Expression analysis of G Protein-Coupled Receptors in mouse macrophages.

BioGPS: an extensible and customizable portal for querying and organizing gene annotation resources. Genome Biol (2009) 11.17

International Union of Basic and Clinical Pharmacology. LXXIX. Cannabinoid receptors and their ligands: beyond CB₁ and CB₂. Pharmacol Rev (2010) 4.31

Angptl4 protects against severe proinflammatory effects of saturated fat by inhibiting fatty acid uptake into mesenteric lymph node macrophages. Cell Metab (2010) 2.95

Gender bias in autoimmunity is influenced by microbiota. Immunity (2013) 2.88

RNA sequencing reveals two major classes of gene expression levels in metazoan cells. Mol Syst Biol (2011) 2.77

Zbtb46 expression distinguishes classical dendritic cells and their committed progenitors from other immune lineages. J Exp Med (2012) 2.74

Identification of RIFL, a novel adipocyte-enriched insulin target gene with a role in lipid metabolism. Am J Physiol Endocrinol Metab (2012) 2.70

clusterMaker: a multi-algorithm clustering plugin for Cytoscape. BMC Bioinformatics (2011) 2.56

The genetic basis of DOORS syndrome: an exome-sequencing study. Lancet Neurol (2013) 2.40

MICU2, a paralog of MICU1, resides within the mitochondrial uniporter complex to regulate calcium handling. PLoS One (2013) 1.99

Mutations in ABHD12 cause the neurodegenerative disease PHARC: An inborn error of endocannabinoid metabolism. Am J Hum Genet (2010) 1.95

5-hmC in the brain is abundant in synaptic genes and shows differences at the exon-intron boundary. Nat Struct Mol Biol (2012) 1.74

MitoCarta2.0: an updated inventory of mammalian mitochondrial proteins. Nucleic Acids Res (2015) 1.73

Conservation and divergence in Toll-like receptor 4-regulated gene expression in primary human versus mouse macrophages. Proc Natl Acad Sci U S A (2012) 1.72

A unique H3K4me2 profile marks tissue-specific gene regulation. Genome Res (2010) 1.58

The Raine syndrome protein FAM20C is a Golgi kinase that phosphorylates bio-mineralization proteins. PLoS One (2012) 1.54

Bicc1 is a genetic determinant of osteoblastogenesis and bone mineral density. J Clin Invest (2014) 1.53

CXC chemokine receptor 4 is a cell surface receptor for extracellular ubiquitin. J Biol Chem (2010) 1.47

Distribution of Misfolded Prion Protein Seeding Activity Alone Does Not Predict Regions of Neurodegeneration. PLoS Biol (2016) 1.44

Population and single-cell genomics reveal the Aire dependency, relief from Polycomb silencing, and distribution of self-antigen expression in thymic epithelia. Genome Res (2014) 1.38

Cooperation between myogenic regulatory factors and SIX family transcription factors is important for myoblast differentiation. Nucleic Acids Res (2010) 1.36

The C3a anaphylatoxin receptor is a key mediator of insulin resistance and functions by modulating adipose tissue macrophage infiltration and activation. Diabetes (2009) 1.32

Single-neuron RNA-Seq: technical feasibility and reproducibility. Front Genet (2012) 1.32

The membrane proteome of the mouse lens fiber cell. Mol Vis (2009) 1.30

Initial characterization of the human central proteome. BMC Syst Biol (2011) 1.18

A gene expression atlas of the domestic pig. BMC Biol (2012) 1.18

Serum response factor utilizes distinct promoter- and enhancer-based mechanisms to regulate cytoskeletal gene expression in macrophages. Mol Cell Biol (2010) 1.15

Neuron-specific ELAV/Hu proteins suppress HuR mRNA during neuronal differentiation by alternative polyadenylation. Nucleic Acids Res (2011) 1.13

An expression atlas of human primary cells: inference of gene function from coexpression networks. BMC Genomics (2013) 1.11

The intramembrane protease Sppl2a is required for B cell and DC development and survival via cleavage of the invariant chain. J Exp Med (2012) 1.07

Transcriptional profiling of intrinsic PNS factors in the postnatal mouse. Mol Cell Neurosci (2010) 1.05

Coordinated expression domains in mammalian genomes. PLoS One (2010) 1.05

Development, composition, and structural arrangements of the ciliary zonule of the mouse. Invest Ophthalmol Vis Sci (2013) 1.04

Expression of mesenchyme-specific gene signatures by follicular dendritic cells: insights from the meta-analysis of microarray data from multiple mouse cell populations. Immunology (2011) 1.04

Mutations in the UQCC1-interacting protein, UQCC2, cause human complex III deficiency associated with perturbed cytochrome b protein expression. PLoS Genet (2013) 1.02

GPR105 ablation prevents inflammation and improves insulin sensitivity in mice with diet-induced obesity. J Immunol (2012) 1.02

A role for epha2 in cell migration and refractive organization of the ocular lens. Invest Ophthalmol Vis Sci (2012) 1.02

GPR35 as a Novel Therapeutic Target. Front Endocrinol (Lausanne) (2011) 0.98

Quantitative expression profile of distinct functional regions in the adult mouse brain. PLoS One (2011) 0.98

Functional genomic analysis of human mitochondrial RNA processing. Cell Rep (2014) 0.98

Nonobese diabetic congenic strain analysis of autoimmune diabetes reveals genetic complexity of the Idd18 locus and identifies Vav3 as a candidate gene. J Immunol (2010) 0.96

The transcription factor paired-related homeobox 1 (Prrx1) inhibits adipogenesis by activating transforming growth factor-β (TGFβ) signaling. J Biol Chem (2012) 0.96

Implication of inflammatory macrophages, nuclear receptors, and interferon regulatory factors in increased virulence of pandemic 2009 H1N1 influenza A virus after host adaptation. J Virol (2012) 0.96

Systems-level analysis of genome-wide association data. G3 (Bethesda) (2013) 0.95

Major shifts in the spatio-temporal distribution of lung antioxidant enzymes during influenza pneumonia. PLoS One (2012) 0.94

STIM1 as a key regulator for Ca2+ homeostasis in skeletal-muscle development and function. Skelet Muscle (2011) 0.94

Systems genetic analysis of osteoblast-lineage cells. PLoS Genet (2012) 0.93

Proteins that bind regulatory regions identified by histone modification chromatin immunoprecipitations and mass spectrometry. Nat Commun (2015) 0.93

The BTB-ZF transcription factors. Cell Cycle (2012) 0.93

Co-expression of FBN1 with mesenchyme-specific genes in mouse cell lines: implications for phenotypic variability in Marfan syndrome. Eur J Hum Genet (2010) 0.93

Role of the DNA Sensor STING in Protection from Lethal Infection following Corneal and Intracerebral Challenge with Herpes Simplex Virus 1. J Virol (2015) 0.92

miR-29 promotes murine osteoclastogenesis by regulating osteoclast commitment and migration. J Biol Chem (2013) 0.92

Metallothionein and the biology of aging. Ageing Res Rev (2010) 0.91

Medium-chain fatty acid-sensing receptor, GPR84, is a proinflammatory receptor. J Biol Chem (2013) 0.91

Diacylglycerol kinases: regulated controllers of T cell activation, function, and development. Int J Mol Sci (2013) 0.90

Bioinformatic analyses identifies novel protein-coding pharmacogenomic markers associated with paclitaxel sensitivity in NCI60 cancer cell lines. BMC Med Genomics (2011) 0.90

REST regulates the pool size of the different neural lineages by restricting the generation of neurons and oligodendrocytes from neural stem/progenitor cells. Development (2012) 0.90

Differentiation of human ESCs to retinal ganglion cells using a CRISPR engineered reporter cell line. Sci Rep (2015) 0.89

Gene and genome parameters of mammalian liver circadian genes (LCGs). PLoS One (2012) 0.89

Spatial coupling of JNK activation to the B cell antigen receptor by tyrosine-phosphorylated ezrin. J Immunol (2013) 0.89

Integrative analysis of low- and high-resolution eQTL. PLoS One (2010) 0.88

Role of runt-related transcription factor 3 (RUNX3) in transcription regulation of natural cytotoxicity receptor 1 (NCR1/NKp46), an activating natural killer (NK) cell receptor. J Biol Chem (2012) 0.88

Spermatogenesis rescue in a mouse deficient for the ubiquitin ligase SCF{beta}-TrCP by single substrate depletion. Genes Dev (2010) 0.87

A lacZ reporter gene expression atlas for 313 adult KOMP mutant mouse lines. Genome Res (2015) 0.86

Current and emerging strategies for the treatment and management of systemic lupus erythematosus based on molecular signatures of acute and chronic inflammation. J Inflamm Res (2010) 0.86

Microarray analysis reveals global modulation of endogenous retroelement transcription by microbes. Retrovirology (2014) 0.86

Cadm1 expression and function in the mouse lens. Invest Ophthalmol Vis Sci (2011) 0.86

EvoCor: a platform for predicting functionally related genes using phylogenetic and expression profiles. Nucleic Acids Res (2014) 0.85

Genome wide analysis of inbred mouse lines identifies a locus containing Ppar-gamma as contributing to enhanced malaria survival. PLoS One (2010) 0.84

Comprehensive analysis of genes expressed by rare microchimeric fetal cells in the maternal mouse lung. Biol Reprod (2012) 0.84

Genetic recapitulation of human pre-eclampsia risk during convergent evolution of reduced placental invasiveness in eutherian mammals. Philos Trans R Soc Lond B Biol Sci (2015) 0.84

Ppm1b negatively regulates necroptosis through dephosphorylating Rip3. Nat Cell Biol (2015) 0.84

hCD2-iCre and Vav-iCre mediated gene recombination patterns in murine hematopoietic cells. PLoS One (2015) 0.84

The Lipid-Modifying Enzyme SMPDL3B Negatively Regulates Innate Immunity. Cell Rep (2015) 0.84

The retinal pigment epithelium utilizes fatty acids for ketogenesis. J Biol Chem (2014) 0.84

High-throughput identification and characterization of novel, species-selective GPR35 agonists. J Pharmacol Exp Ther (2012) 0.83

Mouse Nkrp1-Clr gene cluster sequence and expression analyses reveal conservation of tissue-specific MHC-independent immunosurveillance. PLoS One (2012) 0.83

Mutation of the melastatin-related cation channel, TRPM3, underlies inherited cataract and glaucoma. PLoS One (2014) 0.83

BioGPS and GXD: mouse gene expression data-the benefits and challenges of data integration. Mamm Genome (2012) 0.83

Molecular signatures of the evolving immune response in mice following a Bordetella pertussis infection. PLoS One (2014) 0.82

Alternative promoter and GATA5 transcripts in mouse. Am J Physiol Gastrointest Liver Physiol (2009) 0.82

Tissue-specific targeting of cell fate regulatory genes by E2f factors. Cell Death Differ (2015) 0.82

Several classical mouse inbred strains, including DBA/2, NOD/Lt, FVB/N, and SJL/J, carry a putative loss-of-function allele of Gpr84. J Hered (2013) 0.82

CLYBL is a polymorphic human enzyme with malate synthase and β-methylmalate synthase activity. Hum Mol Genet (2013) 0.81

Claudin 13, a member of the claudin family regulated in mouse stress induced erythropoiesis. PLoS One (2010) 0.81

The role of G-protein receptor 84 in experimental neuropathic pain. J Neurosci (2015) 0.81

Noncoding variation of the gene for ferritin light chain in hereditary and age-related cataract. Mol Vis (2013) 0.81

The G-protein-coupled receptor, GPR84, is important for eye development in Xenopus laevis. Dev Dyn (2010) 0.81

Why Is N-Glycolylneuraminic Acid Rare in the Vertebrate Brain? Top Curr Chem (2015) 0.81

P2Y6 receptor potentiates pro-inflammatory responses in macrophages and exhibits differential roles in atherosclerotic lesion development. PLoS One (2014) 0.80

Defining the Microglia Response during the Time Course of Chronic Neurodegeneration. J Virol (2015) 0.80

C-C chemokine receptor 5 on pulmonary mesenchymal cells promotes experimental metastasis via the induction of erythroid differentiation regulator 1. Mol Cancer Res (2013) 0.80

Aspirin metabolites are GPR35 agonists. Naunyn Schmiedebergs Arch Pharmacol (2012) 0.80

TRPC6 channel translocation into phagosomal membrane augments phagosomal function. Proc Natl Acad Sci U S A (2015) 0.80

Functional characterization of enzymes catalyzing ceramide phosphoethanolamine biosynthesis in mice. J Lipid Res (2015) 0.80

Identification of hematopoietic-specific regulatory elements from the CD45 gene and use for lentiviral tracking of transplanted cells. Exp Hematol (2014) 0.80

Nutritional Signaling via Free Fatty Acid Receptors. Int J Mol Sci (2016) 0.79

CpG island-mediated global gene regulatory modes in mouse embryonic stem cells. Nat Commun (2014) 0.79

A systems biology approach to the analysis of subset-specific responses to lipopolysaccharide in dendritic cells. PLoS One (2014) 0.79

Characterization of the membrane proteome and N-glycoproteome in BV-2 mouse microglia by liquid chromatography-tandem mass spectrometry. BMC Genomics (2014) 0.79

A gene atlas of the mouse and human protein-encoding transcriptomes. Proc Natl Acad Sci U S A (2004) 44.81

Wnt/beta-catenin signaling in development and disease. Cell (2006) 30.09

F4/80, a monoclonal antibody directed specifically against the mouse macrophage. Eur J Immunol (1981) 12.96

Seven-transmembrane receptors. Nat Rev Mol Cell Biol (2002) 11.50

Monitoring of blood vessels and tissues by a population of monocytes with patrolling behavior. Science (2007) 9.54

ATP release guides neutrophil chemotaxis via P2Y2 and A3 receptors. Science (2006) 6.00

Stochastic models inspired by hybridization theory for short oligonucleotide arrays. J Comput Biol (2005) 5.63

CXCR4-SDF-1 signalling, locomotion, chemotaxis and adhesion. J Mol Histol (2004) 4.08

UDP acting at P2Y6 receptors is a mediator of microglial phagocytosis. Nature (2007) 3.78

International Union of Pharmacology. XLVI. G protein-coupled receptor list. Pharmacol Rev (2005) 3.33

Epstein-Barr virus-induced genes: first lymphocyte-specific G protein-coupled peptide receptors. J Virol (1993) 3.19

G protein-coupled receptors. II. Mechanism of agonist activation. J Biol Chem (1998) 2.92

Release of ATP from human erythrocytes in response to a brief period of hypoxia and hypercapnia. Cardiovasc Res (1992) 2.86

Adenosine receptor agonists differentially regulate IL-10, TNF-alpha, and nitric oxide production in RAW 264.7 macrophages and in endotoxemic mice. J Immunol (1996) 2.55

Adenosine inhibits IL-12 and TNF-[alpha] production via adenosine A2a receptor-dependent and independent mechanisms. FASEB J (2000) 2.53

Molecular cloning of F4/80, a murine macrophage-restricted cell surface glycoprotein with homology to the G-protein-linked transmembrane 7 hormone receptor family. J Biol Chem (1996) 2.44

The Wingless homolog WNT5A and its receptor Frizzled-5 regulate inflammatory responses of human mononuclear cells induced by microbial stimulation. Blood (2006) 2.33

Expression of the macrophage-specific antigen F4/80 during differentiation of mouse bone marrow cells in culture. J Exp Med (1981) 2.25

Identification of a new class of molecules, the arachidonyl amino acids, and characterization of one member that inhibits pain. J Biol Chem (2001) 2.19

Adenosine augments IL-10 production by macrophages through an A2B receptor-mediated posttranscriptional mechanism. J Immunol (2005) 1.98

Identification of N-arachidonylglycine as the endogenous ligand for orphan G-protein-coupled receptor GPR18. Biochem Biophys Res Commun (2006) 1.79

WntD is a feedback inhibitor of Dorsal/NF-kappaB in Drosophila development and immunity. Nature (2005) 1.75

Cloning, functional expression and tissue distribution of the human P2Y6 receptor. Biochem Biophys Res Commun (1996) 1.71

Extracellular ATP induces oscillations of intracellular Ca2+ and membrane potential and promotes transcription of IL-6 in macrophages. Proc Natl Acad Sci U S A (2004) 1.65

P2Y(6) nucleotide receptor mediates monocyte interleukin-8 production in response to UDP or lipopolysaccharide. J Biol Chem (2001) 1.63

Differential regulatory effects of adenosine on cytokine release by activated human monocytes. J Immunol (1994) 1.57

Chemokines and chemokine receptors: multipurpose players in neuroinflammation. Int Rev Neurobiol (2007) 1.56

Cellular mechanisms of wingless/Wnt signal transduction. Curr Top Dev Biol (1999) 1.55

Ligand-activation of the adenosine A2a receptors inhibits IL-12 production by human monocytes. J Immunol (2000) 1.54

Increased release of ATP from endothelial cells during acute inflammation. Inflamm Res (1998) 1.53

Signaling by wingless in Drosophila. Dev Biol (1994) 1.53

Oxidative metabolism of anandamide. Prostaglandins Other Lipid Mediat (2000) 1.50

Modelling G-protein-coupled receptors for drug design. Biochim Biophys Acta (1999) 1.50

P2Y-like receptor, GPR105 (P2Y14), identifies and mediates chemotaxis of bone-marrow hematopoietic stem cells. Genes Dev (2003) 1.41

Apoptotic cells promote macrophage survival by releasing the antiapoptotic mediator sphingosine-1-phosphate. Blood (2006) 1.40

PK1/EG-VEGF induces monocyte differentiation and activation. J Leukoc Biol (2005) 1.38

G-protein-coupled receptor expression, function, and signaling in macrophages. J Leukoc Biol (2007) 1.33

Kinetics of the thrombin-induced release of adenosine triphosphate by platelets. Comparison with release of calcium. Biochemistry (1973) 1.29

Demonstration of a specific receptor for human C5a anaphylatoxin on murine macrophages. J Exp Med (1982) 1.28

Selective expression of Gi/o-coupled ATP receptor P2Y12 in microglia in rat brain. Glia (2003) 1.27

Cross genome phylogenetic analysis of human and Drosophila G protein-coupled receptors: application to functional annotation of orphan receptors. BMC Genomics (2005) 1.26

The Edg family G protein-coupled receptors for lysophospholipids: their signaling properties and biological activities. J Biochem (2002) 1.26

P2Y6 nucleotide receptors activate NF-kappaB and increase survival of osteoclasts. J Biol Chem (2005) 1.23

The receptor for complement anaphylatoxin C3a is expressed by myeloid cells and nonmyeloid cells in inflamed human central nervous system: analysis in multiple sclerosis and bacterial meningitis. J Immunol (1998) 1.22

Identification of 6H1 as a P2Y purinoceptor: P2Y5. Biochem Biophys Res Commun (1996) 1.21

PUMA-G, an IFN-gamma-inducible gene in macrophages is a novel member of the seven transmembrane spanning receptor superfamily. Eur J Immunol (2001) 1.15

Characterization of the LPS-stimulated expression of EP2 and EP4 prostaglandin E receptors in mouse macrophage-like cell line, J774.1. Biochem Biophys Res Commun (1998) 1.14

Synergistic effect of acute hypoxia on flow-induced release of ATP from cultured endothelial cells. Experientia (1995) 1.10

G protein-coupled receptor 84, a microglia-associated protein expressed in neuroinflammatory conditions. Glia (2007) 1.08

A novel lipopolysaccharide inducible C-C chemokine receptor related gene in murine macrophages. FEBS Lett (1998) 1.08

Activation of adenosine A3 receptors on macrophages inhibits tumor necrosis factor-alpha. Eur J Pharmacol (1996) 1.06

Purinergic receptor regulation of LPS-induced signaling and pathophysiology. J Endotoxin Res (2003) 1.04

Sphingosine 1-phosphate induces antimicrobial activity both in vitro and in vivo. J Infect Dis (2004) 1.03

The 6H1 orphan receptor, claimed to be the p2y5 receptor, does not mediate nucleotide-promoted second messenger responses. Biochem Biophys Res Commun (1997) 1.02

Murine macrophages produce endothelin-1 after microbial stimulation. Exp Biol Med (Maywood) (2005) 0.96

Lipopolysaccharide induces formyl peptide receptor 1 gene expression in macrophages and neutrophils via transcriptional and posttranscriptional mechanisms. J Immunol (2005) 0.92

A conserved mRNA expression profile of SREB2 (GPR85) in adult human, monkey, and rat forebrain. Brain Res Mol Brain Res (2005) 0.91

The brain-specific G-protein coupled receptor GPR85 with identical protein sequence in man and mouse maps to human chromosome 7q31. Biochim Biophys Acta (2000) 0.87

Human and rat alveolar macrophages express multiple EDG receptors. Eur J Pharmacol (2001) 0.85

Gpr85, a novel member of the G-protein coupled receptor family, prominently expressed in the developing mouse cerebral cortex. Brain Res Gene Expr Patterns (2001) 0.83

Invertebrate molecular neuroimmune processes. Brain Res Brain Res Rev (2000) 0.83

Wingless: from embryo to adult. Trends Genet (1993) 0.83

Immunoregulation of IL-6 secretion by endogenous and exogenous adenosine and by exogenous purinergic agonists in splenic tissue slices. J Neuroimmunol (2002) 0.83

Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project. Nature (2007) 75.09

A gene atlas of the mouse and human protein-encoding transcriptomes. Proc Natl Acad Sci U S A (2004) 44.81

Large-scale analysis of the human and mouse transcriptomes. Proc Natl Acad Sci U S A (2002) 25.47

Simple combinations of lineage-determining transcription factors prime cis-regulatory elements required for macrophage and B cell identities. Mol Cell (2010) 23.97

Genome-wide analysis of mammalian promoter architecture and evolution. Nat Genet (2006) 17.19

Coordinated transcription of key pathways in the mouse by the circadian clock. Cell (2002) 14.07

Interferon-gamma: an overview of signals, mechanisms and functions. J Leukoc Biol (2003) 12.34

Macrophages, inflammation, and insulin resistance. Annu Rev Physiol (2010) 11.77

BioGPS: an extensible and customizable portal for querying and organizing gene annotation resources. Genome Biol (2009) 11.17

Zoledronic acid and clinical fractures and mortality after hip fracture. N Engl J Med (2007) 9.83

The Collaborative Cross, a community resource for the genetic analysis of complex traits. Nat Genet (2004) 9.37

Hepatitis C virus glycoproteins mediate pH-dependent cell entry of pseudotyped retroviral particles. Proc Natl Acad Sci U S A (2003) 8.21

Mechanisms underlying inflammation in neurodegeneration. Cell (2010) 7.66

Induced ncRNAs allosterically modify RNA-binding proteins in cis to inhibit transcription. Nature (2008) 7.18

Uncovering regulatory pathways that affect hematopoietic stem cell function using 'genetical genomics'. Nat Genet (2005) 6.91

A SUMOylation-dependent pathway mediates transrepression of inflammatory response genes by PPAR-gamma. Nature (2005) 6.83

A topoisomerase IIbeta-mediated dsDNA break required for regulated transcription. Science (2006) 6.71

A gene wiki for community annotation of gene function. PLoS Biol (2008) 6.60

HIN-200 proteins regulate caspase activation in response to foreign cytoplasmic DNA. Science (2009) 6.59

A subpopulation of macrophages infiltrates hypertrophic adipose tissue and is activated by free fatty acids via Toll-like receptors 2 and 4 and JNK-dependent pathways. J Biol Chem (2007) 6.58

A comprehensive classification system for lipids. J Lipid Res (2005) 6.52

Sensors and signals: a coactivator/corepressor/epigenetic code for integrating signal-dependent programs of transcriptional response. Genes Dev (2006) 6.32

A promoter-level mammalian expression atlas. Nature (2014) 6.25

An atlas of combinatorial transcriptional regulation in mouse and man. Cell (2010) 6.24

LMSD: LIPID MAPS structure database. Nucleic Acids Res (2006) 6.21

Fate mapping reveals origins and dynamics of monocytes and tissue macrophages under homeostasis. Immunity (2012) 6.18

Reprogramming transcription by distinct classes of enhancers functionally defined by eRNA. Nature (2011) 6.10

The transcriptional network that controls growth arrest and differentiation in a human myeloid leukemia cell line. Nat Genet (2009) 6.02

NLRP3 inflammasome activation: The convergence of multiple signalling pathways on ROS production? Nat Rev Immunol (2010) 5.90

The Unc93b1 mutation 3d disrupts exogenous antigen presentation and signaling via Toll-like receptors 3, 7 and 9. Nat Immunol (2006) 5.83

The regulated retrotransposon transcriptome of mammalian cells. Nat Genet (2009) 5.79

Mammalian RNA polymerase II core promoters: insights from genome-wide studies. Nat Rev Genet (2007) 5.75

Nuclear receptor-induced chromosomal proximity and DNA breaks underlie specific translocations in cancer. Cell (2009) 5.74

Analyses of pig genomes provide insight into porcine demography and evolution. Nature (2012) 5.58

Aryl hydrocarbon receptor antagonists promote the expansion of human hematopoietic stem cells. Science (2010) 5.50

Exchange of N-CoR corepressor and Tip60 coactivator complexes links gene expression by NF-kappaB and beta-amyloid precursor protein. Cell (2002) 5.15

Lanthanide-transition-metal sandwich framework comprising {Cu3} cluster pillars and layered networks of {Er36} wheels. Angew Chem Int Ed Engl (2005) 4.93

Macrophage PPAR gamma is required for normal skeletal muscle and hepatic insulin sensitivity and full antidiabetic effects of thiazolidinediones. J Clin Invest (2007) 4.86

Experimental validation of the regulated expression of large numbers of non-coding RNAs from the mouse genome. Genome Res (2005) 4.86

IFITM3 restricts the morbidity and mortality associated with influenza. Nature (2012) 4.66

Unsupervised learning of an atlas from unlabeled point-sets. IEEE Trans Pattern Anal Mach Intell (2004) 4.63

A Nurr1/CoREST pathway in microglia and astrocytes protects dopaminergic neurons from inflammation-induced death. Cell (2009) 4.60

A corepressor/coactivator exchange complex required for transcriptional activation by nuclear receptors and other regulated transcription factors. Cell (2004) 4.39

Parallel SUMOylation-dependent pathways mediate gene- and signal-specific transrepression by LXRs and PPARgamma. Mol Cell (2007) 4.33

SMRT-mediated repression of an H3K27 demethylase in progression from neural stem cell to neuron. Nature (2007) 4.33

A global network of transcription factors, involving E2A, EBF1 and Foxo1, that orchestrates B cell fate. Nat Immunol (2010) 4.32

Concern Enhancing nuclear receptor-induced transcription requires nuclear motor and LSD1-dependent gene networking in interchromatin granules. Proc Natl Acad Sci U S A (2008) 4.31

Cross-leg flaps: our preferred alternative to free flaps in the treatment of complex traumatic lower extremity wounds. J Am Coll Surg (2013) 4.30

Molecular determinants of crosstalk between nuclear receptors and toll-like receptors. Cell (2005) 4.30

ncRNA- and Pc2 methylation-dependent gene relocation between nuclear structures mediates gene activation programs. Cell (2011) 4.26

Unravelling mononuclear phagocyte heterogeneity. Nat Rev Immunol (2010) 4.25

Melanopsin is required for non-image-forming photic responses in blind mice. Science (2003) 4.22

Tiny RNAs associated with transcription start sites in animals. Nat Genet (2009) 4.19

Somatic retrotransposition alters the genetic landscape of the human brain. Nature (2011) 4.16

Regulation of circadian behaviour and metabolism by REV-ERB-α and REV-ERB-β. Nature (2012) 4.15

Opposing LSD1 complexes function in developmental gene activation and repression programmes. Nature (2007) 4.12

Use of a dense single nucleotide polymorphism map for in silico mapping in the mouse. PLoS Biol (2004) 4.08

A macrophage colony-stimulating factor receptor-green fluorescent protein transgene is expressed throughout the mononuclear phagocyte system of the mouse. Blood (2002) 4.06

An ADIOL-ERβ-CtBP transrepression pathway negatively regulates microglia-mediated inflammation. Cell (2011) 4.04

A randomized comparative effectiveness study of oral triple therapy versus etanercept plus methotrexate in early aggressive rheumatoid arthritis: the treatment of Early Aggressive Rheumatoid Arthritis Trial. Arthritis Rheum (2012) 4.01

Genetic deficiency and pharmacological stabilization of mast cells reduce diet-induced obesity and diabetes in mice. Nat Med (2009) 3.97

Functional roles of enhancer RNAs for oestrogen-dependent transcriptional activation. Nature (2013) 3.93

Myofibroblasts revert to an inactive phenotype during regression of liver fibrosis. Proc Natl Acad Sci U S A (2012) 3.90

Eya protein phosphatase activity regulates Six1-Dach-Eya transcriptional effects in mammalian organogenesis. Nature (2003) 3.72

Recognizing names in biomedical texts: a machine learning approach. Bioinformatics (2004) 3.70

Direct isolation and identification of promoters in the human genome. Genome Res (2005) 3.68

Anti-inflammatory therapy in chronic disease: challenges and opportunities. Science (2013) 3.64

Nuclear receptor transrepression pathways that regulate inflammation in macrophages and T cells. Nat Rev Immunol (2010) 3.60

The Gene Wiki: community intelligence applied to human gene annotation. Nucleic Acids Res (2009) 3.51

Targeting a complex transcriptome: the construction of the mouse full-length cDNA encyclopedia. Genome Res (2003) 3.50

International Union of Pharmacology. LXI. Peroxisome proliferator-activated receptors. Pharmacol Rev (2006) 3.48

Genomic analyses identify distinct patterns of selection in domesticated pigs and Tibetan wild boars. Nat Genet (2013) 3.41

Structural basis for recognition of hemi-methylated DNA by the SRA domain of human UHRF1. Nature (2008) 3.39

Identification of a Wnt/Dvl/beta-Catenin --> Pitx2 pathway mediating cell-type-specific proliferation during development. Cell (2002) 3.37

Tyrosine dephosphorylation of H2AX modulates apoptosis and survival decisions. Nature (2009) 3.36

Rev-Erbs repress macrophage gene expression by inhibiting enhancer-directed transcription. Nature (2013) 3.33

Deconstructing repression: evolving models of co-repressor action. Nat Rev Genet (2010) 3.29

A genome-wide RNAi screen for modifiers of the circadian clock in human cells. Cell (2009) 3.27

Anti-inflammatory actions of PPAR ligands: new insights on cellular and molecular mechanisms. Trends Immunol (2007) 3.23

Genome-wide analysis of CREB target genes reveals a core promoter requirement for cAMP responsiveness. Mol Cell (2003) 3.23

Differential inhibition of macrophage foam-cell formation and atherosclerosis in mice by PPARalpha, beta/delta, and gamma. J Clin Invest (2004) 3.23

Impact of alternative initiation, splicing, and termination on the diversity of the mRNA transcripts encoded by the mouse transcriptome. Genome Res (2003) 3.21

Microglial cell origin and phenotypes in health and disease. Nat Rev Immunol (2011) 3.20

A rescue strategy for multimapping short sequence tags refines surveys of transcriptional activity by CAGE. Genomics (2008) 3.19

Histone H2A monoubiquitination represses transcription by inhibiting RNA polymerase II transcriptional elongation. Mol Cell (2008) 3.18