Published in Nat Struct Biol on May 01, 2002
Searching for IRES. RNA (2006) 2.78
Viral IRES RNA structures and ribosome interactions. Trends Biochem Sci (2008) 2.17
Toward a structural understanding of IRES RNA function. Curr Opin Struct Biol (2009) 1.83
Structure and function of HCV IRES domains. Virus Res (2008) 1.81
Studying hepatitis C virus: making the best of a bad virus. J Virol (2007) 1.62
Crystal structure of the HCV IRES central domain reveals strategy for start-codon positioning. Structure (2011) 1.44
A long-range RNA-RNA interaction between the 5' and 3' ends of the HCV genome. RNA (2009) 1.34
High-resolution functional profiling of hepatitis C virus genome. PLoS Pathog (2008) 1.30
Viral internal ribosome entry site elements: novel ribosome-RNA complexes and roles in viral pathogenesis. J Virol (2003) 1.29
Canonical initiation factor requirements of the Myc family of internal ribosome entry segments. Mol Cell Biol (2009) 1.21
A cross-kingdom internal ribosome entry site reveals a simplified mode of internal ribosome entry. Mol Cell Biol (2005) 1.13
HCV IRES domain IIb affects the configuration of coding RNA in the 40S subunit's decoding groove. RNA (2011) 1.12
The structures of nonprotein-coding RNAs that drive internal ribosome entry site function. Wiley Interdiscip Rev RNA (2012) 1.12
The solution structure of an essential stem-loop of human telomerase RNA. Nucleic Acids Res (2003) 1.06
A hepatitis C virus (HCV) internal ribosome entry site (IRES) domain III-IV-targeted aptamer inhibits translation by binding to an apical loop of domain IIId. Nucleic Acids Res (2005) 1.03
Analysis of natural variants of the hepatitis C virus internal ribosome entry site reveals that primary sequence plays a key role in cap-independent translation. Nucleic Acids Res (2008) 1.03
Intracellular inhibition of hepatitis C virus (HCV) internal ribosomal entry site (IRES)-dependent translation by peptide nucleic acids (PNAs) and locked nucleic acids (LNAs). Nucleic Acids Res (2004) 1.02
Inhibition of the protein kinase PKR by the internal ribosome entry site of hepatitis C virus genomic RNA. RNA (2003) 1.01
Functional analyses of RNA structures shared between the internal ribosome entry sites of hepatitis C virus and the picornavirus porcine teschovirus 1 Talfan. J Virol (2006) 1.01
Hepatitis C virus translation inhibitors targeting the internal ribosomal entry site. J Med Chem (2013) 1.00
Structure of the full-length HCV IRES in solution. Nat Commun (2013) 0.97
Structure-function analysis of the ribozymes of chrysanthemum chlorotic mottle viroid: a loop-loop interaction motif conserved in most natural hammerheads. Nucleic Acids Res (2008) 0.96
Distinct regions of human eIF3 are sufficient for binding to the HCV IRES and the 40S ribosomal subunit. J Mol Biol (2010) 0.92
RNA structural elements of hepatitis C virus controlling viral RNA translation and the implications for viral pathogenesis. Viruses (2012) 0.88
The folding of the hepatitis C virus internal ribosome entry site depends on the 3'-end of the viral genome. Nucleic Acids Res (2012) 0.86
Comparing the three-dimensional structures of Dicistroviridae IGR IRES RNAs with other viral RNA structures. Virus Res (2008) 0.85
Targeted inhibition of the hepatitis C internal ribosomal entry site genomic RNA with oligonucleotide conjugates. Nucleic Acids Res (2007) 0.80
LOOP IIId of the HCV IRES is essential for the structural rearrangement of the 40S-HCV IRES complex. Nucleic Acids Res (2015) 0.79
Understanding the potential of hepatitis C virus internal ribosome entry site domains to modulate translation initiation via their structure and function. Wiley Interdiscip Rev RNA (2014) 0.78
A magnesium-induced RNA conformational switch at the internal ribosome entry site of hepatitis C virus genome visualized by atomic force microscopy. Nucleic Acids Res (2014) 0.78
1.25 Å resolution structure of an RNA 20-mer that binds to the TREX2 complex. Acta Crystallogr F Struct Biol Commun (2015) 0.77
Schizophrenia: a pathogenetic autoimmune disease caused by viruses and pathogens and dependent on genes. J Pathog (2011) 0.76
Design of a novel globular protein fold with atomic-level accuracy. Science (2003) 13.06
RNA-binding proteins: modular design for efficient function. Nat Rev Mol Cell Biol (2007) 5.33
Control of alternative splicing through siRNA-mediated transcriptional gene silencing. Nat Struct Mol Biol (2009) 3.47
Cancer-associated regulation of alternative splicing. Nat Struct Mol Biol (2009) 3.35
Identification of alternative splicing markers for breast cancer. Cancer Res (2008) 2.51
The structure and function of small nucleolar ribonucleoproteins. Nucleic Acids Res (2007) 2.50
Strong correlation between SHAPE chemistry and the generalized NMR order parameter (S2) in RNA. J Am Chem Soc (2008) 2.26
Recognition of GU-rich polyadenylation regulatory elements by human CstF-64 protein. EMBO J (2003) 2.01
Visualizing the chemistry and structure dynamics in lithium-ion batteries by in-situ neutron diffraction. Sci Rep (2012) 1.88
Multiple and specific mRNA processing targets for the major human hnRNP proteins. Mol Cell Biol (2008) 1.78
Protein families and RNA recognition. FEBS J (2005) 1.65
Impact of a more restrictive approach to urinary tract imaging after febrile urinary tract infection. Arch Pediatr Adolesc Med (2011) 1.63
The Cbf5-Nop10 complex is a molecular bracket that organizes box H/ACA RNPs. Nat Struct Mol Biol (2005) 1.52
High-resolution structural and thermodynamic analysis of extreme stabilization of human procarboxypeptidase by computational protein design. J Mol Biol (2006) 1.49
Structure of stem-loop IV of Tetrahymena telomerase RNA. EMBO J (2006) 1.49
The highly cooperative folding of small naturally occurring proteins is likely the result of natural selection. Cell (2007) 1.46
The DNA-binding domain of human PARP-1 interacts with DNA single-strand breaks as a monomer through its second zinc finger. J Mol Biol (2011) 1.38
Rational design of inhibitors of HIV-1 TAR RNA through the stabilisation of electrostatic "hot spots". J Mol Biol (2004) 1.37
Simultaneous recognition of HIV-1 TAR RNA bulge and loop sequences by cyclic peptide mimics of Tat protein. Proc Natl Acad Sci U S A (2009) 1.33
Cooperative interaction of transcription termination factors with the RNA polymerase II C-terminal domain. Nat Struct Mol Biol (2010) 1.32
An all-atom, distance-dependent scoring function for the prediction of protein-DNA interactions from structure. Proteins (2007) 1.28
Structural genomics of infectious disease drug targets: the SSGCID. Acta Crystallogr Sect F Struct Biol Cryst Commun (2011) 1.27
A new hydrogen-bonding potential for the design of protein-RNA interactions predicts specific contacts and discriminates decoys. Nucleic Acids Res (2004) 1.27
Three-way RNA junctions with remote tertiary contacts: a recurrent and highly versatile fold. RNA (2009) 1.26
A knowledge-based potential function predicts the specificity and relative binding energy of RNA-binding proteins. FEBS J (2007) 1.26
Effect of pre-heating resin composite on restoration microleakage. Oper Dent (2008) 1.25
Proteins associated with the exon junction complex also control the alternative splicing of apoptotic regulators. Mol Cell Biol (2011) 1.24
NMR studies of dynamics in RNA and DNA by 13C relaxation. Biopolymers (2007) 1.24
RBFOX2 is an important regulator of mesenchymal tissue-specific splicing in both normal and cancer tissues. Mol Cell Biol (2012) 1.22
Structure-guided peptidomimetic design leads to nanomolar beta-hairpin inhibitors of the Tat-TAR interaction of bovine immunodeficiency virus. Biochemistry (2007) 1.20
How binding of small molecule and peptide ligands to HIV-1 TAR alters the RNA motional landscape. Nucleic Acids Res (2009) 1.20
The C-terminal domains of vertebrate CstF-64 and its yeast orthologue Rna15 form a new structure critical for mRNA 3'-end processing. J Biol Chem (2006) 1.20
Real-time multidimensional NMR follows RNA folding with second resolution. Proc Natl Acad Sci U S A (2010) 1.18
13C NMR relaxation studies of RNA base and ribose nuclei reveal a complex pattern of motions in the RNA binding site for human U1A protein. J Mol Biol (2005) 1.18
Alternative splicing of SYK regulates mitosis and cell survival. Nat Struct Mol Biol (2011) 1.17
Hydration dependent dynamics in RNA. J Biomol NMR (2009) 1.17
A new alpha-helical extension promotes RNA binding by the dsRBD of Rnt1p RNAse III. EMBO J (2004) 1.12
Structural mimicry of retroviral tat proteins by constrained beta-hairpin peptidomimetics: ligands with high affinity and selectivity for viral TAR RNA regulatory elements. J Am Chem Soc (2004) 1.11
Structural basis for contrasting activities of ribosome binding thiazole antibiotics. Chem Biol (2003) 1.10
TAR RNA recognition by a cyclic peptidomimetic of Tat protein. Biochemistry (2005) 1.09
Protein and RNA dynamics play key roles in determining the specific recognition of GU-rich polyadenylation regulatory elements by human Cstf-64 protein. J Mol Biol (2005) 1.07
Structure and stability of wild-type and mutant RNA internal loops from the SL-1 domain of the HIV-1 packaging signal. J Mol Biol (2002) 1.07
How arginine-rich domains coordinate mRNA maturation events. RNA Biol (2007) 1.07
The solution structure of an essential stem-loop of human telomerase RNA. Nucleic Acids Res (2003) 1.06
Structural basis for stabilization of the tau pre-mRNA splicing regulatory element by novantrone (mitoxantrone). Chem Biol (2009) 1.06
The structure of an enzyme-activating fragment of human telomerase RNA. RNA (2005) 1.06
Engineering RNA-binding proteins for biology. FEBS J (2013) 1.06
Towards the discovery of drug-like RNA ligands? Drug Discov Today (2006) 1.06
γ-AApeptides bind to RNA by mimicking RNA-binding proteins. Org Biomol Chem (2011) 1.06
The PUA domain - a structural and functional overview. FEBS J (2007) 1.05
Validation of automated docking programs for docking and database screening against RNA drug targets. J Med Chem (2004) 1.05
Binding of U1A protein changes RNA dynamics as observed by 13C NMR relaxation studies. Biochemistry (2007) 1.05
Solid-state deuterium NMR studies reveal micros-ns motions in the HIV-1 transactivation response RNA recognition site. J Am Chem Soc (2008) 1.05
PRPF mutations are associated with generalized defects in spliceosome formation and pre-mRNA splicing in patients with retinitis pigmentosa. Hum Mol Genet (2011) 1.04
MBNL1 and RBFOX2 cooperate to establish a splicing programme involved in pluripotent stem cell differentiation. Nat Commun (2013) 1.03
Essential structural requirements for specific recognition of HIV TAR RNA by peptide mimetics of Tat protein. Nucleic Acids Res (2010) 1.00
Novel protein-protein contacts facilitate mRNA 3'-processing signal recognition by Rna15 and Hrp1. J Mol Biol (2010) 1.00
The box H/ACA RNP assembly factor Naf1p contains a domain homologous to Gar1p mediating its interaction with Cbf5p. J Mol Biol (2007) 0.99
Inhibition of both HIV-1 reverse transcription and gene expression by a cyclic peptide that binds the Tat-transactivating response element (TAR) RNA. PLoS Pathog (2011) 0.97
Structure-function analysis of the ribozymes of chrysanthemum chlorotic mottle viroid: a loop-loop interaction motif conserved in most natural hammerheads. Nucleic Acids Res (2008) 0.96
High-resolution structural validation of the computational redesign of human U1A protein. Structure (2006) 0.96
Evolving a polymerase for hydrophobic base analogues. J Am Chem Soc (2009) 0.95
Design of beta-hairpin peptidomimetics that inhibit binding of alpha-helical HIV-1 Rev protein to the rev response element RNA. Angew Chem Int Ed Engl (2007) 0.95
Monitoring tat peptide binding to TAR RNA by solid-state 31P-19F REDOR NMR. Nucleic Acids Res (2005) 0.94
Mitoxantrone analogues as ligands for a stem-loop structure of tau pre-mRNA. J Med Chem (2009) 0.94
Cell-free production of functional Plasmodium falciparum dihydrofolate reductase-thymidylate synthase. Mol Biochem Parasitol (2006) 0.93
Structure of the yeast SR protein Npl3 and Interaction with mRNA 3'-end processing signals. J Mol Biol (2007) 0.93
Mis-translation of a computationally designed protein yields an exceptionally stable homodimer: implications for protein engineering and evolution. J Mol Biol (2006) 0.93
Survival advantages conferred to colon cancer cells by E-selectin-induced activation of the PI3K-NFκB survival axis downstream of Death receptor-3. BMC Cancer (2011) 0.91
The structure of a Burkholderia pseudomallei immunophilin-inhibitor complex reveals new approaches to antimicrobial development. Biochem J (2011) 0.91
13C relaxation studies of the DNA target sequence for hhai methyltransferase reveal unique motional properties. Biochemistry (2008) 0.91
Theory of nonrigid rotational motion applied to NMR relaxation in RNA. J Phys Chem A (2011) 0.91
Design and characterization of libraries of molecular fragments for use in NMR screening against protein targets. J Chem Inf Comput Sci (2004) 0.90
Intermediate rate atomic trajectories of RNA by solid-state NMR spectroscopy. J Am Chem Soc (2010) 0.89
A model for C74 addition by CCA-adding enzymes: C74 addition, like C75 and A76 addition, does not involve tRNA translocation. J Biol Chem (2006) 0.89
A G-tract element in apoptotic agents-induced alternative splicing. Nucleic Acids Res (2008) 0.88
Reducing teachers' psychological distress through a mindfulness training program. Span J Psychol (2010) 0.88
Structural insight on the control of urea synthesis: identification of the binding site for N-acetyl-L-glutamate, the essential allosteric activator of mitochondrial carbamoyl phosphate synthetase. Biochem J (2009) 0.87
The H/ACA RNP assembly factor SHQ1 functions as an RNA mimic. Genes Dev (2011) 0.87
Contrasting views of the internal dynamics of the HhaI methyltransferase target DNA reported by solution and solid-state NMR spectroscopy. J Am Chem Soc (2006) 0.87
How a rotavirus hijacks the human protein synthesis machinery. Nat Struct Biol (2002) 0.87
Modulation of 5' splice site selection using tailed oligonucleotides carrying splicing signals. BMC Biotechnol (2006) 0.87
The future of proteomics in the study of alcoholism. Alcohol Clin Exp Res (2004) 0.86
Slow exchange model of nonrigid rotational motion in RNA for combined solid-state and solution NMR studies. J Phys Chem B (2010) 0.86
Solution structure of the influenza A virus cRNA promoter: implications for differential recognition of viral promoter structures by RNA-dependent RNA polymerase. Nucleic Acids Res (2003) 0.85
A small-molecule probe induces a conformation in HIV TAR RNA capable of binding drug-like fragments. J Mol Biol (2011) 0.85
Tumor microenvironment-associated modifications of alternative splicing. RNA (2013) 0.85
Furanose dynamics in the HhaI methyltransferase target DNA studied by solution and solid-state NMR relaxation. J Phys Chem B (2008) 0.85
Multivalent drug design and inhibition of cholera toxin by specific and transient protein-ligand interactions. Chem Biol Drug Des (2008) 0.85
Molecular dynamics simulation of the RNA complex of a double-stranded RNA-binding domain reveals dynamic features of the intermolecular interface and its hydration. Biophys J (2002) 0.85
Structure and functional relevance of a transcription-regulating sequence involved in coronavirus discontinuous RNA synthesis. J Virol (2011) 0.84
Identification of the optimal third generation antifolate against P. falciparum and P. vivax. Mol Biochem Parasitol (2005) 0.83
The box H/ACA snoRNP assembly factor Shq1p is a chaperone protein homologous to Hsp90 cochaperones that binds to the Cbf5p enzyme. J Mol Biol (2009) 0.83
Decoding RNA motional codes. Trends Biochem Sci (2006) 0.82
Next-generation biobanking of metastases to enable multidimensional molecular profiling in personalized medicine. Mod Pathol (2013) 0.82
miRNA sensitivity to Drosha levels correlates with pre-miRNA secondary structure. RNA (2014) 0.82
Nop10 is a conserved H/ACA snoRNP molecular adaptor. Biochemistry (2008) 0.82
Independent alignment of RNA for dynamic studies using residual dipolar couplings. J Biomol NMR (2012) 0.82
A novel small-molecule binds to the influenza A virus RNA promoter and inhibits viral replication. Chem Commun (Camb) (2013) 0.82