain after single oral administration of fluvoxamine: a positron emission tomography study using [11C]SA4503. Biol Psychiatry (2007) 1.33
Eicosapentaenoic acid reduces the progression of carotid intima-media thickness in patients with type 2 diabetes. Atherosclerosis (2006) 1.31
Caloric restriction and aging in primates: Relevance to humans and possible CR mimetics. Microsc Res Tech (2002) 1.30
Expanding the clinical phenotype of SNCA duplication carriers. Mov Disord (2009) 1.25
Annular geometry in patients with chronic ischemic mitral regurgitation: three-dimensional magnetic resonance imaging study. Circulation (2005) 1.25
Statin prevents plaque disruption in apoE-knockout mouse model through pleiotropic effect on acute inflammation. Atherosclerosis (2009) 1.24
PET tracers for imaging of the dopaminergic system. Curr Med Chem (2006) 1.24
Discrepancy between local and central pathological review of radical prostatectomy specimens. J Urol (2010) 1.24
DRD2 gene transfer into the nucleus accumbens core of the alcohol preferring and nonpreferring rats attenuates alcohol drinking. Alcohol Clin Exp Res (2004) 1.23
Characteristics of patients with prostate cancer who have initially been treated by hormone therapy in Japan: J-CaP surveillance. Jpn J Clin Oncol (2004) 1.22
Metformin supplementation and life span in Fischer-344 rats. J Gerontol A Biol Sci Med Sci (2010) 1.21
The clock drawing test as a valid screening method for mild cognitive impairment. Dement Geriatr Cogn Disord (2004) 1.20
Microarray-based identification of CUB-domain containing protein 1 as a potential prognostic marker in conventional renal cell carcinoma. J Cancer Res Clin Oncol (2008) 1.19