Hydrocortisone decreases retinal endothelial cell water and solute flux coincident with increased content and decreased phosphorylation of occludin.

PubWeight™: 1.54‹?› | Rank: Top 4%

🔗 View Article (PMID 11841574)

Published in J Neurochem on February 01, 2002

Authors

David A Antonetti1, Ellen B Wolpert, Lucas DeMaio, Nicole S Harhaj, Russell C Scaduto

Author Affiliations

1: Department of Cellular and Molecular Physiology, Pennsylvania State College of Medicine, Hershey, Pennsylvania 17033, USA. dantonetti@psu.edu

Associated clinical trials:

Combination OZURDEX® & LUCENTIS® vs. OZURDEX® Monotherapy in Incomplete-Responders With Diabetic Macular Edema (COLLIDE) | NCT02684084

Combination OZURDEX® & EyLea® vs. OZURDEX® Monotherapy in IncompLete-Responders wIth Diabetic Macular Edema (COLLIDE) | NCT03629210

Articles citing this

Contributions of inflammatory processes to the development of the early stages of diabetic retinopathy. Exp Diabetes Res (2007) 3.67

Intestinal barrier function: molecular regulation and disease pathogenesis. J Allergy Clin Immunol (2009) 2.63

Rho-mediated regulation of tight junctions during monocyte migration across the blood-brain barrier in HIV-1 encephalitis (HIVE). Blood (2006) 1.85

Glucocorticoid induction of occludin expression and endothelial barrier requires transcription factor p54 NONO. Invest Ophthalmol Vis Sci (2013) 1.46

The effect of a preoperative subconjuntival injection of dexamethasone on blood-retinal barrier breakdown following scleral buckling retinal detachment surgery: a prospective randomized placebo-controlled double blind clinical trial. Graefes Arch Clin Exp Ophthalmol (2010) 1.46

Intravitreal triamcinolone acetonide inhibits breakdown of the blood-retinal barrier through differential regulation of VEGF-A and its receptors in early diabetic rat retinas. Diabetes (2008) 1.39

Occludin as direct target for glucocorticoid-induced improvement of blood-brain barrier properties in a murine in vitro system. J Physiol (2005) 1.30

Endoplasmic reticulum stress and diabetic retinopathy. Vasc Health Risk Manag (2008) 1.21

The role of apoptosis in LDL transport through cultured endothelial cell monolayers. Atherosclerosis (2009) 1.03

Increase in the tight junction protein claudin-1 in intestinal inflammation. Dig Dis Sci (2011) 1.01

Short-term results of intravitreal dexamethasone implant (OZURDEX(®)) in treatment of recalcitrant diabetic macular edema: A case series. Oman J Ophthalmol (2012) 1.00

Glucocorticoids induce transactivation of tight junction genes occludin and claudin-5 in retinal endothelial cells via a novel cis-element. Exp Eye Res (2008) 0.98

Vitreous inflammatory factors in macular edema with central retinal vein occlusion. Jpn J Ophthalmol (2011) 0.98

Volatile anesthetics influence blood-brain barrier integrity by modulation of tight junction protein expression in traumatic brain injury. PLoS One (2012) 0.97

[Cystoid macular edema in uveitis]. Ophthalmologe (2005) 0.96

Trans-Tenon's retrobulbar injection of triamcinolone acetonide for diffuse diabetic macular edema. Jpn J Ophthalmol (2005) 0.93

The role of mitosis in LDL transport through cultured endothelial cell monolayers. Am J Physiol Heart Circ Physiol (2010) 0.92

A novel model for brain iron uptake: introducing the concept of regulation. J Cereb Blood Flow Metab (2014) 0.91

Resistin increases monolayer permeability of human coronary artery endothelial cells. PLoS One (2013) 0.87

Intravitreal triamcinolone injection for chronic diabetic macular oedema with severe hard exudates. Graefes Arch Clin Exp Ophthalmol (2005) 0.86

Aqueous flare and inflammatory factors in macular edema with central retinal vein occlusion: a case series. BMC Ophthalmol (2013) 0.83

Stretch and Shear Interactions Affect Intercellular Junction Protein Expression and Turnover in Endothelial Cells. Cell Mol Bioeng (2009) 0.82

Current and future approaches in the prevention and treatment of diabetic retinopathy. Clin Ophthalmol (2008) 0.81

Clinical trials on corticosteroids for diabetic macular edema. World J Diabetes (2013) 0.81

Dexamethasone intravitreal implant in previously treated patients with diabetic macular edema: subgroup analysis of the MEAD study. BMC Ophthalmol (2015) 0.81

Pegaptanib Sodium versus Pegaptanib Sodium Combined with Macular Laser Photocoagulation or Laser Alone for Diabetic Macular Edema. J Ophthalmol (2010) 0.80

Effect of intravitreal bevacizumab on diabetic macular edema with hard exudates. Clin Ophthalmol (2014) 0.80

Steroid differentiation: the safety profile of various steroids on retinal cells in vitro and their implications for clinical use (an American Ophthalmological Society thesis). Trans Am Ophthalmol Soc (2014) 0.80

Triamcinolone acetonide prevents oxidative stress-induced tight junction disruption of retinal pigment epithelial cells. Graefes Arch Clin Exp Ophthalmol (2009) 0.80

Mechanism of metabolic stroke and spontaneous cerebral hemorrhage in glutaric aciduria type I. Acta Neuropathol Commun (2014) 0.80

bFGF Protects Against Blood-Brain Barrier Damage Through Junction Protein Regulation via PI3K-Akt-Rac1 Pathway Following Traumatic Brain Injury. Mol Neurobiol (2015) 0.80

Etiology and treatment of the inflammatory causes of cystoid macular edema. J Inflamm Res (2009) 0.79

Macular sensitivity and morphology after intravitreal injection of triamcinolone acetonide for macular edema secondary to central retinal vein occlusion. Clin Ophthalmol (2012) 0.78

Efficacy of single-dose dexamethasone implantation in patients with persistent diabetic macular edema. Int Ophthalmol (2015) 0.77

Updates on the Clinical Trials in Diabetic Macular Edema. Middle East Afr J Ophthalmol (2016) 0.77

Foveal sensitivity and morphology in major and macular branch retinal vein occlusion. Open Ophthalmol J (2012) 0.77

Compound 49b Regulates ZO-1 and Occludin Levels in Human Retinal Endothelial Cells and in Mouse Retinal Vasculature. Invest Ophthalmol Vis Sci (2017) 0.77

Effect of intravitreal dexamethasone implant on retinal and choroidal thickness in refractory diabetic macular oedema after multiple anti-VEGF injections. Eye (Lond) (2016) 0.76

Intraoperative intravitreal triamcinolone decreases macular edema after vitrectomy with phacoemulsification. Clin Ophthalmol (2012) 0.76

Microvascular transport and tumor cell adhesion in the microcirculation. Ann Biomed Eng (2012) 0.75

Treatment of polypoidal choroidal vasculopathy by photodynamic therapy, aflibercept and dexamethasone triple therapy. Sci Rep (2016) 0.75

Comparison of the efficacy of intravitreal triamcinolone acetonide for cystoid macular edema with versus without serous retinal detachment in branch retinal vein occlusion: influence on macular sensitivity and morphology. BMC Ophthalmol (2012) 0.75

Long-term follow-up of anatomical and functional macular changes after a single intravitreal implant of dexamethasone 0.7 mg for radiation macular edema secondary to proton beam therapy for choroidal melanoma. Int Med Case Rep J (2016) 0.75

Clinical utility of intravitreal fluocinolone acetonide (Iluvien(®)) implant in the management of patients with chronic diabetic macular edema: a review of the current literature. Clin Ophthalmol (2017) 0.75

Glucocorticoids in the management of peritumoral brain edema: a review of molecular mechanisms. Childs Nerv Syst (2016) 0.75

Articles by these authors

The E3 ligase Itch negatively regulates inflammatory signaling pathways by controlling the function of the ubiquitin-editing enzyme A20. Nat Immunol (2008) 3.55

A diet-induced mouse model for glutaric aciduria type I. Brain (2006) 2.31

The ubiquitin-editing enzyme A20 requires RNF11 to downregulate NF-kappaB signalling. EMBO J (2009) 2.17

Essential role for TAX1BP1 in the termination of TNF-alpha-, IL-1- and LPS-mediated NF-kappaB and JNK signaling. EMBO J (2007) 1.95

VEGF activation of protein kinase C stimulates occludin phosphorylation and contributes to endothelial permeability. Invest Ophthalmol Vis Sci (2006) 1.86

The human T-cell leukemia virus type 1 Tax oncoprotein requires the ubiquitin-conjugating enzyme Ubc13 for NF-kappaB activation. J Virol (2007) 1.66

Characterization of insulin signaling in rat retina in vivo and ex vivo. Am J Physiol Endocrinol Metab (2003) 1.29

Evaluation of the role of P-glycoprotein in the uptake of paroxetine, clozapine, phenytoin and carbamazapine by bovine retinal endothelial cells. Neuropharmacology (2005) 1.07

IGF-I prevents glutamate-mediated bax translocation and cytochrome C release in O4+ oligodendrocyte progenitors. Glia (2004) 1.06

Human T cell leukemia virus type 1 Tax inhibits innate antiviral signaling via NF-kappaB-dependent induction of SOCS1. J Virol (2011) 1.05

The kinase IKKα inhibits activation of the transcription factor NF-κB by phosphorylating the regulatory molecule TAX1BP1. Nat Immunol (2011) 1.05

Mechanisms of alveolar epithelial translocation of a defined population of nanoparticles. Am J Respir Cell Mol Biol (2009) 1.04

Effects of ischemic preconditioning and bevacizumab on apoptosis and vascular permeability following retinal ischemia-reperfusion injury. Invest Ophthalmol Vis Sci (2010) 1.02

A transmural pressure gradient induces mechanical and biological adaptive responses in endothelial cells. Am J Physiol Heart Circ Physiol (2003) 1.01

Mechanisms of persistent NF-kappaB activation by HTLV-I tax. IUBMB Life (2005) 1.01

Pharmacologic manipulation of sphingosine kinase in retinal endothelial cells: implications for angiogenic ocular diseases. Invest Ophthalmol Vis Sci (2006) 0.99

Isolation and characterization of retinal endothelial cells. Methods Mol Med (2003) 0.95

Human T cell leukemia virus type I Tax activates CD40 gene expression via the NF-kappa B pathway. Virology (2005) 0.95

Systemic isotretinoin therapy normalizes exaggerated TLR-2-mediated innate immune responses in acne patients. J Invest Dermatol (2012) 0.90

Troglitazone attenuates TGF-β1-induced EMT in alveolar epithelial cells via a PPARγ-independent mechanism. PLoS One (2012) 0.88

Knockout mice reveal key roles for claudin 18 in alveolar barrier properties and fluid homeostasis. Am J Respir Cell Mol Biol (2014) 0.88

VEGF increases paracellular transport without altering the solvent-drag reflection coefficient. Microvasc Res (2004) 0.84

New insights for glutaric aciduria type I. Brain (2006) 0.75

MEMS shear stress sensors for cardiovascular diagnostics. Conf Proc IEEE Eng Med Biol Soc (2004) 0.75

Detection of oxidized low density lipoproteins by indium oxide nanowires-based field effect transistor. Conf Proc IEEE Eng Med Biol Soc (2004) 0.75