Published in J Immunol on August 15, 2007
Complement: a key system for immune surveillance and homeostasis. Nat Immunol (2010) 10.37
Complement regulators and inhibitory proteins. Nat Rev Immunol (2009) 4.46
Complement evasion by human pathogens. Nat Rev Microbiol (2008) 4.24
Complement-targeted therapeutics. Nat Biotechnol (2007) 3.24
Infections of people with complement deficiencies and patients who have undergone splenectomy. Clin Microbiol Rev (2010) 1.70
Complement control protein factor H: the good, the bad, and the inadequate. Mol Immunol (2010) 1.68
The alternative complement pathway revisited. J Cell Mol Med (2008) 1.62
A genetically encoded multifunctional TRAIL trimer facilitates cell-specific targeting and tumor cell killing. Mol Cancer Ther (2010) 1.53
The complement protein properdin binds apoptotic T cells and promotes complement activation and phagocytosis. Proc Natl Acad Sci U S A (2008) 1.51
Genetic and therapeutic targeting of properdin in mice prevents complement-mediated tissue injury. J Clin Invest (2010) 1.42
Combination of factor H mutation and properdin deficiency causes severe C3 glomerulonephritis. J Am Soc Nephrol (2012) 1.40
Loss of properdin exacerbates C3 glomerulopathy resulting from factor H deficiency. J Am Soc Nephrol (2012) 1.34
Complexity of complement activation in sepsis. J Cell Mol Med (2008) 1.26
Regulation of complement by cartilage oligomeric matrix protein allows for a novel molecular diagnostic principle in rheumatoid arthritis. Arthritis Rheum (2010) 1.23
Recent developments in low molecular weight complement inhibitors. Mol Immunol (2009) 1.23
Complement and periodontitis. Biochem Pharmacol (2010) 1.20
Meningococcal disease and the complement system. Virulence (2013) 1.19
Properdin: New roles in pattern recognition and target clearance. Mol Immunol (2008) 1.16
Complement-dependent neutrophil recruitment is critical for the development of elastase-induced abdominal aortic aneurysm. Circulation (2009) 1.13
Discrimination between host and pathogens by the complement system. Vaccine (2008) 1.11
Targeted inhibition of the complement alternative pathway with complement receptor 2 and factor H attenuates collagen antibody-induced arthritis in mice. J Immunol (2009) 1.09
An evaluation of the role of properdin in alternative pathway activation on Neisseria meningitidis and Neisseria gonorrhoeae. J Immunol (2010) 1.07
Factor H-related protein 4 activates complement by serving as a platform for the assembly of alternative pathway C3 convertase via its interaction with C3b protein. J Biol Chem (2012) 1.06
Structural basis for inhibition of complement C5 by the SSL7 protein from Staphylococcus aureus. Proc Natl Acad Sci U S A (2010) 1.06
Native polymeric forms of properdin selectively bind to targets and promote activation of the alternative pathway of complement. Immunobiology (2010) 1.05
Molecular mechanisms of inflammation and tissue injury after major trauma--is complement the "bad guy"? J Biomed Sci (2011) 1.04
Initiation of the alternative pathway of murine complement by immune complexes is dependent on N-glycans in IgG antibodies. Arthritis Rheum (2008) 1.02
Structural basis for the stabilization of the complement alternative pathway C3 convertase by properdin. Proc Natl Acad Sci U S A (2013) 1.01
Role and mechanism of action of complement in regulating T cell immunity. Mol Immunol (2010) 0.97
Complement activation pathways in murine immune complex-induced arthritis and in C3a and C5a generation in vitro. Clin Exp Immunol (2009) 0.97
New insights into the pathogenesis of IgA nephropathy. Semin Immunopathol (2014) 0.96
Functional analysis of Ficolin-3 mediated complement activation. PLoS One (2010) 0.96
Determination of severity of murine IgA nephropathy by glomerular complement activation by aberrantly glycosylated IgA and immune complexes. Am J Pathol (2012) 0.96
A novel antibody against human properdin inhibits the alternative complement system and specifically detects properdin from blood samples. PLoS One (2014) 0.96
Properdin in complement activation and tissue injury. Mol Immunol (2013) 0.95
Identification of tubular heparan sulfate as a docking platform for the alternative complement component properdin in proteinuric renal disease. J Biol Chem (2010) 0.95
Variability and action mechanism of a family of anticomplement proteins in Ixodes ricinus. PLoS One (2008) 0.94
Local release of properdin in the cellular microenvironment: role in pattern recognition and amplification of the alternative pathway of complement. Front Immunol (2013) 0.94
Protease-dependent mechanisms of complement evasion by bacterial pathogens. Biol Chem (2012) 0.94
Role of complement in host-microbe homeostasis of the periodontium. Semin Immunol (2013) 0.92
Abrogated RANKL expression in properdin-deficient mice is associated with better outcome from collagen-antibody-induced arthritis. Arthritis Res Ther (2012) 0.92
Mechanism of inflammation in age-related macular degeneration: an up-to-date on genetic landmarks. Mediators Inflamm (2013) 0.91
Native properdin binds to Chlamydia pneumoniae and promotes complement activation. Infect Immun (2010) 0.91
Molecules Great and Small: The Complement System. Clin J Am Soc Nephrol (2015) 0.91
The alternative pathway of complement activation may be involved in the renal damage of human anti-glomerular basement membrane disease. PLoS One (2014) 0.87
Identification of a novel mode of complement activation on stimulated platelets mediated by properdin and C3(H2O). J Immunol (2013) 0.87
Properdin and factor h: opposing players on the alternative complement pathway "see-saw". Front Immunol (2013) 0.87
The role of properdin in zymosan- and Escherichia coli-induced complement activation. J Immunol (2012) 0.87
Applying complement therapeutics to rare diseases. Clin Immunol (2015) 0.87
Complement-mediated injury and protection of endothelium: lessons from atypical haemolytic uraemic syndrome. Immunobiology (2011) 0.85
Inhibition of complement activation on a model biomaterial surface by streptococcal M protein-derived peptides. Biomaterials (2009) 0.85
Islet amyloid polypeptide triggers limited complement activation and binds complement inhibitor C4b-binding protein, which enhances fibril formation. J Biol Chem (2012) 0.85
Properdin: a tightly regulated critical inflammatory modulator. Immunol Rev (2016) 0.85
Complement-targeted therapeutics in periodontitis. Adv Exp Med Biol (2013) 0.83
Early complement factors in the local tissue immunocomplex generated during intestinal ischemia/reperfusion injury. Mol Immunol (2009) 0.83
The role of the complement system in acute kidney injury. Semin Nephrol (2013) 0.83
Characteristics of Fc-independent human antimannan antibody-mediated alternative pathway initiation of C3 deposition to Candida albicans. Mol Immunol (2008) 0.82
Review: Complement and its regulatory proteins in kidney diseases. Nephrology (Carlton) (2010) 0.82
Systemic Lupus Erythematosus and Deficiencies of Early Components of the Complement Classical Pathway. Front Immunol (2016) 0.82
Complement activation by CpG in a human whole blood loop system: mechanisms and immunomodulatory effects. J Immunol (2009) 0.81
Do antimicrobial peptides and complement collaborate in the intestinal mucosa? Front Immunol (2015) 0.81
Hijacking Complement Regulatory Proteins for Bacterial Immune Evasion. Front Microbiol (2016) 0.80
Complement diagnostics: concepts, indications, and practical guidelines. Clin Dev Immunol (2012) 0.80
Protein engineering to target complement evasion in cancer. FEBS Lett (2013) 0.80
Membrane-proximal TRAIL species are incapable of inducing short circuit apoptosis signaling: Implications for drug development and basic cytokine biology. Sci Rep (2016) 0.79
Complementing the inflammasome. Immunology (2016) 0.79
Retracted Properdin homeostasis requires turnover of the alternative complement pathway. Proc Natl Acad Sci U S A (2010) 0.78
Complement component C3 - The "Swiss Army Knife" of innate immunity and host defense. Immunol Rev (2016) 0.78
Complement activation in the context of stem cells and tissue repair. World J Stem Cells (2015) 0.78
Properdin has an ascendancy over factor H regulation in complement-mediated renal tubular damage. BMC Nephrol (2014) 0.78
Serum properdin consumption as a biomarker of C5 convertase dysregulation in C3 glomerulopathy. Clin Exp Immunol (2016) 0.77
Alternative Pathway Dysregulation and the Conundrum of Complement Activation by IgG4 Immune Complexes in Membranous Nephropathy. Front Immunol (2016) 0.77
Comparative Analysis of Novel Complement-Targeted Inhibitors, MiniFH, and the Natural Regulators Factor H and Factor H-like Protein 1 Reveal Functional Determinants of Complement Regulation. J Immunol (2015) 0.77
Activation of Human Complement System by Dextran-Coated Iron Oxide Nanoparticles Is Not Affected by Dextran/Fe Ratio, Hydroxyl Modifications, and Crosslinking. Front Immunol (2016) 0.77
Glomerular basement membrane heparan sulfate in health and disease: A regulator of local complement activation. Matrix Biol (2016) 0.76
Properdin binding to complement activating surfaces depends on initial C3b deposition. Proc Natl Acad Sci U S A (2017) 0.76
Complement's hidden arsenal: New insights and novel functions inside the cell. Mol Immunol (2017) 0.75
Low serum ficolin-3 levels are associated with severity and poor outcome in traumatic brain injury. J Neuroinflammation (2015) 0.75
Fluid phase recognition molecules in neutrophil-dependent immune responses. Semin Immunol (2016) 0.75
Quantitative Modeling of the Alternative Pathway of the Complement System. PLoS One (2016) 0.75
An Inhibitor of the Alternative Pathway of Complement in Saliva of New World Anopheline Mosquitoes. J Immunol (2016) 0.75
Trypanosoma cruzi Evades the Complement System as an Efficient Strategy to Survive in the Mammalian Host: The Specific Roles of Host/Parasite Molecules and Trypanosoma cruzi Calreticulin. Front Microbiol (2017) 0.75
Properdin Levels in Individuals with Chemotherapy-Induced Neutropenia. Open Forum Infect Dis (2016) 0.75
The Murine Factor H-Related Protein FHR-B Promotes Complement Activation. Front Immunol (2017) 0.75
Activation of complement factor B contributes to murine and human myocardial ischemia/reperfusion injury. PLoS One (2017) 0.75
Genetics of HUS: the impact of MCP, CFH, and IF mutations on clinical presentation, response to treatment, and outcome. Blood (2006) 4.51
Human T regulatory cells can use the perforin pathway to cause autologous target cell death. Immunity (2004) 4.11
Mutations in complement C3 predispose to development of atypical hemolytic uremic syndrome. Blood (2008) 3.10
Genetic and functional analyses of membrane cofactor protein (CD46) mutations in atypical hemolytic uremic syndrome. J Am Soc Nephrol (2006) 2.88
Activation of human CD4+ cells with CD3 and CD46 induces a T-regulatory cell 1 phenotype. Nature (2003) 2.83
Mutations in human complement regulator, membrane cofactor protein (CD46), predispose to development of familial hemolytic uremic syndrome. Proc Natl Acad Sci U S A (2003) 2.79
Differential expression of granzymes A and B in human cytotoxic lymphocyte subsets and T regulatory cells. Blood (2004) 2.58
Adenovirus type 11 uses CD46 as a cellular receptor. J Virol (2003) 2.52
Virulence differences between monkeypox virus isolates from West Africa and the Congo basin. Virology (2005) 2.36
C-terminal truncations in human 3'-5' DNA exonuclease TREX1 cause autosomal dominant retinal vasculopathy with cerebral leukodystrophy. Nat Genet (2007) 2.35
T-cell regulation: with complements from innate immunity. Nat Rev Immunol (2006) 2.27
Immunology of age-related macular degeneration. Nat Rev Immunol (2013) 2.14
Secreted NS1 of dengue virus attaches to the surface of cells via interactions with heparan sulfate and chondroitin sulfate E. PLoS Pathog (2007) 1.97
West Nile virus nonstructural protein NS1 inhibits complement activation by binding the regulatory protein factor H. Proc Natl Acad Sci U S A (2006) 1.96
Plasma complement components and activation fragments: associations with age-related macular degeneration genotypes and phenotypes. Invest Ophthalmol Vis Sci (2009) 1.86
Implications of the initial mutations in membrane cofactor protein (MCP; CD46) leading to atypical hemolytic uremic syndrome. Mol Immunol (2006) 1.82
CD25 deficiency causes an immune dysregulation, polyendocrinopathy, enteropathy, X-linked-like syndrome, and defective IL-10 expression from CD4 lymphocytes. J Allergy Clin Immunol (2006) 1.81
Rare variants in CFI, C3 and C9 are associated with high risk of advanced age-related macular degeneration. Nat Genet (2013) 1.77
Antagonism of the complement component C4 by flavivirus nonstructural protein NS1. J Exp Med (2010) 1.76
A novel inhibitor of the alternative complement pathway prevents antiphospholipid antibody-induced pregnancy loss in mice. Mol Immunol (2005) 1.67
Complement regulator CD46 temporally regulates cytokine production by conventional and unconventional T cells. Nat Immunol (2010) 1.67
Hepatic IL-17 responses in human and murine primary biliary cirrhosis. J Autoimmun (2008) 1.57
Properdin: emerging roles of a pattern-recognition molecule. Annu Rev Immunol (2010) 1.55
Membrane cofactor protein mutations in atypical hemolytic uremic syndrome (aHUS), fatal Stx-HUS, C3 glomerulonephritis, and the HELLP syndrome. Blood (2007) 1.53
Mutations in complement regulatory proteins predispose to preeclampsia: a genetic analysis of the PROMISSE cohort. PLoS Med (2011) 1.52
The complement protein properdin binds apoptotic T cells and promotes complement activation and phagocytosis. Proc Natl Acad Sci U S A (2008) 1.51
Role of membrane cofactor protein (CD46) in regulation of C4b and C3b deposited on cells. J Immunol (2002) 1.51
Binding of flavivirus nonstructural protein NS1 to C4b binding protein modulates complement activation. J Immunol (2011) 1.45
Characterization of mutations in complement factor I (CFI) associated with hemolytic uremic syndrome. Mol Immunol (2007) 1.42
CD46 is a cellular receptor for all species B adenoviruses except types 3 and 7. J Virol (2005) 1.37
New roles for the major human 3'-5' exonuclease TREX1 in human disease. Cell Cycle (2008) 1.35
CD46: expanding beyond complement regulation. Trends Immunol (2004) 1.32
A prevalent C3 mutation in aHUS patients causes a direct C3 convertase gain of function. Blood (2012) 1.28
Pathogenesis of aortic dilatation in mucopolysaccharidosis VII mice may involve complement activation. Mol Genet Metab (2011) 1.27
Structure of the C3b binding site of CR1 (CD35), the immune adherence receptor. Cell (2002) 1.25
Decay-accelerating factor (DAF), complement receptor 1 (CR1), and factor H dissociate the complement AP C3 convertase (C3bBb) via sites on the type A domain of Bb. J Biol Chem (2001) 1.22
Structure and regulatory profile of the monkeypox inhibitor of complement: comparison to homologs in vaccinia and variola and evidence for dimer formation. J Immunol (2006) 1.21
Variable antibody-dependent activation of complement by functionalized phospholipid nanoparticle surfaces. J Biol Chem (2010) 1.20
Evidence for non-traditional activation of complement factor C3 during murine liver regeneration. Mol Immunol (2008) 1.19
The role of the immune response in age-related macular degeneration. Int J Inflam (2013) 1.16
Interaction of glycoprotein H of human herpesvirus 6 with the cellular receptor CD46. J Biol Chem (2003) 1.16
Emerging roles and new functions of CD46. Springer Semin Immunopathol (2005) 1.16
Properdin: New roles in pattern recognition and target clearance. Mol Immunol (2008) 1.16
Sustained thromboprophylaxis mediated by an RBC-targeted pro-urokinase zymogen activated at the site of clot formation. Blood (2010) 1.14
CD46 is phosphorylated at tyrosine 354 upon infection of epithelial cells by Neisseria gonorrhoeae. J Cell Biol (2002) 1.14
Complement-dependent neutrophil recruitment is critical for the development of elastase-induced abdominal aortic aneurysm. Circulation (2009) 1.13
Screening for complement system abnormalities in patients with atypical hemolytic uremic syndrome. Clin J Am Soc Nephrol (2007) 1.12
Complement-induced regulatory T cells suppress T-cell responses but allow for dendritic-cell maturation. Blood (2005) 1.10
Localization of regions in CD46 that interact with adenovirus. J Virol (2005) 1.08
Clinical and laboratory evaluation of complement deficiency. J Allergy Clin Immunol (2004) 1.07
Surviving mousepox infection requires the complement system. PLoS Pathog (2008) 1.07
Induction of a regulatory phenotype in human CD4+ T cells by streptococcal M protein. J Immunol (2005) 1.07
Targeting of a mutant plasminogen activator to circulating red blood cells for prophylactic fibrinolysis. J Pharmacol Exp Ther (2009) 1.05
Advances in understanding of pathogenesis of aHUS and HELLP. Br J Haematol (2008) 1.05
Membrane protein Crry maintains homeostasis of the complement system. J Immunol (2008) 1.04
Smallpox inhibitor of complement enzymes (SPICE): dissecting functional sites and abrogating activity. J Immunol (2009) 1.03
Modeling how CD46 deficiency predisposes to atypical hemolytic uremic syndrome. Mol Immunol (2006) 1.03
Mutations in CD46, a complement regulatory protein, predispose to atypical HUS. Trends Mol Med (2004) 1.02
Targeted and restricted complement activation on acrosome-reacted spermatozoa. J Clin Invest (2005) 1.02
Plasmodium falciparum uses a key functional site in complement receptor type-1 for invasion of human erythrocytes. Blood (2011) 1.02
N-linked glycosylation of dengue virus NS1 protein modulates secretion, cell-surface expression, hexamer stability, and interactions with human complement. Virology (2011) 1.02
ScFv-mediated in vivo targeting of DAF to erythrocytes inhibits lysis by complement. Mol Immunol (2004) 1.00
Human complement receptor type 1 (CR1) binds to a major malarial adhesin. Trends Mol Med (2002) 0.98
Complement-mediated neutralization of dengue virus requires mannose-binding lectin. MBio (2011) 0.97
Oversulfated heparin by-products induce thrombin generation in human plasmas through contact system activation. Clin Appl Thromb Hemost (2010) 0.97
Structure-based mapping of DAF active site residues that accelerate the decay of C3 convertases. J Biol Chem (2007) 0.97
Antibody directs properdin-dependent activation of the complement alternative pathway in a mouse model of abdominal aortic aneurysm. Proc Natl Acad Sci U S A (2012) 0.96
The Quantification of Glycosaminoglycans: A Comparison of HPLC, Carbazole, and Alcian Blue Methods. Open Glycosci (2008) 0.96
T-cell stimulation and regulation: with complements from CD46. Immunol Res (2005) 0.95
CD46-induced human Treg enhance B-cell responses. Eur J Immunol (2009) 0.94
Inhibiting complement activation on cells at the step of C3 cleavage. Vaccine (2008) 0.94
Complement factor B is the downstream effector of TLRs and plays an important role in a mouse model of severe sepsis. J Immunol (2013) 0.93
Detection of complement activation using monoclonal antibodies against C3d. J Clin Invest (2013) 0.93
Backbone dynamics of complement control protein (CCP) modules reveals mobility in binding surfaces. Protein Sci (2004) 0.92
Smallpox inhibitor of complement enzymes (SPICE): regulation of complement activation on cells and mechanism of its cellular attachment. J Immunol (2008) 0.92
In vivo correction of complement regulatory protein deficiency with an inhibitor targeting the red blood cell membrane. J Immunol (2005) 0.90
Down-regulation of CD46 by piliated Neisseria gonorrhoeae. J Exp Med (2003) 0.89
Characterization of human membrane cofactor protein (MCP; CD46) on spermatozoa. Mol Reprod Dev (2002) 0.89
A corresponding tyrosine residue in the C2/factor B type A domain is a hot spot in the decay acceleration of the complement C3 convertases. J Biol Chem (2003) 0.87
Cutting edge: inhibiting measles virus infection but promoting reproduction: an explanation for splicing and tissue-specific expression of CD46. J Immunol (2002) 0.87
Congenital short bowel syndrome as the presenting symptom in male patients with FLNA mutations. Genet Med (2012) 0.86
Using mutagenesis and structural biology to map the binding site for the Plasmodium falciparum merozoite protein PfRh4 on the human immune adherence receptor. J Biol Chem (2013) 0.86
Lack of evidence from studies of soluble protein fragments that Knops blood group polymorphisms in complement receptor-type 1 are driven by malaria. PLoS One (2012) 0.86
Engagement of CD46 and alpha5beta1 integrin by group A streptococci is required for efficient invasion of epithelial cells. Cell Microbiol (2005) 0.84
Release of host-derived membrane vesicles following pilus-mediated adhesion of Neisseria gonorrhoeae. Cell Microbiol (2005) 0.84
Analysis of genes coding for CD46, CD55, and C4b-binding protein in patients with idiopathic, recurrent, spontaneous pregnancy loss. Eur J Immunol (2013) 0.83
Autoantibody stabilization of the classical pathway C3 convertase leading to C3 deficiency and Neisserial sepsis: C4 nephritic factor revisited. Clin Immunol (2012) 0.83
Rheumatic syndromes associated with complement deficiency. Curr Opin Rheumatol (2003) 0.83