Published in J Hum Genet on January 01, 2002
International network of cancer genome projects. Nature (2010) 20.35
Melanomas acquire resistance to B-RAF(V600E) inhibition by RTK or N-RAS upregulation. Nature (2010) 18.69
ChIP-seq accurately predicts tissue-specific activity of enhancers. Nature (2009) 18.38
Evolution of genes and genomes on the Drosophila phylogeny. Nature (2007) 18.01
A phylogeny-driven genomic encyclopaedia of Bacteria and Archaea. Nature (2009) 15.06
A human genome diversity cell line panel. Science (2002) 14.11
Fever with thrombocytopenia associated with a novel bunyavirus in China. N Engl J Med (2011) 13.18
A systematic survey of loss-of-function variants in human protein-coding genes. Science (2012) 12.25
The developmental transcriptome of Drosophila melanogaster. Nature (2010) 11.85
Multiple recurrent de novo CNVs, including duplications of the 7q11.23 Williams syndrome region, are strongly associated with autism. Neuron (2011) 10.61
Complete Khoisan and Bantu genomes from southern Africa. Nature (2010) 9.06
A complementary transposon tool kit for Drosophila melanogaster using P and piggyBac. Nat Genet (2004) 8.55
A systematic, large-scale resequencing screen of X-chromosome coding exons in mental retardation. Nat Genet (2009) 8.30
Sequencing and analysis of Neanderthal genomic DNA. Science (2006) 8.06
Rapid whole-genome mutational profiling using next-generation sequencing technologies. Genome Res (2008) 8.01
Statistical analysis of real-time PCR data. BMC Bioinformatics (2006) 7.31
Metagenomic discovery of biomass-degrading genes and genomes from cow rumen. Science (2011) 6.93
A genome-wide meta-analysis identifies 22 loci associated with eight hematological parameters in the HaemGen consortium. Nat Genet (2009) 6.31
Genome sequencing of pediatric medulloblastoma links catastrophic DNA rearrangements with TP53 mutations. Cell (2012) 6.07
Genomic minimalism in the early diverging intestinal parasite Giardia lamblia. Science (2007) 5.69
Differential sensitivity of melanoma cell lines with BRAFV600E mutation to the specific Raf inhibitor PLX4032. J Transl Med (2010) 5.57
Insights from the genome of the biotrophic fungal plant pathogen Ustilago maydis. Nature (2006) 5.52
Effect of iodine intake on thyroid diseases in China. N Engl J Med (2006) 5.46
Dissecting the genomic complexity underlying medulloblastoma. Nature (2012) 4.77
A GAL4-driver line resource for Drosophila neurobiology. Cell Rep (2012) 4.67
IFITM3 restricts the morbidity and mortality associated with influenza. Nature (2012) 4.66
Microbial production of recalcitrant dissolved organic matter: long-term carbon storage in the global ocean. Nat Rev Microbiol (2010) 4.58
Twist transcriptionally up-regulates AKT2 in breast cancer cells leading to increased migration, invasion, and resistance to paclitaxel. Cancer Res (2007) 4.48
A new HPV-DNA test for cervical-cancer screening in developing regions: a cross-sectional study of clinical accuracy in rural China. Lancet Oncol (2008) 4.43
The functional spectrum of low-frequency coding variation. Genome Biol (2011) 4.42
Conditional deletion of Gata3 shows its essential function in T(H)1-T(H)2 responses. Nat Immunol (2004) 4.41
Sequence and analysis of rice chromosome 4. Nature (2002) 4.39
Optical absorption enhancement in amorphous silicon nanowire and nanocone arrays. Nano Lett (2009) 4.35
ChIP-Seq identification of weakly conserved heart enhancers. Nat Genet (2010) 4.32
Patterns and implications of gene gain and loss in the evolution of Prochlorococcus. PLoS Genet (2007) 4.25
Abnormal spine morphology and enhanced LTP in LIMK-1 knockout mice. Neuron (2002) 4.18
Experimental factors affecting PCR-based estimates of microbial species richness and evenness. ISME J (2010) 4.15
Insights into hominid evolution from the gorilla genome sequence. Nature (2012) 4.12
iPS cells can support full-term development of tetraploid blastocyst-complemented embryos. Cell Stem Cell (2009) 4.04
Validation of ITD mutations in FLT3 as a therapeutic target in human acute myeloid leukaemia. Nature (2012) 4.01
Caspase cleavage of tau: linking amyloid and neurofibrillary tangles in Alzheimer's disease. Proc Natl Acad Sci U S A (2003) 3.85
The genetic legacy of the Mongols. Am J Hum Genet (2003) 3.84
Genome-wide translocation sequencing reveals mechanisms of chromosome breaks and rearrangements in B cells. Cell (2011) 3.81
Dissection of mechanisms of Chinese medicinal formula Realgar-Indigo naturalis as an effective treatment for promyelocytic leukemia. Proc Natl Acad Sci U S A (2008) 3.71
Synthetic spike-in standards for RNA-seq experiments. Genome Res (2011) 3.58
Genetic variants and risk of lung cancer in never smokers: a genome-wide association study. Lancet Oncol (2010) 3.49
A single-base resolution map of an archaeal transcriptome. Genome Res (2009) 3.42
Evidence that microRNAs are associated with translating messenger RNAs in human cells. Nat Struct Mol Biol (2006) 3.36
LSD1 is a subunit of the NuRD complex and targets the metastasis programs in breast cancer. Cell (2009) 3.34
Complete genome sequence of Kytococcus sedentarius type strain (541). Stand Genomic Sci (2009) 3.30
Phase I and correlative biology study of cilengitide in patients with recurrent malignant glioma. J Clin Oncol (2007) 3.29
MicroRNA-mediated control of oligodendrocyte differentiation. Neuron (2010) 3.24
Identification of a family of cAMP response element-binding protein coactivators by genome-scale functional analysis in mammalian cells. Proc Natl Acad Sci U S A (2003) 3.21
Label-free oxygen-metabolic photoacoustic microscopy in vivo. J Biomed Opt (2011) 3.16
Mammalian target of rapamycin up-regulation of pyruvate kinase isoenzyme type M2 is critical for aerobic glycolysis and tumor growth. Proc Natl Acad Sci U S A (2011) 3.14
The molecular mechanism governing the oncogenic potential of SOX2 in breast cancer. J Biol Chem (2008) 3.01
Single reconstituted neuronal SNARE complexes zipper in three distinct stages. Science (2012) 2.98
Precise segmental renal artery clamping under the guidance of dual-source computed tomography angiography during laparoscopic partial nephrectomy. Eur Urol (2012) 2.95
Complete genome sequence of Yersinia pestis strain 91001, an isolate avirulent to humans. DNA Res (2004) 2.95
Removal of heavy metal ions from wastewaters: a review. J Environ Manage (2010) 2.87
Demasculinization of X chromosomes in the Drosophila genus. Nature (2007) 2.85
A genome-wide association study identifies two new lung cancer susceptibility loci at 13q12.12 and 22q12.2 in Han Chinese. Nat Genet (2011) 2.85
Slippage of mitotic arrest and enhanced tumor development in mice with BubR1 haploinsufficiency. Cancer Res (2004) 2.79
AlphaB-crystallin is a novel oncoprotein that predicts poor clinical outcome in breast cancer. J Clin Invest (2006) 2.74
A common MYBPC3 (cardiac myosin binding protein C) variant associated with cardiomyopathies in South Asia. Nat Genet (2009) 2.67
A comparative study of platelet-rich fibrin (PRF) and platelet-rich plasma (PRP) on the effect of proliferation and differentiation of rat osteoblasts in vitro. Oral Surg Oral Med Oral Pathol Oral Radiol Endod (2009) 2.67
Erythroid GATA1 function revealed by genome-wide analysis of transcription factor occupancy, histone modifications, and mRNA expression. Genome Res (2009) 2.64
The pathogen-associated iroA gene cluster mediates bacterial evasion of lipocalin 2. Proc Natl Acad Sci U S A (2006) 2.63
A genome-wide survey of the prevalence and evolutionary forces acting on human nonsense SNPs. Am J Hum Genet (2009) 2.62
Performance of high-risk human papillomavirus DNA testing as a primary screen for cervical cancer: a pooled analysis of individual patient data from 17 population-based studies from China. Lancet Oncol (2010) 2.61
Intrinsic peroxidase-like activity of ferromagnetic nanoparticles. Nat Nanotechnol (2007) 2.61
Genomic-scale prioritization of drug targets: the TDR Targets database. Nat Rev Drug Discov (2008) 2.58
HDAC6 controls major cell response pathways to cytotoxic accumulation of protein aggregates. Genes Dev (2007) 2.56
Ecology. Importing timber, exporting ecological impact. Science (2005) 2.54
An integrated functional genomics screening program reveals a role for BMP-9 in glucose homeostasis. Nat Biotechnol (2003) 2.53
SUMO-specific protease 2 is essential for suppression of polycomb group protein-mediated gene silencing during embryonic development. Mol Cell (2010) 2.52
HDAC6-p97/VCP controlled polyubiquitin chain turnover. EMBO J (2006) 2.52
CCL2 mediates cross-talk between cancer cells and stromal fibroblasts that regulates breast cancer stem cells. Cancer Res (2012) 2.50
Genome-scale functional profiling of the mammalian AP-1 signaling pathway. Proc Natl Acad Sci U S A (2003) 2.45
The deacetylase HDAC6 is a novel critical component of stress granules involved in the stress response. Genes Dev (2007) 2.43
Rapid induction and long-term self-renewal of primitive neural precursors from human embryonic stem cells by small molecule inhibitors. Proc Natl Acad Sci U S A (2011) 2.39
Evolution of protein-coding genes in Drosophila. Trends Genet (2008) 2.36
COP1 and ELF3 control circadian function and photoperiodic flowering by regulating GI stability. Mol Cell (2008) 2.34
Long-term efficacy and safety of all-trans retinoic acid/arsenic trioxide-based therapy in newly diagnosed acute promyelocytic leukemia. Proc Natl Acad Sci U S A (2009) 2.34
Disulfiram, a clinically used anti-alcoholism drug and copper-binding agent, induces apoptotic cell death in breast cancer cultures and xenografts via inhibition of the proteasome activity. Cancer Res (2006) 2.33
Mechanisms of programmed DNA lesions and genomic instability in the immune system. Cell (2013) 2.32
The orexin system regulates alcohol-seeking in rats. Br J Pharmacol (2006) 2.30
Male demography in East Asia: a north-south contrast in human population expansion times. Genetics (2006) 2.30
Duct tape for the treatment of common warts in adults: a double-blind randomized controlled trial. Arch Dermatol (2007) 2.22
Vasopressin-stimulated increase in phosphorylation at Ser269 potentiates plasma membrane retention of aquaporin-2. J Biol Chem (2008) 2.21
Validation of two ribosomal RNA removal methods for microbial metatranscriptomics. Nat Methods (2010) 2.21
Diffusion-weighted MR imaging in monitoring the effect of a vascular targeting agent on rhabdomyosarcoma in rats. Radiology (2005) 2.18
Replacement of Oct4 by Tet1 during iPSC induction reveals an important role of DNA methylation and hydroxymethylation in reprogramming. Cell Stem Cell (2013) 2.17
Detecting tissue-specific regulation of alternative splicing as a qualitative change in microarray data. Nucleic Acids Res (2004) 2.17
Synchrotron-based infrared and X-ray imaging shows focalized accumulation of Cu and Zn co-localized with beta-amyloid deposits in Alzheimer's disease. J Struct Biol (2005) 2.15
Deletion of fibroblast growth factor receptor 2 from the peri-wolffian duct stroma leads to ureteric induction abnormalities and vesicoureteral reflux. PLoS One (2013) 2.15
Using OrthoMCL to assign proteins to OrthoMCL-DB groups or to cluster proteomes into new ortholog groups. Curr Protoc Bioinformatics (2011) 2.15