PubRank

Stanley J Korsmeyer

Author PubWeight™ 234.64‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Cell death: critical control points. Cell 2004 22.56
2 An inhibitor of Bcl-2 family proteins induces regression of solid tumours. Nature 2005 22.40
3 MLL translocations specify a distinct gene expression profile that distinguishes a unique leukemia. Nat Genet 2001 13.79
4 Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics. Cancer Cell 2002 11.09
5 BAX and BAK regulation of endoplasmic reticulum Ca2+: a control point for apoptosis. Science 2003 9.55
6 Activation of apoptosis in vivo by a hydrocarbon-stapled BH3 helix. Science 2004 7.63
7 Development and maintenance of B and T lymphocytes requires antiapoptotic MCL-1. Nature 2003 6.78
8 A distinct pathway remodels mitochondrial cristae and mobilizes cytochrome c during apoptosis. Dev Cell 2002 5.45
9 VDAC2 inhibits BAK activation and mitochondrial apoptosis. Science 2003 4.92
10 BAD and glucokinase reside in a mitochondrial complex that integrates glycolysis and apoptosis. Nature 2003 4.80
11 Obligate role of anti-apoptotic MCL-1 in the survival of hematopoietic stem cells. Science 2005 4.75
12 Cyclophilin D is a component of mitochondrial permeability transition and mediates neuronal cell death after focal cerebral ischemia. Proc Natl Acad Sci U S A 2005 4.63
13 Proapoptotic BAX and BAK modulate the unfolded protein response by a direct interaction with IRE1alpha. Science 2006 4.46
14 A spatially and temporally restricted mouse model of soft tissue sarcoma. Nat Med 2007 3.96
15 A stapled BID BH3 helix directly binds and activates BAX. Mol Cell 2006 3.86
16 Inhibition of FLT3 in MLL. Validation of a therapeutic target identified by gene expression based classification. Cancer Cell 2003 3.75
17 Bcl2 regulation by the melanocyte master regulator Mitf modulates lineage survival and melanoma cell viability. Cell 2002 3.72
18 Taspase1: a threonine aspartase required for cleavage of MLL and proper HOX gene expression. Cell 2003 3.35
19 Apoptosis in the development and maintenance of the immune system. Nat Immunol 2003 3.02
20 Proapoptotic BAX and BAK regulate the type 1 inositol trisphosphate receptor and calcium leak from the endoplasmic reticulum. Proc Natl Acad Sci U S A 2004 3.00
21 Survival factor-mediated BAD phosphorylation raises the mitochondrial threshold for apoptosis. Dev Cell 2002 2.96
22 Dual role of proapoptotic BAD in insulin secretion and beta cell survival. Nat Med 2008 2.78
23 Phosphorylation of BCL-2 regulates ER Ca2+ homeostasis and apoptosis. EMBO J 2004 2.77
24 Reactivation of the p53 tumor suppressor pathway by a stapled p53 peptide. J Am Chem Soc 2007 2.71
25 Proteolytic cleavage of MLL generates a complex of N- and C-terminal fragments that confers protein stability and subnuclear localization. Mol Cell Biol 2003 2.66
26 Mechanisms of cytochrome c release by proapoptotic BCL-2 family members. Biochem Biophys Res Commun 2003 2.65
27 Bad-deficient mice develop diffuse large B cell lymphoma. Proc Natl Acad Sci U S A 2003 2.54
28 Essential role of BAX,BAK in B cell homeostasis and prevention of autoimmune disease. Proc Natl Acad Sci U S A 2005 2.43
29 Survival factor-induced extracellular signal-regulated kinase phosphorylates BIM, inhibiting its association with BAX and proapoptotic activity. Proc Natl Acad Sci U S A 2004 2.36
30 Gene expression signatures in MLL-rearranged T-lineage and B-precursor acute leukemias: dominance of HOX dysregulation. Blood 2003 2.35
31 A role for proapoptotic BID in the DNA-damage response. Cell 2005 2.30
32 Proteolysis of MLL family proteins is essential for taspase1-orchestrated cell cycle progression. Genes Dev 2006 2.20
33 cdx4 mutants fail to specify blood progenitors and can be rescued by multiple hox genes. Nature 2003 2.16
34 p53 controls radiation-induced gastrointestinal syndrome in mice independent of apoptosis. Science 2009 2.11
35 An Mll-dependent Hox program drives hematopoietic progenitor expansion. Curr Biol 2004 2.10
36 A novel mitochondriotoxic small molecule that selectively inhibits tumor cell growth. Cancer Cell 2002 2.09
37 Definitive hematopoiesis requires the mixed-lineage leukemia gene. Dev Cell 2004 2.09
38 Antiapoptotic BCL-2 is required for maintenance of a model leukemia. Cancer Cell 2004 1.92
39 FLT3 mutations in childhood acute lymphoblastic leukemia. Blood 2003 1.91
40 BID regulation by p53 contributes to chemosensitivity. Nat Cell Biol 2002 1.84
41 Conditional MLL-CBP targets GMP and models therapy-related myeloproliferative disease. EMBO J 2005 1.79
42 A pharmacologic inhibitor of the protease Taspase1 effectively inhibits breast and brain tumor growth. Cancer Res 2011 1.74
43 Proapoptotic BID is required for myeloid homeostasis and tumor suppression. Genes Dev 2003 1.70
44 Multiple signaling pathways promote B lymphocyte stimulator dependent B-cell growth and survival. Blood 2007 1.64
45 Activation of BAD by therapeutic inhibition of epidermal growth factor receptor and transactivation by insulin-like growth factor receptor. J Biol Chem 2002 1.62
46 Inhibition of both the extrinsic and intrinsic death pathways through nonhomotypic death-fold interactions. Mol Cell 2004 1.62
47 Involvement of proapoptotic molecules Bax and Bak in tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced mitochondrial disruption and apoptosis: differential regulation of cytochrome c and Smac/DIABLO release. Cancer Res 2003 1.55
48 Oligomeric Bax is a component of the putative cytochrome c release channel MAC, mitochondrial apoptosis-induced channel. Mol Biol Cell 2005 1.55
49 Uncleaved TFIIA is a substrate for taspase 1 and active in transcription. Mol Cell Biol 2006 1.51
50 The BCL2A1 gene as a pre-T cell receptor-induced regulator of thymocyte survival. J Exp Med 2005 1.46
51 The role of MLL in hematopoiesis and leukemia. Curr Opin Hematol 2002 1.42
52 Bax channel inhibitors prevent mitochondrion-mediated apoptosis and protect neurons in a model of global brain ischemia. J Biol Chem 2005 1.37
53 Traumatic brain injury in mice deficient in Bid: effects on histopathology and functional outcome. J Cereb Blood Flow Metab 2006 1.34
54 Switching mechanisms of cell death in mdm2- and mdm4-null mice by deletion of p53 downstream targets. Cancer Res 2003 1.32
55 Regulation of endoplasmic reticulum Ca2+ dynamics by proapoptotic BCL-2 family members. Biochem Pharmacol 2003 1.30
56 Differential mRNA expression of Ara-C-metabolizing enzymes explains Ara-C sensitivity in MLL gene-rearranged infant acute lymphoblastic leukemia. Blood 2002 1.30
57 A membrane-targeted BID BCL-2 homology 3 peptide is sufficient for high potency activation of BAX in vitro. J Biol Chem 2006 1.26
58 Conformational changes in BID, a pro-apoptotic BCL-2 family member, upon membrane binding. A site-directed spin labeling study. J Biol Chem 2004 1.20
59 Bax-dependent spermatogonia apoptosis is required for testicular development and spermatogenesis. Biol Reprod 2002 1.18
60 MLL-rearranged leukemias: insights from gene expression profiling. Semin Hematol 2003 1.16
61 Proapoptotic BAX and BAK control multiple initiator caspases. EMBO Rep 2005 1.13
62 PP2A regulates BCL-2 phosphorylation and proteasome-mediated degradation at the endoplasmic reticulum. J Biol Chem 2006 1.13
63 Ligand activation of the aromatic hydrocarbon receptor transcription factor drives Bax-dependent apoptosis in developing fetal ovarian germ cells. Endocrinology 2002 1.12
64 Role of proapoptotic BAX in propagation of Chlamydia muridarum (the mouse pneumonitis strain of Chlamydia trachomatis) and the host inflammatory response. J Biol Chem 2002 1.10
65 p600, a unique protein required for membrane morphogenesis and cell survival. Proc Natl Acad Sci U S A 2005 1.09
66 The VDAC2-BAK rheostat controls thymocyte survival. Sci Signal 2009 1.08
67 Loss of Bax alters tumor spectrum and tumor numbers in ARF-deficient mice. Cancer Res 2002 1.05
68 Bax, caspase-2, and caspase-3 are required for ovarian follicle loss caused by 4-vinylcyclohexene diepoxide exposure of female mice in vivo. Endocrinology 2003 1.04
69 Enhanced oligodendrocyte survival after spinal cord injury in Bax-deficient mice and mice with delayed Wallerian degeneration. J Neurosci 2003 1.04
70 Effects of cytochrome c on the mitochondrial apoptosis-induced channel MAC. Am J Physiol Cell Physiol 2003 0.97
71 BAD is a pro-survival factor prior to activation of its pro-apoptotic function. J Biol Chem 2004 0.94
72 Cell death induced by granzyme C. Blood 2002 0.93
73 Untangling the web: mitochondrial fission and apoptosis. Dev Cell 2004 0.85
74 Caspase regulation of genotoxin-induced neural precursor cell death. J Neurosci Res 2003 0.83
75 Genomic approaches to the pathogenesis and treatment of acute lymphoblastic leukemias. Curr Opin Hematol 2002 0.83
76 Proapoptotic histone H1.2 induces CASP-3 and -7 activation by forming a protein complex with CYT c, APAF-1 and CASP-9. FEBS Lett 2007 0.83
77 Function of BID -- a molecule of the bcl-2 family -- in ischemic cell death in the brain. Eur Surg Res 2002 0.83
78 A BAX/BAK and cyclophilin D-independent intrinsic apoptosis pathway. PLoS One 2012 0.80
79 Comparison of human genomics and genetic models of cancer to identify novel therapeutic targets. Cell Cycle 2003 0.75