PubRank

Christopher K Glass

Author PubWeight™ 413.76‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project. Nature 2007 75.09
2 Simple combinations of lineage-determining transcription factors prime cis-regulatory elements required for macrophage and B cell identities. Mol Cell 2010 23.97
3 Macrophages, inflammation, and insulin resistance. Annu Rev Physiol 2010 11.77
4 Induced ncRNAs allosterically modify RNA-binding proteins in cis to inhibit transcription. Nature 2008 7.18
5 A SUMOylation-dependent pathway mediates transrepression of inflammatory response genes by PPAR-gamma. Nature 2005 6.83
6 A topoisomerase IIbeta-mediated dsDNA break required for regulated transcription. Science 2006 6.71
7 A subpopulation of macrophages infiltrates hypertrophic adipose tissue and is activated by free fatty acids via Toll-like receptors 2 and 4 and JNK-dependent pathways. J Biol Chem 2007 6.58
8 A comprehensive classification system for lipids. J Lipid Res 2005 6.52
9 Sensors and signals: a coactivator/corepressor/epigenetic code for integrating signal-dependent programs of transcriptional response. Genes Dev 2006 6.32
10 LMSD: LIPID MAPS structure database. Nucleic Acids Res 2006 6.21
11 Reprogramming transcription by distinct classes of enhancers functionally defined by eRNA. Nature 2011 6.10
12 Nuclear receptor-induced chromosomal proximity and DNA breaks underlie specific translocations in cancer. Cell 2009 5.74
13 Exchange of N-CoR corepressor and Tip60 coactivator complexes links gene expression by NF-kappaB and beta-amyloid precursor protein. Cell 2002 5.15
14 Macrophage PPAR gamma is required for normal skeletal muscle and hepatic insulin sensitivity and full antidiabetic effects of thiazolidinediones. J Clin Invest 2007 4.86
15 A Nurr1/CoREST pathway in microglia and astrocytes protects dopaminergic neurons from inflammation-induced death. Cell 2009 4.60
16 A corepressor/coactivator exchange complex required for transcriptional activation by nuclear receptors and other regulated transcription factors. Cell 2004 4.39
17 Parallel SUMOylation-dependent pathways mediate gene- and signal-specific transrepression by LXRs and PPARgamma. Mol Cell 2007 4.33
18 SMRT-mediated repression of an H3K27 demethylase in progression from neural stem cell to neuron. Nature 2007 4.33
19 A global network of transcription factors, involving E2A, EBF1 and Foxo1, that orchestrates B cell fate. Nat Immunol 2010 4.32
20 Concern Enhancing nuclear receptor-induced transcription requires nuclear motor and LSD1-dependent gene networking in interchromatin granules. Proc Natl Acad Sci U S A 2008 4.31
21 Molecular determinants of crosstalk between nuclear receptors and toll-like receptors. Cell 2005 4.30
22 Regulation of circadian behaviour and metabolism by REV-ERB-α and REV-ERB-β. Nature 2012 4.15
23 Opposing LSD1 complexes function in developmental gene activation and repression programmes. Nature 2007 4.12
24 An ADIOL-ERβ-CtBP transrepression pathway negatively regulates microglia-mediated inflammation. Cell 2011 4.04
25 Functional roles of enhancer RNAs for oestrogen-dependent transcriptional activation. Nature 2013 3.93
26 Myofibroblasts revert to an inactive phenotype during regression of liver fibrosis. Proc Natl Acad Sci U S A 2012 3.90
27 Eya protein phosphatase activity regulates Six1-Dach-Eya transcriptional effects in mammalian organogenesis. Nature 2003 3.72
28 Direct isolation and identification of promoters in the human genome. Genome Res 2005 3.68
29 Anti-inflammatory therapy in chronic disease: challenges and opportunities. Science 2013 3.64
30 Expression analysis of G Protein-Coupled Receptors in mouse macrophages. Immunome Res 2008 3.54
31 International Union of Pharmacology. LXI. Peroxisome proliferator-activated receptors. Pharmacol Rev 2006 3.48
32 Identification of a Wnt/Dvl/beta-Catenin --> Pitx2 pathway mediating cell-type-specific proliferation during development. Cell 2002 3.37
33 Tyrosine dephosphorylation of H2AX modulates apoptosis and survival decisions. Nature 2009 3.36
34 Rev-Erbs repress macrophage gene expression by inhibiting enhancer-directed transcription. Nature 2013 3.33
35 Deconstructing repression: evolving models of co-repressor action. Nat Rev Genet 2010 3.29
36 Anti-inflammatory actions of PPAR ligands: new insights on cellular and molecular mechanisms. Trends Immunol 2007 3.23
37 Differential inhibition of macrophage foam-cell formation and atherosclerosis in mice by PPARalpha, beta/delta, and gamma. J Clin Invest 2004 3.23
38 Microglial cell origin and phenotypes in health and disease. Nat Rev Immunol 2011 3.20
39 Histone H2A monoubiquitination represses transcription by inhibiting RNA polymerase II transcriptional elongation. Mol Cell 2008 3.18
40 Macrophage/cancer cell interactions mediate hormone resistance by a nuclear receptor derepression pathway. Cell 2006 3.12
41 Conditional disruption of the peroxisome proliferator-activated receptor gamma gene in mice results in lowered expression of ABCA1, ABCG1, and apoE in macrophages and reduced cholesterol efflux. Mol Cell Biol 2002 3.02
42 The macrophage foam cell as a target for therapeutic intervention. Nat Med 2002 2.98
43 PHF8 mediates histone H4 lysine 20 demethylation events involved in cell cycle progression. Nature 2010 2.91
44 Kdo2-Lipid A of Escherichia coli, a defined endotoxin that activates macrophages via TLR-4. J Lipid Res 2006 2.85
45 Developmentally regulated activation of a SINE B2 repeat as a domain boundary in organogenesis. Science 2007 2.70
46 Activating the PARP-1 sensor component of the groucho/ TLE1 corepressor complex mediates a CaMKinase IIdelta-dependent neurogenic gene activation pathway. Cell 2004 2.57
47 A nuclear receptor corepressor transcriptional checkpoint controlling activator protein 1-dependent gene networks required for macrophage activation. Proc Natl Acad Sci U S A 2004 2.56
48 Remodeling of the enhancer landscape during macrophage activation is coupled to enhancer transcription. Mol Cell 2013 2.55
49 Cooperative NCoR/SMRT interactions establish a corepressor-based strategy for integration of inflammatory and anti-inflammatory signaling pathways. Genes Dev 2009 2.47
50 PPARgamma and PPARdelta negatively regulate specific subsets of lipopolysaccharide and IFN-gamma target genes in macrophages. Proc Natl Acad Sci U S A 2003 2.40
51 Regulated accumulation of desmosterol integrates macrophage lipid metabolism and inflammatory responses. Cell 2012 2.38
52 TH2 cytokines and allergic challenge induce Ym1 expression in macrophages by a STAT6-dependent mechanism. J Biol Chem 2002 2.35
53 Nuclear receptor coregulators: multiple modes of modification. Trends Endocrinol Metab 2002 2.33
54 Statins enhance formation of phagocyte extracellular traps. Cell Host Microbe 2010 2.28
55 Activation of liver X receptors and retinoid X receptors prevents bacterial-induced macrophage apoptosis. Proc Natl Acad Sci U S A 2004 2.18
56 Sensitive ChIP-DSL technology reveals an extensive estrogen receptor alpha-binding program on human gene promoters. Proc Natl Acad Sci U S A 2007 2.17
57 Global changes in the nuclear positioning of genes and intra- and interdomain genomic interactions that orchestrate B cell fate. Nat Immunol 2012 2.16
58 A mouse macrophage lipidome. J Biol Chem 2010 2.14
59 Promoter-specific roles for liver X receptor/corepressor complexes in the regulation of ABCA1 and SREBP1 gene expression. Mol Cell Biol 2003 2.10
60 PPARs and molecular mechanisms of transrepression. Biochim Biophys Acta 2007 2.10
61 A histone H2A deubiquitinase complex coordinating histone acetylation and H1 dissociation in transcriptional regulation. Mol Cell 2007 1.98
62 The transcription factor STAT-1 couples macrophage synthesis of 25-hydroxycholesterol to the interferon antiviral response. Immunity 2012 1.96
63 Evidence mandating earlier and more aggressive treatment of hypercholesterolemia. Circulation 2008 1.91
64 Non-coding RNAs as regulators of gene expression and epigenetics. Cardiovasc Res 2011 1.85
65 Genome-wide analysis of estrogen receptor alpha DNA binding and tethering mechanisms identifies Runx1 as a novel tethering factor in receptor-mediated transcriptional activation. Mol Cell Biol 2010 1.75
66 Coronin 2A mediates actin-dependent de-repression of inflammatory response genes. Nature 2011 1.74
67 Conserved role for autophagy in Rho1-mediated cortical remodeling and blood cell recruitment. Proc Natl Acad Sci U S A 2010 1.71
68 PPAR- and LXR-dependent pathways controlling lipid metabolism and the development of atherosclerosis. J Lipid Res 2004 1.70
69 Regulated subset of G1 growth-control genes in response to derepression by the Wnt pathway. Proc Natl Acad Sci U S A 2003 1.68
70 Multilineage priming of enhancer repertoires precedes commitment to the B and myeloid cell lineages in hematopoietic progenitors. Immunity 2011 1.66
71 MOZ-TIF2-induced acute myeloid leukemia requires the MOZ nucleosome binding motif and TIF2-mediated recruitment of CBP. Cancer Cell 2003 1.65
72 TBL1 and TBLR1 phosphorylation on regulated gene promoters overcomes dual CtBP and NCoR/SMRT transcriptional repression checkpoints. Mol Cell 2008 1.65
73 Transcriptional integration of TLR2 and TLR4 signaling at the NCoR derepression checkpoint. Mol Cell 2009 1.64
74 An induced Ets repressor complex regulates growth arrest during terminal macrophage differentiation. Cell 2002 1.63
75 FoxO1 regulates Tlr4 inflammatory pathway signalling in macrophages. EMBO J 2010 1.60
76 Maternal hypercholesterolemia during pregnancy promotes early atherogenesis in LDL receptor-deficient mice and alters aortic gene expression determined by microarray. Circulation 2002 1.58
77 Mechanisms establishing TLR4-responsive activation states of inflammatory response genes. PLoS Genet 2011 1.58
78 Nuclear receptors versus inflammation: mechanisms of transrepression. Trends Endocrinol Metab 2006 1.57
79 Efficient regulation of VEGF expression by promoter-targeted lentiviral shRNAs based on epigenetic mechanism: a novel example of epigenetherapy. Circ Res 2009 1.55
80 Low doses of lipopolysaccharide and minimally oxidized low-density lipoprotein cooperatively activate macrophages via nuclear factor kappa B and activator protein-1: possible mechanism for acceleration of atherosclerosis by subclinical endotoxemia. Circ Res 2010 1.51
81 Minireview: Evolution of NURSA, the Nuclear Receptor Signaling Atlas. Mol Endocrinol 2009 1.49
82 Regulation of cytokine expression by ligands of peroxisome proliferator activated receptors. J Immunol 2002 1.44
83 The long arm of long noncoding RNAs: roles as sensors regulating gene transcriptional programs. Cold Spring Harb Perspect Biol 2011 1.43
84 Sterols and oxysterols in immune cell function. Nat Immunol 2013 1.41
85 Roles of peroxisome proliferator-activated receptor gamma in lipid homeostasis and inflammatory responses of macrophages. Curr Opin Lipidol 2002 1.36
86 Pharmacological correction of a defect in PPAR-gamma signaling ameliorates disease severity in Cftr-deficient mice. Nat Med 2010 1.36
87 Decoding transcriptional programs regulated by PPARs and LXRs in the macrophage: effects on lipid homeostasis, inflammation, and atherosclerosis. Arterioscler Thromb Vasc Biol 2003 1.33
88 Regulation of macrophage function in inflammation and atherosclerosis. J Lipid Res 2008 1.32
89 Control of proinflammatory gene programs by regulated trimethylation and demethylation of histone H4K20. Mol Cell 2012 1.29
90 Kdo2-lipid A, a TLR4-specific agonist, induces de novo sphingolipid biosynthesis in RAW264.7 macrophages, which is essential for induction of autophagy. J Biol Chem 2010 1.29
91 Retracted Nuclear receptor-enhanced transcription requires motor- and LSD1-dependent gene networking in interchromatin granules. Cell 2008 1.27
92 Positive intergenic feedback circuitry, involving EBF1 and FOXO1, orchestrates B-cell fate. Proc Natl Acad Sci U S A 2012 1.24
93 PE-1/METS, an antiproliferative Ets repressor factor, is induced by CREB-1/CREM-1 during macrophage differentiation. J Biol Chem 2004 1.17
94 Migration of fibrocytes in fibrogenic liver injury. Am J Pathol 2011 1.17
95 Interleukin-4 induction of the CC chemokine TARC (CCL17) in murine macrophages is mediated by multiple STAT6 sites in the TARC gene promoter. BMC Mol Biol 2006 1.15
96 Serum response factor utilizes distinct promoter- and enhancer-based mechanisms to regulate cytoskeletal gene expression in macrophages. Mol Cell Biol 2010 1.15
97 The type I interferon signaling pathway is a target for glucocorticoid inhibition. Mol Cell Biol 2010 1.14
98 Regulation of microglia activation and deactivation by nuclear receptors. Glia 2012 1.13
99 Retinoid X receptor alpha controls innate inflammatory responses through the up-regulation of chemokine expression. Proc Natl Acad Sci U S A 2010 1.13
100 Macrophages, oxysterols and atherosclerosis. Circ J 2010 1.13
101 Nuclear receptors and inflammation control: molecular mechanisms and pathophysiological relevance. Arterioscler Thromb Vasc Biol 2010 1.11
102 WY14,643, a PPAR alpha ligand, has profound effects on immune responses in vivo. J Immunol 2002 1.09
103 Specificity of eicosanoid production depends on the TLR-4-stimulated macrophage phenotype. J Leukoc Biol 2011 1.06
104 PPARs and lipid ligands in inflammation and metabolism. Chem Rev 2011 1.06
105 Repression of IFN-gamma expression by peroxisome proliferator-activated receptor gamma. J Immunol 2004 1.04
106 DICER- and AGO3-dependent generation of retinoic acid-induced DR2 Alu RNAs regulates human stem cell proliferation. Nat Struct Mol Biol 2012 1.03
107 Fibrocyte-like cells recruited to the spleen support innate and adaptive immune responses to acute injury or infection. J Mol Med (Berl) 2011 1.02
108 Structure-guided design of N-phenyl tertiary amines as transrepression-selective liver X receptor modulators with anti-inflammatory activity. J Med Chem 2008 0.96
109 Mnt-deficient mammary glands exhibit impaired involution and tumors with characteristics of myc overexpression. Cancer Res 2006 0.94
110 Anti-inflammatory and antidiabetic roles of PPARgamma. Novartis Found Symp 2007 0.93
111 Normal hematopoiesis after conditional targeting of RXRalpha in murine hematopoietic stem/progenitor cells. J Leukoc Biol 2006 0.93
112 Transcriptional regulation through noncoding RNAs and epigenetic modifications. RNA Biol 2009 0.92
113 A global clustering algorithm to identify long intergenic non-coding RNA--with applications in mouse macrophages. PLoS One 2011 0.92
114 Signaling by nuclear receptors. Cold Spring Harb Perspect Biol 2013 0.92
115 Gaining weight: the Keystone Symposium on PPAR and LXR. Genes Dev 2005 0.91
116 Macrophage PPAR gamma Co-activator-1 alpha participates in repressing foam cell formation and atherosclerosis in response to conjugated linoleic acid. EMBO Mol Med 2013 0.91
117 Integration of lipidomics and transcriptomics data towards a systems biology model of sphingolipid metabolism. BMC Syst Biol 2011 0.91
118 A protective strategy against hyperinflammatory responses requiring the nontranscriptional actions of GPS2. Mol Cell 2012 0.90
119 The interferon stimulated gene 12 inactivates vasculoprotective functions of NR4A nuclear receptors. Circ Res 2012 0.88
120 Nuclear receptors, inflammation, and neurodegenerative diseases. Adv Immunol 2010 0.88
121 Differential repression of c-myc and cdc2 gene expression by ERF and PE-1/METS. Cell Cycle 2007 0.87
122 Analysis of inflammatory and lipid metabolic networks across RAW264.7 and thioglycolate-elicited macrophages. J Lipid Res 2013 0.87
123 25-Hydroxycholesterol activates the integrated stress response to reprogram transcription and translation in macrophages. J Biol Chem 2013 0.84
124 Epigenomics of macrophages. Immunol Rev 2014 0.84
125 Vespucci: a system for building annotated databases of nascent transcripts. Nucleic Acids Res 2013 0.84
126 Roles of lineage-determining transcription factors in establishing open chromatin: lessons from high-throughput studies. Curr Top Microbiol Immunol 2012 0.83
127 Towards an understanding of cell-specific functions of signal-dependent transcription factors. J Mol Endocrinol 2013 0.83
128 Facilitated replacement of Kupffer cells expressing a paraoxonase-1 transgene is essential for ameliorating atherosclerosis in mice. Proc Natl Acad Sci U S A 2005 0.82
129 Epigenomic control of the innate immune response. Curr Opin Pharmacol 2013 0.82
130 The role of transcription factors in allergic inflammation. J Allergy Clin Immunol 2002 0.82
131 Transcription factor ISL1 is essential for pacemaker development and function. J Clin Invest 2015 0.81
132 Nuclear receptor-enhanced transcription requires motor- and LSD1-dependent gene networking in interchromatin granules. Cell 2008 0.80
133 A new role for cyclic phosphatidic acid as a PPARgamma antagonist. Cell Metab 2010 0.79
134 A combined omics study on activated macrophages--enhanced role of STATs in apoptosis, immunity and lipid metabolism. Bioinformatics 2013 0.79
135 Serum response factor indirectly regulates type I interferon-signaling in macrophages. J Interferon Cytokine Res 2013 0.79
136 Novel prostaglandin D(2)-derived activators of peroxisome proliferator-activated receptor-gamma are formed in macrophage cell cultures. Biochim Biophys Acta 2003 0.78
137 Immunology: Oxysterols hold T cells in check. Nature 2008 0.78
138 Review focus on epigenetics and the histone code in vascular biology. Cardiovasc Res 2011 0.77
139 Novel eicosanoid activators of PPAR gamma formed by RAW 264.7 macrophage cultures. Adv Exp Med Biol 2002 0.77
140 Research resource: Comparative nuclear receptor atlas: basal and activated peritoneal B-1 and B-2 cells. Mol Endocrinol 2011 0.76
141 Genome-Wide Approaches to Defining Macrophage Identity and Function. Microbiol Spectr 2016 0.75
142 Factor XIIIA (cross)links AT1 receptors to atherosclerosis. Cell 2004 0.75