Published in Nature on March 28, 2007
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The Rpd3/Hda1 family of lysine deacetylases: from bacteria and yeast to mice and men. Nat Rev Mol Cell Biol (2008) 6.90
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The lysine demethylase LSD1 (KDM1) is required for maintenance of global DNA methylation. Nat Genet (2008) 4.40
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Histone demethylase LSD1 regulates neural stem cell proliferation. Mol Cell Biol (2010) 1.47
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Histone demethylase Lsd1 represses hematopoietic stem and progenitor cell signatures during blood cell maturation. Elife (2013) 1.44
ZEB1 regulates the latent-lytic switch in infection by Epstein-Barr virus. PLoS Pathog (2007) 1.33
Involvement of histone demethylase LSD1 in Blimp-1-mediated gene repression during plasma cell differentiation. Mol Cell Biol (2009) 1.29
Expanding roles of ZEB factors in tumorigenesis and tumor progression. Am J Cancer Res (2011) 1.26
Transrepressive function of TLX requires the histone demethylase LSD1. Mol Cell Biol (2008) 1.24
FAD-dependent lysine-specific demethylase-1 regulates cellular energy expenditure. Nat Commun (2012) 1.21
Metastasis suppressor genes at the interface between the environment and tumor cell growth. Int Rev Cell Mol Biol (2011) 1.18
Either ZEB1 or ZEB2/SIP1 can play a central role in regulating the Epstein-Barr virus latent-lytic switch in a cell-type-specific manner. J Virol (2010) 1.17
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p53-targeted LSD1 functions in repression of chromatin structure and transcription in vivo. Mol Cell Biol (2008) 1.15
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Genome-wide profiles of CtBP link metabolism with genome stability and epithelial reprogramming in breast cancer. Nat Commun (2013) 1.13
Targeting Huntington's disease through histone deacetylases. Clin Epigenetics (2011) 1.13
Mixed lineage leukemia: histone H3 lysine 4 methyltransferases from yeast to human. FEBS J (2010) 1.12
Cellular microRNAs 200b and 429 regulate the Epstein-Barr virus switch between latency and lytic replication. J Virol (2010) 1.09
Evolutionary history of histone demethylase families: distinct evolutionary patterns suggest functional divergence. BMC Evol Biol (2008) 1.08
Histone H3 lysine 4 methyltransferases and demethylases in self-renewal and differentiation of stem cells. Cell Biosci (2013) 1.07
Evolutionary functional analysis and molecular regulation of the ZEB transcription factors. Cell Mol Life Sci (2012) 1.06
ZNF198 stabilizes the LSD1-CoREST-HDAC1 complex on chromatin through its MYM-type zinc fingers. PLoS One (2008) 1.06
SUMOylation of pontin chromatin-remodeling complex reveals a signal integration code in prostate cancer cells. Proc Natl Acad Sci U S A (2007) 1.03
Signaling and epigenetic regulation of pituitary development. Curr Opin Cell Biol (2007) 1.02
Pro-inflammatory role of microrna-200 in vascular smooth muscle cells from diabetic mice. Arterioscler Thromb Vasc Biol (2012) 1.02
Differential interactions of the autonomous pathway RRM proteins and chromatin regulators in the silencing of Arabidopsis targets. PLoS One (2008) 1.00
LSD1 promotes oxidative metabolism of white adipose tissue. Nat Commun (2014) 0.99
Unliganded progesterone receptor-mediated targeting of an RNA-containing repressive complex silences a subset of hormone-inducible genes. Genes Dev (2013) 0.99
Phosphorylation of CtBP1 by cAMP-dependent protein kinase modulates induction of CYP17 by stimulating partnering of CtBP1 and 2. J Biol Chem (2008) 0.98
Analysis of epigenetic alterations to chromatin during development. Genesis (2009) 0.98
Overexpression of lysine specific demethylase 1 predicts worse prognosis in primary hepatocellular carcinoma patients. World J Gastroenterol (2012) 0.97
Five friends of methylated chromatin target of protein-arginine-methyltransferase[prmt]-1 (chtop), a complex linking arginine methylation to desumoylation. Mol Cell Proteomics (2012) 0.97
The deubiquitinase USP28 stabilizes LSD1 and confers stem-cell-like traits to breast cancer cells. Cell Rep (2013) 0.97
Loss of LSD1 (lysine-specific demethylase 1) suppresses growth and alters gene expression of human colon cancer cells in a p53- and DNMT1(DNA methyltransferase 1)-independent manner. Biochem J (2013) 0.96
The histone demethylase LSD1/KDM1A promotes the DNA damage response. J Cell Biol (2013) 0.96
KDM5B focuses H3K4 methylation near promoters and enhancers during embryonic stem cell self-renewal and differentiation. Genome Biol (2014) 0.95
USP28 is recruited to sites of DNA damage by the tandem BRCT domains of 53BP1 but plays a minor role in double-strand break metabolism. Mol Cell Biol (2014) 0.94
Antagonistic actions of Rcor proteins regulate LSD1 activity and cellular differentiation. Proc Natl Acad Sci U S A (2014) 0.94
Targeting histone deacetylases for the treatment of disease. J Cell Mol Med (2008) 0.94
Histone demethylase LSD1 deficiency during high-salt diet is associated with enhanced vascular contraction, altered NO-cGMP relaxation pathway, and hypertension. Am J Physiol Heart Circ Physiol (2011) 0.94
Retracted NF-Y substitutes H2A-H2B on active cell-cycle promoters: recruitment of CoREST-KDM1 and fine-tuning of H3 methylations. Nucleic Acids Res (2008) 0.94
Involvement of histone demethylase LSD1 in short-time-scale gene expression changes during cell cycle progression in embryonic stem cells. Mol Cell Biol (2012) 0.94
ZEB1-associated drug resistance in cancer cells is reversed by the class I HDAC inhibitor mocetinostat. EMBO Mol Med (2015) 0.93
The molecular basis of hypopituitarism. Trends Endocrinol Metab (2009) 0.93
Lysine-specific demethylase 1 has dual functions as a major regulator of androgen receptor transcriptional activity. Cell Rep (2014) 0.93
Epigenetic regulation of adipogenesis by PHF2 histone demethylase. Diabetes (2012) 0.92
MassSQUIRM: An assay for quantitative measurement of lysine demethylase activity. Epigenetics (2011) 0.92
A role of the LIM-homeobox gene Lhx2 in the regulation of pituitary development. Dev Biol (2009) 0.90
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Lysine-specific histone demethylase 1 inhibitors control breast cancer proliferation in ERα-dependent and -independent manners. ACS Chem Biol (2012) 0.89
Upregulation of long intergenic noncoding RNA 00673 promotes tumor proliferation via LSD1 interaction and repression of NCALD in non-small-cell lung cancer. Oncotarget (2016) 0.89
LSD1n is an H4K20 demethylase regulating memory formation via transcriptional elongation control. Nat Neurosci (2015) 0.88
Genome-wide identification of calcium-response factor (CaRF) binding sites predicts a role in regulation of neuronal signaling pathways. PLoS One (2010) 0.88
Global expression profiling of globose basal cells and neurogenic progression within the olfactory epithelium. J Comp Neurol (2013) 0.88
Silencing of the DNA mismatch repair gene MLH1 induced by hypoxic stress in a pathway dependent on the histone demethylase LSD1. Cell Rep (2014) 0.88
NF-κB repression by PIAS3 mediated RelA SUMOylation. PLoS One (2012) 0.87
Lysine-specific demethylase 1: an epigenetic regulator of salt-sensitive hypertension. Am J Hypertens (2012) 0.87
Cell cycle association of the retinoblastoma protein Rb and the histone demethylase LSD1 with the Epstein-Barr virus latency promoter Cp. J Virol (2008) 0.87
A noncoding point mutation of Zeb1 causes multiple developmental malformations and obesity in Twirler mice. PLoS Genet (2011) 0.87
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Ligand-dependent corepressor (LCoR) recruitment by Kruppel-like factor 6 (KLF6) regulates expression of the cyclin-dependent kinase inhibitor CDKN1A gene. J Biol Chem (2012) 0.86
Analysis of the TGFβ-induced program in primary airway epithelial cells shows essential role of NF-κB/RelA signaling network in type II epithelial mesenchymal transition. BMC Genomics (2015) 0.86
Translational isoforms of FOG1 regulate GATA1-interacting complexes. J Biol Chem (2009) 0.85
Analysis of the levels of lysine-specific demethylase 1 (LSD1) mRNA in human ovarian tumors and the effects of chemical LSD1 inhibitors in ovarian cancer cell lines. J Ovarian Res (2013) 0.85
Intersection of nuclear receptors and the proteasome on the epigenetic landscape. Environ Mol Mutagen (2008) 0.85
Corepressor Rcor1 is essential for murine erythropoiesis. Blood (2014) 0.85
Identification of myelin transcription factor 1 (MyT1) as a subunit of the neural cell type-specific lysine-specific demethylase 1 (LSD1) complex. J Biol Chem (2014) 0.85
Genetic regulation of murine pituitary development. J Mol Endocrinol (2015) 0.84
Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project. Nature (2007) 75.09
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Molecular determinants of resistance to antiandrogen therapy. Nat Med (2003) 18.90
Determination of tag density required for digital transcriptome analysis: application to an androgen-sensitive prostate cancer model. Proc Natl Acad Sci U S A (2008) 11.86
Macrophages, inflammation, and insulin resistance. Annu Rev Physiol (2010) 11.77
Zoledronic acid and clinical fractures and mortality after hip fracture. N Engl J Med (2007) 9.83
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A SUMOylation-dependent pathway mediates transrepression of inflammatory response genes by PPAR-gamma. Nature (2005) 6.83
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Antibody domain exchange is an immunological solution to carbohydrate cluster recognition. Science (2003) 6.68
A subpopulation of macrophages infiltrates hypertrophic adipose tissue and is activated by free fatty acids via Toll-like receptors 2 and 4 and JNK-dependent pathways. J Biol Chem (2007) 6.58
A comprehensive classification system for lipids. J Lipid Res (2005) 6.52
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9p21 DNA variants associated with coronary artery disease impair interferon-γ signalling response. Nature (2011) 6.25
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Reprogramming transcription by distinct classes of enhancers functionally defined by eRNA. Nature (2011) 6.10
Nuclear receptor-induced chromosomal proximity and DNA breaks underlie specific translocations in cancer. Cell (2009) 5.74
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The RNA-binding protein KSRP promotes the biogenesis of a subset of microRNAs. Nature (2009) 4.61
A Nurr1/CoREST pathway in microglia and astrocytes protects dopaminergic neurons from inflammation-induced death. Cell (2009) 4.60
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Parallel SUMOylation-dependent pathways mediate gene- and signal-specific transrepression by LXRs and PPARgamma. Mol Cell (2007) 4.33
SMRT-mediated repression of an H3K27 demethylase in progression from neural stem cell to neuron. Nature (2007) 4.33
A global network of transcription factors, involving E2A, EBF1 and Foxo1, that orchestrates B cell fate. Nat Immunol (2010) 4.32
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Corepressor-dependent silencing of chromosomal regions encoding neuronal genes. Science (2002) 4.19
A versatile assay for high-throughput gene expression profiling on universal array matrices. Genome Res (2004) 4.19
Regulation of circadian behaviour and metabolism by REV-ERB-α and REV-ERB-β. Nature (2012) 4.15
An ADIOL-ERβ-CtBP transrepression pathway negatively regulates microglia-mediated inflammation. Cell (2011) 4.04
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Functional roles of enhancer RNAs for oestrogen-dependent transcriptional activation. Nature (2013) 3.93
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Eya protein phosphatase activity regulates Six1-Dach-Eya transcriptional effects in mammalian organogenesis. Nature (2003) 3.72
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Glucocorticoid receptor confers resistance to antiandrogens by bypassing androgen receptor blockade. Cell (2013) 3.59
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