Published in Development on June 06, 2007
The primary cilium: a signalling centre during vertebrate development. Nat Rev Genet (2010) 8.81
Inactivation of the Fto gene protects from obesity. Nature (2009) 5.61
The vertebrate primary cilium in development, homeostasis, and disease. Cell (2009) 5.29
A transition zone complex regulates mammalian ciliogenesis and ciliary membrane composition. Nat Genet (2011) 3.57
Regulation of Fto/Ftm gene expression in mice and humans. Am J Physiol Regul Integr Comp Physiol (2008) 3.49
THM1 negatively modulates mouse sonic hedgehog signal transduction and affects retrograde intraflagellar transport in cilia. Nat Genet (2008) 3.19
Mechanistic insights into Bardet-Biedl syndrome, a model ciliopathy. J Clin Invest (2009) 3.19
Loss of nephrocystin-3 function can cause embryonic lethality, Meckel-Gruber-like syndrome, situs inversus, and renal-hepatic-pancreatic dysplasia. Am J Hum Genet (2008) 2.74
Mutations in the cilia gene ARL13B lead to the classical form of Joubert syndrome. Am J Hum Genet (2008) 2.65
Primary cilia are required for cerebellar development and Shh-dependent expansion of progenitor pool. Dev Biol (2008) 2.38
The base of the cilium: roles for transition fibres and the transition zone in ciliary formation, maintenance and compartmentalization. EMBO Rep (2012) 2.17
Primary cilia and signaling pathways in mammalian development, health and disease. Nephron Physiol (2009) 2.09
Dampened Hedgehog signaling but normal Wnt signaling in zebrafish without cilia. Development (2009) 1.93
The genetics of obesity: FTO leads the way. Trends Genet (2010) 1.90
Joubert syndrome: congenital cerebellar ataxia with the molar tooth. Lancet Neurol (2013) 1.83
OFD1 is mutated in X-linked Joubert syndrome and interacts with LCA5-encoded lebercilin. Am J Hum Genet (2009) 1.83
The primary cilium at the crossroads of mammalian hedgehog signaling. Curr Top Dev Biol (2008) 1.75
TMEM237 is mutated in individuals with a Joubert syndrome related disorder and expands the role of the TMEM family at the ciliary transition zone. Am J Hum Genet (2011) 1.65
Mutations in KIF7 link Joubert syndrome with Sonic Hedgehog signaling and microtubule dynamics. J Clin Invest (2011) 1.60
Scoring a backstage pass: mechanisms of ciliogenesis and ciliary access. J Cell Biol (2012) 1.55
A mouse model for Meckel syndrome reveals Mks1 is required for ciliogenesis and Hedgehog signaling. Hum Mol Genet (2009) 1.55
Arl13b regulates ciliogenesis and the dynamic localization of Shh signaling proteins. Mol Biol Cell (2011) 1.51
Cilia in vertebrate development and disease. Development (2012) 1.50
Role of primary cilia in brain development and cancer. Curr Opin Neurobiol (2010) 1.49
Joubert syndrome: insights into brain development, cilium biology, and complex disease. Semin Pediatr Neurol (2009) 1.48
The Talpid3 gene (KIAA0586) encodes a centrosomal protein that is essential for primary cilia formation. Development (2009) 1.45
B9D1 is revealed as a novel Meckel syndrome (MKS) gene by targeted exon-enriched next-generation sequencing and deletion analysis. Hum Mol Genet (2011) 1.45
Cilia in the nervous system: linking cilia function and neurodevelopmental disorders. Curr Opin Neurol (2011) 1.43
Hypomorphism for RPGRIP1L, a ciliary gene vicinal to the FTO locus, causes increased adiposity in mice. Cell Metab (2014) 1.42
Neurogenesis at the brain-cerebrospinal fluid interface. Annu Rev Cell Dev Biol (2011) 1.42
Nephronophthisis. Pediatr Nephrol (2008) 1.40
Disruption of a ciliary B9 protein complex causes Meckel syndrome. Am J Hum Genet (2011) 1.40
The primary cilium as a Hedgehog signal transduction machine. Methods Cell Biol (2009) 1.35
Ahi1, whose human ortholog is mutated in Joubert syndrome, is required for Rab8a localization, ciliogenesis and vesicle trafficking. Hum Mol Genet (2009) 1.33
Association of FTO variants with BMI and fat mass in the self-contained population of Sorbs in Germany. Eur J Hum Genet (2010) 1.26
Cut-like homeobox 1 (CUX1) regulates expression of the fat mass and obesity-associated and retinitis pigmentosa GTPase regulator-interacting protein-1-like (RPGRIP1L) genes and coordinates leptin receptor signaling. J Biol Chem (2010) 1.26
Functional interactions between the ciliopathy-associated Meckel syndrome 1 (MKS1) protein and two novel MKS1-related (MKSR) proteins. J Cell Sci (2009) 1.26
Broad-minded links cell cycle-related kinase to cilia assembly and hedgehog signal transduction. Dev Cell (2010) 1.25
Disruption of Mks1 localization to the mother centriole causes cilia defects and developmental malformations in Meckel-Gruber syndrome. Dis Model Mech (2010) 1.18
The relationship between sonic Hedgehog signaling, cilia, and neural tube defects. Birth Defects Res A Clin Mol Teratol (2010) 1.16
Mouse hitchhiker mutants have spina bifida, dorso-ventral patterning defects and polydactyly: identification of Tulp3 as a novel negative regulator of the Sonic hedgehog pathway. Hum Mol Genet (2009) 1.16
Primary cilia in neurodevelopmental disorders. Nat Rev Neurol (2013) 1.14
A meckelin-filamin A interaction mediates ciliogenesis. Hum Mol Genet (2011) 1.12
Human retinopathy-associated ciliary protein retinitis pigmentosa GTPase regulator mediates cilia-dependent vertebrate development. Hum Mol Genet (2010) 1.11
Primary cilia in the developing and mature brain. Neuron (2014) 1.11
CSPP is a ciliary protein interacting with Nephrocystin 8 and required for cilia formation. Mol Biol Cell (2010) 1.10
The ciliopathy gene cc2d2a controls zebrafish photoreceptor outer segment development through a role in Rab8-dependent vesicle trafficking. Hum Mol Genet (2011) 1.09
Generation of mice with functional inactivation of talpid3, a gene first identified in chicken. Development (2011) 1.07
Cilia involvement in patterning and maintenance of the skeleton. Curr Top Dev Biol (2008) 1.06
The Hedgehog gene family of the cnidarian, Nematostella vectensis, and implications for understanding metazoan Hedgehog pathway evolution. Dev Biol (2007) 1.06
Meckel-Gruber syndrome and the role of primary cilia in kidney, skeleton, and central nervous system development. Organogenesis (2013) 0.98
The role of primary cilia in the development and disease of the retina. Organogenesis (2013) 0.98
Dishevelled stabilization by the ciliopathy protein Rpgrip1l is essential for planar cell polarity. J Cell Biol (2012) 0.96
The ciliogenic transcription factor RFX3 regulates early midline distribution of guidepost neurons required for corpus callosum development. PLoS Genet (2012) 0.96
Mouse models of ciliopathies: the state of the art. Dis Model Mech (2012) 0.94
The emerging face of primary cilia. Genesis (2011) 0.94
Ciliary signaling cascades in photoreceptors. Vision Res (2012) 0.93
Ciliopathies: the trafficking connection. Traffic (2014) 0.93
The primary cilia, a 'Rab-id' transit system for hedgehog signaling. Curr Opin Cell Biol (2007) 0.91
The ciliary protein Ftm is required for ventricular wall and septal development. PLoS One (2013) 0.87
Cilia and coordination of signaling networks during heart development. Organogenesis (2013) 0.87
Analysis of hedgehog signaling in mouse intraflagellar transport mutants. Methods Cell Biol (2009) 0.86
Ins and outs of GPCR signaling in primary cilia. EMBO Rep (2015) 0.84
Ofd1 controls dorso-ventral patterning and axoneme elongation during embryonic brain development. PLoS One (2012) 0.83
Cilia in cell signaling and human disorders. Protein Cell (2010) 0.83
Consistent left-right asymmetry cannot be established by late organizers in Xenopus unless the late organizer is a conjoined twin. Development (2010) 0.83
Subcellular distribution of patched and smoothened in the cerebellar neurons. Cerebellum (2012) 0.82
The Ciliary Transition Zone: Finding the Pieces and Assembling the Gate. Mol Cells (2017) 0.82
The cilia-regulated proteasome and its role in the development of ciliopathies and cancer. Cilia (2016) 0.80
The transition zone protein Rpgrip1l regulates proteasomal activity at the primary cilium. J Cell Biol (2015) 0.80
The Role of RPGR and Its Interacting Proteins in Ciliopathies. J Ophthalmol (2015) 0.79
The ciliopathy gene Rpgrip1l is essential for hair follicle development. J Invest Dermatol (2014) 0.78
Tectonic‑1 contributes to the growth and migration of prostate cancer cells in vitro. Int J Mol Med (2015) 0.77
Genetic determinants of fibro-osseous lesions in aged inbred mice. Exp Mol Pathol (2015) 0.76
A tissue-specific role for intraflagellar transport genes during craniofacial development. PLoS One (2017) 0.75
The molecular motor Myosin Va interacts with the cilia-centrosomal protein RPGRIP1L. Sci Rep (2017) 0.75
Hedgehog signalling within airway epithelial progenitors and in small-cell lung cancer. Nature (2003) 6.07
Inactivation of the Fto gene protects from obesity. Nature (2009) 5.61
The ciliary gene RPGRIP1L is mutated in cerebello-oculo-renal syndrome (Joubert syndrome type B) and Meckel syndrome. Nat Genet (2007) 4.63
Mouse intraflagellar transport proteins regulate both the activator and repressor functions of Gli transcription factors. Development (2005) 4.32
The mouse Fused toes (Ft) mutation is the result of a 1.6-Mb deletion including the entire Iroquois B gene cluster. Mamm Genome (2002) 4.06
Loss of the retrograde motor for IFT disrupts localization of Smo to cilia and prevents the expression of both activator and repressor functions of Gli. Dev Biol (2005) 3.63
Sonic hedgehog signaling regulates Gli2 transcriptional activity by suppressing its processing and degradation. Mol Cell Biol (2006) 3.29
NMR spectroscopy techniques for screening and identifying ligand binding to protein receptors. Angew Chem Int Ed Engl (2003) 2.98
Improvement in glucose metabolism after bariatric surgery: comparison of laparoscopic Roux-en-Y gastric bypass and laparoscopic sleeve gastrectomy: a prospective randomized trial. Ann Surg (2009) 2.73
Discovery and optimization of a natural HIV-1 entry inhibitor targeting the gp41 fusion peptide. Cell (2007) 2.22
Primary cilia regulate hippocampal neurogenesis by mediating sonic hedgehog signaling. Proc Natl Acad Sci U S A (2008) 2.17
Dorsal-ventral patterning of the spinal cord requires Gli3 transcriptional repressor activity. Genes Dev (2002) 2.10
Hedgehog signal transduction via Smoothened association with a cytoplasmic complex scaffolded by the atypical kinesin, Costal-2. Mol Cell (2003) 2.02
A splice site mutation in the murine Opa1 gene features pathology of autosomal dominant optic atrophy. Brain (2007) 1.82
Metabolic and hormonal changes after laparoscopic Roux-en-Y gastric bypass and sleeve gastrectomy: a randomized, prospective trial. Obes Surg (2012) 1.71
Suppressor of fused and Spop regulate the stability, processing and function of Gli2 and Gli3 full-length activators but not their repressors. Development (2010) 1.65
The Wnt antagonist Dickkopf-1 is regulated by Bmp signaling and c-Jun and modulates programmed cell death. EMBO J (2002) 1.57
The fat mass and obesity associated gene (Fto) regulates activity of the dopaminergic midbrain circuitry. Nat Neurosci (2013) 1.57
Pegylated interferon alpha therapy in acute hepatitis C: relation to hepatitis C virus-specific T cell response kinetics. Hepatology (2004) 1.51
Pallister-Hall syndrome phenotype in mice mutant for Gli3. Hum Mol Genet (2002) 1.49
Phosphorylation of Gli2 by protein kinase A is required for Gli2 processing and degradation and the Sonic Hedgehog-regulated mouse development. Dev Biol (2008) 1.48
Early results of the Swiss Multicentre Bypass or Sleeve Study (SM-BOSS): a prospective randomized trial comparing laparoscopic sleeve gastrectomy and Roux-en-Y gastric bypass. Ann Surg (2013) 1.47
The Shh-independent activator function of the full-length Gli3 protein and its role in vertebrate limb digit patterning. Dev Biol (2007) 1.45
Genome-wide RNAi screen reveals disease-associated genes that are common to Hedgehog and Wnt signaling. Sci Signal (2011) 1.45
Peginterferon alone or with ribavirin enhances HCV-specific CD4 T-helper 1 responses in patients with chronic hepatitis C. Gastroenterology (2002) 1.44
Fewer nutrient deficiencies after laparoscopic sleeve gastrectomy (LSG) than after laparoscopic Roux-Y-gastric bypass (LRYGB)-a prospective study. Obes Surg (2010) 1.39
Opposing gradients of Gli repressor and activators mediate Shh signaling along the dorsoventral axis of the inner ear. Development (2007) 1.37
A novel protein-processing domain in Gli2 and Gli3 differentially blocks complete protein degradation by the proteasome. J Biol Chem (2007) 1.36
Autoimmunity and inflammation due to a gain-of-function mutation in phospholipase C gamma 2 that specifically increases external Ca2+ entry. Immunity (2005) 1.33
Wnt and Bmp signalling cooperatively regulate graded Emx2 expression in the dorsal telencephalon. Development (2002) 1.32
Hedgehog signaling regulates sensory cell formation and auditory function in mice and humans. J Neurosci (2008) 1.30
Thalidomide induces limb deformities by perturbing the Bmp/Dkk1/Wnt signaling pathway. FASEB J (2007) 1.26
Influence of Mycobacterium bovis BCG vaccination on cellular immune response of guinea pigs challenged with Mycobacterium tuberculosis. Clin Vaccine Immunol (2008) 1.26
Satellite Remote Sensing for Developing Time and Space Resolved Estimates of Ambient Particulate in Cleveland, OH. Aerosol Sci Technol (2011) 1.22
Disruption of Mks1 localization to the mother centriole causes cilia defects and developmental malformations in Meckel-Gruber syndrome. Dis Model Mech (2010) 1.18
Effects of postbariatric surgery weight loss on adipokines and metabolic parameters: comparison of laparoscopic Roux-en-Y gastric bypass and laparoscopic sleeve gastrectomy--a prospective randomized trial. Surg Obes Relat Dis (2011) 1.18
Shedding light on an old mystery: thalidomide suppresses survival pathways to induce limb defects. Cell Cycle (2008) 1.17
Reciprocal intraepithelial interactions between TP63 and hedgehog signaling regulate quiescence and activation of progenitor elaboration by mammary stem cells. Stem Cells (2008) 1.15
Activation of Hedgehog signaling by the environmental toxicant arsenic may contribute to the etiology of arsenic-induced tumors. Cancer Res (2010) 1.15
The decoupling of Smoothened from Galphai proteins has little effect on Gli3 protein processing and Hedgehog-regulated chick neural tube patterning. Dev Biol (2008) 1.13
Bile acids and gut peptide secretion after bariatric surgery: a 1-year prospective randomized pilot trial. Obesity (Silver Spring) (2013) 1.13
Defects in brain patterning and head morphogenesis in the mouse mutant Fused toes. Dev Biol (2006) 1.10
Inhibition of microtubule assembly in osteoblasts stimulates bone morphogenetic protein 2 expression and bone formation through transcription factor Gli2. Mol Cell Biol (2008) 1.10
A disrupted balance between Bmp/Wnt and Fgf signaling underlies the ventralization of the Gli3 mutant telencephalon. Dev Biol (2003) 1.08
Generation of thyrotropin-releasing hormone receptor 1-deficient mice as an animal model of central hypothyroidism. Mol Endocrinol (2004) 1.05
Critical involvement of hydrogen peroxide in exercise-induced up-regulation of endothelial NO synthase. Cardiovasc Res (2005) 1.04
LPS induces interleukin-6 and interleukin-8 but not tumor necrosis factor-alpha in human adipocytes. Cytokine (2007) 1.03
A structure-guided mutation in the major capsid protein retargets BK polyomavirus. PLoS Pathog (2013) 1.02
Levels of Gli3 repressor correlate with Bmp4 expression and apoptosis during limb development. Dev Dyn (2004) 1.02
The alphaGal epitope of the histo-blood group antigen family is a ligand for bovine norovirus Newbury2 expected to prevent cross-species transmission. PLoS Pathog (2009) 1.02
Reduction in co-morbidities 4 years after laparoscopic adjustable gastric banding. Obes Surg (2004) 1.01
Structures of Merkel cell polyomavirus VP1 complexes define a sialic acid binding site required for infection. PLoS Pathog (2012) 1.01
Small molecule inhibitors of mammalian thioredoxin reductase. Free Radic Biol Med (2011) 1.00
FTO levels affect RNA modification and the transcriptome. Eur J Hum Genet (2012) 1.00
Oncologic outcomes of laparoscopy-assisted gastrectomy for advanced gastric cancer: a large-scale multicenter retrospective cohort study from China. Surg Endosc (2014) 0.99
Laparoscopic versus open total gastrectomy with D2 dissection for gastric cancer: a meta-analysis. J Cancer Res Clin Oncol (2013) 0.98
Thalidomide resistance is based on the capacity of the glutathione-dependent antioxidant defense. Mol Pharm (2009) 0.97
NMR experiments reveal the molecular basis of receptor recognition by a calicivirus. J Am Chem Soc (2008) 0.97
Ligand specificity of CS-35, a monoclonal antibody that recognizes mycobacterial lipoarabinomannan: a model system for oligofuranoside-protein recognition. J Am Chem Soc (2007) 0.96
Primary cilia control telencephalic patterning and morphogenesis via Gli3 proteolytic processing. Development (2011) 0.96
Expression and localization of melanocortin-1 receptor in human adipose tissues of severely obese patients. Obesity (Silver Spring) (2007) 0.96
Expression of the zebrafish Iroquois genes during early nervous system formation and patterning. J Comp Neurol (2005) 0.95
Targeting norovirus infection-multivalent entry inhibitor design based on NMR experiments. Chemistry (2011) 0.95
Midterm results of primary vs. secondary laparoscopic sleeve gastrectomy (LSG) as an isolated operation. Obes Surg (2009) 0.94
"Double-click" protocol for synthesis of heterobifunctional multivalent ligands: toward a focused library of specific norovirus inhibitors. Chemistry (2011) 0.94
A SHH-independent regulation of Gli3 is a significant determinant of anteroposterior patterning of the limb bud. Dev Biol (2009) 0.94
Bmp, Fgf and Wnt signalling in programmed cell death and chondrogenesis during vertebrate limb development: the role of Dickkopf-1. Int J Dev Biol (2002) 0.94
The molecular basis of Pallister Hall associated polydactyly. Hum Mol Genet (2007) 0.93
A genetic variation in APE1 is associated with gastric cancer survival in a Chinese population. Cancer Sci (2011) 0.92
In vivo adaptation of the Wayne model of latent tuberculosis. Infect Immun (2007) 0.92
Dual relationship between large gold clusters (antifullerenes) and carbon fullerenes: a new lowest-energy cage structure for Au50. J Phys Chem A (2007) 0.92
Predictors of outcome in treatment of morbid obesity by laparoscopic adjustable gastric banding: results of a prospective study of 380 patients. Surg Obes Relat Dis (2008) 0.92
Molecular details of the recognition of blood group antigens by a human norovirus as determined by STD NMR spectroscopy. Angew Chem Int Ed Engl (2011) 0.92
Recombinant BCG coexpressing Ag85B, ESAT-6 and mouse-IFN-gamma confers effective protection against Mycobacterium tuberculosis in C57BL/6 mice. FEMS Immunol Med Microbiol (2007) 0.91
Centrosomal protein DZIP1 regulates Hedgehog signaling by promoting cytoplasmic retention of transcription factor GLI3 and affecting ciliogenesis. J Biol Chem (2013) 0.90
Primary cilia and Gli3 activity regulate cerebral cortical size. Dev Neurobiol (2012) 0.90
Neutralization of a common cold virus by concatemers of the third ligand binding module of the VLDL-receptor strongly depends on the number of modules. Virology (2005) 0.89
Epitope mapping of sialyl Lewis(x) bound to E-selectin using saturation transfer difference NMR experiments. Glycobiology (2003) 0.89
Prospective study of a two-stage operative concept in the treatment of morbid obesity: primary lap-band followed if needed by sleeve gastrectomy with duodenal switch. Obes Surg (2007) 0.88
Improved identification including MALDI-TOF mass spectrometry analysis of group D streptococci from bovine mastitis and subsequent molecular characterization of corresponding Enterococcus faecalis and Enterococcus faecium isolates. Vet Microbiol (2012) 0.88
Homozygous Ft embryos are affected in floor plate maintenance and ventral neural tube patterning. Dev Dyn (2005) 0.88
Blood group B galactosyltransferase: insights into substrate binding from NMR experiments. J Am Chem Soc (2006) 0.88
Consistent bioactive conformation of the Neu5Acalpha(2-->3)Gal epitope upon lectin binding. Chembiochem (2008) 0.87
Forward genetics uncovers Transmembrane protein 107 as a novel factor required for ciliogenesis and Sonic hedgehog signaling. Dev Biol (2012) 0.87
The ciliary protein Ftm is required for ventricular wall and septal development. PLoS One (2013) 0.87
Organization of Iroquois genes in fish. Dev Genes Evol (2004) 0.87
Hepatitis A virus proteinase 3C binding to viral RNA: correlation with substrate binding and enzyme dimerization. Biochem J (2005) 0.86
Binding of an acceptor substrate analog enhances the enzymatic activity of human blood group B galactosyltransferase. Glycobiology (2010) 0.86
Thalidomide induces limb anomalies by PTEN stabilization, Akt suppression, and stimulation of caspase-dependent cell death. Mol Cell Biol (2008) 0.86
Small ubiquitin-like Modifier (SUMO) modification inhibits GLI2 protein transcriptional activity in vitro and in vivo. J Biol Chem (2012) 0.86
Red meat consumption and stomach cancer risk: a meta-analysis. J Cancer Res Clin Oncol (2014) 0.86
Myoglobin: Just an Oxygen Store or Also an Oxygen Transporter? News Physiol Sci (2000) 0.85
Cardiospecific overexpression of the prostaglandin EP3 receptor attenuates ischemia-induced myocardial injury. Circulation (2005) 0.85
Genetic variant in 8q24 is associated with prognosis for gastric cancer in a Chinese population. J Gastroenterol Hepatol (2015) 0.85