Blueberry polyphenols increase lifespan and thermotolerance in Caenorhabditis elegans.

PubWeight™: 2.01‹?› | Rank: Top 2%

🔗 View Article (PMC 1413581)

Published in Aging Cell on February 01, 2006

Authors

Mark A Wilson1, Barbara Shukitt-Hale, Wilhelmina Kalt, Donald K Ingram, James A Joseph, Catherine A Wolkow

Author Affiliations

1: Laboratory of Neurosciences, National Institute on Aging, Intramural Research Program, Baltimore, MD 21224, USA.

Articles citing this

Dietary deprivation extends lifespan in Caenorhabditis elegans. Aging Cell (2006) 2.54

Dynamic O-GlcNAc cycling at promoters of Caenorhabditis elegans genes regulating longevity, stress, and immunity. Proc Natl Acad Sci U S A (2010) 1.86

Hormetic dietary phytochemicals. Neuromolecular Med (2008) 1.21

Açai palm fruit (Euterpe oleracea Mart.) pulp improves survival of flies on a high fat diet. Exp Gerontol (2010) 1.15

A cytoprotective perspective on longevity regulation. Trends Cell Biol (2013) 1.15

Comparative approaches to facilitate the discovery of prolongevity interventions: effects of tocopherols on lifespan of three invertebrate species. Mech Ageing Dev (2006) 1.06

Icariin and its derivative icariside II extend healthspan via insulin/IGF-1 pathway in C. elegans. PLoS One (2011) 1.06

Measuring Caenorhabditis elegans life span in 96 well microtiter plates. J Vis Exp (2011) 1.06

Altered bacterial metabolism, not coenzyme Q content, is responsible for the lifespan extension in Caenorhabditis elegans fed an Escherichia coli diet lacking coenzyme Q. Aging Cell (2008) 1.06

Proanthocyanidin from blueberry leaves suppresses expression of subgenomic hepatitis C virus RNA. J Biol Chem (2009) 1.04

A pharmacological network for lifespan extension in Caenorhabditis elegans. Aging Cell (2013) 1.04

Antidepressants of the serotonin-antagonist type increase body fat and decrease lifespan of adult Caenorhabditis elegans. PLoS One (2008) 1.03

Genetic dissection of late-life fertility in Caenorhabditis elegans. J Gerontol A Biol Sci Med Sci (2011) 1.01

The longevity effect of cranberry extract in Caenorhabditis elegans is modulated by daf-16 and osr-1. Age (Dordr) (2012) 1.00

Xenohormetic and anti-aging activity of secoiridoid polyphenols present in extra virgin olive oil: a new family of gerosuppressant agents. Cell Cycle (2013) 1.00

Compounds that confer thermal stress resistance and extended lifespan. Exp Gerontol (2008) 0.98

Lifespan-extending effects of royal jelly and its related substances on the nematode Caenorhabditis elegans. PLoS One (2011) 0.97

Prolongevity effects of an oregano and cranberry extract are diet dependent in the Mexican fruit fly (Anastrepha ludens). J Gerontol A Biol Sci Med Sci (2009) 0.96

Nectarine promotes longevity in Drosophila melanogaster. Free Radic Biol Med (2011) 0.96

Cinnamomum cassia bark in two herbal formulas increases life span in Caenorhabditis elegans via insulin signaling and stress response pathways. PLoS One (2010) 0.95

Myricetin-mediated lifespan extension in Caenorhabditis elegans is modulated by DAF-16. Int J Mol Sci (2013) 0.94

Pharmacological lifespan extension of invertebrates. Ageing Res Rev (2012) 0.93

Biology of ageing and role of dietary antioxidants. Biomed Res Int (2014) 0.93

Nutraceutical interventions for promoting healthy aging in invertebrate models. Oxid Med Cell Longev (2012) 0.90

The biological responses to resveratrol and other polyphenols from alcoholic beverages. Alcohol Clin Exp Res (2009) 0.90

Drug absorption efficiency in Caenorhbditis elegans delivered by different methods. PLoS One (2013) 0.90

The anticonvulsant ethosuximide disrupts sensory function to extend C. elegans lifespan. PLoS Genet (2008) 0.90

Meta-Analysis of Global Transcriptomics Suggests that Conserved Genetic Pathways are Responsible for Quercetin and Tannic Acid Mediated Longevity in C. elegans. Front Genet (2012) 0.88

Dietary antiaging phytochemicals and mechanisms associated with prolonged survival. J Nutr Biochem (2014) 0.88

Adaptive cellular stress pathways as therapeutic targets of dietary phytochemicals: focus on the nervous system. Pharmacol Rev (2014) 0.87

Methoxylation enhances stilbene bioactivity in Caenorhabditis elegans. BMC Pharmacol (2008) 0.87

Prolongevity effects of a botanical with oregano and cranberry extracts in Mexican fruit flies: examining interactions of diet restriction and age. Age (Dordr) (2011) 0.87

Allyl isothiocyanate that induces GST and UGT expression confers oxidative stress resistance on C. elegans, as demonstrated by nematode biosensor. PLoS One (2010) 0.87

Cranberry interacts with dietary macronutrients to promote healthy aging in Drosophila. J Gerontol A Biol Sci Med Sci (2013) 0.87

Curcumin and neurodegenerative diseases. Biofactors (2013) 0.86

Nutraceuticals for geriatrics. J Tradit Complement Med (2014) 0.85

The Nematode Caenorhabditis elegans, Stress and Aging: Identifying the Complex Interplay of Genetic Pathways Following the Treatment with Humic Substances. Front Genet (2012) 0.83

Extension of lifespan and protection against oxidative stress by an antioxidant herb mixture complex (KPG-7) in Caenorhabditis elegans. J Clin Biochem Nutr (2013) 0.83

Pharmacological classes that extend lifespan of Caenorhabditis elegans. Front Genet (2015) 0.81

Whole apple extracts increase lifespan, healthspan and resistance to stress in Caenorhabditis elegans. J Funct Foods (2013) 0.81

Using Caenorhabditis elegans as a model organism for evaluating extracellular signal-regulated kinase docking domain inhibitors. J Cell Commun Signal (2008) 0.81

Supplement timing of cranberry extract plays a key role in promoting Caenorhabditis elegans healthspan. Nutrients (2014) 0.79

Down regulation effect of Rosmarinus officinalis polyphenols on cellular stress proteins in rat pheochromocytoma PC12 cells. Cytotechnology (2011) 0.79

Lifespan extension and increased resistance to environmental stressors by N-acetyl-L-cysteine in Caenorhabditis elegans. Clinics (Sao Paulo) (2015) 0.79

Pharmacological maintenance of protein homeostasis could postpone age-related disease. Aging Cell (2012) 0.79

Apple Procyanidins Suppress Amyloid β-Protein Aggregation. Biochem Res Int (2011) 0.79

Bisdemethoxycurcumin Increases Sirt1 to Antagonize t-BHP-Induced Premature Senescence in WI38 Fibroblast Cells. Evid Based Complement Alternat Med (2013) 0.78

Antioxidant capacity of "Mexican arnica" Heterotheca inuloides Cass natural products and some derivatives: their anti-inflammatory evaluation and effect on C. elegans life span. Oxid Med Cell Longev (2015) 0.78

Potentiation of dietary restriction-induced lifespan extension by polyphenols. Biochim Biophys Acta (2012) 0.78

The Lifespan-Promoting Effect of Otophylloside B in Caenorhabditis elegans. Nat Prod Bioprospect (2015) 0.78

Life span effects of Hypericum perforatum extracts on Caenorhabditis elegans under heat stress. Pharmacogn Mag (2012) 0.78

Angiotensin Converting Enzyme (ACE) Inhibitor Extends Caenorhabditis elegans Life Span. PLoS Genet (2016) 0.78

Mulberry leaf polyphenols delay aging and regulate fat metabolism via the germline signaling pathway in Caenorhabditis elegans. Age (Dordr) (2014) 0.78

Caffeic acid phenethylester increases stress resistance and enhances lifespan in Caenorhabditis elegans by modulation of the insulin-like DAF-16 signalling pathway. PLoS One (2014) 0.77

Green Tea Extract Induces the Resistance of Caenorhabditis elegans against Oxidative Stress. Antioxidants (Basel) (2014) 0.77

Açaí (Euterpe oleracea Mart.) modulates oxidative stress resistance in Caenorhabditis elegans by direct and indirect mechanisms. PLoS One (2014) 0.77

Role of CYP eicosanoids in the regulation of pharyngeal pumping and food uptake in Caenorhabditis elegans. J Lipid Res (2015) 0.77

Anti-aging effect of polysaccharide from Bletilla striata on nematode Caenorhabditis elegans. Pharmacogn Mag (2015) 0.76

Ambient temperature reduction extends lifespan via activating cellular degradation activity in an annual fish (Nothobranchius rachovii). Age (Dordr) (2015) 0.76

Geroscience approaches to increase healthspan and slow aging. F1000Res (2016) 0.76

Monascus-fermented dioscorea enhances oxidative stress resistance via DAF-16/FOXO in Caenorhabditis elegans. PLoS One (2012) 0.76

Withania somnifera root extract extends lifespan of Caenorhabditis elegans. Ann Neurosci (2013) 0.75

The odor of a plant metabolite affects life history traits in dietary restricted adult olive flies. Sci Rep (2016) 0.75

Formation of phosphoglycosides in Caenorhabditis elegans: a novel biotransformation pathway. PLoS One (2012) 0.75

Mechanosensory Neuron Aging: Differential Trajectories with Lifespan-Extending Alaskan Berry and Fungal Treatments in Caenorhabditis elegans. Front Aging Neurosci (2016) 0.75

Natural Marine and Synthetic Xenobiotics Get on Nematode's Nerves: Neuro-Stimulating and Neurotoxic Findings in Caenorhabditis elegans. Mar Drugs (2015) 0.75

Bacopa monnieri promotes longevity in Caenorhabditis elegans under stress conditions. Pharmacogn Mag (2015) 0.75

Healthspan Pharmacology. Rejuvenation Res (2015) 0.75

Can consumption of antioxidant rich mushrooms extend longevity?: antioxidant activity of Pleurotus spp. and its effects on Mexican fruit flies' (Anastrepha ludens) longevity. Age (Dordr) (2015) 0.75

A steroid like phytochemical Antcin M is an anti-aging reagent that eliminates hyperglycemia-accelerated premature senescence in dermal fibroblasts by direct activation of Nrf2 and SIRT-1. Oncotarget (2016) 0.75

Caenorhabditis elegans as model system in pharmacology and toxicology: effects of flavonoids on redox-sensitive signalling pathways and ageing. ScientificWorldJournal (2014) 0.75

Life Span and Motility Effects of Ethanolic Extracts from Sophora moorcroftiana Seeds on Caenorhabditis elegans. Pharmacogn Mag (2016) 0.75

Ilex paraguariensis Extract Increases Lifespan and Protects Against the Toxic Effects Caused by Paraquat in Caenorhabditis elegans. Int J Environ Res Public Health (2014) 0.75

Isolation, structure determination, and antiaging effects of 2,3-pentanediol from endophytic fungus of Curcuma amada and docking studies. Protoplasma (2014) 0.75

Phycoerythrin averts intracellular ROS generation and physiological functional decline in eukaryotes under oxidative stress. Protoplasma (2016) 0.75

Gene expression profiling to investigate tyrosol-induced lifespan extension in Caenorhabditis elegans. Eur J Nutr (2015) 0.75

Aspirin increases metabolism through germline signalling to extend the lifespan of Caenorhabditis elegans. PLoS One (2017) 0.75

Longevity effect of a polysaccharide from Chlorophytum borivilianum on Caenorhabditis elegans and Saccharomyces cerevisiae. PLoS One (2017) 0.75

Articles cited by this

The genetics of Caenorhabditis elegans. Genetics (1974) 102.14

Oxidants, oxidative stress and the biology of ageing. Nature (2000) 23.21

A C. elegans mutant that lives twice as long as wild type. Nature (1993) 20.42

Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans. Nature (2003) 14.49

Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans. Nature (2001) 14.44

Sirtuin activators mimic caloric restriction and delay ageing in metazoans. Nature (2004) 10.36

Regulation of aging and age-related disease by DAF-16 and heat-shock factor. Science (2003) 8.43

Stochastic and genetic factors influence tissue-specific decline in ageing C. elegans. Nature (2002) 8.35

Genetic pathways that regulate ageing in model organisms. Nature (2000) 8.19

The genetics of caloric restriction in Caenorhabditis elegans. Proc Natl Acad Sci U S A (1998) 7.21

A conserved p38 MAP kinase pathway in Caenorhabditis elegans innate immunity. Science (2002) 5.97

Genetic analysis of tissue aging in Caenorhabditis elegans: a role for heat-shock factor and bacterial proliferation. Genetics (2002) 5.52

Two pleiotropic classes of daf-2 mutation affect larval arrest, adult behavior, reproduction and longevity in Caenorhabditis elegans. Genetics (1998) 5.37

Thermotolerance and extended life-span conferred by single-gene mutations and induced by thermal stress. Proc Natl Acad Sci U S A (1995) 5.18

DAF-16 target genes that control C. elegans life-span and metabolism. Science (2003) 4.57

Biosynthesis of flavonoids and effects of stress. Curr Opin Plant Biol (2002) 4.45

Health benefits of fruit and vegetables are from additive and synergistic combinations of phytochemicals. Am J Clin Nutr (2003) 4.15

A mutation in succinate dehydrogenase cytochrome b causes oxidative stress and ageing in nematodes. Nature (1998) 4.06

Aging and resistance to oxidative damage in Caenorhabditis elegans. Proc Natl Acad Sci U S A (1993) 3.97

SKN-1 links C. elegans mesendodermal specification to a conserved oxidative stress response. Genes Dev (2003) 3.92

Lipofuscin: mechanisms of age-related accumulation and influence on cell function. Free Radic Biol Med (2002) 3.09

Transcriptional profile of aging in C. elegans. Curr Biol (2002) 3.02

Measurements of age-related changes of physiological processes that predict lifespan of Caenorhabditis elegans. Proc Natl Acad Sci U S A (2004) 2.84

Genetic, behavioral and environmental determinants of male longevity in Caenorhabditis elegans. Genetics (2000) 2.41

Reversals of age-related declines in neuronal signal transduction, cognitive, and motor behavioral deficits with blueberry, spinach, or strawberry dietary supplementation. J Neurosci (1999) 2.41

Serotonin-deficient mutants and male mating behavior in the nematode Caenorhabditis elegans. J Neurosci (1993) 2.03

A defect in the cytochrome b large subunit in complex II causes both superoxide anion overproduction and abnormal energy metabolism in Caenorhabditis elegans. J Biol Chem (2001) 1.84

Microarray analysis of gene expression with age in individual nematodes. Aging Cell (2004) 1.50

Oxygen radical absorbing capacity of phenolics in blueberries, cranberries, chokeberries, and lingonberries. J Agric Food Chem (2003) 1.49

Caenorhabditis elegans OSR-1 regulates behavioral and physiological responses to hyperosmotic environments. Genetics (2004) 1.49

Quantitative measures of aging in the nematode Caenorhabditis elegans. I. Population and longitudinal studies of two behavioral parameters. Mech Ageing Dev (1981) 1.45

Positive selection of Caenorhabditis elegans mutants with increased stress resistance and longevity. Genetics (2003) 1.37

Behavioral deficits during early stages of aging in Caenorhabditis elegans result from locomotory deficits possibly linked to muscle frailty. J Gerontol A Biol Sci Med Sci (2004) 1.35

Reversing the deleterious effects of aging on neuronal communication and behavior: beneficial properties of fruit polyphenolic compounds. Am J Clin Nutr (2005) 1.32

Ginkgo biloba extract EGb 761 increases stress resistance and extends life span of Caenorhabditis elegans. Cell Mol Biol (Noisy-le-grand) (2002) 1.28

Lifespan and stress resistance of Caenorhabditis elegans are increased by expression of glutathione transferases capable of metabolizing the lipid peroxidation product 4-hydroxynonenal. Aging Cell (2005) 1.23

Rapid accumulation of fluorescent material with aging in an oxygen-sensitive mutant mev-1 of Caenorhabditis elegans. Mech Ageing Dev (1994) 1.22

Effects of tocotrienols on life span and protein carbonylation in Caenorhabditis elegans. J Gerontol A Biol Sci Med Sci (2000) 1.20

The p38 signal transduction pathway participates in the oxidative stress-mediated translocation of DAF-16 to Caenorhabditis elegans nuclei. Mech Ageing Dev (2005) 1.18

Polyphenolics enhance red blood cell resistance to oxidative stress: in vitro and in vivo. Biochim Biophys Acta (2000) 1.16

Effect of vitamin E on lifespan and reproduction in Caenorhabditis elegans. Mech Ageing Dev (1988) 1.10

Metabolism of 4-hydroxy-2-nonenal and aging. Biochem Biophys Res Commun (1995) 0.81

Articles by these authors

Resveratrol improves health and survival of mice on a high-calorie diet. Nature (2006) 20.91

Resveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending life span. Cell Metab (2008) 6.22

Impact of caloric restriction on health and survival in rhesus monkeys from the NIA study. Nature (2012) 5.00

AGEMAP: a gene expression database for aging in mice. PLoS Genet (2007) 3.22

Intermittent fasting dissociates beneficial effects of dietary restriction on glucose metabolism and neuronal resistance to injury from calorie intake. Proc Natl Acad Sci U S A (2003) 2.82

Metformin improves healthspan and lifespan in mice. Nat Commun (2013) 2.68

Dietary deprivation extends lifespan in Caenorhabditis elegans. Aging Cell (2006) 2.54

Calorie restriction in rhesus monkeys. Exp Gerontol (2003) 2.52

Aging in rhesus monkeys: relevance to human health interventions. Science (2004) 2.37

Biomarkers of caloric restriction may predict longevity in humans. Science (2002) 2.32

A controlled trial of reduced meal frequency without caloric restriction in healthy, normal-weight, middle-aged adults. Am J Clin Nutr (2007) 2.16

Delay of T cell senescence by caloric restriction in aged long-lived nonhuman primates. Proc Natl Acad Sci U S A (2006) 2.03

Transient improvement in cognitive function and synaptic plasticity in rats following cancer chemotherapy. Clin Cancer Res (2006) 1.97

Nrf2 mediates cancer protection but not prolongevity induced by caloric restriction. Proc Natl Acad Sci U S A (2008) 1.97

Caloric restriction increases neurotrophic factor levels and attenuates neurochemical and behavioral deficits in a primate model of Parkinson's disease. Proc Natl Acad Sci U S A (2004) 1.86

Dynamic O-GlcNAc cycling at promoters of Caenorhabditis elegans genes regulating longevity, stress, and immunity. Proc Natl Acad Sci U S A (2010) 1.86

Cognitive impairment following high fat diet consumption is associated with brain inflammation. J Neuroimmunol (2009) 1.82

Effects of high fat diet on Morris maze performance, oxidative stress, and inflammation in rats: contributions of maternal diet. Neurobiol Dis (2009) 1.80

Involvement of Notch signaling in hippocampal synaptic plasticity. Proc Natl Acad Sci U S A (2004) 1.77

Effects of caffeine, sleep loss, and stress on cognitive performance and mood during U.S. Navy SEAL training. Sea-Air-Land. Psychopharmacology (Berl) (2002) 1.73

Age and gender effects on microglia and astrocyte numbers in brains of mice. Brain Res (2002) 1.67

Circulating adiponectin levels increase in rats on caloric restriction: the potential for insulin sensitization. Exp Gerontol (2004) 1.64

Selective butyrylcholinesterase inhibition elevates brain acetylcholine, augments learning and lowers Alzheimer beta-amyloid peptide in rodent. Proc Natl Acad Sci U S A (2005) 1.61

Effects of long-term diet restriction on aging and longevity in primates remain uncertain. J Gerontol A Biol Sci Med Sci (2004) 1.60

Age-associated learning and memory deficits in two mouse versions of the Stone T-maze. Neurobiol Aging (2012) 1.55

Resveratrol, pterostilbene, and piceatannol in vaccinium berries. J Agric Food Chem (2004) 1.50

Impact of age and caloric restriction on neurogenesis in the dentate gyrus of C57BL/6 mice. Neurobiol Aging (2004) 1.46

Canonical Nlrp3 inflammasome links systemic low-grade inflammation to functional decline in aging. Cell Metab (2013) 1.45

Anthocyanins in aged blueberry-fed rats are found centrally and may enhance memory. Nutr Neurosci (2005) 1.45

High fat diet increases hippocampal oxidative stress and cognitive impairment in aged mice: implications for decreased Nrf2 signaling. J Neurochem (2010) 1.43

Effects of caloric restriction on inflammatory periodontal disease. Nutrition (2008) 1.43

BHT blocks NF-kappaB activation and ethanol-induced brain damage. Alcohol Clin Exp Res (2006) 1.42

Common physical and functional changes associated with aging in dogs. J Am Vet Med Assoc (2015) 1.40

Defining healthy aging in older dogs and differentiating healthy aging from disease. J Am Vet Med Assoc (2015) 1.40

Effect of age and caloric restriction on circadian adrenal steroid rhythms in rhesus macaques. Neurobiol Aging (2007) 1.39

B-vitamin deficiency causes hyperhomocysteinemia and vascular cognitive impairment in mice. Proc Natl Acad Sci U S A (2008) 1.37

Behavioral deficits during early stages of aging in Caenorhabditis elegans result from locomotory deficits possibly linked to muscle frailty. J Gerontol A Biol Sci Med Sci (2004) 1.35

Reversing the deleterious effects of aging on neuronal communication and behavior: beneficial properties of fruit polyphenolic compounds. Am J Clin Nutr (2005) 1.32

Blueberry supplementation improves memory in older adults. J Agric Food Chem (2010) 1.30

Caloric restriction and aging in primates: Relevance to humans and possible CR mimetics. Microsc Res Tech (2002) 1.30

Sarcopenia in the Caenorhabditis elegans pharynx correlates with muscle contraction rate over lifespan. Exp Gerontol (2006) 1.29

The beneficial effects of fruit polyphenols on brain aging. Neurobiol Aging (2005) 1.27

Quantitative image analysis reveals distinct structural transitions during aging in Caenorhabditis elegans tissues. PLoS One (2008) 1.24

DRD2 gene transfer into the nucleus accumbens core of the alcohol preferring and nonpreferring rats attenuates alcohol drinking. Alcohol Clin Exp Res (2004) 1.23

Grape juice, berries, and walnuts affect brain aging and behavior. J Nutr (2009) 1.22

Effects of Concord grape juice on cognitive and motor deficits in aging. Nutrition (2006) 1.22

Metformin supplementation and life span in Fischer-344 rats. J Gerontol A Biol Sci Med Sci (2010) 1.21

Amyloid-beta and tau serve antioxidant functions in the aging and Alzheimer brain. Free Radic Biol Med (2002) 1.17

Concord grape juice supplementation improves memory function in older adults with mild cognitive impairment. Br J Nutr (2009) 1.17

Modulation of hippocampal plasticity and cognitive behavior by short-term blueberry supplementation in aged rats. Nutr Neurosci (2005) 1.17

Inhibitory effects of blueberry extract on the production of inflammatory mediators in lipopolysaccharide-activated BV2 microglia. J Neurosci Res (2007) 1.16

Ovarian aging and menopause: current theories, hypotheses, and research models. Exp Biol Med (Maywood) (2005) 1.14

Quantitative measurement of aging using image texture entropy. Bioinformatics (2009) 1.13

Impact of reduced meal frequency without caloric restriction on glucose regulation in healthy, normal-weight middle-aged men and women. Metabolism (2007) 1.13

Dietary restriction in aging nonhuman primates. Interdiscip Top Gerontol (2007) 1.12

Berry fruit supplementation and the aging brain. J Agric Food Chem (2008) 1.12

Fruit polyphenolics and brain aging: nutritional interventions targeting age-related neuronal and behavioral deficits. Ann N Y Acad Sci (2002) 1.11

Insulin signaling in Caenorhabditis elegans regulates both endocrine-like and cell-autonomous outputs. Dev Biol (2006) 1.11

Catecholaminergic neuronal loss in locus coeruleus of aged female dtg APP/PS1 mice. J Chem Neuroanat (2007) 1.11

Milk fat globule protein epidermal growth factor-8: a pivotal relay element within the angiotensin II and monocyte chemoattractant protein-1 signaling cascade mediating vascular smooth muscle cells invasion. Circ Res (2009) 1.10

Age-related decline in caloric intake and motivation for food in rhesus monkeys. Neurobiol Aging (2004) 1.10

Optimal window of caloric restriction onset limits its beneficial impact on T-cell senescence in primates. Aging Cell (2008) 1.09

A blueberry-enriched diet provides cellular protection against oxidative stress and reduces a kainate-induced learning impairment in rats. Neurobiol Aging (2007) 1.08

Adipogenic signaling in rat white adipose tissue: modulation by aging and calorie restriction. Exp Gerontol (2007) 1.07

Comparative approaches to facilitate the discovery of prolongevity interventions: effects of tocopherols on lifespan of three invertebrate species. Mech Ageing Dev (2006) 1.06

Caloric restriction attenuates amyloid deposition in middle-aged dtg APP/PS1 mice. Neurosci Lett (2009) 1.05

Xenobiotic metabolism and berry flavonoid transport across the blood-brain barrier. J Agric Food Chem (2010) 1.04

Chronic ingestion of 2-deoxy-D-glucose induces cardiac vacuolization and increases mortality in rats. Toxicol Appl Pharmacol (2009) 1.03

Studies of Caenorhabditis elegans DAF-2/insulin signaling reveal targets for pharmacological manipulation of lifespan. Aging Cell (2006) 1.02

Regulation of Caenorhabditis elegans vitellogenesis by DAF-2/IIS through separable transcriptional and posttranscriptional mechanisms. BMC Physiol (2011) 1.02

Blueberry polyphenols attenuate kainic acid-induced decrements in cognition and alter inflammatory gene expression in rat hippocampus. Nutr Neurosci (2008) 1.02

Caloric restriction mimetics: the next phase. Ann N Y Acad Sci (2005) 1.02

Activated AKT/PKB signaling in C. elegans uncouples temporally distinct outputs of DAF-2/insulin-like signaling. BMC Dev Biol (2006) 1.01

Caloric restriction mimetics: a novel approach for biogerontology. Methods Mol Biol (2007) 1.01

Flavonoids and the brain: interactions at the blood-brain barrier and their physiological effects on the central nervous system. Free Radic Biol Med (2004) 1.01

Bioenergetics of aging and calorie restriction. Ageing Res Rev (2006) 1.01

Stereological analysis of microvascular parameters in a double transgenic model of Alzheimer's disease. Brain Res Bull (2005) 1.00

Blueberry supplemented diet: effects on object recognition memory and nuclear factor-kappa B levels in aged rats. Nutr Neurosci (2004) 0.99

Drusenoid maculopathy in rhesus monkeys (Macaca mulatta): effects of age and gender. Graefes Arch Clin Exp Ophthalmol (2008) 0.99

Neuropathological quantification of dtg APP/PS1: neuroimaging, stereology, and biochemistry. Age (Dordr) (2007) 0.99

Modulation of cognition and behavior in aged animals: role for antioxidant- and essential fatty acid-rich plant foods. Am J Clin Nutr (2009) 0.98

The prolongevity effect of resveratrol depends on dietary composition and calorie intake in a tephritid fruit fly. Exp Gerontol (2009) 0.98

In vitro cellular adaptations of indicators of longevity in response to treatment with serum collected from humans on calorie restricted diets. PLoS One (2008) 0.97

Adiponectin protects rat hippocampal neurons against excitotoxicity. Age (Dordr) (2010) 0.97

A blueberry-enriched diet attenuates nephropathy in a rat model of hypertension via reduction in oxidative stress. PLoS One (2011) 0.97