A Rae1-containing ribonucleoprotein complex is required for mitotic spindle assembly.

PubWeight™: 3.65‹?› | Rank: Top 1%

🔗 View Article (PMID 15851029)

Published in Cell on April 22, 2005

Authors

Michael D Blower1, Maxence Nachury, Rebecca Heald, Karsten Weis

Author Affiliations

1: Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, California 94720, USA.

Articles citing this

(truncated to the top 100)

Long noncoding RNAs: functional surprises from the RNA world. Genes Dev (2009) 9.14

Genes required for mitotic spindle assembly in Drosophila S2 cells. Science (2007) 5.58

MENepsilon/beta noncoding RNAs are essential for structural integrity of nuclear paraspeckles. Proc Natl Acad Sci U S A (2009) 3.63

A complex containing the Sm protein CAR-1 and the RNA helicase CGH-1 is required for embryonic cytokinesis in Caenorhabditis elegans. J Cell Biol (2005) 3.18

Structure, dynamics and function of nuclear pore complexes. Trends Cell Biol (2008) 2.85

Orchestrating nuclear envelope disassembly and reassembly during mitosis. Nat Rev Mol Cell Biol (2009) 2.66

A high-throughput drug screen for Entamoeba histolytica identifies a new lead and target. Nat Med (2012) 2.39

Chromosomal enrichment and activation of the aurora B pathway are coupled to spatially regulate spindle assembly. Dev Cell (2007) 2.25

ELYS is a dual nucleoporin/kinetochore protein required for nuclear pore assembly and proper cell division. Proc Natl Acad Sci U S A (2006) 2.14

The Nup107-160 nucleoporin complex is required for correct bipolar spindle assembly. Mol Biol Cell (2006) 1.93

A whole-genome RNAi Screen for C. elegans miRNA pathway genes. Curr Biol (2007) 1.77

Xenopus tropicalis egg extracts provide insight into scaling of the mitotic spindle. J Cell Biol (2007) 1.63

Identification and characterization of nuclear pore complex components in Arabidopsis thaliana. Plant Cell (2010) 1.59

Genome-wide analysis demonstrates conserved localization of messenger RNAs to mitotic microtubules. J Cell Biol (2007) 1.55

Border control at the nucleus: biogenesis and organization of the nuclear membrane and pore complexes. Dev Cell (2009) 1.55

Rae1 interaction with NuMA is required for bipolar spindle formation. Proc Natl Acad Sci U S A (2006) 1.55

A novel Crumbs3 isoform regulates cell division and ciliogenesis via importin beta interactions. J Cell Biol (2007) 1.53

RNA interference knockdown of hU2AF35 impairs cell cycle progression and modulates alternative splicing of Cdc25 transcripts. Mol Biol Cell (2006) 1.49

The nucleolar RNA methyltransferase Misu (NSun2) is required for mitotic spindle stability. J Cell Biol (2009) 1.49

NuMA after 30 years: the matrix revisited. Trends Cell Biol (2010) 1.48

Systematic deletion and mitotic localization of the nuclear pore complex proteins of Aspergillus nidulans. Mol Biol Cell (2006) 1.48

Reorganization of the nuclear envelope during open mitosis. Curr Opin Cell Biol (2008) 1.46

Whole genome functional analysis identifies novel components required for mitotic spindle integrity in human cells. Genome Biol (2008) 1.46

Nuclear pore proteins and cancer. Semin Cell Dev Biol (2009) 1.44

The conserved kinase NHK-1 is essential for mitotic progression and unifying acentrosomal meiotic spindles in Drosophila melanogaster. J Cell Biol (2005) 1.41

Identification of Drosophila mitotic genes by combining co-expression analysis and RNA interference. PLoS Genet (2008) 1.41

ATX-2, the C. elegans Ortholog of Human Ataxin-2, Regulates Centrosome Size and Microtubule Dynamics. PLoS Genet (2016) 1.39

Enhanced genomic instabilities caused by deregulated microtubule dynamics and chromosome segregation: a perspective from genetic studies in mice. Carcinogenesis (2009) 1.38

NuSAP, a mitotic RanGTP target that stabilizes and cross-links microtubules. Mol Biol Cell (2006) 1.37

Integrating high-throughput genetic interaction mapping and high-content screening to explore yeast spindle morphogenesis. J Cell Biol (2010) 1.36

CAR-1, a protein that localizes with the mRNA decapping component DCAP-1, is required for cytokinesis and ER organization in Caenorhabditis elegans embryos. Mol Biol Cell (2005) 1.34

Proteomic and functional analysis of the mitotic Drosophila centrosome. EMBO J (2010) 1.27

Versatility at the nuclear pore complex: lessons learned from the nucleoporin Nup153. Chromosoma (2005) 1.27

The conserved protein SZY-20 opposes the Plk4-related kinase ZYG-1 to limit centrosome size. Dev Cell (2008) 1.27

Kinesin-14 family proteins HSET/XCTK2 control spindle length by cross-linking and sliding microtubules. Mol Biol Cell (2008) 1.25

Interplay between innate immunity and negative-strand RNA viruses: towards a rational model. Microbiol Mol Biol Rev (2011) 1.22

Interaction between Poly(ADP-ribose) and NuMA contributes to mitotic spindle pole assembly. Mol Biol Cell (2009) 1.20

Diazonamide toxins reveal an unexpected function for ornithine delta-amino transferase in mitotic cell division. Proc Natl Acad Sci U S A (2007) 1.19

The perichromosomal layer. Chromosoma (2005) 1.16

Nuclear pore proteins and the control of genome functions. Genes Dev (2015) 1.16

The Nup107-160 nucleoporin complex promotes mitotic events via control of the localization state of the chromosome passenger complex. Mol Biol Cell (2009) 1.15

Cohesin subunit SMC1 associates with mitotic microtubules at the spindle pole. Proc Natl Acad Sci U S A (2008) 1.15

Structural and functional analysis of the interaction between the nucleoporin Nup98 and the mRNA export factor Rae1. Proc Natl Acad Sci U S A (2010) 1.11

Mlp1 acts as a mitotic scaffold to spatially regulate spindle assembly checkpoint proteins in Aspergillus nidulans. Mol Biol Cell (2009) 1.10

Centrin 2 localizes to the vertebrate nuclear pore and plays a role in mRNA and protein export. Mol Cell Biol (2008) 1.10

CAR-1 and trailer hitch: driving mRNP granule function at the ER? J Cell Biol (2006) 1.10

PinX1 is a novel microtubule-binding protein essential for accurate chromosome segregation. J Biol Chem (2009) 1.09

Importin-beta and the small guanosine triphosphatase Ran mediate chromosome loading of the human chromokinesin Kid. J Cell Biol (2008) 1.07

RNA localization and polarity: from A(PC) to Z(BP). Trends Cell Biol (2009) 1.07

Yeast Rrp14p is required for ribosomal subunit synthesis and for correct positioning of the mitotic spindle during mitosis. Nucleic Acids Res (2007) 1.06

Nup98 regulates bipolar spindle assembly through association with microtubules and opposition of MCAK. Mol Biol Cell (2011) 1.05

Core exosome-independent roles for Rrp6 in cell cycle progression. Mol Biol Cell (2009) 1.05

hnRNPs Relocalize to the cytoplasm following infection with vesicular stomatitis virus. J Virol (2008) 1.04

Do nuclear envelope and intranuclear proteins reorganize during mitosis to form an elastic, hydrogel-like spindle matrix? Chromosome Res (2011) 1.03

Translational regulation of the cell cycle: when, where, how and why? Philos Trans R Soc Lond B Biol Sci (2011) 1.03

The function of spliceosome components in open mitosis. Nucleus (2010) 1.01

Cohesin associates with spindle poles in a mitosis-specific manner and functions in spindle assembly in vertebrate cells. Mol Biol Cell (2008) 1.00

Inner/Outer nuclear membrane fusion in nuclear pore assembly: biochemical demonstration and molecular analysis. Mol Biol Cell (2010) 1.00

Centromeres were derived from telomeres during the evolution of the eukaryotic chromosome. Proc Natl Acad Sci U S A (2007) 0.99

Crystal structure of the 25 kDa subunit of human cleavage factor Im. Nucleic Acids Res (2008) 0.99

Nucleo-cytoplasmic transport of proteins and RNA in plants. Plant Cell Rep (2010) 0.98

Double duty for nuclear proteins--the price of more open forms of mitosis. Trends Genet (2009) 0.98

Transportin regulates major mitotic assembly events: from spindle to nuclear pore assembly. Mol Biol Cell (2009) 0.98

A spatio-temporal analysis of matrix protein and nucleocapsid trafficking during vesicular stomatitis virus uncoating. PLoS Pathog (2010) 0.97

Viral subversion of nucleocytoplasmic trafficking. Traffic (2013) 0.97

RAE-1, a novel PHR binding protein, is required for axon termination and synapse formation in Caenorhabditis elegans. J Neurosci (2012) 0.97

Organization of cytokeratin cytoskeleton and germ plasm in the vegetal cortex of Xenopus laevis oocytes depends on coding and non-coding RNAs: three-dimensional and ultrastructural analysis. Exp Cell Res (2007) 0.97

Characterization of the role of the tumor marker Nup88 in mitosis. Mol Cancer (2010) 0.96

Centrosomal RNA correlates with intron-poor nuclear genes in Spisula oocytes. Proc Natl Acad Sci U S A (2008) 0.95

Deficiency of ALADIN impairs redox homeostasis in human adrenal cells and inhibits steroidogenesis. Endocrinology (2013) 0.95

Xenopus Shugoshin 2 regulates the spindle assembly pathway mediated by the chromosomal passenger complex. EMBO J (2012) 0.95

Regulation of microtubule assembly and organization in mitosis by the AAA+ ATPase Pontin. Mol Biol Cell (2008) 0.94

The Prp19 complex directly functions in mitotic spindle assembly. PLoS One (2013) 0.93

The RanGTP Pathway: From Nucleo-Cytoplasmic Transport to Spindle Assembly and Beyond. Front Cell Dev Biol (2016) 0.93

Vesicular stomatitis virus inhibits mitotic progression and triggers cell death. EMBO Rep (2009) 0.92

Complexes of vesicular stomatitis virus matrix protein with host Rae1 and Nup98 involved in inhibition of host transcription. PLoS Pathog (2012) 0.92

Interferon response and viral evasion by members of the family rhabdoviridae. Viruses (2009) 0.92

SBDS expression and localization at the mitotic spindle in human myeloid progenitors. PLoS One (2009) 0.92

Mechanisms of plant spindle formation. Chromosome Res (2011) 0.89

RNA-binding protein RBM8A (Y14) and MAGOH localize to centrosome in human A549 cells. Histochem Cell Biol (2013) 0.89

Reprofiled drug targets ancient protozoans: drug discovery for parasitic diarrheal diseases. Gut Microbes (2012) 0.88

The nuclear envelopathies and human diseases. J Biomed Sci (2009) 0.87

Translational control of maskin mRNA by its 3' untranslated region. Biol Cell (2007) 0.86

CaM kinase II initiates meiotic spindle depolymerization independently of APC/C activation. J Cell Biol (2008) 0.86

Assembly of RNP granules in stressed and aging oocytes requires nucleoporins and is coordinated with nuclear membrane blebbing. Dev Biol (2011) 0.85

RNA stimulates Aurora B kinase activity during mitosis. PLoS One (2014) 0.84

Molecular insights into intracellular RNA localization. Int Rev Cell Mol Biol (2013) 0.84

The mitotic arrest deficient protein MAD2B interacts with the small GTPase RAN throughout the cell cycle. PLoS One (2009) 0.84

RNA in centrosomes: structure and possible functions. Protoplasma (2012) 0.84

Learning about cancer from frogs: analysis of mitotic spindles in Xenopus egg extracts. Dis Model Mech (2009) 0.84

InsP6-sensitive variants of the Gle1 mRNA export factor rescue growth and fertility defects of the ipk1 low-phytic-acid mutation in Arabidopsis. Plant Cell (2015) 0.83

Non-coding RNAs enter mitosis: functions, conservation and implications. Cell Div (2011) 0.82

Nuclear imprisonment: viral strategies to arrest host mRNA nuclear export. Viruses (2013) 0.82

Centromeric Transcription Regulates Aurora-B Localization and Activation. Cell Rep (2016) 0.82

Nuclear transport factors: global regulation of mitosis. Curr Opin Cell Biol (2015) 0.81

Schizosaccharomyces pombe Dss1p is a DNA damage checkpoint protein that recruits Rad24p, Cdc25p, and Rae1p to DNA double-strand breaks. J Biol Chem (2010) 0.80

Xenopus importin beta validates human importin beta as a cell cycle negative regulator. BMC Cell Biol (2008) 0.80

New mitotic regulators released from chromatin. Front Oncol (2013) 0.80

The centrosome and spindle as a ribonucleoprotein complex. Chromosome Res (2011) 0.78

The PHR proteins: intracellular signaling hubs in neuronal development and axon degeneration. Neural Dev (2016) 0.78

Articles by these authors

Visualization of a Ran-GTP gradient in interphase and mitotic Xenopus egg extracts. Science (2002) 4.26

Dissection of the mammalian midbody proteome reveals conserved cytokinesis mechanisms. Science (2004) 3.48

Analysis of a RanGTP-regulated gradient in mitotic somatic cells. Nature (2006) 3.47

Mechanisms of mitotic spindle assembly and function. Int Rev Cytol (2008) 3.44

Mechanisms and molecules of the mitotic spindle. Curr Biol (2004) 3.25

The RanGTP gradient - a GPS for the mitotic spindle. J Cell Sci (2008) 2.78

The DEAD box protein Dhh1 stimulates the decapping enzyme Dcp1. EMBO J (2002) 2.65

Activation of the DExD/H-box protein Dbp5 by the nuclear-pore protein Gle1 and its coactivator InsP6 is required for mRNA export. Nat Cell Biol (2006) 2.58

Katanin contributes to interspecies spindle length scaling in Xenopus. Cell (2011) 2.16

Cytoplasmic volume modulates spindle size during embryogenesis. Science (2013) 1.88

Investigating mitotic spindle assembly and function in vitro using Xenopus laevis egg extracts. Nat Protoc (2006) 1.80

Nuclear size is regulated by importin α and Ntf2 in Xenopus. Cell (2010) 1.79

A conserved mechanism of DEAD-box ATPase activation by nucleoporins and InsP6 in mRNA export. Nature (2011) 1.70

Methods for studying spindle assembly and chromosome condensation in Xenopus egg extracts. Methods Mol Biol (2006) 1.65

Identification of a novel protein regulating microtubule stability through a chemical approach. Chem Biol (2004) 1.64

Xenopus tropicalis egg extracts provide insight into scaling of the mitotic spindle. J Cell Biol (2007) 1.63

REEP3/4 ensure endoplasmic reticulum clearance from metaphase chromatin and proper nuclear envelope architecture. Dev Cell (2013) 1.62

The N-terminal domain of Nup159 forms a beta-propeller that functions in mRNA export by tethering the helicase Dbp5 to the nuclear pore. Mol Cell (2004) 1.59

Genome-wide analysis demonstrates conserved localization of messenger RNAs to mitotic microtubules. J Cell Biol (2007) 1.55

Dynamic profiling of mRNA turnover reveals gene-specific and system-wide regulation of mRNA decay. Mol Biol Cell (2011) 1.54

A computational model predicts Xenopus meiotic spindle organization. J Cell Biol (2010) 1.53

Role of the Ndc1 interaction network in yeast nuclear pore complex assembly and maintenance. J Cell Biol (2009) 1.49

Histone H1 is essential for mitotic chromosome architecture and segregation in Xenopus laevis egg extracts. J Cell Biol (2005) 1.43

Yeast poly(A)-binding protein Pab1 shuttles between the nucleus and the cytoplasm and functions in mRNA export. RNA (2005) 1.42

Importazole, a small molecule inhibitor of the transport receptor importin-β. ACS Chem Biol (2011) 1.39

Mechanisms of intracellular scaling. Annu Rev Cell Dev Biol (2012) 1.35

Selectivity mechanism of the nuclear pore complex characterized by single cargo tracking. Nature (2010) 1.33

Xorbit/CLASP links dynamic microtubules to chromosomes in the Xenopus meiotic spindle. J Cell Biol (2006) 1.31

Micromanipulation studies of chromatin fibers in Xenopus egg extracts reveal ATP-dependent chromatin assembly dynamics. Mol Biol Cell (2006) 1.27

The role of the integral membrane nucleoporins Ndc1p and Pom152p in nuclear pore complex assembly and function. J Cell Biol (2006) 1.25

The nucleoporins Nup170p and Nup157p are essential for nuclear pore complex assembly. J Cell Biol (2009) 1.24

The FG-repeat asymmetry of the nuclear pore complex is dispensable for bulk nucleocytoplasmic transport in vivo. J Cell Biol (2004) 1.20

Mitotic spindle scaling during Xenopus development by kif2a and importin α. Elife (2013) 1.18

Nuclear actin and protein 4.1: essential interactions during nuclear assembly in vitro. Proc Natl Acad Sci U S A (2003) 1.17

The perichromosomal layer. Chromosoma (2005) 1.16

Centrosome proteins form an insoluble perinuclear matrix during muscle cell differentiation. BMC Cell Biol (2009) 1.10

Nuclear transport is becoming crystal clear. Chromosoma (2006) 1.09

The condensin complex is required for proper spindle assembly and chromosome segregation in Xenopus egg extracts. J Cell Biol (2003) 1.07

Essential roles for cohesin in kinetochore and spindle function in Xenopus egg extracts. J Cell Sci (2006) 1.07

Multiple domains of human CLASP contribute to microtubule dynamics and organization in vitro and in Xenopus egg extracts. Cytoskeleton (Hoboken) (2012) 1.02

A negative feedback loop at the nuclear periphery regulates GAL gene expression. Mol Biol Cell (2012) 1.01

Nuclear pore complex-a coat specifically tailored for the nuclear envelope. Curr Opin Cell Biol (2011) 1.01

Discovery of selective aminothiazole aurora kinase inhibitors. ACS Chem Biol (2008) 1.00

The DExD/H box ATPase Dhh1 functions in translational repression, mRNA decay, and processing body dynamics. J Cell Biol (2011) 0.98

Scaffold nucleoporins Nup188 and Nup192 share structural and functional properties with nuclear transport receptors. Elife (2013) 0.98

Adenomatous polyposis coli associates with the microtubule-destabilizing protein XMCAK. Curr Biol (2004) 0.97

Xnf7 contributes to spindle integrity through its microtubule-bundling activity. Curr Biol (2005) 0.96

Mitotic chromosome size scaling in Xenopus. Cell Cycle (2011) 0.94

Analysis of microtubule polymerization in vitro and during the cell cycle in Xenopus egg extracts. Methods (2006) 0.94

Structure of the C-terminus of the mRNA export factor Dbp5 reveals the interaction surface for the ATPase activator Gle1. Proc Natl Acad Sci U S A (2009) 0.92

Spatial distribution and mobility of the Ran GTPase in live interphase cells. Biophys J (2009) 0.90

Mitotic spindle assembly around RCC1-coated beads in Xenopus egg extracts. PLoS Biol (2011) 0.90

Characterization of hCINAP, a novel coilin-interacting protein encoded by a transcript from the transcription factor TAFIID32 locus. J Biol Chem (2005) 0.89

Interplay between spindle architecture and function. Int Rev Cell Mol Biol (2013) 0.89

Scratch n' screen for inhibitors of cell migration. Chem Biol (2005) 0.88

Atomic force microscope imaging of chromatin assembled in Xenopus laevis egg extract. Chromosoma (2011) 0.88

Functional comparison of H1 histones in Xenopus reveals isoform-specific regulation by Cdk1 and RanGTP. Curr Biol (2010) 0.88

Two distinct domains of protein 4.1 critical for assembly of functional nuclei in vitro. J Biol Chem (2002) 0.87

The long and the short of it: linker histone H1 is required for metaphase chromosome compaction. Cell Cycle (2006) 0.87

Histone H1 compacts DNA under force and during chromatin assembly. Mol Biol Cell (2012) 0.86

RanGTP and CLASP1 cooperate to position the mitotic spindle. Mol Biol Cell (2013) 0.86

The C-terminal extension of the small GTPase Ran is essential for defining the GDP-bound form. J Mol Biol (2002) 0.86

Two protein 4.1 domains essential for mitotic spindle and aster microtubule dynamics and organization in vitro. J Biol Chem (2004) 0.84

SnapShot: motor proteins in spindle assembly. Cell (2008) 0.84

Cell biology. An alternative route for nuclear mRNP export by membrane budding. Science (2012) 0.83

Xenopus egg extracts increase dynamics of histone H1 on sperm chromatin. PLoS One (2010) 0.81

N-terminal phosphorylation of p60 katanin directly regulates microtubule severing. J Mol Biol (2012) 0.80

Analysis of DEAD-box proteins in mRNA export. Methods Enzymol (2012) 0.80

Centrosomes and kinetochores, who needs 'Em? The role of noncentromeric chromatin in spindle assembly. Curr Top Dev Biol (2003) 0.79

Cell structure and dynamics. Curr Opin Cell Biol (2010) 0.78

Chromosome congression: another fine mesh we've gotten into. Dev Cell (2005) 0.76

Challenges facing the biologist doing chemical genetics. Nat Chem Biol (2006) 0.76

Correction: Mitotic noncoding RNA processing promotes kinetochore and spindle assembly in Xenopus. J Cell Biol (2016) 0.75

Altering membrane topology with Sar1 does not impair spindle assembly in Xenopus egg extracts. Cytoskeleton (Hoboken) (2012) 0.75

Cryptic no longer: arrays of CLASP1 TOG domains. Structure (2013) 0.75

Rebecca Heald: passionate about cycles. Interview by Caitlin Sedwick. J Cell Biol (2008) 0.75

Centromere glue provides spindle cue. Cell (2004) 0.75

Maxence Nachury: a transporting view of the primary cilium. Interview by Ben Short. J Cell Biol (2010) 0.75

The role of chromosome architecture in spindle assembly and anaphase: the condensed version. Cell Cycle (2003) 0.75

Durhane Wong-Rieger: championing patients. Lancet Diabetes Endocrinol (2014) 0.75

Infectious disease surveillance update. Lancet Infect Dis (2013) 0.75

Rebecca Heald. Curr Biol (2010) 0.75