Published in Nat Rev Immunol on June 01, 2013
Infliximab, Sirolimus and Daclizumab to Treat Age-Related Macular Degeneration (AMDB1) | NCT00304954
Fluocinolone Acetonide Intravitreal Inserts in Geographic Atrophy | NCT00695318
Copaxone in Age Related Macular Degeneration | NCT00466076
Combination Ranibizumab and Bromfenac for Neovascular Age-related Macular Degeneration | NCT00805233
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Sustained thromboprophylaxis mediated by an RBC-targeted pro-urokinase zymogen activated at the site of clot formation. Blood (2010) 1.14
CD46 is phosphorylated at tyrosine 354 upon infection of epithelial cells by Neisseria gonorrhoeae. J Cell Biol (2002) 1.14
Complement-dependent neutrophil recruitment is critical for the development of elastase-induced abdominal aortic aneurysm. Circulation (2009) 1.13
Screening for complement system abnormalities in patients with atypical hemolytic uremic syndrome. Clin J Am Soc Nephrol (2007) 1.12
TLR-independent and P2X7-dependent signaling mediate Alu RNA-induced NLRP3 inflammasome activation in geographic atrophy. Invest Ophthalmol Vis Sci (2013) 1.11
Complement-induced regulatory T cells suppress T-cell responses but allow for dendritic-cell maturation. Blood (2005) 1.10
Short-interfering RNAs induce retinal degeneration via TLR3 and IRF3. Mol Ther (2011) 1.09
Localization of regions in CD46 that interact with adenovirus. J Virol (2005) 1.08
Clinical and laboratory evaluation of complement deficiency. J Allergy Clin Immunol (2004) 1.07
Surviving mousepox infection requires the complement system. PLoS Pathog (2008) 1.07
Induction of a regulatory phenotype in human CD4+ T cells by streptococcal M protein. J Immunol (2005) 1.07
Targeting of a mutant plasminogen activator to circulating red blood cells for prophylactic fibrinolysis. J Pharmacol Exp Ther (2009) 1.05
Advances in understanding of pathogenesis of aHUS and HELLP. Br J Haematol (2008) 1.05
Membrane protein Crry maintains homeostasis of the complement system. J Immunol (2008) 1.04
Smallpox inhibitor of complement enzymes (SPICE): dissecting functional sites and abrogating activity. J Immunol (2009) 1.03
Modeling how CD46 deficiency predisposes to atypical hemolytic uremic syndrome. Mol Immunol (2006) 1.03
Mutations in CD46, a complement regulatory protein, predispose to atypical HUS. Trends Mol Med (2004) 1.02
Plasmodium falciparum uses a key functional site in complement receptor type-1 for invasion of human erythrocytes. Blood (2011) 1.02
Targeted and restricted complement activation on acrosome-reacted spermatozoa. J Clin Invest (2005) 1.02
N-linked glycosylation of dengue virus NS1 protein modulates secretion, cell-surface expression, hexamer stability, and interactions with human complement. Virology (2011) 1.02
ScFv-mediated in vivo targeting of DAF to erythrocytes inhibits lysis by complement. Mol Immunol (2004) 1.00
ERK1/2 activation is a therapeutic target in age-related macular degeneration. Proc Natl Acad Sci U S A (2012) 0.99
Human complement receptor type 1 (CR1) binds to a major malarial adhesin. Trends Mol Med (2002) 0.98
Complement-mediated neutralization of dengue virus requires mannose-binding lectin. MBio (2011) 0.97
Oversulfated heparin by-products induce thrombin generation in human plasmas through contact system activation. Clin Appl Thromb Hemost (2010) 0.97
Antibody directs properdin-dependent activation of the complement alternative pathway in a mouse model of abdominal aortic aneurysm. Proc Natl Acad Sci U S A (2012) 0.96
T-cell stimulation and regulation: with complements from CD46. Immunol Res (2005) 0.95
CD46-induced human Treg enhance B-cell responses. Eur J Immunol (2009) 0.94
Inhibiting complement activation on cells at the step of C3 cleavage. Vaccine (2008) 0.94
Complement factor B is the downstream effector of TLRs and plays an important role in a mouse model of severe sepsis. J Immunol (2013) 0.93
Backbone dynamics of complement control protein (CCP) modules reveals mobility in binding surfaces. Protein Sci (2004) 0.92
Smallpox inhibitor of complement enzymes (SPICE): regulation of complement activation on cells and mechanism of its cellular attachment. J Immunol (2008) 0.92
In vivo correction of complement regulatory protein deficiency with an inhibitor targeting the red blood cell membrane. J Immunol (2005) 0.90
Human haemodynamic frequency harmonics regulate the inflammatory phenotype of vascular endothelial cells. Nat Commun (2013) 0.89
Down-regulation of CD46 by piliated Neisseria gonorrhoeae. J Exp Med (2003) 0.89
Characterization of human membrane cofactor protein (MCP; CD46) on spermatozoa. Mol Reprod Dev (2002) 0.89
A corresponding tyrosine residue in the C2/factor B type A domain is a hot spot in the decay acceleration of the complement C3 convertases. J Biol Chem (2003) 0.87
Cutting edge: inhibiting measles virus infection but promoting reproduction: an explanation for splicing and tissue-specific expression of CD46. J Immunol (2002) 0.87
Congenital short bowel syndrome as the presenting symptom in male patients with FLNA mutations. Genet Med (2012) 0.86
Using mutagenesis and structural biology to map the binding site for the Plasmodium falciparum merozoite protein PfRh4 on the human immune adherence receptor. J Biol Chem (2013) 0.86
Lack of evidence from studies of soluble protein fragments that Knops blood group polymorphisms in complement receptor-type 1 are driven by malaria. PLoS One (2012) 0.86
Release of host-derived membrane vesicles following pilus-mediated adhesion of Neisseria gonorrhoeae. Cell Microbiol (2005) 0.84
Engagement of CD46 and alpha5beta1 integrin by group A streptococci is required for efficient invasion of epithelial cells. Cell Microbiol (2005) 0.84
Analysis of genes coding for CD46, CD55, and C4b-binding protein in patients with idiopathic, recurrent, spontaneous pregnancy loss. Eur J Immunol (2013) 0.83
Autoantibody stabilization of the classical pathway C3 convertase leading to C3 deficiency and Neisserial sepsis: C4 nephritic factor revisited. Clin Immunol (2012) 0.83
Rheumatic syndromes associated with complement deficiency. Curr Opin Rheumatol (2003) 0.83
Cutting edge: treatment of complement regulatory protein deficiency by retroviral in vivo gene therapy. J Immunol (2006) 0.82
CD46 in Neisseria pathogenesis. Trends Mol Med (2004) 0.82
The complement system in pediatric systemic lupus erythematosus, atypical hemolytic uremic syndrome, and complocentric membranoglomerulopathies. Curr Opin Rheumatol (2012) 0.82
Targeting recombinant thrombomodulin fusion protein to red blood cells provides multifaceted thromboprophylaxis. Blood (2012) 0.81
CD46 engagement on human CD4+ T cells produces T regulatory type 1-like regulation of antimycobacterial T cell responses. Infect Immun (2010) 0.81
Systemic humoral autoimmunity but joint-specific inflammation: the syndrome of rheumatoid arthritis. Arthritis Rheum (2007) 0.80
Ectromelia virus inhibitor of complement enzymes protects intracellular mature virus and infected cells from mouse complement. J Virol (2010) 0.80
Human immunodeficiency virus infection presenting as an unusual arthropathy. Arthritis Care Res (Hoboken) (2010) 0.80
Hepatitis C virus infection upregulates CD55 expression on the hepatocyte surface and promotes association with virus particles. J Virol (2013) 0.80
Too much of a good thing at the site of tissue injury: the instructive example of the complement system predisposing to thrombotic microangiopathy. Hematology Am Soc Hematol Educ Program (2011) 0.79