Published in Science on March 29, 2002
Cell-signalling dynamics in time and space. Nat Rev Mol Cell Biol (2006) 7.25
Classical nuclear localization signals: definition, function, and interaction with importin alpha. J Biol Chem (2006) 5.34
Signalling ballet in space and time. Nat Rev Mol Cell Biol (2010) 3.32
Branching microtubule nucleation in Xenopus egg extracts mediated by augmin and TPX2. Cell (2013) 3.26
Human centromere chromatin protein hMis12, essential for equal segregation, is independent of CENP-A loading pathway. J Cell Biol (2003) 3.18
Chromosome- and spindle-pole-derived signals generate an intrinsic code for spindle position and orientation. Nat Cell Biol (2012) 3.08
The nuclear pore complex and nuclear transport. Cold Spring Harb Perspect Biol (2010) 2.71
The mechanism of spindle assembly: functions of Ran and its target TPX2. J Cell Biol (2004) 2.58
Molecular requirements for kinetochore-associated microtubule formation in mammalian cells. Curr Biol (2006) 2.48
Tension-dependent regulation of microtubule dynamics at kinetochores can explain metaphase congression in yeast. Mol Biol Cell (2005) 2.27
Chromatin-bound Xenopus Dppa2 shapes the nucleus by locally inhibiting microtubule assembly. Dev Cell (2013) 2.09
Characterization of Ran-driven cargo transport and the RanGTPase system by kinetic measurements and computer simulation. EMBO J (2003) 2.06
Localized regulation of axonal RanGTPase controls retrograde injury signaling in peripheral nerve. Neuron (2008) 2.04
K-fibre minus ends are stabilized by a RanGTP-dependent mechanism essential for functional spindle assembly. Nat Cell Biol (2011) 2.00
The Nup107-160 nucleoporin complex is required for correct bipolar spindle assembly. Mol Biol Cell (2006) 1.93
Mechanisms of microtubule-based kinetochore positioning in the yeast metaphase spindle. Biophys J (2003) 1.93
Exportin 6: a novel nuclear export receptor that is specific for profilin.actin complexes. EMBO J (2003) 1.89
Nercc1, a mammalian NIMA-family kinase, binds the Ran GTPase and regulates mitotic progression. Genes Dev (2002) 1.87
Fundamental limits to position determination by concentration gradients. PLoS Comput Biol (2007) 1.76
Phosphorylation of RCC1 in mitosis is essential for producing a high RanGTP concentration on chromosomes and for spindle assembly in mammalian cells. Genes Dev (2004) 1.73
Ran GTPase cycle and importins alpha and beta are essential for spindle formation and nuclear envelope assembly in living Caenorhabditis elegans embryos. Mol Biol Cell (2002) 1.69
Importin beta negatively regulates nuclear membrane fusion and nuclear pore complex assembly. Mol Biol Cell (2003) 1.62
A picornavirus protein interacts with Ran-GTPase and disrupts nucleocytoplasmic transport. Proc Natl Acad Sci U S A (2006) 1.60
Importin alpha/beta and Ran-GTP regulate XCTK2 microtubule binding through a bipartite nuclear localization signal. Mol Biol Cell (2003) 1.60
A centriole- and RanGTP-independent spindle assembly pathway in meiosis I of vertebrate oocytes. J Cell Biol (2007) 1.58
Part of Ran is associated with AKAP450 at the centrosome: involvement in microtubule-organizing activity. Mol Biol Cell (2003) 1.57
Spatial organization of intracellular communication: insights from imaging. Nat Rev Mol Cell Biol (2010) 1.55
A computational model predicts Xenopus meiotic spindle organization. J Cell Biol (2010) 1.53
Long-range signaling by phosphoprotein waves arising from bistability in protein kinase cascades. Mol Syst Biol (2006) 1.49
NuMA after 30 years: the matrix revisited. Trends Cell Biol (2010) 1.48
Regulated degradation of spindle assembly factors by the anaphase-promoting complex. Mol Cell (2010) 1.48
Requirements for NuMA in maintenance and establishment of mammalian spindle poles. J Cell Biol (2009) 1.47
Reorganization of the nuclear envelope during open mitosis. Curr Opin Cell Biol (2008) 1.46
Anaphase-promoting complex/cyclosome controls the stability of TPX2 during mitotic exit. Mol Cell Biol (2005) 1.46
Three-dimensional distribution of transient interactions in the nuclear pore complex obtained from single-molecule snapshots. Proc Natl Acad Sci U S A (2010) 1.45
Microtubule plus-end dynamics in Xenopus egg extract spindles. Mol Biol Cell (2004) 1.45
Yeast kinetochores do not stabilize Stu2p-dependent spindle microtubule dynamics. Mol Biol Cell (2003) 1.45
A mechanism of coupling RCC1 mobility to RanGTP production on the chromatin in vivo. J Cell Biol (2003) 1.44
Ran-dependent nuclear export mediators: a structural perspective. EMBO J (2011) 1.42
Importazole, a small molecule inhibitor of the transport receptor importin-β. ACS Chem Biol (2011) 1.39
Biology and biophysics of the nuclear pore complex and its components. Int Rev Cell Mol Biol (2008) 1.39
SMN, the spinal muscular atrophy protein, forms a pre-import snRNP complex with snurportin1 and importin beta. Hum Mol Genet (2002) 1.36
The Ran GTPase cycle is required for yeast nuclear pore complex assembly. J Cell Biol (2003) 1.33
Nucleo-cytoplasmic partitioning of proteins in plants: implications for the regulation of environmental and developmental signalling. Curr Genet (2003) 1.28
Controlled damage in thick specimens by multiphoton excitation. Mol Biol Cell (2003) 1.27
Versatility at the nuclear pore complex: lessons learned from the nucleoporin Nup153. Chromosoma (2005) 1.27
Kinesin-14 family proteins HSET/XCTK2 control spindle length by cross-linking and sliding microtubules. Mol Biol Cell (2008) 1.25
Regulation of chromatin binding by a conformational switch in the tail of the Ran exchange factor RCC1. J Cell Biol (2008) 1.22
Variations on theme: spindle assembly in diverse cells. Protoplasma (2010) 1.22
Relative contributions of chromatin and kinetochores to mitotic spindle assembly. J Cell Biol (2009) 1.20
Spindle assembly in the absence of a RanGTP gradient requires localized CPC activity. Curr Biol (2009) 1.19
Mitotic spindle scaling during Xenopus development by kif2a and importin α. Elife (2013) 1.18
Regulation of the MEX-5 gradient by a spatially segregated kinase/phosphatase cycle. Cell (2011) 1.17
Exportin 7 defines a novel general nuclear export pathway. EMBO J (2004) 1.17
Nuclear targeting of adenovirus type 2 requires CRM1-mediated nuclear export. Mol Biol Cell (2005) 1.16
Ran is required before metaphase for spindle assembly and chromosome alignment and after metaphase for chromosome segregation and spindle midbody organization. Mol Biol Cell (2006) 1.15
Cdk11 is a RanGTP-dependent microtubule stabilization factor that regulates spindle assembly rate. J Cell Biol (2008) 1.13
Overexpression of OsRAN2 in rice and Arabidopsis renders transgenic plants hypersensitive to salinity and osmotic stress. J Exp Bot (2009) 1.13
Two distinct interacting classes of nuclear envelope-associated coiled-coil proteins are required for the tissue-specific nuclear envelope targeting of Arabidopsis RanGAP. Plant Cell (2008) 1.11
Dual roles of Incenp crucial to the assembly of the acentrosomal metaphase spindle in female meiosis. Development (2008) 1.10
Eukaryotic cells and their cell bodies: Cell Theory revised. Ann Bot (2004) 1.10
PinX1 is a novel microtubule-binding protein essential for accurate chromosome segregation. J Biol Chem (2009) 1.09
Use of virtual cell in studies of cellular dynamics. Int Rev Cell Mol Biol (2010) 1.09
Nuclear localization signal peptides induce molecular delivery along microtubules. Biophys J (2005) 1.09
Live-cell fluorescence microscopy with molecular biosensors: what are we really measuring? Biophys J (2012) 1.08
The nucleoporin Nup358 associates with and regulates interphase microtubules. FEBS Lett (2007) 1.08
Importin-beta and the small guanosine triphosphatase Ran mediate chromosome loading of the human chromokinesin Kid. J Cell Biol (2008) 1.07
Signaling cascades as cellular devices for spatial computations. J Math Biol (2008) 1.07
The condensin complex is required for proper spindle assembly and chromosome segregation in Xenopus egg extracts. J Cell Biol (2003) 1.07
RanBP10 is a cytoplasmic guanine nucleotide exchange factor that modulates noncentrosomal microtubules. J Biol Chem (2008) 1.06
Four-dimensional dynamics of MAPK information processing systems. Wiley Interdiscip Rev Syst Biol Med (2010) 1.06
Individual binding pockets of importin-beta for FG-nucleoporins have different binding properties and different sensitivities to RanGTP. Proc Natl Acad Sci U S A (2008) 1.05
Model for Protein Concentration Gradients in the Cytoplasm. Cell Mol Bioeng (2008) 1.05
The karyopherin Kap95 regulates nuclear pore complex assembly into intact nuclear envelopes in vivo. Mol Biol Cell (2006) 1.04
Biochemical characterization of the Ran-RanBP1-RanGAP system: are RanBP proteins and the acidic tail of RanGAP required for the Ran-RanGAP GTPase reaction? Mol Cell Biol (2003) 1.02
Visualizing and quantifying adhesive signals. Curr Opin Cell Biol (2008) 1.02
The mobile FG nucleoporin Nup98 is a cofactor for Crm1-dependent protein export. Mol Biol Cell (2010) 1.01
The strategy for coupling the RanGTP gradient to nuclear protein export. Proc Natl Acad Sci U S A (2003) 1.00
TPX2 levels modulate meiotic spindle size and architecture in Xenopus egg extracts. J Cell Biol (2014) 1.00
Inner/Outer nuclear membrane fusion in nuclear pore assembly: biochemical demonstration and molecular analysis. Mol Biol Cell (2010) 1.00
Positional information generated by spatially distributed signaling cascades. PLoS Comput Biol (2009) 1.00
Reaction-diffusion systems in intracellular molecular transport and control. Angew Chem Int Ed Engl (2010) 1.00
Enzyme localization can drastically affect signal amplification in signal transduction pathways. PLoS Comput Biol (2007) 0.99
Nucleo-cytoplasmic transport of proteins and RNA in plants. Plant Cell Rep (2010) 0.98
Transportin regulates major mitotic assembly events: from spindle to nuclear pore assembly. Mol Biol Cell (2009) 0.98
Building a nuclear envelope at the end of mitosis: coordinating membrane reorganization, nuclear pore complex assembly, and chromatin de-condensation. Chromosoma (2012) 0.97
Spatially distributed cell signalling. FEBS Lett (2009) 0.97
Regulation of Aurora-A kinase on the mitotic spindle. Chromosoma (2003) 0.96
Spatial cycles in G-protein crowd control. EMBO J (2010) 0.96
Thirty years of search and capture: The complex simplicity of mitotic spindle assembly. J Cell Biol (2015) 0.95
An epigenetic regulator emerges as microtubule minus-end binding and stabilizing factor in mitosis. Nat Commun (2015) 0.95
Subgroup II PAK-mediated phosphorylation regulates Ran activity during mitosis. J Cell Biol (2010) 0.94
Regulation of microtubule assembly and organization in mitosis by the AAA+ ATPase Pontin. Mol Biol Cell (2008) 0.94
The RanGTP Pathway: From Nucleo-Cytoplasmic Transport to Spindle Assembly and Beyond. Front Cell Dev Biol (2016) 0.93
The Ran GTPase system in fission yeast affects microtubules and cytokinesis in cells that are competent for nucleocytoplasmic protein transport. Mol Cell Biol (2002) 0.92
Endocytosis and signalling: a meeting with mathematics. Mol Oncol (2009) 0.92
Localized accumulation of tubulin during semi-open mitosis in the Caenorhabditis elegans embryo. Mol Biol Cell (2012) 0.92
Aurora-A regulates MCRS1 function during mitosis. Cell Cycle (2016) 0.91
RAN nucleo-cytoplasmic transport and mitotic spindle assembly partners XPO7 and TPX2 are new prognostic biomarkers in serous epithelial ovarian cancer. PLoS One (2014) 0.90
A Rae1-containing ribonucleoprotein complex is required for mitotic spindle assembly. Cell (2005) 3.65
Dissection of the mammalian midbody proteome reveals conserved cytokinesis mechanisms. Science (2004) 3.48
Analysis of a RanGTP-regulated gradient in mitotic somatic cells. Nature (2006) 3.47
Mechanisms of mitotic spindle assembly and function. Int Rev Cytol (2008) 3.44
Mechanisms and molecules of the mitotic spindle. Curr Biol (2004) 3.25
The RanGTP gradient - a GPS for the mitotic spindle. J Cell Sci (2008) 2.78
The DEAD box protein Dhh1 stimulates the decapping enzyme Dcp1. EMBO J (2002) 2.65
Activation of the DExD/H-box protein Dbp5 by the nuclear-pore protein Gle1 and its coactivator InsP6 is required for mRNA export. Nat Cell Biol (2006) 2.58
Katanin contributes to interspecies spindle length scaling in Xenopus. Cell (2011) 2.16
Cytoplasmic volume modulates spindle size during embryogenesis. Science (2013) 1.88
Investigating mitotic spindle assembly and function in vitro using Xenopus laevis egg extracts. Nat Protoc (2006) 1.80
Nuclear size is regulated by importin α and Ntf2 in Xenopus. Cell (2010) 1.79
A conserved mechanism of DEAD-box ATPase activation by nucleoporins and InsP6 in mRNA export. Nature (2011) 1.70
Methods for studying spindle assembly and chromosome condensation in Xenopus egg extracts. Methods Mol Biol (2006) 1.65
Identification of a novel protein regulating microtubule stability through a chemical approach. Chem Biol (2004) 1.64
Xenopus tropicalis egg extracts provide insight into scaling of the mitotic spindle. J Cell Biol (2007) 1.63
REEP3/4 ensure endoplasmic reticulum clearance from metaphase chromatin and proper nuclear envelope architecture. Dev Cell (2013) 1.62
The N-terminal domain of Nup159 forms a beta-propeller that functions in mRNA export by tethering the helicase Dbp5 to the nuclear pore. Mol Cell (2004) 1.59
Genome-wide analysis demonstrates conserved localization of messenger RNAs to mitotic microtubules. J Cell Biol (2007) 1.55
Dynamic profiling of mRNA turnover reveals gene-specific and system-wide regulation of mRNA decay. Mol Biol Cell (2011) 1.54
A computational model predicts Xenopus meiotic spindle organization. J Cell Biol (2010) 1.53
Role of the Ndc1 interaction network in yeast nuclear pore complex assembly and maintenance. J Cell Biol (2009) 1.49
Histone H1 is essential for mitotic chromosome architecture and segregation in Xenopus laevis egg extracts. J Cell Biol (2005) 1.43
Yeast poly(A)-binding protein Pab1 shuttles between the nucleus and the cytoplasm and functions in mRNA export. RNA (2005) 1.42
Importazole, a small molecule inhibitor of the transport receptor importin-β. ACS Chem Biol (2011) 1.39
Mechanisms of intracellular scaling. Annu Rev Cell Dev Biol (2012) 1.35
Selectivity mechanism of the nuclear pore complex characterized by single cargo tracking. Nature (2010) 1.33
Xorbit/CLASP links dynamic microtubules to chromosomes in the Xenopus meiotic spindle. J Cell Biol (2006) 1.31
Micromanipulation studies of chromatin fibers in Xenopus egg extracts reveal ATP-dependent chromatin assembly dynamics. Mol Biol Cell (2006) 1.27
The role of the integral membrane nucleoporins Ndc1p and Pom152p in nuclear pore complex assembly and function. J Cell Biol (2006) 1.25
The nucleoporins Nup170p and Nup157p are essential for nuclear pore complex assembly. J Cell Biol (2009) 1.24
The FG-repeat asymmetry of the nuclear pore complex is dispensable for bulk nucleocytoplasmic transport in vivo. J Cell Biol (2004) 1.20
Mitotic spindle scaling during Xenopus development by kif2a and importin α. Elife (2013) 1.18
Nuclear actin and protein 4.1: essential interactions during nuclear assembly in vitro. Proc Natl Acad Sci U S A (2003) 1.17
The perichromosomal layer. Chromosoma (2005) 1.16
Centrosome proteins form an insoluble perinuclear matrix during muscle cell differentiation. BMC Cell Biol (2009) 1.10
Nuclear transport is becoming crystal clear. Chromosoma (2006) 1.09
The condensin complex is required for proper spindle assembly and chromosome segregation in Xenopus egg extracts. J Cell Biol (2003) 1.07
Essential roles for cohesin in kinetochore and spindle function in Xenopus egg extracts. J Cell Sci (2006) 1.07
Multiple domains of human CLASP contribute to microtubule dynamics and organization in vitro and in Xenopus egg extracts. Cytoskeleton (Hoboken) (2012) 1.02
Nuclear pore complex-a coat specifically tailored for the nuclear envelope. Curr Opin Cell Biol (2011) 1.01
A negative feedback loop at the nuclear periphery regulates GAL gene expression. Mol Biol Cell (2012) 1.01
Discovery of selective aminothiazole aurora kinase inhibitors. ACS Chem Biol (2008) 1.00
The DExD/H box ATPase Dhh1 functions in translational repression, mRNA decay, and processing body dynamics. J Cell Biol (2011) 0.98
Scaffold nucleoporins Nup188 and Nup192 share structural and functional properties with nuclear transport receptors. Elife (2013) 0.98
Adenomatous polyposis coli associates with the microtubule-destabilizing protein XMCAK. Curr Biol (2004) 0.97
Xnf7 contributes to spindle integrity through its microtubule-bundling activity. Curr Biol (2005) 0.96
Mitotic chromosome size scaling in Xenopus. Cell Cycle (2011) 0.94
Analysis of microtubule polymerization in vitro and during the cell cycle in Xenopus egg extracts. Methods (2006) 0.94
Structure of the C-terminus of the mRNA export factor Dbp5 reveals the interaction surface for the ATPase activator Gle1. Proc Natl Acad Sci U S A (2009) 0.92
Spatial distribution and mobility of the Ran GTPase in live interphase cells. Biophys J (2009) 0.90
Mitotic spindle assembly around RCC1-coated beads in Xenopus egg extracts. PLoS Biol (2011) 0.90
Characterization of hCINAP, a novel coilin-interacting protein encoded by a transcript from the transcription factor TAFIID32 locus. J Biol Chem (2005) 0.89
Interplay between spindle architecture and function. Int Rev Cell Mol Biol (2013) 0.89
Scratch n' screen for inhibitors of cell migration. Chem Biol (2005) 0.88
Atomic force microscope imaging of chromatin assembled in Xenopus laevis egg extract. Chromosoma (2011) 0.88
Functional comparison of H1 histones in Xenopus reveals isoform-specific regulation by Cdk1 and RanGTP. Curr Biol (2010) 0.88
Two distinct domains of protein 4.1 critical for assembly of functional nuclei in vitro. J Biol Chem (2002) 0.87
The long and the short of it: linker histone H1 is required for metaphase chromosome compaction. Cell Cycle (2006) 0.87
Histone H1 compacts DNA under force and during chromatin assembly. Mol Biol Cell (2012) 0.86
RanGTP and CLASP1 cooperate to position the mitotic spindle. Mol Biol Cell (2013) 0.86
The C-terminal extension of the small GTPase Ran is essential for defining the GDP-bound form. J Mol Biol (2002) 0.86
Two protein 4.1 domains essential for mitotic spindle and aster microtubule dynamics and organization in vitro. J Biol Chem (2004) 0.84
SnapShot: motor proteins in spindle assembly. Cell (2008) 0.84
Cell biology. An alternative route for nuclear mRNP export by membrane budding. Science (2012) 0.83
Xenopus egg extracts increase dynamics of histone H1 on sperm chromatin. PLoS One (2010) 0.81
N-terminal phosphorylation of p60 katanin directly regulates microtubule severing. J Mol Biol (2012) 0.80
Analysis of DEAD-box proteins in mRNA export. Methods Enzymol (2012) 0.80
Centrosomes and kinetochores, who needs 'Em? The role of noncentromeric chromatin in spindle assembly. Curr Top Dev Biol (2003) 0.79
Cell structure and dynamics. Curr Opin Cell Biol (2010) 0.78
Challenges facing the biologist doing chemical genetics. Nat Chem Biol (2006) 0.76
Chromosome congression: another fine mesh we've gotten into. Dev Cell (2005) 0.76
Correction: Mitotic noncoding RNA processing promotes kinetochore and spindle assembly in Xenopus. J Cell Biol (2016) 0.75
Altering membrane topology with Sar1 does not impair spindle assembly in Xenopus egg extracts. Cytoskeleton (Hoboken) (2012) 0.75
Rebecca Heald: passionate about cycles. Interview by Caitlin Sedwick. J Cell Biol (2008) 0.75
Centromere glue provides spindle cue. Cell (2004) 0.75
Cryptic no longer: arrays of CLASP1 TOG domains. Structure (2013) 0.75
Rebecca Heald. Curr Biol (2010) 0.75
The role of chromosome architecture in spindle assembly and anaphase: the condensed version. Cell Cycle (2003) 0.75
Durhane Wong-Rieger: championing patients. Lancet Diabetes Endocrinol (2014) 0.75
Infectious disease surveillance update. Lancet Infect Dis (2013) 0.75