Published in J Biol Chem on February 01, 2002
The Mus81/Mms4 endonuclease acts independently of double-Holliday junction resolution to promote a distinct subset of crossovers during meiosis in budding yeast. Genetics (2003) 3.22
The Mus81 solution to resolution: generating meiotic crossovers without Holliday junctions. Genes Dev (2004) 2.89
Slx1-Slx4 is a second structure-specific endonuclease functionally redundant with Sgs1-Top3. Genes Dev (2003) 2.53
Evidence suggesting that Pif1 helicase functions in DNA replication with the Dna2 helicase/nuclease and DNA polymerase delta. Mol Cell Biol (2006) 2.35
Removal of oxidative DNA damage via FEN1-dependent long-patch base excision repair in human cell mitochondria. Mol Cell Biol (2008) 1.95
A network of multi-tasking proteins at the DNA replication fork preserves genome stability. PLoS Genet (2005) 1.61
WRN helicase and FEN-1 form a complex upon replication arrest and together process branchmigrating DNA structures associated with the replication fork. Mol Biol Cell (2003) 1.61
The human Rad9-Rad1-Hus1 checkpoint complex stimulates flap endonuclease 1. Proc Natl Acad Sci U S A (2004) 1.49
Pif1 helicase directs eukaryotic Okazaki fragments toward the two-nuclease cleavage pathway for primer removal. J Biol Chem (2008) 1.43
Isolation of human Dna2 endonuclease and characterization of its enzymatic properties. Nucleic Acids Res (2006) 1.42
Mutations in yeast replication proteins that increase CAG/CTG expansions also increase repeat fragility. Mol Cell Biol (2003) 1.41
Proliferating cell nuclear antigen loaded onto double-stranded DNA: dynamics, minor groove interactions and functional implications. Nucleic Acids Res (2006) 1.37
Sensitivity to phosphonoacetic acid: a new phenotype to probe DNA polymerase delta in Saccharomyces cerevisiae. Genetics (2005) 1.36
Processing of G4 DNA by Dna2 helicase/nuclease and replication protein A (RPA) provides insights into the mechanism of Dna2/RPA substrate recognition. J Biol Chem (2008) 1.28
DNA base excision repair: a mechanism of trinucleotide repeat expansion. Trends Biochem Sci (2012) 1.27
The 3'-flap pocket of human flap endonuclease 1 is critical for substrate binding and catalysis. J Biol Chem (2009) 1.27
Pif1 helicase lengthens some Okazaki fragment flaps necessitating Dna2 nuclease/helicase action in the two-nuclease processing pathway. J Biol Chem (2009) 1.27
Dynamic removal of replication protein A by Dna2 facilitates primer cleavage during Okazaki fragment processing in Saccharomyces cerevisiae. J Biol Chem (2008) 1.24
The flexible loop of human FEN1 endonuclease is required for flap cleavage during DNA replication and repair. EMBO J (2002) 1.23
Saccharomyces cerevisiae flap endonuclease 1 uses flap equilibration to maintain triplet repeat stability. Mol Cell Biol (2004) 1.22
Flap endonuclease 1. Annu Rev Biochem (2013) 1.21
Domain swapping between FEN-1 and XPG defines regions in XPG that mediate nucleotide excision repair activity and substrate specificity. Nucleic Acids Res (2007) 1.18
Flap endonuclease 1 mechanism analysis indicates flap base binding prior to threading. J Biol Chem (2010) 1.09
Long patch base excision repair proceeds via coordinated stimulation of the multienzyme DNA repair complex. J Biol Chem (2009) 1.08
The interaction site of Flap Endonuclease-1 with WRN helicase suggests a coordination of WRN and PCNA. Nucleic Acids Res (2005) 1.08
A junction branch point adjacent to a DNA backbone nick directs substrate cleavage by Saccharomyces cerevisiae Mus81-Mms4. Nucleic Acids Res (2009) 1.06
The Fen1 extrahelical 3'-flap pocket is conserved from archaea to human and regulates DNA substrate specificity. Nucleic Acids Res (2004) 1.05
Nucleolar localization and dynamic roles of flap endonuclease 1 in ribosomal DNA replication and damage repair. Mol Cell Biol (2008) 1.02
Unpairing and gating: sequence-independent substrate recognition by FEN superfamily nucleases. Trends Biochem Sci (2011) 1.02
Dna2 is a structure-specific nuclease, with affinity for 5'-flap intermediates. Nucleic Acids Res (2009) 0.97
G-quartets assembly within a G-rich DNA flap. A possible event at the center of the HIV-1 genome. Nucleic Acids Res (2002) 0.97
Comparison of the catalytic parameters and reaction specificities of a phage and an archaeal flap endonuclease. J Mol Biol (2007) 0.97
An alternative pathway for Okazaki fragment processing: resolution of fold-back flaps by Pif1 helicase. J Biol Chem (2010) 0.97
Significance of the dissociation of Dna2 by flap endonuclease 1 to Okazaki fragment processing in Saccharomyces cerevisiae. J Biol Chem (2009) 0.96
Evidence that base stacking potential in annealed 3' overhangs determines polymerase utilization in yeast nonhomologous end joining. DNA Repair (Amst) (2007) 0.95
In vivo and in vitro studies of Mgs1 suggest a link between genome instability and Okazaki fragment processing. Nucleic Acids Res (2005) 0.95
Single-molecule characterization of Fen1 and Fen1/PCNA complexes acting on flap substrates. Nucleic Acids Res (2013) 0.94
Genetic and functional interactions between Mus81-Mms4 and Rad27. Nucleic Acids Res (2010) 0.92
The Rad27 (Fen-1) nuclease inhibits Ty1 mobility in Saccharomyces cerevisiae. Genetics (2003) 0.92
Msh2-Msh3 interferes with Okazaki fragment processing to promote trinucleotide repeat expansions. Cell Rep (2012) 0.92
The wonders of flap endonucleases: structure, function, mechanism and regulation. Subcell Biochem (2012) 0.90
Complementary non-radioactive assays for investigation of human flap endonuclease 1 activity. Nucleic Acids Res (2010) 0.88
Okazaki fragment maturation involves α-segment error editing by the mammalian FEN1/MutSα functional complex. EMBO J (2015) 0.88
Biochemical analyses indicate that binding and cleavage specificities define the ordered processing of human Okazaki fragments by Dna2 and FEN1. Nucleic Acids Res (2012) 0.86
Resolving individual steps of Okazaki-fragment maturation at a millisecond timescale. Nat Struct Mol Biol (2016) 0.85
Reconstitution of eukaryotic lagging strand DNA replication. Methods (2010) 0.84
Human replication factor C stimulates flap endonuclease 1. J Biol Chem (2009) 0.84
The Saccharomyces cerevisiae Dna2 can function as a sole nuclease in the processing of Okazaki fragments in DNA replication. Nucleic Acids Res (2015) 0.84
Components of the secondary pathway stimulate the primary pathway of eukaryotic Okazaki fragment processing. J Biol Chem (2010) 0.83
Dynamics of enzymatic interactions during short flap human Okazaki fragment processing by two forms of human DNA polymerase δ. DNA Repair (Amst) (2013) 0.83
A novel function for the Mre11-Rad50-Xrs2 complex in base excision repair. Nucleic Acids Res (2009) 0.81
Genetic instability in budding and fission yeast-sources and mechanisms. FEMS Microbiol Rev (2015) 0.80
The telomere resolvase of the Lyme disease spirochete, Borrelia burgdorferi, promotes DNA single-strand annealing and strand exchange. Nucleic Acids Res (2013) 0.80
Base excision repair in chromatin: Insights from reconstituted systems. DNA Repair (Amst) (2015) 0.80
Activity of FEN1 endonuclease on nucleosome substrates is dependent upon DNA sequence but not flap orientation. J Biol Chem (2011) 0.78
An alternative novel tool for DNA editing without target sequence limitation: the structure-guided nuclease. Genome Biol (2016) 0.78
Targeting DNA Flap Endonuclease 1 to Impede Breast Cancer Progression. EBioMedicine (2016) 0.77
Archaeal genome guardians give insights into eukaryotic DNA replication and damage response proteins. Archaea (2014) 0.77
Flap endonuclease activity of gene 6 exonuclease of bacteriophage T7. J Biol Chem (2014) 0.77
Expression and biochemical characterization of the Plasmodium falciparum DNA repair enzyme, flap endonuclease-1 (PfFEN-1). Mol Biochem Parasitol (2007) 0.76
Crystallization and preliminary crystallographic analysis of the catalytic domain of human flap endonuclease 1 in complex with a nicked DNA product: use of a DPCS kit for efficient protein-DNA complex crystallization. Acta Crystallogr Sect F Struct Biol Cryst Commun (2007) 0.76
Shade avoidance 6 encodes an Arabidopsis flap endonuclease required for maintenance of genome integrity and development. Nucleic Acids Res (2015) 0.76
MGME1 processes flaps into ligatable nicks in concert with DNA polymerase γ during mtDNA replication. Nucleic Acids Res (2016) 0.76
Rate-determining Step of Flap Endonuclease 1 (FEN1) Reflects a Kinetic Bias against Long Flaps and Trinucleotide Repeat Sequences. J Biol Chem (2015) 0.76
Wuho Is a New Member in Maintaining Genome Stability through its Interaction with Flap Endonuclease 1. PLoS Biol (2016) 0.76
Single-molecule FRET unveils induced-fit mechanism for substrate selectivity in flap endonuclease 1. Elife (2017) 0.75
Repair of the major lesion resulting from C5'-oxidation of DNA. Biochemistry (2011) 0.75
Esc2 promotes Mus81 complex-activity via its SUMO-like and DNA binding domains. Nucleic Acids Res (2016) 0.75
Serial intermediates with a 1 nt 3'-flap and 5' variable-length flaps are formed by cooperative functioning of Pyrococcus horikoshii FEN-1 with either B or D DNA polymerases. Extremophiles (2014) 0.75
Prognostic or predictive plasma cytokines and angiogenic factors for patients treated with pazopanib for metastatic renal-cell cancer: a retrospective analysis of phase 2 and phase 3 trials. Lancet Oncol (2012) 4.58
High-speed graphene transistors with a self-aligned nanowire gate. Nature (2010) 3.48
Flap endonuclease 1: a central component of DNA metabolism. Annu Rev Biochem (2004) 3.16
Novel mechanism of lapatinib resistance in HER2-positive breast tumor cells: activation of AXL. Cancer Res (2009) 3.10
Macrophage tropism of HIV-1 depends on efficient cellular dNTP utilization by reverse transcriptase. J Biol Chem (2004) 3.10
OGG1 initiates age-dependent CAG trinucleotide expansion in somatic cells. Nature (2007) 3.03
ATM regulates Mre11-dependent DNA end-degradation and microhomology-mediated end joining. Cell Cycle (2010) 2.32
Algal genomes reveal evolutionary mosaicism and the fate of nucleomorphs. Nature (2012) 2.15
Nuclear factor high-mobility group box1 mediating the activation of Toll-like receptor 4 signaling in hepatocytes in the early stage of nonalcoholic fatty liver disease in mice. Hepatology (2011) 2.13
Comparison of methods in the detection of ALK and ROS1 rearrangements in lung cancer. J Thorac Oncol (2015) 2.12
Low prevalence of knee and back pain in southeast China; the Shantou COPCORD study. J Rheumatol (2004) 2.06
Therapeutic misconception, misestimation, and optimism in participants enrolled in phase 1 trials. Cancer (2012) 1.94
Biosynthesis of the salinosporamide A polyketide synthase substrate chloroethylmalonyl-coenzyme A from S-adenosyl-L-methionine. Proc Natl Acad Sci U S A (2009) 1.91
Proarrhythmic risk of embryonic stem cell-derived cardiomyocyte transplantation in infarcted myocardium. Heart Rhythm (2010) 1.89
Coordinated redistribution of leukocyte LFA-1 and endothelial cell ICAM-1 accompany neutrophil transmigration. J Exp Med (2004) 1.85
On the roles of Saccharomyces cerevisiae Dna2p and Flap endonuclease 1 in Okazaki fragment processing. J Biol Chem (2004) 1.72
Highly efficient gate-tunable photocurrent generation in vertical heterostructures of layered materials. Nat Nanotechnol (2013) 1.72
Lagging strand replication proteins in genome stability and DNA repair. Chem Rev (2006) 1.71
Age-specific effects of hormone therapy use on overall mortality and ischemic heart disease mortality among women in the California Teachers Study. Menopause (2011) 1.67
Ataxia telangiectasia mutated (ATM) and ATM and Rad3-related protein exhibit selective target specificities in response to different forms of DNA damage. J Biol Chem (2004) 1.63
WRN helicase and FEN-1 form a complex upon replication arrest and together process branchmigrating DNA structures associated with the replication fork. Mol Biol Cell (2003) 1.61
Genome-wide signatures of convergent evolution in echolocating mammals. Nature (2013) 1.59
Ten years' experience with needle biopsy in the early diagnosis of sacroiliitis. Arthritis Rheum (2012) 1.59
The protein components and mechanism of eukaryotic Okazaki fragment maturation. Crit Rev Biochem Mol Biol (2003) 1.57
Chemical vapour deposition growth of large single crystals of monolayer and bilayer graphene. Nat Commun (2013) 1.57
Neutrophil migration across tight junctions is mediated by adhesive interactions between epithelial coxsackie and adenovirus receptor and a junctional adhesion molecule-like protein on neutrophils. Mol Biol Cell (2005) 1.57
BMP4-mediated brown fat-like changes in white adipose tissue alter glucose and energy homeostasis. Proc Natl Acad Sci U S A (2013) 1.55
Effects of cellulose crystallinity, hemicellulose, and lignin on the enzymatic hydrolysis of Miscanthus sinensis to monosaccharides. Biosci Biotechnol Biochem (2008) 1.54
Strand transfer events during HIV-1 reverse transcription. Virus Res (2008) 1.51
HMGB1 is a cofactor in mammalian base excision repair. Mol Cell (2007) 1.49
The human Rad9-Rad1-Hus1 checkpoint complex stimulates flap endonuclease 1. Proc Natl Acad Sci U S A (2004) 1.49
Biosynthesis of the allylmalonyl-CoA extender unit for the FK506 polyketide synthase proceeds through a dedicated polyketide synthase and facilitates the mutasynthesis of analogues. J Am Chem Soc (2010) 1.49
Argonaute 2 complexes selectively protect the circulating microRNAs in cell-secreted microvesicles. PLoS One (2012) 1.47
Genome-wide association study identifies two new susceptibility loci for atopic dermatitis in the Chinese Han population. Nat Genet (2011) 1.46
Peregrine and saker falcon genome sequences provide insights into evolution of a predatory lifestyle. Nat Genet (2013) 1.45
Pif1 helicase directs eukaryotic Okazaki fragments toward the two-nuclease cleavage pathway for primer removal. J Biol Chem (2008) 1.43
Emergency medical rescue efforts after a major earthquake: lessons from the 2008 Wenchuan earthquake. Lancet (2012) 1.41
A role for dNTP binding of human immunodeficiency virus type 1 reverse transcriptase in viral mutagenesis. Biochemistry (2004) 1.41
Withaferin A inhibits breast cancer invasion and metastasis at sub-cytotoxic doses by inducing vimentin disassembly and serine 56 phosphorylation. Int J Cancer (2011) 1.39
Reconstituted Okazaki fragment processing indicates two pathways of primer removal. J Biol Chem (2006) 1.38
Flexible solid-state supercapacitors based on three-dimensional graphene hydrogel films. ACS Nano (2013) 1.38
CD44v4 is a major E-selectin ligand that mediates breast cancer cell transendothelial migration. PLoS One (2008) 1.36
Dna2p helicase/nuclease is a tracking protein, like FEN1, for flap cleavage during Okazaki fragment maturation. J Biol Chem (2004) 1.34
Multifaceted intervention by the Hsp90 inhibitor ganetespib (STA-9090) in cancer cells with activated JAK/STAT signaling. PLoS One (2011) 1.31
Scalar generalized nonlinear Schrödinger equation-quantified continuum generation in an all-normal dispersion photonic crystal fiber for broadband coherent optical sources. Opt Express (2010) 1.30
Tissue-autonomous function of Drosophila seipin in preventing ectopic lipid droplet formation. PLoS Genet (2011) 1.30
JAM-C is a component of desmosomes and a ligand for CD11b/CD18-mediated neutrophil transepithelial migration. Mol Biol Cell (2004) 1.29
Phase II study evaluating 2 dosing schedules of oral foretinib (GSK1363089), cMET/VEGFR2 inhibitor, in patients with metastatic gastric cancer. PLoS One (2013) 1.28
Interleukin-17 contributes to the pathogenesis of autoimmune hepatitis through inducing hepatic interleukin-6 expression. PLoS One (2011) 1.27
Pif1 helicase lengthens some Okazaki fragment flaps necessitating Dna2 nuclease/helicase action in the two-nuclease processing pathway. J Biol Chem (2009) 1.27
Dynamic removal of replication protein A by Dna2 facilitates primer cleavage during Okazaki fragment processing in Saccharomyces cerevisiae. J Biol Chem (2008) 1.24
Template dimerization promotes an acceptor invasion-induced transfer mechanism during human immunodeficiency virus type 1 minus-strand synthesis. J Virol (2003) 1.24
Thirteen Camellia chloroplast genome sequences determined by high-throughput sequencing: genome structure and phylogenetic relationships. BMC Evol Biol (2014) 1.24
Evidence that DNA damage detection machinery participates in DNA repair. Cell Cycle (2005) 1.23
Single-chain estrogen receptors (ERs) reveal that the ERalpha/beta heterodimer emulates functions of the ERalpha dimer in genomic estrogen signaling pathways. Mol Cell Biol (2004) 1.23
Reduced dNTP binding affinity of 3TC-resistant M184I HIV-1 reverse transcriptase variants responsible for viral infection failure in macrophage. J Biol Chem (2008) 1.23
Confirmation by exome sequencing of the pathogenic role of NCSTN mutations in acne inversa (hidradenitis suppurativa). J Invest Dermatol (2011) 1.23
Cloning and characterization of Disc1, the mouse ortholog of DISC1 (Disrupted-in-Schizophrenia 1). Genomics (2002) 1.22
Saccharomyces cerevisiae flap endonuclease 1 uses flap equilibration to maintain triplet repeat stability. Mol Cell Biol (2004) 1.22
PRPF4 mutations cause autosomal dominant retinitis pigmentosa. Hum Mol Genet (2014) 1.22
Graphene: an emerging electronic material. Adv Mater (2012) 1.21
Flap endonuclease 1. Annu Rev Biochem (2013) 1.21
Characteristics of particulate carbon emissions from real-world Chinese coal combustion. Environ Sci Technol (2008) 1.19
Mortality and morbidity associated with simultaneous bilateral or staged bilateral total knee arthroplasty: a meta-analysis. Arch Orthop Trauma Surg (2011) 1.19
Targeted sequencing of 179 genes associated with hereditary retinal dystrophies and 10 candidate genes identifies novel and known mutations in patients with various retinal diseases. Invest Ophthalmol Vis Sci (2013) 1.19
Acetylation of Dna2 endonuclease/helicase and flap endonuclease 1 by p300 promotes DNA stability by creating long flap intermediates. J Biol Chem (2009) 1.18
The effects of estrogen-responsive element- and ligand-induced structural changes on the recruitment of cofactors and transcriptional responses by ER alpha and ER beta. Mol Endocrinol (2002) 1.18
Survival After Sublobar Resection versus Lobectomy for Clinical Stage IA Lung Cancer: An Analysis from the National Cancer Data Base. J Thorac Oncol (2015) 1.18
Okazaki fragment metabolism. Cold Spring Harb Perspect Biol (2013) 1.17
Expression of voltage-gated potassium channels in human and rhesus pancreatic islets. Diabetes (2004) 1.16
Mechanism of stimulation of human DNA ligase I by the Rad9-rad1-Hus1 checkpoint complex. J Biol Chem (2006) 1.15
Permanent Genetic Resources added to Molecular Ecology Resources Database 1 May 2009-31 July 2009. Mol Ecol Resour (2009) 1.15
MicroRNA-204 regulates vascular smooth muscle cell calcification in vitro and in vivo. Cardiovasc Res (2012) 1.14
Mechanistic understanding of an altered fidelity simian immunodeficiency virus reverse transcriptase mutation, V148I, identified in a pig-tailed macaque. J Biol Chem (2003) 1.13
The DIADEM and beyond. Neuroinformatics (2011) 1.12
Exome sequencing identifies MVK mutations in disseminated superficial actinic porokeratosis. Nat Genet (2012) 1.12
CD11b/CD18-dependent interactions of neutrophils with intestinal epithelium are mediated by fucosylated proteoglycans. J Immunol (2002) 1.12
Apparent defects in processive DNA synthesis, strand transfer, and primer elongation of Met-184 mutants of HIV-1 reverse transcriptase derive solely from a dNTP utilization defect. J Biol Chem (2008) 1.12
Electroluminescence and photocurrent generation from atomically sharp WSe2/MoS2 heterojunction p-n diodes. Nano Lett (2014) 1.12
Role of miR-150-targeting c-Myb in colonic epithelial disruption during dextran sulphate sodium-induced murine experimental colitis and human ulcerative colitis. J Pathol (2011) 1.11
Analysis of human flap endonuclease 1 mutants reveals a mechanism to prevent triplet repeat expansion. J Biol Chem (2003) 1.10
Tupaia CD81, SR-BI, claudin-1, and occludin support hepatitis C virus infection. J Virol (2010) 1.10
The role of aberrant VHL/HIF pathway elements in predicting clinical outcome to pazopanib therapy in patients with metastatic clear-cell renal cell carcinoma. Clin Cancer Res (2013) 1.10
Runx2 integrates estrogen activity in osteoblasts. J Biol Chem (2003) 1.10
Association of BAP31 with CD11b/CD18. Potential role in intracellular trafficking of CD11b/CD18 in neutrophils. J Biol Chem (2004) 1.09
Flap endonuclease 1 mechanism analysis indicates flap base binding prior to threading. J Biol Chem (2010) 1.09
Intensity-modulated radiation therapy reduces radiation-induced trismus in patients with nasopharyngeal carcinoma: a prospective study with >5 years of follow-up. Cancer (2011) 1.09
GTP is the primary activator of the anti-HIV restriction factor SAMHD1. J Biol Chem (2013) 1.09
Eukaryotic lagging strand DNA replication employs a multi-pathway mechanism that protects genome integrity. J Biol Chem (2010) 1.08
Targeting cell-impermeable prodrug activation to tumor microenvironment eradicates multiple drug-resistant neoplasms. Cancer Res (2006) 1.08
Long patch base excision repair proceeds via coordinated stimulation of the multienzyme DNA repair complex. J Biol Chem (2009) 1.08
Synergistic angiogenesis promoting effects of extracellular matrix scaffolds and adipose-derived stem cells during wound repair. Tissue Eng Part A (2010) 1.07
Role of the Reverse Transcriptase, Nucleocapsid Protein, and Template Structure in the Two-step Transfer Mechanism in Retroviral Recombination. J Biol Chem (2003) 1.07
AP endonuclease 1 coordinates flap endonuclease 1 and DNA ligase I activity in long patch base excision repair. J Biol Chem (2002) 1.07
Synergistic effects of foretinib with HER-targeted agents in MET and HER1- or HER2-coactivated tumor cells. Mol Cancer Ther (2011) 1.06
Characterization of adipocyte differentiation from human mesenchymal stem cells in bone marrow. BMC Dev Biol (2010) 1.06