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1
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Inactivation of the Fto gene protects from obesity.
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Nature
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2009
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5.61
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2
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The ciliary gene RPGRIP1L is mutated in cerebello-oculo-renal syndrome (Joubert syndrome type B) and Meckel syndrome.
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Nat Genet
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2007
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4.63
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3
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The mouse Fused toes (Ft) mutation is the result of a 1.6-Mb deletion including the entire Iroquois B gene cluster.
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Mamm Genome
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2002
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4.06
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4
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Ftm is a novel basal body protein of cilia involved in Shh signalling.
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Development
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2007
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2.25
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5
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Dorsal-ventral patterning of the spinal cord requires Gli3 transcriptional repressor activity.
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Genes Dev
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2002
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2.10
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6
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The Wnt antagonist Dickkopf-1 is regulated by Bmp signaling and c-Jun and modulates programmed cell death.
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EMBO J
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2002
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1.57
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7
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The fat mass and obesity associated gene (Fto) regulates activity of the dopaminergic midbrain circuitry.
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Nat Neurosci
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2013
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1.57
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8
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Pallister-Hall syndrome phenotype in mice mutant for Gli3.
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Hum Mol Genet
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2002
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1.49
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9
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The Shh-independent activator function of the full-length Gli3 protein and its role in vertebrate limb digit patterning.
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Dev Biol
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2007
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1.45
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10
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Opposing gradients of Gli repressor and activators mediate Shh signaling along the dorsoventral axis of the inner ear.
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Development
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2007
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1.37
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11
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Wnt and Bmp signalling cooperatively regulate graded Emx2 expression in the dorsal telencephalon.
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Development
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2002
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1.32
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12
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Hedgehog signaling regulates sensory cell formation and auditory function in mice and humans.
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J Neurosci
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2008
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1.30
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13
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Thalidomide induces limb deformities by perturbing the Bmp/Dkk1/Wnt signaling pathway.
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FASEB J
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2007
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1.26
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14
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Shedding light on an old mystery: thalidomide suppresses survival pathways to induce limb defects.
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Cell Cycle
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2008
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1.17
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15
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Defects in brain patterning and head morphogenesis in the mouse mutant Fused toes.
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Dev Biol
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2006
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1.10
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16
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A disrupted balance between Bmp/Wnt and Fgf signaling underlies the ventralization of the Gli3 mutant telencephalon.
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Dev Biol
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2003
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1.08
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17
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Generation of thyrotropin-releasing hormone receptor 1-deficient mice as an animal model of central hypothyroidism.
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Mol Endocrinol
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2004
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1.05
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18
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Critical involvement of hydrogen peroxide in exercise-induced up-regulation of endothelial NO synthase.
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Cardiovasc Res
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2005
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1.04
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19
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FTO levels affect RNA modification and the transcriptome.
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Eur J Hum Genet
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2012
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1.00
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20
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Thalidomide resistance is based on the capacity of the glutathione-dependent antioxidant defense.
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Mol Pharm
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2009
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0.97
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21
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Primary cilia control telencephalic patterning and morphogenesis via Gli3 proteolytic processing.
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Development
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2011
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0.96
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22
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Expression of the zebrafish Iroquois genes during early nervous system formation and patterning.
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J Comp Neurol
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2005
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0.95
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23
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Bmp, Fgf and Wnt signalling in programmed cell death and chondrogenesis during vertebrate limb development: the role of Dickkopf-1.
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Int J Dev Biol
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2002
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0.94
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24
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A SHH-independent regulation of Gli3 is a significant determinant of anteroposterior patterning of the limb bud.
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Dev Biol
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2009
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0.94
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25
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The molecular basis of Pallister Hall associated polydactyly.
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Hum Mol Genet
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2007
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0.93
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26
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Homozygous Ft embryos are affected in floor plate maintenance and ventral neural tube patterning.
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Dev Dyn
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2005
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0.88
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27
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The ciliary protein Ftm is required for ventricular wall and septal development.
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PLoS One
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2013
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0.87
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28
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Organization of Iroquois genes in fish.
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Dev Genes Evol
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2004
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0.87
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29
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Thalidomide induces limb anomalies by PTEN stabilization, Akt suppression, and stimulation of caspase-dependent cell death.
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Mol Cell Biol
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2008
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0.86
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30
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Cardiospecific overexpression of the prostaglandin EP3 receptor attenuates ischemia-induced myocardial injury.
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Circulation
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2005
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0.85
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31
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Expression of the human Cathepsin L inhibitor hurpin in mice: skin alterations and increased carcinogenesis.
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Exp Dermatol
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2007
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0.84
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32
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The Fused toes (Ft) mouse mutation causes anteroposterior and dorsoventral polydactyly.
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Dev Biol
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2002
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0.83
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33
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Primordial germ cell proliferation is impaired in Fused Toes mutant embryos.
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Dev Biol
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2010
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0.81
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34
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The Dkk1 dose is critical for eye development.
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Dev Biol
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2011
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0.80
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35
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Laminar and subcellular heterogeneity of GLAST and GLT-1 immunoreactivity in the developing postnatal mouse hippocampus.
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J Comp Neurol
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2014
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0.79
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36
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The fused toes locus is essential for somatic-germ cell interactions that foster germ cell maturation in developing gonads in mice.
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Biol Reprod
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2011
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0.79
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37
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The regulation of Dkk1 expression during embryonic development.
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Dev Biol
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2010
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0.78
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