Published in Neuron on February 28, 2002
Genome-wide analysis of genetic loci associated with Alzheimer disease. JAMA (2010) 9.52
Dynamin, a membrane-remodelling GTPase. Nat Rev Mol Cell Biol (2012) 3.92
Direct observation of Bin/amphiphysin/Rvs (BAR) domain-induced membrane curvature by means of molecular dynamics simulations. Proc Natl Acad Sci U S A (2006) 2.37
The dual phosphatase activity of synaptojanin1 is required for both efficient synaptic vesicle endocytosis and reavailability at nerve terminals. Neuron (2007) 2.36
SNX9 regulates dynamin assembly and is required for efficient clathrin-mediated endocytosis. Mol Biol Cell (2005) 2.08
Syndapin I is the phosphorylation-regulated dynamin I partner in synaptic vesicle endocytosis. Nat Neurosci (2006) 1.99
The BAR domain proteins: molding membranes in fission, fusion, and phagy. Microbiol Mol Biol Rev (2006) 1.94
Synaptic vesicle endocytosis. Cold Spring Harb Perspect Biol (2012) 1.84
RIM binding proteins (RBPs) couple Rab3-interacting molecules (RIMs) to voltage-gated Ca(2+) channels. Neuron (2002) 1.81
The stimulatory action of amphiphysin on dynamin function is dependent on lipid bilayer curvature. EMBO J (2004) 1.72
Let's go bananas: revisiting the endocytic BAR code. EMBO J (2011) 1.66
Cophosphorylation of amphiphysin I and dynamin I by Cdk5 regulates clathrin-mediated endocytosis of synaptic vesicles. J Cell Biol (2003) 1.65
Alzheimer's disease risk genes and mechanisms of disease pathogenesis. Biol Psychiatry (2014) 1.42
Meta-analysis for genome-wide association study identifies multiple variants at the BIN1 locus associated with late-onset Alzheimer's disease. PLoS One (2011) 1.32
Targeted disruption of the murine Bin1/Amphiphysin II gene does not disable endocytosis but results in embryonic cardiomyopathy with aberrant myofibril formation. Mol Cell Biol (2003) 1.26
Cooperative recruitment of dynamin and BIN/amphiphysin/Rvs (BAR) domain-containing proteins leads to GTP-dependent membrane scission. J Biol Chem (2013) 1.26
Disruption of the endocytic protein HIP1 results in neurological deficits and decreased AMPA receptor trafficking. EMBO J (2003) 1.19
Dissecting BAR domain function in the yeast Amphiphysins Rvs161 and Rvs167 during endocytosis. Mol Biol Cell (2010) 1.14
BAR the door: cancer suppression by amphiphysin-like genes. Biochim Biophys Acta (2008) 1.12
Inhibition of RhoA pathway rescues the endocytosis defects in Oligophrenin1 mouse model of mental retardation. Hum Mol Genet (2009) 1.12
Essential role of cyclin-G-associated kinase (Auxilin-2) in developing and mature mice. Mol Biol Cell (2008) 1.11
Proper synaptic vesicle formation and neuronal network activity critically rely on syndapin I. EMBO J (2011) 1.11
Dynamic interaction of amphiphysin with N-WASP regulates actin assembly. J Biol Chem (2009) 1.10
Structure and dynamics of helix-0 of the N-BAR domain in lipid micelles and bilayers. Biophys J (2008) 1.10
Synucleins regulate the kinetics of synaptic vesicle endocytosis. J Neurosci (2014) 1.10
A null mutation in VAMP1/synaptobrevin is associated with neurological defects and prewean mortality in the lethal-wasting mouse mutant. Neurogenetics (2006) 1.07
Defective membrane remodeling in neuromuscular diseases: insights from animal models. PLoS Genet (2012) 1.05
The Rho-linked mental retardation protein OPHN1 controls synaptic vesicle endocytosis via endophilin A1. Curr Biol (2009) 1.05
Intersectin regulates dendritic spine development and somatodendritic endocytosis but not synaptic vesicle recycling in hippocampal neurons. J Biol Chem (2009) 1.03
Role of epsin 1 in synaptic vesicle endocytosis. Proc Natl Acad Sci U S A (2008) 1.02
Initial assessment of the pathogenic mechanisms of the recently identified Alzheimer risk Loci. Ann Hum Genet (2013) 1.02
Superfluous role of mammalian septins 3 and 5 in neuronal development and synaptic transmission. Mol Cell Biol (2008) 1.00
prickle modulates microtubule polarity and axonal transport to ameliorate seizures in flies. Proc Natl Acad Sci U S A (2014) 0.99
Live imaging of synaptic vesicle release and retrieval in dopaminergic neurons. Front Neural Circuits (2009) 0.97
Clathrin and synaptic vesicle endocytosis: studies at the squid giant synapse. Biochem Soc Trans (2006) 0.96
Polyunsaturated fatty acids influence synaptojanin localization to regulate synaptic vesicle recycling. Mol Biol Cell (2007) 0.96
SH3P7/mAbp1 deficiency leads to tissue and behavioral abnormalities and impaired vesicle transport. EMBO J (2006) 0.94
Clathrin-mediated endocytosis at the synaptic terminal: bridging the gap between physiology and molecules. Traffic (2010) 0.92
Case report of intrafamilial variability in autosomal recessive centronuclear myopathy associated to a novel BIN1 stop mutation. Orphanet J Rare Dis (2010) 0.91
Bending "on the rocks"--a cocktail of biophysical modules to build endocytic pathways. Cold Spring Harb Perspect Biol (2014) 0.91
Altered splicing of the BIN1 muscle-specific exon in humans and dogs with highly progressive centronuclear myopathy. PLoS Genet (2013) 0.90
Syndapin is dispensable for synaptic vesicle endocytosis at the Drosophila larval neuromuscular junction. Mol Cell Neurosci (2008) 0.89
Amphiphysin 1 is important for actin polymerization during phagocytosis. Mol Biol Cell (2007) 0.89
Genomic convergence and network analysis approach to identify candidate genes in Alzheimer's disease. BMC Genomics (2014) 0.88
The NECAP PHear domain increases clathrin accessory protein binding potential. EMBO J (2007) 0.88
Control of Rho GTPase function by BAR-domains. Small GTPases (2012) 0.87
Human IgG directed against amphiphysin induces anxiety behavior in a rat model after intrathecal passive transfer. J Neural Transm (Vienna) (2012) 0.86
Pharmacogenetic analysis reveals a post-developmental role for Rac GTPases in Caenorhabditis elegans GABAergic neurotransmission. Genetics (2009) 0.84
BIN1 is decreased in sporadic but not familial Alzheimer's disease or in aging. PLoS One (2013) 0.83
BAR domain proteins regulate Rho GTPase signaling. Small GTPases (2014) 0.83
Working memory impairment in calcineurin knock-out mice is associated with alterations in synaptic vesicle cycling and disruption of high-frequency synaptic and network activity in prefrontal cortex. J Neurosci (2013) 0.82
The F-BAR protein family Actin' on the membrane. Commun Integr Biol (2010) 0.80
Amphiphysin-1 protein level changes associated with tau-mediated neurodegeneration. Neuroreport (2012) 0.80
Regulation of glutamate receptor internalization by the spine cytoskeleton is mediated by its PKA-dependent association with CPG2. Proc Natl Acad Sci U S A (2013) 0.80
Reduced gamma oscillations in a mouse model of intellectual disability: a role for impaired repetitive neurotransmission? PLoS One (2014) 0.78
Neurotransmission and the synaptic vesicle cycle. Yale J Biol Med (2003) 0.78
Autoantibodies to Synaptic Receptors and Neuronal Cell Surface Proteins in Autoimmune Diseases of the Central Nervous System. Physiol Rev (2017) 0.78
The endocytic adaptor Eps15 controls marginal zone B cell numbers. PLoS One (2012) 0.77
Synaptotagmin-11 inhibits clathrin-mediated and bulk endocytosis. EMBO Rep (2015) 0.76
Novel autoimmune response in a tauopathy mouse model. Front Neurosci (2014) 0.75
Bin1 and CD2AP polarise the endocytic generation of beta-amyloid. EMBO Rep (2016) 0.75
Proteomics Analysis of Dorsal Striatum Reveals Changes in Synaptosomal Proteins following Methamphetamine Self-Administration in Rats. PLoS One (2015) 0.75
Mutation of orthologous prickle genes causes a similar epilepsy syndrome in flies and humans. Ann Clin Transl Neurol (2016) 0.75
Loss of SYNJ1 dual phosphatase activity leads to early onset refractory seizures and progressive neurological decline. Brain (2016) 0.75
Synaptic Vesicle-Recycling Machinery Components as Potential Therapeutic Targets. Pharmacol Rev (2017) 0.75
Parkinson Sac Domain Mutation in Synaptojanin 1 Impairs Clathrin Uncoating at Synapses and Triggers Dystrophic Changes in Dopaminergic Axons. Neuron (2017) 0.75
Drosophila Nedd4-long reduces Amphiphysin levels in muscles and leads to impaired T-tubule formation. Mol Biol Cell (2016) 0.75
Phosphoinositides in cell regulation and membrane dynamics. Nature (2006) 14.00
Inflammasomes in health and disease. Nature (2012) 6.75
A single motif responsible for ubiquitin recognition and monoubiquitination in endocytic proteins. Nature (2002) 6.22
Inflammasome recognition of influenza virus is essential for adaptive immune responses. J Exp Med (2009) 5.77
Structural basis of membrane invagination by F-BAR domains. Cell (2008) 5.41
Dynamin and the actin cytoskeleton cooperatively regulate plasma membrane invagination by BAR and F-BAR proteins. Dev Cell (2005) 5.02
A selective activity-dependent requirement for dynamin 1 in synaptic vesicle endocytosis. Science (2007) 4.86
Viral infection switches non-plasmacytoid dendritic cells into high interferon producers. Nature (2003) 4.60
Yellow fever vaccine YF-17D activates multiple dendritic cell subsets via TLR2, 7, 8, and 9 to stimulate polyvalent immunity. J Exp Med (2006) 4.23
GTP-dependent twisting of dynamin implicates constriction and tension in membrane fission. Nature (2006) 4.18
Recruitment and regulation of phosphatidylinositol phosphate kinase type 1 gamma by the FERM domain of talin. Nature (2002) 4.03
Dynamin, a membrane-remodelling GTPase. Nat Rev Mol Cell Biol (2012) 3.92
BAR, F-BAR (EFC) and ENTH/ANTH domains in the regulation of membrane-cytosol interfaces and membrane curvature. Biochim Biophys Acta (2006) 3.83
Ghrelin modulates the activity and synaptic input organization of midbrain dopamine neurons while promoting appetite. J Clin Invest (2006) 3.81
The BAR domain superfamily: membrane-molding macromolecules. Cell (2009) 3.74
Guidelines on nicotine dose selection for in vivo research. Psychopharmacology (Berl) (2006) 3.68
Amphiphysin 2 (Bin1) and T-tubule biogenesis in muscle. Science (2002) 3.68
Wnk4 controls blood pressure and potassium homeostasis via regulation of mass and activity of the distal convoluted tubule. Nat Genet (2006) 3.57
Dual role of 3-methyladenine in modulation of autophagy via different temporal patterns of inhibition on class I and III phosphoinositide 3-kinase. J Biol Chem (2010) 3.45
Coordinated actions of actin and BAR proteins upstream of dynamin at endocytic clathrin-coated pits. Dev Cell (2009) 3.42
Cholesterol-induced macrophage apoptosis requires ER stress pathways and engagement of the type A scavenger receptor. J Cell Biol (2005) 3.14
Actin has a molecular scaffolding, not propulsive, role in presynaptic function. Nat Neurosci (2003) 3.06
Detrimental contribution of the Toll-like receptor (TLR)3 to influenza A virus-induced acute pneumonia. PLoS Pathog (2006) 3.04
An enzymatic cascade of Rab5 effectors regulates phosphoinositide turnover in the endocytic pathway. J Cell Biol (2005) 2.97
Fld1p, a functional homologue of human seipin, regulates the size of lipid droplets in yeast. J Cell Biol (2008) 2.85
Impaired PtdIns(4,5)P2 synthesis in nerve terminals produces defects in synaptic vesicle trafficking. Nature (2004) 2.81
A phosphoinositide switch controls the maturation and signaling properties of APPL endosomes. Cell (2009) 2.77
Synaptic vesicles interchange their membrane proteins with a large surface reservoir during recycling. Neuron (2006) 2.75
Free cholesterol-loaded macrophages are an abundant source of tumor necrosis factor-alpha and interleukin-6: model of NF-kappaB- and map kinase-dependent inflammation in advanced atherosclerosis. J Biol Chem (2005) 2.74
PI(4,5)P(2)-dependent and Ca(2+)-regulated ER-PM interactions mediated by the extended synaptotagmins. Cell (2013) 2.72
Lipid-induced insulin resistance mediated by the proinflammatory receptor TLR4 requires saturated fatty acid-induced ceramide biosynthesis in mice. J Clin Invest (2011) 2.68
Protein-lipid interactions and phosphoinositide metabolism in membrane traffic: insights from vesicle recycling in nerve terminals. Proc Natl Acad Sci U S A (2004) 2.61
Mechanisms of membrane deformation. Curr Opin Cell Biol (2003) 2.57
Cell biology of the presynaptic terminal. Annu Rev Neurosci (2003) 2.48
Recruitment of endophilin to clathrin-coated pit necks is required for efficient vesicle uncoating after fission. Neuron (2011) 2.45
Retroviruses human immunodeficiency virus and murine leukemia virus are enriched in phosphoinositides. J Virol (2008) 2.43
Nicotine decreases food intake through activation of POMC neurons. Science (2011) 2.41
The dual phosphatase activity of synaptojanin1 is required for both efficient synaptic vesicle endocytosis and reavailability at nerve terminals. Neuron (2007) 2.36
Dynamin at actin tails. Proc Natl Acad Sci U S A (2002) 2.31
The kinetics of synaptic vesicle pool depletion at CNS synaptic terminals. Neuron (2004) 2.29
Effect of nicotine and nicotinic receptors on anxiety and depression. Neuroreport (2002) 2.28
Varenicline reduces alcohol self-administration in heavy-drinking smokers. Biol Psychiatry (2009) 2.25
Molecular circuitry of endocytosis at nerve terminals. Annu Rev Cell Dev Biol (2009) 2.22
A role of the Lowe syndrome protein OCRL in early steps of the endocytic pathway. Dev Cell (2007) 2.21
CDK5 serves as a major control point in neurotransmitter release. Neuron (2010) 2.21
Sequential MyD88-independent and -dependent activation of innate immune responses to intracellular bacterial infection. Immunity (2003) 2.20
Chondroitin fragments are odorants that trigger fear behavior in fish. Curr Biol (2012) 2.20
ARF6 stimulates clathrin/AP-2 recruitment to synaptic membranes by activating phosphatidylinositol phosphate kinase type Igamma. J Cell Biol (2003) 2.19
Functional interactions between sphingolipids and sterols in biological membranes regulating cell physiology. Mol Biol Cell (2009) 2.17
Health correlates of recreational gambling in older adults. Am J Psychiatry (2004) 2.08
Antidepressant-like effects of ceftriaxone in male C57BL/6J mice. Biol Psychiatry (2006) 2.07
Salmonella modulates vesicular traffic by altering phosphoinositide metabolism. Science (2004) 2.06
Synaptic vesicle mobilization is regulated by distinct synapsin I phosphorylation pathways at different frequencies. Neuron (2003) 2.04
Contrasting membrane interaction mechanisms of AP180 N-terminal homology (ANTH) and epsin N-terminal homology (ENTH) domains. J Biol Chem (2003) 2.03
Imaging direct, dynamin-dependent recapture of fusing secretory granules on plasma membrane lawns from PC12 cells. Proc Natl Acad Sci U S A (2002) 2.03
Role of dynamin, synaptojanin, and endophilin in podocyte foot processes. J Clin Invest (2012) 2.02
Human tobacco smokers in early abstinence have higher levels of beta2* nicotinic acetylcholine receptors than nonsmokers. J Neurosci (2006) 1.99
Inhibitory effect of dietary lipids on chaperone-mediated autophagy. Proc Natl Acad Sci U S A (2012) 1.97
The transcription factor STAT-1 couples macrophage synthesis of 25-hydroxycholesterol to the interferon antiviral response. Immunity (2012) 1.96
Genetic dissection of the cellular pathways and signaling mechanisms in modeled tumor necrosis factor-induced Crohn's-like inflammatory bowel disease. J Exp Med (2002) 1.94
Defective microtubule-dependent podosome organization in osteoclasts leads to increased bone density in Pyk2(-/-) mice. J Cell Biol (2007) 1.92
Optogenetic control of phosphoinositide metabolism. Proc Natl Acad Sci U S A (2012) 1.92
Cell- and stimulus-dependent heterogeneity of synaptic vesicle endocytic recycling mechanisms revealed by studies of dynamin 1-null neurons. Proc Natl Acad Sci U S A (2008) 1.91
α2δ expression sets presynaptic calcium channel abundance and release probability. Nature (2012) 1.90
Toll-like receptor 3 is a potent negative regulator of axonal growth in mammals. J Neurosci (2007) 1.88
Endothelial epsin deficiency decreases tumor growth by enhancing VEGF signaling. J Clin Invest (2012) 1.87
Two synaptojanin 1 isoforms are recruited to clathrin-coated pits at different stages. Proc Natl Acad Sci U S A (2006) 1.85
Synaptic vesicle endocytosis. Cold Spring Harb Perspect Biol (2012) 1.84
Regulation of synaptojanin 1 by cyclin-dependent kinase 5 at synapses. Proc Natl Acad Sci U S A (2004) 1.84
Deletion of interleukin (IL)-12p35 induces liver fibrosis in dominant-negative TGFβ receptor type II mice. Hepatology (2013) 1.78
The association of epsin with ubiquitinated cargo along the endocytic pathway is negatively regulated by its interaction with clathrin. Proc Natl Acad Sci U S A (2005) 1.78
Rare nonsynonymous variants in alpha-4 nicotinic acetylcholine receptor gene protect against nicotine dependence. Biol Psychiatry (2011) 1.76
Calcium control of endocytic capacity at a CNS synapse. J Neurosci (2008) 1.76
The kinetics of synaptic vesicle reacidification at hippocampal nerve terminals. J Neurosci (2006) 1.75
Nicotine induces glutamate release from thalamocortical terminals in prefrontal cortex. Neuropsychopharmacology (2003) 1.74
Tuba, a novel protein containing bin/amphiphysin/Rvs and Dbl homology domains, links dynamin to regulation of the actin cytoskeleton. J Biol Chem (2003) 1.72
The stimulatory action of amphiphysin on dynamin function is dependent on lipid bilayer curvature. EMBO J (2004) 1.72
Nicotine receptors and depression: revisiting and revising the cholinergic hypothesis. Trends Pharmacol Sci (2010) 1.71
Synaptic vesicle recycling at CNS snapses without AP-2. J Neurosci (2009) 1.69
A role for phosphatidic acid in the formation of "supersized" lipid droplets. PLoS Genet (2011) 1.69