Published in J Cell Biol on March 18, 2002
A human functional protein interaction network and its application to cancer data analysis. Genome Biol (2010) 4.73
Single pilus motor forces exceed 100 pN. Proc Natl Acad Sci U S A (2002) 2.93
Alterations in CD46-mediated Tr1 regulatory T cells in patients with multiple sclerosis. J Clin Invest (2006) 1.91
A force-dependent switch reverses type IV pilus retraction. Proc Natl Acad Sci U S A (2004) 1.61
Estradiol-Treated Female Mice as Surrogate Hosts for Neisseria gonorrhoeae Genital Tract Infections. Front Microbiol (2011) 1.33
CD46-independent binding of neisserial type IV pili and the major pilus adhesin, PilC, to human epithelial cells. Infect Immun (2005) 1.22
Emerging roles and new functions of CD46. Springer Semin Immunopathol (2005) 1.16
Global gene expression and the role of sigma factors in Neisseria gonorrhoeae in interactions with epithelial cells. Infect Immun (2005) 1.00
IFN-gamma amplifies NFkappaB-dependent Neisseria meningitidis invasion of epithelial cells via specific upregulation of CEA-related cell adhesion molecule 1. Cell Microbiol (2007) 0.93
T-cell regulation by CD46 and its relevance in multiple sclerosis. Immunology (2008) 0.92
In vivo selection for Neisseria gonorrhoeae opacity protein expression in the absence of human carcinoembryonic antigen cell adhesion molecules. Infect Immun (2006) 0.91
Presenilin/gamma-secretase cleaves CD46 in response to Neisseria infection. J Immunol (2009) 0.91
CD46 processing: a means of expression. Immunobiology (2011) 0.89
Down-regulation of CD46 by piliated Neisseria gonorrhoeae. J Exp Med (2003) 0.89
Monoclonal antibody detection of CD46 clustering beneath Neisseria gonorrhoeae microcolonies. Infect Immun (2006) 0.88
CD46-utilizing adenoviruses inhibit C/EBPbeta-dependent expression of proinflammatory cytokines. J Virol (2005) 0.86
RpoH mediates the expression of some, but not all, genes induced in Neisseria gonorrhoeae adherent to epithelial cells. Infect Immun (2006) 0.83
Pro-inflammatory cytokines can act as intracellular modulators of commensal bacterial virulence. Open Biol (2013) 0.81
A novel role for CD46 in wound repair. Front Immunol (2011) 0.80
Pathogenic Neisseria hitchhike on the uropod of human neutrophils. PLoS One (2011) 0.78
Expression capable library for studies of Neisseria gonorrhoeae, version 1.0. BMC Microbiol (2005) 0.78
Impact of calcium signaling during infection of Neisseria meningitidis to human brain microvascular endothelial cells. PLoS One (2014) 0.76
CD46 plasticity and its inflammatory bias in multiple sclerosis. Arch Immunol Ther Exp (Warsz) (2011) 0.76
Discovery of a novel, potent, and Src family-selective tyrosine kinase inhibitor. Study of Lck- and FynT-dependent T cell activation. J Biol Chem (1996) 10.08
Studies on gonococcus infection. IV. Pili: their role in attachment of gonococci to tissue culture cells. J Exp Med (1973) 8.95
Multiple beta 1 chain integrins are receptors for invasin, a protein that promotes bacterial penetration into mammalian cells. Cell (1990) 8.41
The human CD46 molecule is a receptor for measles virus (Edmonston strain). Cell (1993) 7.71
Exploitation of mammalian host cell functions by bacterial pathogens. Science (1997) 6.06
Pilus retraction powers bacterial twitching motility. Nature (2000) 5.69
Type IV pili and cell motility. Mol Microbiol (1999) 4.87
Membrane cofactor protein (MCP or CD46): newest member of the regulators of complement activation gene cluster. Annu Rev Immunol (1991) 4.27
Signal transduction in the mammalian cell during bacterial attachment and entry. Cell (1993) 3.41
PilT mutations lead to simultaneous defects in competence for natural transformation and twitching motility in piliated Neisseria gonorrhoeae. Mol Microbiol (1998) 3.16
Molecular interactions in cell adhesion complexes. Curr Opin Cell Biol (1997) 2.79
Molecular cloning and chromosomal localization of human membrane cofactor protein (MCP). Evidence for inclusion in the multigene family of complement-regulatory proteins. J Exp Med (1988) 2.75
Interactions of pathogenic neisseriae with epithelial cell membranes. Annu Rev Cell Dev Biol (2000) 2.74
CD46 is a cellular receptor for human herpesvirus 6. Cell (1999) 2.67
Membrane cofactor protein (MCP or CD46) is a cellular pilus receptor for pathogenic Neisseria. Mol Microbiol (1997) 2.67
Ezrin is an effector of hepatocyte growth factor-mediated migration and morphogenesis in epithelial cells. J Cell Biol (1997) 2.51
Antigenic variation of pilin regulates adhesion of Neisseria meningitidis to human epithelial cells. Mol Microbiol (1993) 2.44
Model for invasion of human tissue culture cells by Neisseria gonorrhoeae. Infect Immun (1988) 2.24
Yes-associated protein 65 localizes p62(c-Yes) to the apical compartment of airway epithelia by association with EBP50. J Cell Biol (1999) 2.11
Ezrin: a protein requiring conformational activation to link microfilaments to the plasma membrane in the assembly of cell surface structures. J Cell Sci (1997) 2.11
Type IV pili of pathogenic Neisseriae elicit cortical plaque formation in epithelial cells. Mol Microbiol (1999) 2.01
Invasion of epithelial cells by Shigella flexneri induces tyrosine phosphorylation of cortactin by a pp60c-src-mediated signalling pathway. EMBO J (1995) 1.95
Membrane cofactor protein (CD46) is a keratinocyte receptor for the M protein of the group A streptococcus. Proc Natl Acad Sci U S A (1995) 1.86
Intercellular communication and cell-cell adhesion. Science (1992) 1.83
Membrane cofactor protein (MCP; CD46): isoform-specific tyrosine phosphorylation. J Immunol (2000) 1.59
Several carcinoembryonic antigens (CD66) serve as receptors for gonococcal opacity proteins. J Exp Med (1997) 1.54
CD66-mediated phagocytosis of Opa52 Neisseria gonorrhoeae requires a Src-like tyrosine kinase- and Rac1-dependent signalling pathway. EMBO J (1998) 1.53
Salmonella typhimurium invasion of epithelial cells: role of induced host cell tyrosine protein phosphorylation. Infect Immun (1994) 1.46
Attachment of piliated, Opa- and Opc- gonococci and meningococci to epithelial cells elicits cortical actin rearrangements and clustering of tyrosine-phosphorylated proteins. Infect Immun (1997) 1.41
Cell signaling by the type IV pili of pathogenic Neisseria. J Biol Chem (1998) 1.30
Activation of ErbB2 receptor tyrosine kinase supports invasion of endothelial cells by Neisseria meningitidis. J Cell Biol (2001) 1.29
Attachment of Neisseria gonorrhoeae to the cellular pilus receptor CD46: identification of domains important for bacterial adherence. Cell Microbiol (2001) 1.21
Measurements of invasion by antibody labeling and electron microscopy. Methods Enzymol (1994) 1.20
Identification, localization, and distribution of the PilT protein in Neisseria gonorrhoeae. Infect Immun (1994) 1.19
The opaH locus of Neisseria gonorrhoeae MS11A is involved in epithelial cell invasion. Mol Microbiol (1994) 1.16
Alternative splicing regulates the subcellular localization of A-kinase anchoring protein 18 isoforms. J Cell Biol (1999) 1.13
Expression of cellular-yes protein in mammalian tissues. Oncogene (1990) 1.10
Invasion of human epithelial cells by Pseudomonas aeruginosa involves src-like tyrosine kinases p60Src and p59Fyn. Infect Immun (2001) 1.07
Human cell receptor CD46 is down regulated through recognition of a membrane-proximal region of the cytoplasmic domain in persistent measles virus infection. J Virol (1996) 1.01
Inverse relationship between pilus-mediated gonococcal adherence and surface expression of the pilus receptor, CD46. Microbiology (2001) 0.98
Infection of epithelial cells by pathogenic neisseriae reduces the levels of multiple lysosomal constituents. Infect Immun (1998) 0.97
A functional interaction between CD46 and DLG4: a role for DLG4 in epithelial polarization. J Biol Chem (2001) 0.96
Identification of a cytoplasmic Tyr-X-X-Leu motif essential for down regulation of the human cell receptor CD46 in persistent measles virus infection. J Virol (1997) 0.94
The cytoplasmic domains of complement regulatory protein CD46 interact with multiple kinases in macrophages. J Leukoc Biol (1997) 0.90
Human regulator of complement activation (RCA) gene family proteins and their relationship to microbial infection. Microbiol Immunol (1995) 0.90
Host cell protein tyrosine kinases are activated during the entry of Listeria monocytogenes. Possible role of pp60c-src family protein kinases. FEMS Microbiol Lett (1998) 0.90
Do pathogenic neisseriae need several ways to modify the host cell cytoskeleton? Microbes Infect (2000) 0.80
Genetics of HUS: the impact of MCP, CFH, and IF mutations on clinical presentation, response to treatment, and outcome. Blood (2006) 4.51
Human T regulatory cells can use the perforin pathway to cause autologous target cell death. Immunity (2004) 4.11
Defects in yolk sac vasculogenesis, chorioallantoic fusion, and embryonic axis elongation in mice with targeted disruption of Yap65. Mol Cell Biol (2006) 3.15
Mutations in complement C3 predispose to development of atypical hemolytic uremic syndrome. Blood (2008) 3.10
Single pilus motor forces exceed 100 pN. Proc Natl Acad Sci U S A (2002) 2.93
Genetic and functional analyses of membrane cofactor protein (CD46) mutations in atypical hemolytic uremic syndrome. J Am Soc Nephrol (2006) 2.88
Activation of human CD4+ cells with CD3 and CD46 induces a T-regulatory cell 1 phenotype. Nature (2003) 2.83
Mutations in human complement regulator, membrane cofactor protein (CD46), predispose to development of familial hemolytic uremic syndrome. Proc Natl Acad Sci U S A (2003) 2.79
Differential expression of granzymes A and B in human cytotoxic lymphocyte subsets and T regulatory cells. Blood (2004) 2.58
Adenovirus type 11 uses CD46 as a cellular receptor. J Virol (2003) 2.52
Virulence differences between monkeypox virus isolates from West Africa and the Congo basin. Virology (2005) 2.36
C-terminal truncations in human 3'-5' DNA exonuclease TREX1 cause autosomal dominant retinal vasculopathy with cerebral leukodystrophy. Nat Genet (2007) 2.35
T-cell regulation: with complements from innate immunity. Nat Rev Immunol (2006) 2.27
Immunology of age-related macular degeneration. Nat Rev Immunol (2013) 2.14
Properdin can initiate complement activation by binding specific target surfaces and providing a platform for de novo convertase assembly. J Immunol (2007) 2.00
Secreted NS1 of dengue virus attaches to the surface of cells via interactions with heparan sulfate and chondroitin sulfate E. PLoS Pathog (2007) 1.97
West Nile virus nonstructural protein NS1 inhibits complement activation by binding the regulatory protein factor H. Proc Natl Acad Sci U S A (2006) 1.96
Plasma complement components and activation fragments: associations with age-related macular degeneration genotypes and phenotypes. Invest Ophthalmol Vis Sci (2009) 1.86
Implications of the initial mutations in membrane cofactor protein (MCP; CD46) leading to atypical hemolytic uremic syndrome. Mol Immunol (2006) 1.82
Genome sequencing reveals widespread virulence gene exchange among human Neisseria species. PLoS One (2010) 1.81
CD25 deficiency causes an immune dysregulation, polyendocrinopathy, enteropathy, X-linked-like syndrome, and defective IL-10 expression from CD4 lymphocytes. J Allergy Clin Immunol (2006) 1.81
Rare variants in CFI, C3 and C9 are associated with high risk of advanced age-related macular degeneration. Nat Genet (2013) 1.77
Antagonism of the complement component C4 by flavivirus nonstructural protein NS1. J Exp Med (2010) 1.76
Phosphodiesterase 4D forms a cAMP diffusion barrier at the apical membrane of the airway epithelium. J Biol Chem (2004) 1.73
Structure of FitAB from Neisseria gonorrhoeae bound to DNA reveals a tetramer of toxin-antitoxin heterodimers containing pin domains and ribbon-helix-helix motifs. J Biol Chem (2006) 1.71
Complement regulator CD46 temporally regulates cytokine production by conventional and unconventional T cells. Nat Immunol (2010) 1.67
Hepatic IL-17 responses in human and murine primary biliary cirrhosis. J Autoimmun (2008) 1.57
Properdin: emerging roles of a pattern-recognition molecule. Annu Rev Immunol (2010) 1.55
Cooperative retraction of bundled type IV pili enables nanonewton force generation. PLoS Biol (2008) 1.55
Membrane cofactor protein mutations in atypical hemolytic uremic syndrome (aHUS), fatal Stx-HUS, C3 glomerulonephritis, and the HELLP syndrome. Blood (2007) 1.53
Mutations in complement regulatory proteins predispose to preeclampsia: a genetic analysis of the PROMISSE cohort. PLoS Med (2011) 1.52
Role of membrane cofactor protein (CD46) in regulation of C4b and C3b deposited on cells. J Immunol (2002) 1.51
The N. gonorrhoeae type IV pilus stimulates mechanosensitive pathways and cytoprotection through a pilT-dependent mechanism. PLoS Biol (2005) 1.50
Binding of flavivirus nonstructural protein NS1 to C4b binding protein modulates complement activation. J Immunol (2011) 1.45
Characterization of mutations in complement factor I (CFI) associated with hemolytic uremic syndrome. Mol Immunol (2007) 1.42
CD46 is a cellular receptor for all species B adenoviruses except types 3 and 7. J Virol (2005) 1.37
Spinophilin regulates Ca2+ signalling by binding the N-terminal domain of RGS2 and the third intracellular loop of G-protein-coupled receptors. Nat Cell Biol (2005) 1.36
New roles for the major human 3'-5' exonuclease TREX1 in human disease. Cell Cycle (2008) 1.35
Transient anchorage of cross-linked glycosyl-phosphatidylinositol-anchored proteins depends on cholesterol, Src family kinases, caveolin, and phosphoinositides. J Cell Biol (2006) 1.34
Force-dependent polymorphism in type IV pili reveals hidden epitopes. Proc Natl Acad Sci U S A (2010) 1.33
CD46: expanding beyond complement regulation. Trends Immunol (2004) 1.32
Direct interaction with filamins modulates the stability and plasma membrane expression of CFTR. J Clin Invest (2007) 1.29
A prevalent C3 mutation in aHUS patients causes a direct C3 convertase gain of function. Blood (2012) 1.28
Heterogeneous nuclear ribonuclear protein U associates with YAP and regulates its co-activation of Bax transcription. J Biol Chem (2004) 1.27
Pathogenesis of aortic dilatation in mucopolysaccharidosis VII mice may involve complement activation. Mol Genet Metab (2011) 1.27
Structure of the C3b binding site of CR1 (CD35), the immune adherence receptor. Cell (2002) 1.25
Dynamics of Neisseria gonorrhoeae attachment: microcolony development, cortical plaque formation, and cytoprotection. Infect Immun (2007) 1.24
Decay-accelerating factor (DAF), complement receptor 1 (CR1), and factor H dissociate the complement AP C3 convertase (C3bBb) via sites on the type A domain of Bb. J Biol Chem (2001) 1.22
Structure and regulatory profile of the monkeypox inhibitor of complement: comparison to homologs in vaccinia and variola and evidence for dimer formation. J Immunol (2006) 1.21
PilT is required for PI(3,4,5)P3-mediated crosstalk between Neisseria gonorrhoeae and epithelial cells. Cell Microbiol (2005) 1.20
Neisseria meningitidis accelerates ferritin degradation in host epithelial cells to yield an essential iron source. Mol Microbiol (2004) 1.17
The role of the immune response in age-related macular degeneration. Int J Inflam (2013) 1.16
Interaction of glycoprotein H of human herpesvirus 6 with the cellular receptor CD46. J Biol Chem (2003) 1.16
Emerging roles and new functions of CD46. Springer Semin Immunopathol (2005) 1.16
Sustained thromboprophylaxis mediated by an RBC-targeted pro-urokinase zymogen activated at the site of clot formation. Blood (2010) 1.14
Complement-dependent neutrophil recruitment is critical for the development of elastase-induced abdominal aortic aneurysm. Circulation (2009) 1.13
Screening for complement system abnormalities in patients with atypical hemolytic uremic syndrome. Clin J Am Soc Nephrol (2007) 1.12
Complement-induced regulatory T cells suppress T-cell responses but allow for dendritic-cell maturation. Blood (2005) 1.10
The apical compartment: trafficking pathways, regulators and scaffolding proteins. Curr Opin Cell Biol (2003) 1.08
Localization of regions in CD46 that interact with adenovirus. J Virol (2005) 1.08
Replication of Neisseria meningitidis within epithelial cells requires TonB-dependent acquisition of host cell iron. Infect Immun (2002) 1.08
Clinical and laboratory evaluation of complement deficiency. J Allergy Clin Immunol (2004) 1.07
The neuronal actin-binding proteins, neurabin I and neurabin II, recruit specific isoforms of protein phosphatase-1 catalytic subunits. J Biol Chem (2002) 1.07
Surviving mousepox infection requires the complement system. PLoS Pathog (2008) 1.07
Induction of a regulatory phenotype in human CD4+ T cells by streptococcal M protein. J Immunol (2005) 1.07
The cystic fibrosis transmembrane conductance regulator is regulated by a direct interaction with the protein phosphatase 2A. J Biol Chem (2005) 1.06
Targeting of a mutant plasminogen activator to circulating red blood cells for prophylactic fibrinolysis. J Pharmacol Exp Ther (2009) 1.05
Yes-associated protein 65 (YAP) expands neural progenitors and regulates Pax3 expression in the neural plate border zone. PLoS One (2011) 1.05
Advances in understanding of pathogenesis of aHUS and HELLP. Br J Haematol (2008) 1.05
Membrane protein Crry maintains homeostasis of the complement system. J Immunol (2008) 1.04
Smallpox inhibitor of complement enzymes (SPICE): dissecting functional sites and abrogating activity. J Immunol (2009) 1.03
A novel PDZ protein regulates the activity of guanylyl cyclase C, the heat-stable enterotoxin receptor. J Biol Chem (2002) 1.03
Modeling how CD46 deficiency predisposes to atypical hemolytic uremic syndrome. Mol Immunol (2006) 1.03
C-terminal phosphorylation of MRP2 modulates its interaction with PDZ proteins. Biochem Biophys Res Commun (2003) 1.03
Mutations in CD46, a complement regulatory protein, predispose to atypical HUS. Trends Mol Med (2004) 1.02
Characterization of an A-kinase anchoring protein in human ciliary axonemes. Mol Biol Cell (2002) 1.02
Targeted and restricted complement activation on acrosome-reacted spermatozoa. J Clin Invest (2005) 1.02
Plasmodium falciparum uses a key functional site in complement receptor type-1 for invasion of human erythrocytes. Blood (2011) 1.02
N-linked glycosylation of dengue virus NS1 protein modulates secretion, cell-surface expression, hexamer stability, and interactions with human complement. Virology (2011) 1.02
Sorting nexin 27 protein regulates trafficking of a p21-activated kinase (PAK) interacting exchange factor (β-Pix)-G protein-coupled receptor kinase interacting protein (GIT) complex via a PDZ domain interaction. J Biol Chem (2011) 1.01
Toll-like receptor 4 and CD14 expression in human ciliary body and TLR-4 in human iris endothelial cells. Exp Eye Res (2004) 1.01
The dynamic processing of CD46 intracellular domains provides a molecular rheostat for T cell activation. PLoS One (2011) 1.00
ScFv-mediated in vivo targeting of DAF to erythrocytes inhibits lysis by complement. Mol Immunol (2004) 1.00
Extracellular signal-regulated kinase activation by Neisseria gonorrhoeae downregulates epithelial cell proapoptotic proteins Bad and Bim. Infect Immun (2008) 0.99
Neisseria gonorrhoeae FitA interacts with FitB to bind DNA through its ribbon-helix-helix motif. Biochemistry (2005) 0.98
Human complement receptor type 1 (CR1) binds to a major malarial adhesin. Trends Mol Med (2002) 0.98
Complement-mediated neutralization of dengue virus requires mannose-binding lectin. MBio (2011) 0.97
Oversulfated heparin by-products induce thrombin generation in human plasmas through contact system activation. Clin Appl Thromb Hemost (2010) 0.97
Influence of type IV pilus retraction on the architecture of the Neisseria gonorrhoeae-infected cell cortex. Microbiology (2009) 0.96
Antibody directs properdin-dependent activation of the complement alternative pathway in a mouse model of abdominal aortic aneurysm. Proc Natl Acad Sci U S A (2012) 0.96
T-cell stimulation and regulation: with complements from CD46. Immunol Res (2005) 0.95
Inhibiting complement activation on cells at the step of C3 cleavage. Vaccine (2008) 0.94
CD46-induced human Treg enhance B-cell responses. Eur J Immunol (2009) 0.94
Complement factor B is the downstream effector of TLRs and plays an important role in a mouse model of severe sepsis. J Immunol (2013) 0.93
Backbone dynamics of complement control protein (CCP) modules reveals mobility in binding surfaces. Protein Sci (2004) 0.92