Published in Biochem Biophys Res Commun on May 09, 2003
Control of mitochondrial motility and distribution by the calcium signal: a homeostatic circuit. J Cell Biol (2004) 3.12
Inhibiting the mitochondrial fission machinery does not prevent Bax/Bak-dependent apoptosis. Mol Cell Biol (2006) 2.71
Assessing bioenergetic function in response to oxidative stress by metabolic profiling. Free Radic Biol Med (2011) 2.40
Apolipoprotein L1, a novel Bcl-2 homology domain 3-only lipid-binding protein, induces autophagic cell death. J Biol Chem (2008) 2.30
Opa1-mediated cristae opening is Bax/Bak and BH3 dependent, required for apoptosis, and independent of Bak oligomerization. Mol Cell (2008) 2.26
Sequential activation of poly(ADP-ribose) polymerase 1, calpains, and Bax is essential in apoptosis-inducing factor-mediated programmed necrosis. Mol Cell Biol (2007) 2.22
An intimate liaison: spatial organization of the endoplasmic reticulum-mitochondria relationship. EMBO J (2010) 2.01
Akt inhibits apoptosis downstream of BID cleavage via a glucose-dependent mechanism involving mitochondrial hexokinases. Mol Cell Biol (2004) 1.85
Proinflammatory cytokines activate the intrinsic apoptotic pathway in beta-cells. Diabetes (2009) 1.60
Prostaglandin E2 reduces radiation-induced epithelial apoptosis through a mechanism involving AKT activation and bax translocation. J Clin Invest (2004) 1.59
The mitochondrial fission protein hFis1 requires the endoplasmic reticulum gateway to induce apoptosis. Mol Biol Cell (2006) 1.58
Dual autonomous mitochondrial cell death pathways are activated by Nix/BNip3L and induce cardiomyopathy. Proc Natl Acad Sci U S A (2010) 1.54
Metformin inhibits mitochondrial permeability transition and cell death: a pharmacological in vitro study. Biochem J (2004) 1.37
Mitochondrial oxidant stress triggers cell death in simulated ischemia-reperfusion. Biochim Biophys Acta (2010) 1.35
The vaccinia virus F1L protein interacts with the proapoptotic protein Bak and inhibits Bak activation. J Virol (2005) 1.34
Is mPTP the gatekeeper for necrosis, apoptosis, or both? Biochim Biophys Acta (2010) 1.32
Galectin-1 induces nuclear translocation of endonuclease G in caspase- and cytochrome c-independent T cell death. Cell Death Differ (2004) 1.29
Expression of Bmi-1 in epidermis enhances cell survival by altering cell cycle regulatory protein expression and inhibiting apoptosis. J Invest Dermatol (2007) 1.28
Myxoma virus M11L prevents apoptosis through constitutive interaction with Bak. J Virol (2004) 1.27
Neuroprotective effect of crocin on acrylamide-induced cytotoxicity in PC12 cells. Cell Mol Neurobiol (2011) 1.27
Mutually exclusive subsets of BH3-only proteins are activated by the p53 and c-Jun N-terminal kinase/c-Jun signaling pathways during cortical neuron apoptosis induced by arsenite. Mol Cell Biol (2005) 1.25
Bench-to-bedside review: Mitochondrial injury, oxidative stress and apoptosis--there is nothing more practical than a good theory. Crit Care (2008) 1.22
Bcl-2 homodimerization involves two distinct binding surfaces, a topographic arrangement that provides an effective mechanism for Bcl-2 to capture activated Bax. J Biol Chem (2004) 1.20
TW-37, a small-molecule inhibitor of Bcl-2, inhibits cell growth and induces apoptosis in pancreatic cancer: involvement of Notch-1 signaling pathway. Cancer Res (2009) 1.20
The role of anti-alpha-enolase autoantibodies in pathogenicity of autoimmune-mediated retinopathy. J Clin Immunol (2007) 1.19
Sphingosine-dependent apoptosis: a unified concept based on multiple mechanisms operating in concert. Proc Natl Acad Sci U S A (2004) 1.17
Protein kinase Cdelta regulates keratinocyte death and survival by regulating activity and subcellular localization of a p38delta-extracellular signal-regulated kinase 1/2 complex. Mol Cell Biol (2004) 1.17
Elevated hydrostatic pressure triggers release of OPA1 and cytochrome C, and induces apoptotic cell death in differentiated RGC-5 cells. Mol Vis (2009) 1.15
Calcium elevation in mitochondria is the main Ca2+ requirement for mitochondrial permeability transition pore (mPTP) opening. J Biol Chem (2009) 1.11
Mediation of the antiapoptotic activity of Bcl-xL protein upon interaction with VDAC1 protein. J Biol Chem (2012) 1.11
Dynamics of RASSF1A/MOAP-1 association with death receptors. Mol Cell Biol (2008) 1.10
Genetic dissection of the permeability transition pore. J Bioenerg Biomembr (2005) 1.09
Inhibition of lung cancer growth: ATP citrate lyase knockdown and statin treatment leads to dual blockade of mitogen-activated protein kinase (MAPK) and phosphatidylinositol-3-kinase (PI3K)/AKT pathways. J Cell Physiol (2012) 1.08
ER-Golgi network--a future target for anti-cancer therapy. Leuk Res (2009) 1.08
Mitochondria in traumatic brain injury and mitochondrial-targeted multipotential therapeutic strategies. Br J Pharmacol (2012) 1.07
Cell death of bioenergetically compromised and transcriptionally challenged CLL lymphocytes by chlorinated ATP. Blood (2005) 1.06
MAC and Bcl-2 family proteins conspire in a deadly plot. Biochim Biophys Acta (2010) 1.05
Bax, Bcl2, and p53 differentially regulate neomycin- and gentamicin-induced hair cell death in the zebrafish lateral line. J Assoc Res Otolaryngol (2013) 1.05
Combined modality therapy with TRAIL or agonistic death receptor antibodies. Cancer Biol Ther (2011) 1.02
Caspase-mediated Bak activation and cytochrome c release during intrinsic apoptotic cell death in Jurkat cells. J Biol Chem (2008) 1.01
Histone deacetylase inhibitors and cell death. Cell Mol Life Sci (2014) 1.00
The role of the mitochondrial apoptosis induced channel MAC in cytochrome c release. J Bioenerg Biomembr (2005) 0.99
Hdm2 is a ubiquitin ligase of Ku70-Akt promotes cell survival by inhibiting Hdm2-dependent Ku70 destabilization. Cell Death Differ (2009) 0.99
Hexokinase II detachment from the mitochondria potentiates cisplatin induced cytotoxicity through a caspase-2 dependent mechanism. Cell Cycle (2009) 0.99
Cell survival and apoptosis signaling as therapeutic target for cancer: marine bioactive compounds. Int J Mol Sci (2013) 0.98
The natural triterpene maslinic acid induces apoptosis in HT29 colon cancer cells by a JNK-p53-dependent mechanism. BMC Cancer (2011) 0.96
E2F-1 induces melanoma cell apoptosis via PUMA up-regulation and Bax translocation. BMC Cancer (2007) 0.95
Programmed cell death and new discoveries in the genetics of parkinsonism. J Neurochem (2007) 0.94
Static mechanical stress induces apoptosis in rat endplate chondrocytes through MAPK and mitochondria-dependent caspase activation signaling pathways. PLoS One (2013) 0.94
Mechanisms of acupuncture and moxibustion in regulation of epithelial cell apoptosis in rat ulcerative colitis. World J Gastroenterol (2004) 0.93
The Differential Effect of Toxoplasma Gondii Infection on the Stability of BCL2-Family Members Involves Multiple Activities. Front Microbiol (2011) 0.93
Cadmium induces apoptosis in pancreatic β-cells through a mitochondria-dependent pathway: the role of oxidative stress-mediated c-Jun N-terminal kinase activation. PLoS One (2013) 0.92
Regulation of lymphocyte progenitor survival by the proapoptotic activities of Bim and Bid. Proc Natl Acad Sci U S A (2008) 0.92
Amphiregulin promotes resistance to gefitinib in nonsmall cell lung cancer cells by regulating Ku70 acetylation. Mol Ther (2009) 0.90
Long-chain ceramide is a potent inhibitor of the mitochondrial permeability transition pore. J Biol Chem (2008) 0.90
Host-cell interactions with pathogenic Rickettsia species. Future Microbiol (2009) 0.89
Mitochondrial-targeted active Akt protects SH-SY5Y neuroblastoma cells from staurosporine-induced apoptotic cell death. J Cell Biochem (2007) 0.89
Increased stability of Bcl-2 in HSP70-mediated protection against apoptosis induced by oxidative stress. Cell Stress Chaperones (2010) 0.89
The Bmi-1 polycomb group gene in skin cancer: regulation of function by (-)-epigallocatechin-3-gallate. Nutr Rev (2008) 0.89
Sirt3 protects cortical neurons against oxidative stress via regulating mitochondrial Ca2+ and mitochondrial biogenesis. Int J Mol Sci (2014) 0.88
Iridoid glycosides fraction of Folium syringae leaves modulates NF-κB signal pathway and intestinal epithelial cells apoptosis in experimental colitis. PLoS One (2011) 0.88
Anti-apoptotic genes in the survival of monocytic cells during infection. Curr Genomics (2009) 0.88
Hydrogen peroxide signaling is required for glucocorticoid-induced apoptosis in lymphoma cells. Free Radic Biol Med (2011) 0.88
A role of cell apoptosis in lipopolysaccharide (LPS)-induced nonlethal liver injury in D-galactosamine (D-GalN)-sensitized rats. Dig Dis Sci (2007) 0.87
Mitochondrial and endoplasmic reticulum stress pathways cooperate in zearalenone-induced apoptosis of human leukemic cells. J Hematol Oncol (2010) 0.87
Intracellular mechanisms of aminoglycoside-induced cytotoxicity. Integr Biol (Camb) (2011) 0.87
Neuronal apoptosis in cerebral ischemia/reperfusion area following electrical stimulation of fastigial nucleus. Neural Regen Res (2014) 0.86
Bcl-x(L) blocks a mitochondrial inner membrane channel and prevents Ca2+ overload-mediated cell death. PLoS One (2011) 0.86
TIP30 regulates apoptosis-related genes in its apoptotic signal transduction pathway. World J Gastroenterol (2005) 0.86
Inhibitory effect of Curcuma purpurascens BI. rhizome on HT-29 colon cancer cells through mitochondrial-dependent apoptosis pathway. BMC Complement Altern Med (2015) 0.86
Viruses as modulators of mitochondrial functions. Adv Virol (2013) 0.85
Apoptosis-inducing factor (AIF) is targeted in IFN-α2a-induced Bid-mediated apoptosis through Bak activation in ovarian cancer cells. Biochim Biophys Acta (2012) 0.85
Combination of epinephrine with esmolol attenuates post-resuscitation myocardial dysfunction in a porcine model of cardiac arrest. PLoS One (2013) 0.85
Alpha1,3 Fucosyltransferase-VII modifies the susceptibility of apoptosis induced by ultraviolet and retinoic acid in human hepatocarcinoma cells. Glycoconj J (2007) 0.83
Additive inhibition of colorectal cancer cell lines by aspirin and bortezomib. Int J Colorectal Dis (2010) 0.82
Chemoresistance is associated with increased cytoprotective autophagy and diminished apoptosis in bladder cancer cells treated with the BH3 mimetic (-)-Gossypol (AT-101). BMC Cancer (2015) 0.82
The roles of traditional chinese medicine: shen-fu injection on the postresuscitation care bundle. Evid Based Complement Alternat Med (2013) 0.81
Dissimilar mechanisms of cytochrome c release induced by octyl glucoside-activated BAX and by BAX activated with truncated BID. Biochim Biophys Acta (2009) 0.81
Protective effects of onion-derived quercetin on glutamate-mediated hippocampal neuronal cell death. Pharmacogn Mag (2013) 0.81
Role and mechanism of hypoxia-inducible factor-1 in cell growth and apoptosis of breast cancer cell line MDA-MB-231. Oncol Lett (2010) 0.80
Salvianolic acid A attenuates TNF-α- and D-GalN-induced ER stress-mediated and mitochondrial-dependent apoptosis by modulating Bax/Bcl-2 ratio and calcium release in hepatocyte LO2 cells. Naunyn Schmiedebergs Arch Pharmacol (2015) 0.80
BAG1: the guardian of anti-apoptotic proteins in acute myeloid leukemia. PLoS One (2011) 0.80
Cyclosporin A inhibits programmed cell death and cytochrome c release induced by fusicoccin in sycamore cells. Protoplasma (2007) 0.80
Knockdown of long non-coding RNA TP73-AS1 inhibits cell proliferation and induces apoptosis in esophageal squamous cell carcinoma. Oncotarget (2016) 0.79
The role of the mitochondria in mediating cytotoxicity of anti-cancer therapies. J Bioenerg Biomembr (2007) 0.79
Heroin activates ATF3 and CytC via c-Jun N-terminal kinase pathways to mediate neuronal apoptosis. Med Sci Monit Basic Res (2015) 0.79
Electroacupuncture stimulates remodeling of extracellular matrix by inhibiting apoptosis in a rabbit model of disc degeneration. Evid Based Complement Alternat Med (2015) 0.78
Mitochondrial adaptations to oxidative stress confer resistance to apoptosis in lymphoma cells. Int J Mol Sci (2012) 0.78
Toxoplasma gondii infection inhibits the mitochondrial apoptosis through induction of Bcl-2 and HSP70. Parasitol Res (2010) 0.78
BaxΔ2 is a novel bax isoform unique to microsatellite unstable tumors. J Biol Chem (2012) 0.78
Antitumor activity of SA12, a novel peptide, on SKBr-3 breast cancer cells via the mitochondrial apoptosis pathway. Drug Des Devel Ther (2015) 0.78
Human platelet lysate improves human cord blood derived ECFC survival and vasculogenesis in three dimensional (3D) collagen matrices. Microvasc Res (2015) 0.78
A comparison of the biological effects of 125I seeds continuous low-dose-rate radiation and 60Co high-dose-rate gamma radiation on non-small cell lung cancer cells. PLoS One (2015) 0.77
FFA-ROS-P53-mediated mitochondrial apoptosis contributes to reduction of osteoblastogenesis and bone mass in type 2 diabetes mellitus. Sci Rep (2015) 0.77
A nucleus-targeted alternately spliced Nix/Bnip3L protein isoform modifies nuclear factor κB (NFκB)-mediated cardiac transcription. J Biol Chem (2013) 0.77
The Protective Effect of Beraprost Sodium on Diabetic Cardiomyopathy through the Inhibition of the p38 MAPK Signaling Pathway in High-Fat-Induced SD Rats. Int J Endocrinol (2014) 0.77
Caspase-8 goes cardiolipin: a new platform to provide mitochondria with microdomains of apoptotic signals? J Cell Biol (2008) 0.77
Effect of Nigella sativa fixed oil on ethanol toxicity in rats. Iran J Basic Med Sci (2014) 0.77
Cell death: critical control points. Cell (2004) 22.56
An inhibitor of Bcl-2 family proteins induces regression of solid tumours. Nature (2005) 22.40
MLL translocations specify a distinct gene expression profile that distinguishes a unique leukemia. Nat Genet (2001) 13.79
Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics. Cancer Cell (2002) 11.09
BAX and BAK regulation of endoplasmic reticulum Ca2+: a control point for apoptosis. Science (2003) 9.55
Activation of apoptosis in vivo by a hydrocarbon-stapled BH3 helix. Science (2004) 7.63
Development and maintenance of B and T lymphocytes requires antiapoptotic MCL-1. Nature (2003) 6.78
A distinct pathway remodels mitochondrial cristae and mobilizes cytochrome c during apoptosis. Dev Cell (2002) 5.45
VDAC2 inhibits BAK activation and mitochondrial apoptosis. Science (2003) 4.92
BAD and glucokinase reside in a mitochondrial complex that integrates glycolysis and apoptosis. Nature (2003) 4.80
Obligate role of anti-apoptotic MCL-1 in the survival of hematopoietic stem cells. Science (2005) 4.75
Cyclophilin D is a component of mitochondrial permeability transition and mediates neuronal cell death after focal cerebral ischemia. Proc Natl Acad Sci U S A (2005) 4.63
Proapoptotic BAX and BAK modulate the unfolded protein response by a direct interaction with IRE1alpha. Science (2006) 4.46
A spatially and temporally restricted mouse model of soft tissue sarcoma. Nat Med (2007) 3.96
A stapled BID BH3 helix directly binds and activates BAX. Mol Cell (2006) 3.86
Inhibition of FLT3 in MLL. Validation of a therapeutic target identified by gene expression based classification. Cancer Cell (2003) 3.75
Bcl2 regulation by the melanocyte master regulator Mitf modulates lineage survival and melanoma cell viability. Cell (2002) 3.72
Taspase1: a threonine aspartase required for cleavage of MLL and proper HOX gene expression. Cell (2003) 3.35
Apoptosis in the development and maintenance of the immune system. Nat Immunol (2003) 3.02
Proapoptotic BAX and BAK regulate the type 1 inositol trisphosphate receptor and calcium leak from the endoplasmic reticulum. Proc Natl Acad Sci U S A (2004) 3.00
Survival factor-mediated BAD phosphorylation raises the mitochondrial threshold for apoptosis. Dev Cell (2002) 2.96
Dual role of proapoptotic BAD in insulin secretion and beta cell survival. Nat Med (2008) 2.78
Phosphorylation of BCL-2 regulates ER Ca2+ homeostasis and apoptosis. EMBO J (2004) 2.77
Reactivation of the p53 tumor suppressor pathway by a stapled p53 peptide. J Am Chem Soc (2007) 2.71
Proteolytic cleavage of MLL generates a complex of N- and C-terminal fragments that confers protein stability and subnuclear localization. Mol Cell Biol (2003) 2.66
Bad-deficient mice develop diffuse large B cell lymphoma. Proc Natl Acad Sci U S A (2003) 2.54
Essential role of BAX,BAK in B cell homeostasis and prevention of autoimmune disease. Proc Natl Acad Sci U S A (2005) 2.43
Survival factor-induced extracellular signal-regulated kinase phosphorylates BIM, inhibiting its association with BAX and proapoptotic activity. Proc Natl Acad Sci U S A (2004) 2.36
Gene expression signatures in MLL-rearranged T-lineage and B-precursor acute leukemias: dominance of HOX dysregulation. Blood (2003) 2.35
A role for proapoptotic BID in the DNA-damage response. Cell (2005) 2.30
Proteolysis of MLL family proteins is essential for taspase1-orchestrated cell cycle progression. Genes Dev (2006) 2.20
cdx4 mutants fail to specify blood progenitors and can be rescued by multiple hox genes. Nature (2003) 2.16
p53 controls radiation-induced gastrointestinal syndrome in mice independent of apoptosis. Science (2009) 2.11
An Mll-dependent Hox program drives hematopoietic progenitor expansion. Curr Biol (2004) 2.10
A novel mitochondriotoxic small molecule that selectively inhibits tumor cell growth. Cancer Cell (2002) 2.09
Definitive hematopoiesis requires the mixed-lineage leukemia gene. Dev Cell (2004) 2.09
Antiapoptotic BCL-2 is required for maintenance of a model leukemia. Cancer Cell (2004) 1.92
FLT3 mutations in childhood acute lymphoblastic leukemia. Blood (2003) 1.91
BID regulation by p53 contributes to chemosensitivity. Nat Cell Biol (2002) 1.84
Conditional MLL-CBP targets GMP and models therapy-related myeloproliferative disease. EMBO J (2005) 1.79
A pharmacologic inhibitor of the protease Taspase1 effectively inhibits breast and brain tumor growth. Cancer Res (2011) 1.74
Proapoptotic BID is required for myeloid homeostasis and tumor suppression. Genes Dev (2003) 1.70
Multiple signaling pathways promote B lymphocyte stimulator dependent B-cell growth and survival. Blood (2007) 1.64
Activation of BAD by therapeutic inhibition of epidermal growth factor receptor and transactivation by insulin-like growth factor receptor. J Biol Chem (2002) 1.62
Inhibition of both the extrinsic and intrinsic death pathways through nonhomotypic death-fold interactions. Mol Cell (2004) 1.62
Oligomeric Bax is a component of the putative cytochrome c release channel MAC, mitochondrial apoptosis-induced channel. Mol Biol Cell (2005) 1.55
Uncleaved TFIIA is a substrate for taspase 1 and active in transcription. Mol Cell Biol (2006) 1.51
The BCL2A1 gene as a pre-T cell receptor-induced regulator of thymocyte survival. J Exp Med (2005) 1.46
The role of MLL in hematopoiesis and leukemia. Curr Opin Hematol (2002) 1.42
Bax channel inhibitors prevent mitochondrion-mediated apoptosis and protect neurons in a model of global brain ischemia. J Biol Chem (2005) 1.37
Traumatic brain injury in mice deficient in Bid: effects on histopathology and functional outcome. J Cereb Blood Flow Metab (2006) 1.34
Switching mechanisms of cell death in mdm2- and mdm4-null mice by deletion of p53 downstream targets. Cancer Res (2003) 1.32
Differential mRNA expression of Ara-C-metabolizing enzymes explains Ara-C sensitivity in MLL gene-rearranged infant acute lymphoblastic leukemia. Blood (2002) 1.30
Regulation of endoplasmic reticulum Ca2+ dynamics by proapoptotic BCL-2 family members. Biochem Pharmacol (2003) 1.30
A membrane-targeted BID BCL-2 homology 3 peptide is sufficient for high potency activation of BAX in vitro. J Biol Chem (2006) 1.26
Conformational changes in BID, a pro-apoptotic BCL-2 family member, upon membrane binding. A site-directed spin labeling study. J Biol Chem (2004) 1.20
Bax-dependent spermatogonia apoptosis is required for testicular development and spermatogenesis. Biol Reprod (2002) 1.18
MLL-rearranged leukemias: insights from gene expression profiling. Semin Hematol (2003) 1.16
Proapoptotic BAX and BAK control multiple initiator caspases. EMBO Rep (2005) 1.13
PP2A regulates BCL-2 phosphorylation and proteasome-mediated degradation at the endoplasmic reticulum. J Biol Chem (2006) 1.13
Ligand activation of the aromatic hydrocarbon receptor transcription factor drives Bax-dependent apoptosis in developing fetal ovarian germ cells. Endocrinology (2002) 1.12
Role of proapoptotic BAX in propagation of Chlamydia muridarum (the mouse pneumonitis strain of Chlamydia trachomatis) and the host inflammatory response. J Biol Chem (2002) 1.10
p600, a unique protein required for membrane morphogenesis and cell survival. Proc Natl Acad Sci U S A (2005) 1.09
The VDAC2-BAK rheostat controls thymocyte survival. Sci Signal (2009) 1.08
Loss of Bax alters tumor spectrum and tumor numbers in ARF-deficient mice. Cancer Res (2002) 1.05
Enhanced oligodendrocyte survival after spinal cord injury in Bax-deficient mice and mice with delayed Wallerian degeneration. J Neurosci (2003) 1.04
Bax, caspase-2, and caspase-3 are required for ovarian follicle loss caused by 4-vinylcyclohexene diepoxide exposure of female mice in vivo. Endocrinology (2003) 1.04
Effects of cytochrome c on the mitochondrial apoptosis-induced channel MAC. Am J Physiol Cell Physiol (2003) 0.97
BAD is a pro-survival factor prior to activation of its pro-apoptotic function. J Biol Chem (2004) 0.94
Cell death induced by granzyme C. Blood (2002) 0.93
Untangling the web: mitochondrial fission and apoptosis. Dev Cell (2004) 0.85
Caspase regulation of genotoxin-induced neural precursor cell death. J Neurosci Res (2003) 0.83
Function of BID -- a molecule of the bcl-2 family -- in ischemic cell death in the brain. Eur Surg Res (2002) 0.83
Proapoptotic histone H1.2 induces CASP-3 and -7 activation by forming a protein complex with CYT c, APAF-1 and CASP-9. FEBS Lett (2007) 0.83
Genomic approaches to the pathogenesis and treatment of acute lymphoblastic leukemias. Curr Opin Hematol (2002) 0.83
A BAX/BAK and cyclophilin D-independent intrinsic apoptosis pathway. PLoS One (2012) 0.80
Comparison of human genomics and genetic models of cancer to identify novel therapeutic targets. Cell Cycle (2003) 0.75