Published in EMBO J on March 01, 2002
Antibody-based inhibition of DKK1 suppresses tumor-induced bone resorption and multiple myeloma growth in vivo. Blood (2006) 2.91
FGF-20 and DKK1 are transcriptional targets of beta-catenin and FGF-20 is implicated in cancer and development. EMBO J (2004) 2.24
The role of Dickkopf-1 in bone development, homeostasis, and disease. Blood (2008) 2.05
Secreted and transmembrane wnt inhibitors and activators. Cold Spring Harb Perspect Biol (2013) 2.01
Shift of localized growth zones contributes to skin appendage morphogenesis: role of the Wnt/beta-catenin pathway. J Invest Dermatol (2003) 1.95
Kinase-mediated regulation of common transcription factors accounts for the bone-protective effects of sex steroids. J Clin Invest (2003) 1.84
Lrp4, a novel receptor for Dickkopf 1 and sclerostin, is expressed by osteoblasts and regulates bone growth and turnover in vivo. PLoS One (2009) 1.67
Mesenchymal-epithelial interactions in the skin: increased expression of dickkopf1 by palmoplantar fibroblasts inhibits melanocyte growth and differentiation. J Cell Biol (2004) 1.56
Wnt inhibitors Dkk1 and Sost are downstream targets of BMP signaling through the type IA receptor (BMPRIA) in osteoblasts. J Bone Miner Res (2010) 1.54
Winding through the WNT pathway during cellular development and demise. Histol Histopathol (2006) 1.50
A soluble bone morphogenetic protein type IA receptor increases bone mass and bone strength. Proc Natl Acad Sci U S A (2012) 1.48
Targeted disruption of the Wnt regulator Kremen induces limb defects and high bone density. Mol Cell Biol (2008) 1.41
The Wnt signaling pathway: aging gracefully as a protectionist? Pharmacol Ther (2008) 1.38
Processing by proprotein convertases is required for glypican-3 modulation of cell survival, Wnt signaling, and gastrulation movements. J Cell Biol (2003) 1.36
The oxidative stress response regulates DKK1 expression through the JNK signaling cascade in multiple myeloma plasma cells. Blood (2007) 1.33
Role of Dickkopf-1, an antagonist of the Wnt/beta-catenin signaling pathway, in estrogen-induced neuroprotection and attenuation of tau phosphorylation. J Neurosci (2008) 1.31
Induction of osteoblast differentiation by selective activation of kinase-mediated actions of the estrogen receptor. Mol Cell Biol (2006) 1.28
Programmed cell death remodels lace plant leaf shape during development. Plant Cell (2003) 1.24
Vital elements of the Wnt-Frizzled signaling pathway in the nervous system. Curr Neurovasc Res (2005) 1.21
WNTS and WNT receptors as therapeutic tools and targets in human disease processes. Front Biosci (2007) 1.11
Mutations in PVRL4, encoding cell adhesion molecule nectin-4, cause ectodermal dysplasia-syndactyly syndrome. Am J Hum Genet (2010) 1.06
Wnt signaling in amygdala-dependent learning and memory. J Neurosci (2011) 1.05
S100B induces tau protein hyperphosphorylation via Dickopff-1 up-regulation and disrupts the Wnt pathway in human neural stem cells. J Cell Mol Med (2008) 1.04
Triple play: promoting neurovascular longevity with nicotinamide, WNT, and erythropoietin in diabetes mellitus. Biomed Pharmacother (2008) 1.02
Tfap2a and Foxd3 regulate early steps in the development of the neural crest progenitor population. Dev Biol (2011) 1.01
SMAD4-mediated WNT signaling controls the fate of cranial neural crest cells during tooth morphogenesis. Development (2011) 1.00
REIC/Dkk-3 induces cell death in human malignant glioma. Neuro Oncol (2008) 1.00
DKK1 mediated inhibition of Wnt signaling in postnatal mice leads to loss of TEC progenitors and thymic degeneration. PLoS One (2010) 0.99
p21CIP-1/WAF-1 induction is required to inhibit prostate cancer growth elicited by deficient expression of the Wnt inhibitor Dickkopf-1. Cancer Res (2010) 0.99
Mapping of Wnt, frizzled, and Wnt inhibitor gene expression domains in the avian otic primordium. J Comp Neurol (2009) 0.97
Brachy-syndactyly caused by loss of Sfrp2 function. J Cell Physiol (2008) 0.94
GeneChip analysis of human embryonic stem cell differentiation into hemangioblasts: an in silico dissection of mixed phenotypes. Genome Biol (2007) 0.92
Post-natal effect of overexpressed DKK1 on mandibular molar formation. J Dent Res (2011) 0.90
Induction of the Wnt antagonist Dickkopf-1 is involved in stress-induced hippocampal damage. PLoS One (2011) 0.89
Dkk1 in the peri-cloaca mesenchyme regulates formation of anorectal and genitourinary tracts. Dev Biol (2014) 0.88
Tbx2 terminates shh/fgf signaling in the developing mouse limb bud by direct repression of gremlin1. PLoS Genet (2013) 0.86
Involvement of Wnt signaling in dermal fibroblasts. Am J Pathol (2009) 0.86
Wnt/β-catenin pathway regulates bone morphogenetic protein (BMP2)-mediated differentiation of dental follicle cells. J Periodontal Res (2011) 0.86
Parathyroid hormone-related protein inhibits DKK1 expression through c-Jun-mediated inhibition of β-catenin activation of the DKK1 promoter in prostate cancer. Oncogene (2013) 0.86
Deciphering gene expression program of MAP3K1 in mouse eyelid morphogenesis. Dev Biol (2012) 0.85
Estrogen regulation of Dkk1 and Wnt/β-Catenin signaling in neurodegenerative disease. Brain Res (2012) 0.84
Dkk1, -2, and -3 expression in mouse craniofacial development. J Mol Histol (2005) 0.84
A novel sLRP6E1E2 inhibits canonical Wnt signaling, epithelial-to-mesenchymal transition, and induces mitochondria-dependent apoptosis in lung cancer. PLoS One (2012) 0.84
Dysregulation of Wnt inhibitory factor 1 (Wif1) expression resulted in aberrant Wnt-β-catenin signaling and cell death of the cloaca endoderm, and anorectal malformations. Cell Death Differ (2014) 0.81
Embryonic origin and remodeling of the urinary and digestive outlets. PLoS One (2013) 0.81
Developmental expression of Dkk1-3 and Mmp9 and apoptosis in cranial base of mice. J Mol Histol (2006) 0.80
Long-term estrogen deprivation leads to elevation of Dickkopf-1 and dysregulation of Wnt/β-Catenin signaling in hippocampal CA1 neurons. Steroids (2012) 0.79
Role of wnt signaling in the control of adult hippocampal functioning in health and disease: therapeutic implications. Curr Neuropharmacol (2013) 0.78
Modulating Dickkopf-1: A Strategy to Monitor or Treat Cancer? Cancers (Basel) (2016) 0.77
Differential binding of Lef1 and Msx1/2 transcription factors to Dkk1 CNEs correlates with reporter gene expression in vivo. PLoS One (2014) 0.75
Surfing the p53 network. Nature (2000) 35.36
Wnt signaling and cancer. Genes Dev (2000) 18.53
JNK1: a protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain. Cell (1994) 16.30
Wnt signaling: a common theme in animal development. Genes Dev (1997) 12.94
TGFbeta signaling in growth control, cancer, and heritable disorders. Cell (2000) 12.38
Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function. Nature (1996) 11.46
The stress-activated protein kinase subfamily of c-Jun kinases. Nature (1994) 11.45
Dickkopf-1 is a member of a new family of secreted proteins and functions in head induction. Nature (1998) 8.02
The jun proto-oncogene is positively autoregulated by its product, Jun/AP-1. Cell (1988) 7.76
LDL-receptor-related protein 6 is a receptor for Dickkopf proteins. Nature (2001) 7.44
Low-density lipoprotein receptor-related protein-5 binds to Axin and regulates the canonical Wnt signaling pathway. Mol Cell (2001) 5.19
Siah-1, SIP, and Ebi collaborate in a novel pathway for beta-catenin degradation linked to p53 responses. Mol Cell (2001) 4.62
Inhibition of Wnt activity induces heart formation from posterior mesoderm. Genes Dev (2001) 4.41
Smad3 and Smad4 cooperate with c-Jun/c-Fos to mediate TGF-beta-induced transcription. Nature (1998) 4.13
The TAK1-NLK-MAPK-related pathway antagonizes signalling between beta-catenin and transcription factor TCF. Nature (1999) 4.01
c-jun is essential for normal mouse development and hepatogenesis. Nature (1993) 3.43
Amino-terminal phosphorylation of c-Jun regulates stress-induced apoptosis and cellular proliferation. Nat Genet (1999) 3.42
Siah-1 mediates a novel beta-catenin degradation pathway linking p53 to the adenomatous polyposis coli protein. Mol Cell (2001) 3.34
Dickkopf1 is required for embryonic head induction and limb morphogenesis in the mouse. Dev Cell (2001) 3.30
The roles of FGFs in the early development of vertebrate limbs. Genes Dev (1998) 2.86
Dual roles of Wnt signaling during chondrogenesis in the chicken limb. Development (2000) 2.61
Immediate early up-regulation of bax expression by p53 but not TGF beta 1: a paradigm for distinct apoptotic pathways. Oncogene (1994) 2.49
Distortion of proximodistal information causes JNK-dependent apoptosis in Drosophila wing. Nature (1999) 2.42
TAK1 is activated in the myocardium after pressure overload and is sufficient to provoke heart failure in transgenic mice. Nat Med (2000) 2.29
Role of TAK1 and TAB1 in BMP signaling in early Xenopus development. EMBO J (1998) 2.15
Smad3-Smad4 and AP-1 complexes synergize in transcriptional activation of the c-Jun promoter by transforming growth factor beta. Mol Cell Biol (1999) 2.08
Induction of apoptosis by the transcription factor c-Jun. EMBO J (1997) 2.02
BMP2-induced apoptosis is mediated by activation of the TAK1-p38 kinase pathway that is negatively regulated by Smad6. J Biol Chem (2000) 1.93
The mammalian UV response: c-Jun induction is required for exit from p53-imposed growth arrest. Cell (2000) 1.81
WNT signals control FGF-dependent limb initiation and AER induction in the chick embryo. Cell (2001) 1.79
Wnt signalling: antagonistic Dickkopfs. Curr Biol (2001) 1.57
Role of BMP-2 and OP-1 (BMP-7) in programmed cell death and skeletogenesis during chick limb development. Development (1997) 1.56
Overexpression of BMP-2 and BMP-4 alters the size and shape of developing skeletal elements in the chick limb. Mech Dev (1996) 1.54
TAK1 participates in c-Jun N-terminal kinase signaling during Drosophila development. Mol Cell Biol (2000) 1.41
BMP-2/-4 mediate programmed cell death in chicken limb buds. Development (1996) 1.36
Molecular mechanism of staurosporine-induced apoptosis in osteoblasts. Pharmacol Res (2000) 1.32
Msx2 is a transcriptional regulator in the BMP4-mediated programmed cell death pathway. Dev Biol (1997) 1.32
Tissue-specific expression of c-jun and junB during organogenesis in the mouse. Development (1989) 1.29
BMPs negatively regulate structure and function of the limb apical ectodermal ridge. Development (1999) 1.29
Dickkopf-1, an inhibitor of the Wnt signaling pathway, is induced by p53. Oncogene (2000) 1.23
Bambi is coexpressed with Bmp-4 during mouse embryogenesis. Mech Dev (2001) 1.20
c-Jun interacts with the corepressor TG-interacting factor (TGIF) to suppress Smad2 transcriptional activity. Proc Natl Acad Sci U S A (2001) 1.17
Autoregulation of Shh expression and Shh induction of cell death suggest a mechanism for modulating polarising activity during chick limb development. Development (2000) 1.12
Zebrafish Dkk1, induced by the pre-MBT Wnt signaling, is secreted from the prechordal plate and patterns the anterior neural plate. Mech Dev (2000) 1.10
Expression pattern of Dkk-1 during mouse limb development. Mech Dev (1999) 1.03
Antagonistic effects of FGF4 on BMP induction of apoptosis and chondrogenesis in the chick limb bud. Mech Dev (1998) 0.96
Mode of cell injury and death after hydrogen peroxide exposure in cultured oligodendroglia cells. Exp Cell Res (1998) 0.95
Differential induction of c-fos, c-jun, and apoptosis in lung epithelial cells exposed to ROS or RNS. Am J Physiol (1997) 0.94
Axin-induced apoptosis depends on the extent of its JNK activation and its ability to down-regulate beta-catenin levels. Biochem Biophys Res Commun (2000) 0.93
Wnt signaling: an embarrassment of receptors. Curr Biol (2001) 0.92
Role of FGFs in the control of programmed cell death during limb development. Development (2001) 0.92
Amino-terminal-derived JNK fragment alters expression and activity of c-Jun, ATF2, and p53 and increases H2O2-induced cell death. J Biol Chem (2000) 0.92
Expression profile of Gli family members and Shh in normal and mutant mouse limb development. Dev Dyn (1998) 0.91
Transforming growth factor-beta 1 induces apoptosis independently of p53 and selectively reduces expression of Bcl-2 in multipotent hematopoietic cells. J Biol Chem (2000) 0.89
Transforming growth factor-beta 1 induces apoptosis in gastric cancer cells through a p53-independent pathway. Cancer (1996) 0.88
BMP signaling and vertebrate limb development. Cold Spring Harb Symp Quant Biol (1997) 0.84
Morphology and significance of programmed cell death in the developing limb bud of the vertebrate embryo. Microsc Res Tech (1996) 0.82
Protein kinase C inhibitor and irradiation-induced apoptosis: relevance of the cytochrome c-mediated caspase-9 death pathway. Cell Growth Differ (2000) 0.82
Pattern of expression of the jun family of transcription factors during the early development of the inner ear: implications in apoptosis. J Cell Sci (1999) 0.80
Syndactyly of Ft/+ mice correlates with an imbalance in bmp4 and fgf8 expression. Mech Dev (1999) 0.78
Inactivation of the Fto gene protects from obesity. Nature (2009) 5.61
The ciliary gene RPGRIP1L is mutated in cerebello-oculo-renal syndrome (Joubert syndrome type B) and Meckel syndrome. Nat Genet (2007) 4.63
The mouse Fused toes (Ft) mutation is the result of a 1.6-Mb deletion including the entire Iroquois B gene cluster. Mamm Genome (2002) 4.06
Ftm is a novel basal body protein of cilia involved in Shh signalling. Development (2007) 2.25
Dorsal-ventral patterning of the spinal cord requires Gli3 transcriptional repressor activity. Genes Dev (2002) 2.10
The fat mass and obesity associated gene (Fto) regulates activity of the dopaminergic midbrain circuitry. Nat Neurosci (2013) 1.57
Pallister-Hall syndrome phenotype in mice mutant for Gli3. Hum Mol Genet (2002) 1.49
The Shh-independent activator function of the full-length Gli3 protein and its role in vertebrate limb digit patterning. Dev Biol (2007) 1.45
Opposing gradients of Gli repressor and activators mediate Shh signaling along the dorsoventral axis of the inner ear. Development (2007) 1.37
Wnt and Bmp signalling cooperatively regulate graded Emx2 expression in the dorsal telencephalon. Development (2002) 1.32
Hedgehog signaling regulates sensory cell formation and auditory function in mice and humans. J Neurosci (2008) 1.30
Thalidomide induces limb deformities by perturbing the Bmp/Dkk1/Wnt signaling pathway. FASEB J (2007) 1.26
Shedding light on an old mystery: thalidomide suppresses survival pathways to induce limb defects. Cell Cycle (2008) 1.17
Defects in brain patterning and head morphogenesis in the mouse mutant Fused toes. Dev Biol (2006) 1.10
A disrupted balance between Bmp/Wnt and Fgf signaling underlies the ventralization of the Gli3 mutant telencephalon. Dev Biol (2003) 1.08
Generation of thyrotropin-releasing hormone receptor 1-deficient mice as an animal model of central hypothyroidism. Mol Endocrinol (2004) 1.05
Critical involvement of hydrogen peroxide in exercise-induced up-regulation of endothelial NO synthase. Cardiovasc Res (2005) 1.04
FTO levels affect RNA modification and the transcriptome. Eur J Hum Genet (2012) 1.00
Thalidomide resistance is based on the capacity of the glutathione-dependent antioxidant defense. Mol Pharm (2009) 0.97
Primary cilia control telencephalic patterning and morphogenesis via Gli3 proteolytic processing. Development (2011) 0.96
Expression of the zebrafish Iroquois genes during early nervous system formation and patterning. J Comp Neurol (2005) 0.95
Bmp, Fgf and Wnt signalling in programmed cell death and chondrogenesis during vertebrate limb development: the role of Dickkopf-1. Int J Dev Biol (2002) 0.94
A SHH-independent regulation of Gli3 is a significant determinant of anteroposterior patterning of the limb bud. Dev Biol (2009) 0.94
The molecular basis of Pallister Hall associated polydactyly. Hum Mol Genet (2007) 0.93
Homozygous Ft embryos are affected in floor plate maintenance and ventral neural tube patterning. Dev Dyn (2005) 0.88
The ciliary protein Ftm is required for ventricular wall and septal development. PLoS One (2013) 0.87
Organization of Iroquois genes in fish. Dev Genes Evol (2004) 0.87
Thalidomide induces limb anomalies by PTEN stabilization, Akt suppression, and stimulation of caspase-dependent cell death. Mol Cell Biol (2008) 0.86
Cardiospecific overexpression of the prostaglandin EP3 receptor attenuates ischemia-induced myocardial injury. Circulation (2005) 0.85
Expression of the human Cathepsin L inhibitor hurpin in mice: skin alterations and increased carcinogenesis. Exp Dermatol (2007) 0.84
The Fused toes (Ft) mouse mutation causes anteroposterior and dorsoventral polydactyly. Dev Biol (2002) 0.83
Primordial germ cell proliferation is impaired in Fused Toes mutant embryos. Dev Biol (2010) 0.81
The Dkk1 dose is critical for eye development. Dev Biol (2011) 0.80
The fused toes locus is essential for somatic-germ cell interactions that foster germ cell maturation in developing gonads in mice. Biol Reprod (2011) 0.79
Laminar and subcellular heterogeneity of GLAST and GLT-1 immunoreactivity in the developing postnatal mouse hippocampus. J Comp Neurol (2014) 0.79
The regulation of Dkk1 expression during embryonic development. Dev Biol (2010) 0.78