Published in Arterioscler Thromb Vasc Biol on March 01, 2002
Simvastatin inhibited cardiac hypertrophy and fibrosis in apolipoprotein E-deficient mice fed a "Western-style diet" by increasing PPAR α and γ expression and reducing TC, MMP-9, and Cat S levels. Acta Pharmacol Sin (2010) 1.05
mTOR-STAT3-notch signalling contributes to ALDH2-induced protection against cardiac contractile dysfunction and autophagy under alcoholism. J Cell Mol Med (2012) 1.02
Cardiac and vascular phenotypes in the apolipoprotein E-deficient mouse. J Biomed Sci (2012) 0.99
FGF23 directly impairs endothelium-dependent vasorelaxation by increasing superoxide levels and reducing nitric oxide bioavailability. Am J Physiol Endocrinol Metab (2014) 0.97
AMP-dependent kinase and autophagic flux are involved in aldehyde dehydrogenase-2-induced protection against cardiac toxicity of ethanol. Free Radic Biol Med (2011) 0.93
Unilateral renal artery stenosis causes a chronic vascular inflammatory response in ApoE-/- mice. Trans Am Clin Climatol Assoc (2010) 0.88
Increased atherosclerosis and smooth muscle cell hypertrophy in natriuretic peptide receptor A-/-apolipoprotein E-/- mice. Arterioscler Thromb Vasc Biol (2003) 0.86
An in vivo murine model of low-magnitude oscillatory wall shear stress to address the molecular mechanisms of mechanotransduction--brief report. Arterioscler Thromb Vasc Biol (2010) 0.85
Cathepsin K knockout alleviates pressure overload-induced cardiac hypertrophy. Hypertension (2013) 0.85
Hypercholesterolemia and myocardial function evaluated via tissue doppler imaging. Cardiovasc Ultrasound (2009) 0.85
Protective effect of resveratrol against pressure overload-induced heart failure. Food Sci Nutr (2014) 0.81
Up-regulation of the cardiac lipid metabolism at the onset of heart failure. Cardiovasc Hematol Agents Med Chem (2011) 0.79
Serum neutrophil gelatinase-associated lipocalin concentration reflects severity of coronary artery disease in patients without heart failure and chronic kidney disease. Heart Vessels (2015) 0.78
Antineutrophil cytoplasmic autoantibodies specific for myeloperoxidase cause glomerulonephritis and vasculitis in mice. J Clin Invest (2002) 5.42
Classification of proliferative pulmonary lesions of the mouse: recommendations of the mouse models of human cancers consortium. Cancer Res (2004) 3.43
Targeted inactivation of hepatic Abca1 causes profound hypoalphalipoproteinemia and kidney hypercatabolism of apoA-I. J Clin Invest (2005) 3.25
Increased cellular free cholesterol in macrophage-specific Abca1 knock-out mice enhances pro-inflammatory response of macrophages. J Biol Chem (2008) 2.87
Dietary cholesterol, rather than liver steatosis, leads to hepatic inflammation in hyperlipidemic mouse models of nonalcoholic steatohepatitis. Hepatology (2008) 2.73
Recipes for creating animal models of diabetic cardiovascular disease. Circ Res (2007) 2.34
Targeted deletion of the ileal bile acid transporter eliminates enterohepatic cycling of bile acids in mice. J Biol Chem (2003) 2.26
Tamm-Horsfall protein knockout mice are more prone to urinary tract infection: rapid communication. Kidney Int (2004) 2.17
Molecular phenotyping for analyzing subtle genetic effects in mice: application to an angiotensinogen gene titration. Proc Natl Acad Sci U S A (2002) 2.08
Harmful effects of increased LDLR expression in mice with human APOE*4 but not APOE*3. Arterioscler Thromb Vasc Biol (2003) 2.00
The role of natriuretic peptides in cardioprotection. Cardiovasc Res (2005) 2.00
The role of neutrophils in the induction of glomerulonephritis by anti-myeloperoxidase antibodies. Am J Pathol (2005) 1.97
Hypertension and abnormal fat distribution but not insulin resistance in mice with P465L PPARgamma. J Clin Invest (2004) 1.91
Mitochondrial glycerol-3-phosphate acyltransferase-deficient mice have reduced weight and liver triacylglycerol content and altered glycerolipid fatty acid composition. Mol Cell Biol (2002) 1.77
Salt-sensitive blood pressure in mice with increased expression of aldosterone synthase. Hypertension (2007) 1.70
Vitamin C is dispensable for oxygen sensing in vivo. Blood (2011) 1.68
Vulnerable atherosclerotic plaque morphology in apolipoprotein E-deficient mice unable to make ascorbic Acid. Circulation (2002) 1.66
CCR5 deficiency is not protective in the early stages of atherogenesis in apoE knockout mice. Atherosclerosis (2003) 1.63
Interference with PPARgamma signaling causes cerebral vascular dysfunction, hypertrophy, and remodeling. Hypertension (2008) 1.55
Genes contributing to prion pathogenesis. J Gen Virol (2008) 1.51
Endogenous production of lipoic acid is essential for mouse development. Mol Cell Biol (2005) 1.49
Tissue inhibitor of metalloproteinase-3 deficiency inhibits blood pressure elevation and myocardial microvascular remodeling induced by chronic administration of Nomega-nitro-L-arginine methyl ester in mice. Hypertens Res (2007) 1.47
Anatomical differences and atherosclerosis in apolipoprotein E-deficient mice with 129/SvEv and C57BL/6 genetic backgrounds. Atherosclerosis (2007) 1.42
Early diet-induced non-alcoholic steatohepatitis in APOE2 knock-in mice and its prevention by fibrates. J Hepatol (2005) 1.40
Senescence-associated phenotypes in Akita diabetic mice are enhanced by absence of bradykinin B2 receptors. J Clin Invest (2006) 1.38
Human apoE4-targeted replacement mice display synaptic deficits in the absence of neuropathology. Neurobiol Dis (2005) 1.32
Diabetic eNOS knockout mice develop distinct macro- and microvascular complications. Lab Invest (2008) 1.32
Minireview: estrogen and mouse models of atherosclerosis. Endocrinology (2002) 1.31
Ligand-activated peroxisome proliferator-activated receptor-gamma protects against ischemic cerebral infarction and neuronal apoptosis by 14-3-3 epsilon upregulation. Circulation (2009) 1.30
Experimental arthritis in CC chemokine receptor 2-null mice closely mimics severe human rheumatoid arthritis. J Clin Invest (2004) 1.28
A mouse model of sitosterolemia: absence of Abcg8/sterolin-2 results in failure to secrete biliary cholesterol. BMC Med (2004) 1.28
Contributions from self-renewal and trafficking to the uterine NK cell population of early pregnancy. J Immunol (2002) 1.26
Apolipoprotein E knock-out and knock-in mice: atherosclerosis, metabolic syndrome, and beyond. J Lipid Res (2008) 1.26
Neurotoxicity from innate immune response is greatest with targeted replacement of E4 allele of apolipoprotein E gene and is mediated by microglial p38MAPK. FASEB J (2006) 1.24
Dominant-negative loss of PPARgamma function enhances smooth muscle cell proliferation, migration, and vascular remodeling. Arterioscler Thromb Vasc Biol (2009) 1.23
Disruption of LDL but not VLDL clearance in autosomal recessive hypercholesterolemia. J Clin Invest (2007) 1.22
RNA repair restores hemoglobin expression in IVS2-654 thalassemic mice. Proc Natl Acad Sci U S A (2009) 1.21
CIB1 is essential for mouse spermatogenesis. Mol Cell Biol (2006) 1.17
Viral-associated trichodysplasia spinulosa: a case with electron microscopic and molecular detection of the trichodysplasia spinulosa-associated human polyomavirus. J Cutan Pathol (2011) 1.17
CC chemokine receptor 5 influences late-stage atherosclerosis. Atherosclerosis (2007) 1.16
Critical role of myeloperoxidase and nicotinamide adenine dinucleotide phosphate-oxidase in high-burden systemic infection of mice with Candida albicans. J Infect Dis (2002) 1.16
Apolipoprotein E-specific innate immune response in astrocytes from targeted replacement mice. J Neuroinflammation (2006) 1.14
Apolipoprotein E isoforms and apolipoprotein AI protect from amyloid precursor protein carboxy terminal fragment-associated cytotoxicity. J Neurochem (2004) 1.14
Transplantation of monocyte CC-chemokine receptor 2-deficient bone marrow into ApoE3-Leiden mice inhibits atherogenesis. Arterioscler Thromb Vasc Biol (2003) 1.13
Quantitative effects of common genetic variations in the 3'UTR of the human LDL-receptor gene and their associations with plasma lipid levels in the Atherosclerosis Risk in Communities study. Hum Genet (2007) 1.12
Intra-organ variation in age-related mutation accumulation in the mouse. PLoS One (2007) 1.11
Targeted deletion of hepatocyte ABCA1 leads to very low density lipoprotein triglyceride overproduction and low density lipoprotein hypercatabolism. J Biol Chem (2010) 1.11
Shc coordinates signals from intercellular junctions and integrins to regulate flow-induced inflammation. J Cell Biol (2008) 1.11
Loss of TIMP3 enhances interstitial nephritis and fibrosis. J Am Soc Nephrol (2009) 1.10
A modest decrease in endothelial NOS in mice comparable to that associated with human NOS3 variants exacerbates diabetic nephropathy. Proc Natl Acad Sci U S A (2011) 1.10
Adipose tissue ATP binding cassette transporter A1 contributes to high-density lipoprotein biogenesis in vivo. Circulation (2011) 1.09
Development of a synthetic promoter for macrophage gene therapy. Hum Gene Ther (2006) 1.09
Aortic arch curvature and atherosclerosis have overlapping quantitative trait loci in a cross between 129S6/SvEvTac and C57BL/6J apolipoprotein E-null mice. Circ Res (2010) 1.09
SCP-2/SCP-x gene ablation alters lipid raft domains in primary cultured mouse hepatocytes. J Lipid Res (2007) 1.06
Genetic variation at the LDL receptor and HMG-CoA reductase gene loci, lipid levels, statin response, and cardiovascular disease incidence in PROSPER. Atherosclerosis (2008) 1.06
Npr1-regulated gene pathways contributing to cardiac hypertrophy and fibrosis. J Mol Endocrinol (2007) 1.06
eNOS deficiency acts through endothelin to aggravate sFlt-1-induced pre-eclampsia-like phenotype. J Am Soc Nephrol (2012) 1.05
Effect of SCP-x gene ablation on branched-chain fatty acid metabolism. Am J Physiol Gastrointest Liver Physiol (2006) 1.05
Bioinformatic analysis of gene sets regulated by ligand-activated and dominant-negative peroxisome proliferator-activated receptor gamma in mouse aorta. Arterioscler Thromb Vasc Biol (2009) 1.05
An exon 10 deletion in the mouse ferrochelatase gene has a dominant-negative effect and causes mild protoporphyria. Blood (2002) 1.05
Deficiency of myeloperoxidase increases infarct volume and nitrotyrosine formation in mouse brain. J Cereb Blood Flow Metab (2002) 1.03
alpha-Lipoic acid prevents the increase in atherosclerosis induced by diabetes in apolipoprotein E-deficient mice fed high-fat/low-cholesterol diet. Diabetes (2006) 1.03
Tissue-specific regulation of ACE/ACE2 and AT1/AT2 receptor gene expression by oestrogen in apolipoprotein E/oestrogen receptor-alpha knock-out mice. Exp Physiol (2008) 1.03
Altering the expression in mice of genes by modifying their 3' regions. Dev Cell (2004) 1.00
Role of CYP27A in cholesterol and bile acid metabolism. J Lipid Res (2004) 0.99
Role of astrocytes and chemokine systems in acute TNFalpha induced demyelinating syndrome: CCR2-dependent signals promote astrocyte activation and survival via NF-kappaB and Akt. Mol Cell Neurosci (2007) 0.98
Early activation of matrix metalloproteinases underlies the exacerbated systolic and diastolic dysfunction in mice lacking TIMP3 following myocardial infarction. Am J Physiol Heart Circ Physiol (2010) 0.98
Ascorbic acid-independent synthesis of collagen in mice. Am J Physiol Endocrinol Metab (2005) 0.97
Contribution of the myeloperoxidase-dependent oxidative system to host defence against Cryptococcus neoformans. J Med Microbiol (2006) 0.97
Decreased PPAR gamma expression compromises perigonadal-specific fat deposition and insulin sensitivity. Mol Endocrinol (2009) 0.95
Regulation of macrophage apoE secretion and sterol efflux by the LDL receptor. J Lipid Res (2006) 0.95
Natriuretic peptide/natriuretic peptide receptor-A (NPR-A) system has inhibitory effects in renal fibrosis in mice. Regul Pept (2009) 0.94
Amino acids as modulators of endothelium-derived nitric oxide. Am J Physiol Renal Physiol (2006) 0.94
Profound biopterin oxidation and protein tyrosine nitration in tissues of ApoE-null mice on an atherogenic diet: contribution of inducible nitric oxide synthase. Am J Physiol Heart Circ Physiol (2007) 0.94
The sodium-dependent ascorbic acid transporter family SLC23. Mol Aspects Med (2013) 0.94
Apolipoprotein E4 in macrophages enhances atherogenesis in a low density lipoprotein receptor-dependent manner. J Biol Chem (2007) 0.94
CC chemokine receptor 2 expression in donor cells serves an essential role in graft-versus-host-disease. J Immunol (2003) 0.94
Repopulation of apolipoprotein E knockout mice with CCR2-deficient bone marrow progenitor cells does not inhibit ongoing atherosclerotic lesion development. Arterioscler Thromb Vasc Biol (2005) 0.93
Adrenomedullin gene expression differences in mice do not affect blood pressure but modulate hypertension-induced pathology in males. Proc Natl Acad Sci U S A (2007) 0.92
Prevention of metastases with a Mage-b DNA vaccine in a mouse breast tumor model: potential for breast cancer therapy. Breast Cancer Res Treat (2005) 0.91
Relationship between hemodynamics and atherosclerosis in aortic arches of apolipoprotein E-null mice on 129S6/SvEvTac and C57BL/6J genetic backgrounds. Atherosclerosis (2011) 0.91
Dietary resveratrol prevents development of high-grade prostatic intraepithelial neoplastic lesions: involvement of SIRT1/S6K axis. Cancer Prev Res (Phila) (2012) 0.90
α-Lipoic acid protects diabetic apolipoprotein E-deficient mice from nephropathy. J Diabetes Complications (2010) 0.90
The atheroprotective effect of dietary soy isoflavones in apolipoprotein E-/- mice requires the presence of estrogen receptor-alpha. Arterioscler Thromb Vasc Biol (2002) 0.90
IFN-gamma primes RAW264 macrophages and human monocytes for enhanced oxidant production in response to CpG DNA via metabolic signaling: roles of TLR9 and myeloperoxidase trafficking. J Immunol (2006) 0.90
Discordant on/off switching of gene expression in myocytes during cardiac hypertrophy in vivo. Proc Natl Acad Sci U S A (2008) 0.90
Differences in aortic arch geometry, hemodynamics, and plaque patterns between C57BL/6 and 129/SvEv mice. J Biomech Eng (2009) 0.90
Human LDL receptor enhances sequestration of ApoE4 and VLDL remnants on the surface of hepatocytes but not their internalization in mice. Arterioscler Thromb Vasc Biol (2008) 0.90
Defective VLDL metabolism and severe atherosclerosis in mice expressing human apolipoprotein E isoforms but lacking the LDL receptor. Biochim Biophys Acta (2004) 0.90
Interactions between endothelial nitric oxide synthase and sex hormones in vascular protection in mice. J Clin Invest (2002) 0.90
PPARgamma: a critical determinant of body fat distribution in humans and mice. Trends Cardiovasc Med (2005) 0.89
Malignancy arising in seminal vesicles in the transgenic adenocarcinoma of mouse prostate (TRAMP) model. Prostate (2009) 0.89
Mitochondrial DNA polymerase editing mutation, PolgD257A, disturbs stem-progenitor cell cycling in the small intestine and restricts excess fat absorption. Am J Physiol Gastrointest Liver Physiol (2012) 0.88